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Genomes and Genes | Nihal TumerSummaryAffiliation: University of Florida Country: USA Publications
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Publications
Induction of tyrosine hydroxylase and neuropeptide Y by carbachol: modulation with ageN Tumer
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
J Gerontol A Biol Sci Med Sci 54:B418-23. 1999..The present findings cannot explain why the adrenal medullae from senescent rats are resistant to the cold-induced elevation of TH mRNA and TH activity observed in young rats...- Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertensionNihal Tumer
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
J Hypertens 25:2471-8. 2007..The present study employed a rat leptin antagonist to evaluate the role of elevated leptin in obesity-associated hypertension... - Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesityNihal Tumer
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
Neurobiol Aging 27:459-70. 2006..Our observations in aged rats suggest that GDNF may be especially effective in reducing obesity in aged obese rats... - Gene expression of catecholamine biosynthetic enzymes following exercise: modulation by ageN Tumer
Geriatric Research, Education and Clinical Center, Malcom Randall VA Medical Center, Gainesville, FL 32610, USA
Neuroscience 103:703-11. 2001..The responses for exercise training of aged animals differed from the young in brain noradrenergic and dopaminergic nuclei, especially in the substantia nigra, and to some extent in the locus coeruleus and the ventral tegmental area... 
Effect of age on high-fat diet-induced hypertensionBenedek Erdos
Dept of Pharmacology and Therapeutics, Univ of Florida, College of Medicine, P O Box 100267, Gainesville, FL 32610 0267, USA
Am J Physiol Heart Circ Physiol 301:H164-72. 2011..In conclusion, our experiments led to the surprising finding that HF diet has a more serious impact on cardiovascular regulation in young animals compared with old...- Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulationBenedek Erdos
Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Gainesville, FL, USA
Hypertens Res 32:983-8. 2009.... 
Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasisMichael Matheny
Department of Pharmacology and Therapeutic, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Am J Physiol Regul Integr Comp Physiol 297:R1254-61. 2009..These findings underscore the critical role of unrestrained leptin receptor activity in long-term energy homeostasis and suggest that even minor disruption of leptin receptor function can promote obesity...- Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesityFredric P Manfredsson
Department of Neuroscience, Powell Gene Therapy Center, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida, USA
Mol Ther 17:980-91. 2009..Activation of these hypothalamic CRH neurons likely accounted for the observed metabolic effects leading to weight loss in obese rats... - POMC overexpression in the ventral tegmental area ameliorates dietary obesityLourdes M Andino
Departments of Pharmacology and Therapeutics Aging and Geriatrics, University of Florida College of Medicine, PO Box 100267, Gainesville, Florida 32610, USA
J Endocrinol 210:199-207. 2011..In conclusion, these data indicate a role for POMC overexpression within the VTA reward center to combat HF-induced obesity... - Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant ratsAlexandra Shapiro
Department of Pharmacology and Therapeutics, Box 100267, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Diabetes 57:614-22. 2008..Second, we examined if voluntary wheel running is beneficial in reducing the trajectory of weight gain in high-fat-raised leptin-resistant rats... - The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese ratsAlexandra Shapiro
Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Gerontology 57:335-42. 2011..It appears to trigger a response that substitutes for the reward of highly palatable food that may be mediated by increased leptin signaling in the VTA... - Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistancePhilip J Scarpace
Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA
J Pharmacol Exp Ther 320:706-12. 2007..These data reveal an uncoupling between leptin receptor activation and metabolic responses with central leptin resistance... - Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesityYi Zhang
Malcom Randall Veterans Affairs Medical Center, Gainesville, FL 32608, USA
Eur J Neurosci 33:1541-50. 2011..The latter finding provides a clue for countering age-related decline in physical activity... - Hypertensive effects of central angiotensin II infusion and restraint stress are reduced with ageBenedek Erdos
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
J Hypertens 28:1298-306. 2010..We investigated the effect of age on cardiovascular responses mediated by central angiotensin II (AngII) after intracerebroventricular infusion of AngII, and during restraint stress... - Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamusBenedek Erdos
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
Exp Gerontol 42:745-52. 2007..05). These data indicate that a small decrease in daily food intake can avert age-related changes in catecholamine biosynthetic enzyme levels in the adrenal medulla and hypothalamus, possibly through affecting angiotensin II signaling... - Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymesBenedek Erdos
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
Exp Gerontol 43:806-9. 2008.... - Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT IIPhilip J Scarpace
Geriatric Research, Education and Clinical Center 182, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
Neuropharmacology 45:211-9. 2003..We suggest that defective endogenous melanocortin activation may represent one element of leptin resistance, leading to compensatory hypersensitivity of the melanocortin pathway... - Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fastingYi Zhang
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
Biochim Biophys Acta 1584:115-22. 2002..The long-term regulation of adiponectin expression in WAT appears to be the opposite of that of leptin and may be more sensitive to changes in adiposity or insulin sensitivity... - Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nucleiBenedek Erdos
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
J Hypertens 24:109-16. 2006..Centrally applied angiotensin II (Ang II) increases sympathetic nervous activity and mean arterial blood pressure (MAP), but the mediation of these effects is not fully understood... - Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway ratsMelissa A Whidden
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States
Biochem Biophys Res Commun 408:454-8. 2011..Caloric restriction could be a potential non-pharmacological intervention to prevent increased oxidative stress in the sympathetic adrenomedullary system with age... - Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat contentAlexandra Shapiro
Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Box 100267, Gainesville, FL 32610, USA
Br J Nutr 106:390-7. 2011..These data suggest that fructose is the bioactive component of a HF/high-sugar diet that is essential for the induction of leptin resistance... - The age-related discrepancy in the effect of neuropeptide Y on select catecholamine biosynthetic enzymes in the adrenal medulla and hypothalamus in ratsS Remzi Erdem
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA
Neuropharmacology 43:1280-8. 2002..The stimulatory effect of NPY on adrenomedullary CA biosynthetic pathway is blunted with age... - Effect of exercise on mRNA expression of select adrenal medullary catecholamine biosynthetic enzymesS Remzi Erdem
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Appl Physiol 93:463-8. 2002.... - Central angiotensin II increases biosynthesis of tyrosine hydroxylase in the rat adrenal medullaM Devrim Dogan
Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL 32610, USA
Biochem Biophys Res Commun 313:623-6. 2004..In conclusion, one component of central angiotensin II elevation of blood pressure may be the result of increased catecholamine synthesis in the adrenal gland and elevated TH synthesis represents one underlying mechanism... - Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistanceYi Zhang
Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Gainesville, FL 32608-1197, USA
Neurobiol Aging 25:1349-60. 2004..The equally strong orexigenic response to SHU9119 coupled with unaltered POMC expression and food intake in the young versus old suggest that melanocortin tone is unchanged with age despite impaired melanocortin activation by leptin... - Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenancePhilip J Scarpace
Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
Endocrinology 143:3026-35. 2002..We propose that both elevated leptin and obesity may be necessary for the development of leptin resistance... - Increased temperature and protein oxidation lead to HSP72 mRNA and protein accumulation in the in vivo exercised rat heartJessica L Staib
Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118225, Gainesville, FL 32611, USA
Exp Physiol 94:71-80. 2009....