Nihal Tumer

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla
    Nihal Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
    Neurosci Lett 544:62-7. 2013
  2. ncbi request reprint Induction of tyrosine hydroxylase and neuropeptide Y by carbachol: modulation with age
    N Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Gerontol A Biol Sci Med Sci 54:B418-23. 1999
  3. ncbi request reprint Gene expression of catecholamine biosynthetic enzymes following exercise: modulation by age
    N Tumer
    Geriatric Research, Education and Clinical Center, Malcom Randall VA Medical Center, Gainesville, FL 32610, USA
    Neuroscience 103:703-11. 2001
  4. ncbi request reprint Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension
    Nihal Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Hypertens 25:2471-8. 2007
  5. ncbi request reprint Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity
    Nihal Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
    Neurobiol Aging 27:459-70. 2006
  6. doi request reprint Effect of age on high-fat diet-induced hypertension
    Benedek Erdos
    Dept of Pharmacology and Therapeutics, Univ of Florida, College of Medicine, P O Box 100267, Gainesville, FL 32610 0267, USA
    Am J Physiol Heart Circ Physiol 301:H164-72. 2011
  7. doi request reprint Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation
    Benedek Erdos
    Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Gainesville, FL, USA
    Hypertens Res 32:983-8. 2009
  8. pmc Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis
    Michael Matheny
    Department of Pharmacology and Therapeutic, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1254-61. 2009
  9. pmc Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity
    Fredric P Manfredsson
    Department of Neuroscience, Powell Gene Therapy Center, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida, USA
    Mol Ther 17:980-91. 2009
  10. doi request reprint POMC overexpression in the ventral tegmental area ameliorates dietary obesity
    Lourdes M Andino
    Departments of Pharmacology and Therapeutics Aging and Geriatrics, University of Florida College of Medicine, PO Box 100267, Gainesville, Florida 32610, USA
    J Endocrinol 210:199-207. 2011

