KENNETH SK TUNG

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control
    K S K Tung
    Department of Pathology, Health Science Center, University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
    Curr Top Microbiol Immunol 293:209-47. 2005
  2. ncbi request reprint Mechanism of infertility in male guinea pigs immunized with sperm PH-20
    K S Tung
    Department of Pathology and Microbiology, University of Virginia, Charlottesville 22908, USA
    Biol Reprod 56:1133-41. 1997
  3. ncbi request reprint Autoimmune ovarian disease: mechanism of induction and prevention
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Soc Gynecol Investig 8:S49-51. 2001
  4. ncbi request reprint Autoimmune ovarian disease: mechanism of disease induction and prevention
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Curr Opin Immunol 9:839-45. 1997
  5. ncbi request reprint Regulatory T-cell, endogenous antigen and neonatal environment in the prevention and induction of autoimmune disease
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    Immunol Rev 182:135-48. 2001
  6. ncbi request reprint Rapid induction of autoantibodies by endogenous ovarian antigens and activated T cells: implication in autoimmune disease pathogenesis and B cell tolerance
    Y H Lou
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    J Immunol 156:3535-40. 1996
  7. ncbi request reprint Retargeting T cell-mediated inflammation: a new perspective on autoantibody action
    Y H Lou
    Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 164:5251-7. 2000
  8. ncbi request reprint Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction
    K M Garza
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    J Immunol 155:5444-8. 1995
  9. ncbi request reprint Mechanism of ovarian autoimmunity: induction of T cell and antibody responses by T cell epitope mimicry and epitope spreading
    K M Garza
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    J Reprod Immunol 37:87-101. 1998
  10. pmc The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells
    N D Griggs
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    J Exp Med 183:801-10. 1996

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Autoimmune ovarian disease in day 3-thymectomized mice: the neonatal time window, antigen specificity of disease suppression, and genetic control
    K S K Tung
    Department of Pathology, Health Science Center, University of Virginia, PO Box 800214, Charlottesville, VA 22908, USA
    Curr Top Microbiol Immunol 293:209-47. 2005
    ..The candidate genes include Pdcd1, TNFR superfamily genes, H2, Il2, Tgfb, Nalp5 or Mater, an oocyte autoAg that reacts with autoantibody in sera of d3tx mice...
  2. ncbi request reprint Mechanism of infertility in male guinea pigs immunized with sperm PH-20
    K S Tung
    Department of Pathology and Microbiology, University of Virginia, Charlottesville 22908, USA
    Biol Reprod 56:1133-41. 1997
    ..Return to fertility, after 6-12 mo, was accompanied by regression of EAO and reappearance of spermatozoa in the caudae epididymides...
  3. ncbi request reprint Autoimmune ovarian disease: mechanism of induction and prevention
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Soc Gynecol Investig 8:S49-51. 2001
    ..Future studies should determine the applicability of these findings to human ovarian autoimmunity...
  4. ncbi request reprint Autoimmune ovarian disease: mechanism of disease induction and prevention
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Curr Opin Immunol 9:839-45. 1997
    ....
  5. ncbi request reprint Regulatory T-cell, endogenous antigen and neonatal environment in the prevention and induction of autoimmune disease
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    Immunol Rev 182:135-48. 2001
    ....
  6. ncbi request reprint Rapid induction of autoantibodies by endogenous ovarian antigens and activated T cells: implication in autoimmune disease pathogenesis and B cell tolerance
    Y H Lou
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    J Immunol 156:3535-40. 1996
    ..As evidence for their pathogenic potentials, amAb were produced in response to oophoritogenic, nonovarian T cell peptides that mimic ZP3; moreover, an excellent correlation existed between amAb titers and fertility reduction...
  7. ncbi request reprint Retargeting T cell-mediated inflammation: a new perspective on autoantibody action
    Y H Lou
    Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 164:5251-7. 2000
    ..We propose that this is a clinically important and previously unappreciated element of Ab action in autoimmune disease...
  8. ncbi request reprint Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction
    K M Garza
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    J Immunol 155:5444-8. 1995
    ..On the other hand, the sharing of critical residue motif per se is not sufficient for mimicry to occur, nor does it predict peptide cross-reaction...
  9. ncbi request reprint Mechanism of ovarian autoimmunity: induction of T cell and antibody responses by T cell epitope mimicry and epitope spreading
    K M Garza
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    J Reprod Immunol 37:87-101. 1998
    ..However, studies reported on systemic lupus erythematosus models have shown that similar events may result in autoantibody response in systemic autoimmunity...
  10. pmc The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells
    N D Griggs
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    J Exp Med 183:801-10. 1996
    ....
  11. ncbi request reprint Intestinal parasitism terminates self tolerance and enhances neonatal induction of autoimmune disease and memory
    S S Agersborg
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Eur J Immunol 31:851-9. 2001
    ....
  12. ncbi request reprint Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy
    P Alard
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 166:4363-9. 2001
    ..Similar results were obtained in mice OX at 4 wk. Thus endogenous tissue Ag are critical in autoimmune disease induction and progression that occur spontaneously upon regulatory T cell depletion...
  13. ncbi request reprint Persistence of physiological self antigen is required for the regulation of self tolerance
    K M Garza
    Departments of Microbiology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 164:3982-9. 2000
    ..In contrast, exposure to endogenous ovarian Ag confined to the neonatal period is insufficient for the induction and maintenance of tolerance to ZP3...
  14. ncbi request reprint Contraceptive vaccine assessment based on a murine ZP3 mini-autoantigen
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville 22901
    Reprod Fertil Dev 6:349-55. 1994
    ....
  15. pmc Antigen mimicry in autoimmune disease sharing of amino acid residues critical for pathogenic T cell activation
    A M Luo
    Department of Pathology, University of Virginia, Charlottesville 22908
    J Clin Invest 92:2117-23. 1993
    ....
  16. ncbi request reprint Altered target organ. A mechanism of postrecovery resistance to murine autoimmune oophoritis
    Y H Lou
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    J Immunol 155:3667-73. 1995
    ..We conclude that altered local environment of the target organ following autoimmune disease recovery can contribute to the complex disease-resistant state...
  17. ncbi request reprint ZP3 peptide vaccine that induces antibody and reversible infertility without autoimmune oophoritis
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Am J Reprod Immunol 35:181-3. 1996
    ..The vaccine contains (1) a promiscuous foreign T-cell peptide capable of eliciting a T-cell response regardless of the animals' MHC haplotype, and (2) a modified native B-cell peptide of ZP3...
  18. ncbi request reprint Mechanism of self-tolerance and events leading to autoimmune disease and autoantibody response
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville 22908
    Clin Immunol Immunopathol 73:275-82. 1994
    ..Finally, when T cells that recognize the ZP3 peptide are activated, endogenous ovarian antigens can spontaneously stimulate B cells to produce antibodies that react with ZP3 domains outside the immunizing T cell peptide...
  19. ncbi request reprint Elucidation of autoimmune disease mechanism based on testicular and ovarian autoimmune disease models
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    Horm Metab Res 27:539-43. 1995
    ..Importantly, the autoantibodies react with native antigenic determinants, and are potentially important in autoimmune disease pathogenesis...
  20. ncbi request reprint Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccine
    H Bagavant
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Biol Reprod 56:764-70. 1997
    ....
  21. ncbi request reprint Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in mice
    H Bagavant
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 61:635-42. 1999
    ..Despite these changes, fertility rates and gonadotropin-induced follicular development remained essentially normal. Therefore, normal ovarian function is compatible with severe ovarian inflammation mediated by autoreactive T cells...
  22. ncbi request reprint Acute testicular ischemia results in germ cell-specific apoptosis in the rat
    T T Turner
    Department of Urology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Biol Reprod 57:1267-74. 1997
    ..These events were contemporaneous with the first appearance of apoptosis and consistent with the hypothesis that post-torsion, germ cell-specific apoptosis is induced by reactive oxygen species...
  23. ncbi request reprint Mechanisms of autoimmune disease in the testis and ovary
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Hum Reprod Update 1:35-50. 1995
    ..A novel mechanism of autoantibody induction and an immunogenetic approach to autoimmune oophoritis and orchitis, based on molecular linkage analysis of inbred mice, are also reviewed...
  24. pmc Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization
    M S Chen
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 96:11830-5. 1999
    ..Our results suggest that high-avidity binding between fertilin beta (ADAM 2) and alpha6beta1 requires cooperation between alpha6beta1 and CD9. Such cooperation may assist sperm passage into the oviduct as well as sperm-egg interactions...
  25. ncbi request reprint NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci
    S T Waters
    Division of Rheumatology and Immunology, The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, Charlottesville, Virginia 22908, USA
    Clin Immunol 100:372-83. 2001
    ..These results provide evidence for the importance of background genes on the expression of SLE, with implications for genetic studies of human SLE...

Research Grants22

  1. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
  2. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Nurnbet_ Face Page .................................................................................................................................................. 1 Description, ..
  3. Zona Pellucida - Immunopathological Study
    Kenneth Tung; Fiscal Year: 2007
    ..By exploiting appropriate autoimmune disease models, we aim to elucidate important cellular mechanisms whereby the autoimmune process is normally controlled, and how clinical autoimmunity is induced. ..
  4. Antibody induced T cell-mediated neonatal autoimmunity.
    Kenneth Tung; Fiscal Year: 2009
    ....
  5. Zona Pellucida - Immunopathological Study
    Kenneth Tung; Fiscal Year: 2009
    ..By exploiting appropriate autoimmune disease models, we aim to elucidate important cellular mechanisms whereby the autoimmune process is normally controlled, and how clinical autoimmunity is induced. ..
  6. Antibody induced T cell-mediated neonatal autoimmunity.
    Kenneth S K Tung; Fiscal Year: 2010
    ....
  7. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2006
    ..This proposal will therefore address fundamental mechanisms responsible for autoimmune induction and prevention, and specifically, neonatal autoimmune diseases including systemic lupus-related congenital heart block. ..
  8. ZONA PELLUCIDA--IMMUNOPATHOLOGIC STUDY
    Kenneth Tung; Fiscal Year: 1999
    ....
  9. Antibody induced T cell mediated neonatal autoimmunity
    Kenneth Tung; Fiscal Year: 2003
    ..This proposal will therefore address fundamental mechanisms responsible for autoimmune induction and prevention, and specifically, neonatal autoimmune diseases including systemic lupus-related congenital heart block. ..
  10. ZONA PELLUCIDA--IMMUNOPATHOLOGIC STUDY
    Kenneth Tung; Fiscal Year: 2004
    ..abstract_text> ..
  11. Zona Pellucida - Immunopathological Study
    Kenneth S K Tung; Fiscal Year: 2010
    ..By exploiting appropriate autoimmune disease models, we aim to elucidate important cellular mechanisms whereby the autoimmune process is normally controlled, and how clinical autoimmunity is induced. ..