Collaborators

Detail Information

Publications30

  1. doi request reprint Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla
    Nihal Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
    Neurosci Lett 544:62-7. 2013
    ..Taken together, such effects may be important factors contributing to pathology of brain injury and autonomic dysfunction associated with the clinical profile of patients following OBI...
  2. ncbi request reprint Induction of tyrosine hydroxylase and neuropeptide Y by carbachol: modulation with age
    N Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Gerontol A Biol Sci Med Sci 54:B418-23. 1999
    ..The present findings cannot explain why the adrenal medullae from senescent rats are resistant to the cold-induced elevation of TH mRNA and TH activity observed in young rats...
  3. ncbi request reprint Gene expression of catecholamine biosynthetic enzymes following exercise: modulation by age
    N Tumer
    Geriatric Research, Education and Clinical Center, Malcom Randall VA Medical Center, Gainesville, FL 32610, USA
    Neuroscience 103:703-11. 2001
    ..The responses for exercise training of aged animals differed from the young in brain noradrenergic and dopaminergic nuclei, especially in the substantia nigra, and to some extent in the locus coeruleus and the ventral tegmental area...
  4. ncbi request reprint Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension
    Nihal Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Hypertens 25:2471-8. 2007
    ..The present study employed a rat leptin antagonist to evaluate the role of elevated leptin in obesity-associated hypertension...
  5. ncbi request reprint Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity
    Nihal Tumer
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
    Neurobiol Aging 27:459-70. 2006
    ..Our observations in aged rats suggest that GDNF may be especially effective in reducing obesity in aged obese rats...
  6. doi request reprint Effect of age on high-fat diet-induced hypertension
    Benedek Erdos
    Dept of Pharmacology and Therapeutics, Univ of Florida, College of Medicine, P O Box 100267, Gainesville, FL 32610 0267, USA
    Am J Physiol Heart Circ Physiol 301:H164-72. 2011
    ..In conclusion, our experiments led to the surprising finding that HF diet has a more serious impact on cardiovascular regulation in young animals compared with old...
  7. doi request reprint Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation
    Benedek Erdos
    Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Gainesville, FL, USA
    Hypertens Res 32:983-8. 2009
    ....
  8. pmc Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis
    Michael Matheny
    Department of Pharmacology and Therapeutic, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1254-61. 2009
    ..These findings underscore the critical role of unrestrained leptin receptor activity in long-term energy homeostasis and suggest that even minor disruption of leptin receptor function can promote obesity...
  9. pmc Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity
    Fredric P Manfredsson
    Department of Neuroscience, Powell Gene Therapy Center, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida, USA
    Mol Ther 17:980-91. 2009
    ..Activation of these hypothalamic CRH neurons likely accounted for the observed metabolic effects leading to weight loss in obese rats...
  10. doi request reprint POMC overexpression in the ventral tegmental area ameliorates dietary obesity
    Lourdes M Andino
    Departments of Pharmacology and Therapeutics Aging and Geriatrics, University of Florida College of Medicine, PO Box 100267, Gainesville, Florida 32610, USA
    J Endocrinol 210:199-207. 2011
    ..In conclusion, these data indicate a role for POMC overexpression within the VTA reward center to combat HF-induced obesity...
  11. ncbi request reprint Effect of exercise on mRNA expression of select adrenal medullary catecholamine biosynthetic enzymes
    S Remzi Erdem
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Appl Physiol 93:463-8. 2002
    ....
  12. ncbi request reprint Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats
    Alexandra Shapiro
    Department of Pharmacology and Therapeutics, Box 100267, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Diabetes 57:614-22. 2008
    ..Second, we examined if voluntary wheel running is beneficial in reducing the trajectory of weight gain in high-fat-raised leptin-resistant rats...
  13. ncbi request reprint The age-related discrepancy in the effect of neuropeptide Y on select catecholamine biosynthetic enzymes in the adrenal medulla and hypothalamus in rats
    S Remzi Erdem
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA
    Neuropharmacology 43:1280-8. 2002
    ..The stimulatory effect of NPY on adrenomedullary CA biosynthetic pathway is blunted with age...
  14. pmc The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats
    Alexandra Shapiro
    Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Gerontology 57:335-42. 2011
    ..It appears to trigger a response that substitutes for the reward of highly palatable food that may be mediated by increased leptin signaling in the VTA...
  15. pmc Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity
    Yi Zhang
    Malcom Randall Veterans Affairs Medical Center, Gainesville, FL 32608, USA
    Eur J Neurosci 33:1541-50. 2011
    ..The latter finding provides a clue for countering age-related decline in physical activity...
  16. ncbi request reprint Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance
    Philip J Scarpace
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA
    J Pharmacol Exp Ther 320:706-12. 2007
    ..These data reveal an uncoupling between leptin receptor activation and metabolic responses with central leptin resistance...
  17. ncbi request reprint Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance
    Yi Zhang
    Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Gainesville, FL 32608 1197, USA
    Neurobiol Aging 25:1349-60. 2004
    ..The equally strong orexigenic response to SHU9119 coupled with unaltered POMC expression and food intake in the young versus old suggest that melanocortin tone is unchanged with age despite impaired melanocortin activation by leptin...
  18. pmc Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus
    Benedek Erdos
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
    Exp Gerontol 42:745-52. 2007
    ..05). These data indicate that a small decrease in daily food intake can avert age-related changes in catecholamine biosynthetic enzyme levels in the adrenal medulla and hypothalamus, possibly through affecting angiotensin II signaling...
  19. doi request reprint Hypertensive effects of central angiotensin II infusion and restraint stress are reduced with age
    Benedek Erdos
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Hypertens 28:1298-306. 2010
    ..We investigated the effect of age on cardiovascular responses mediated by central angiotensin II (AngII) after intracerebroventricular infusion of AngII, and during restraint stress...
  20. pmc Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats
    Melissa A Whidden
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States
    Biochem Biophys Res Commun 408:454-8. 2011
    ..Caloric restriction could be a potential non-pharmacological intervention to prevent increased oxidative stress in the sympathetic adrenomedullary system with age...
  21. doi request reprint Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymes
    Benedek Erdos
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, USA
    Exp Gerontol 43:806-9. 2008
    ....
  22. ncbi request reprint Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II
    Philip J Scarpace
    Geriatric Research, Education and Clinical Center 182, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
    Neuropharmacology 45:211-9. 2003
    ..We suggest that defective endogenous melanocortin activation may represent one element of leptin resistance, leading to compensatory hypersensitivity of the melanocortin pathway...
  23. ncbi request reprint Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of beta3-adrenergic agonists, retinoic acid, leptin and fasting
    Yi Zhang
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
    Biochim Biophys Acta 1584:115-22. 2002
    ..The long-term regulation of adiponectin expression in WAT appears to be the opposite of that of leptin and may be more sensitive to changes in adiposity or insulin sensitivity...
  24. ncbi request reprint Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei
    Benedek Erdos
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    J Hypertens 24:109-16. 2006
    ..Centrally applied angiotensin II (Ang II) increases sympathetic nervous activity and mean arterial blood pressure (MAP), but the mediation of these effects is not fully understood...
  25. doi request reprint Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content
    Alexandra Shapiro
    Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Box 100267, Gainesville, FL 32610, USA
    Br J Nutr 106:390-7. 2011
    ..These data suggest that fructose is the bioactive component of a HF/high-sugar diet that is essential for the induction of leptin resistance...
  26. ncbi request reprint Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance
    Philip J Scarpace
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
    Endocrinology 143:3026-35. 2002
    ..We propose that both elevated leptin and obesity may be necessary for the development of leptin resistance...
  27. ncbi request reprint Central angiotensin II increases biosynthesis of tyrosine hydroxylase in the rat adrenal medulla
    M Devrim Dogan
    Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Biochem Biophys Res Commun 313:623-6. 2004
    ..In conclusion, one component of central angiotensin II elevation of blood pressure may be the result of increased catecholamine synthesis in the adrenal gland and elevated TH synthesis represents one underlying mechanism...
  28. ncbi request reprint The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats
    Hale Zerrin Toklu
    Malcom Randall Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center, Gainesville, Florida Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida Department of Pharmacology, Marmara University School of Pharmacy, Istanbul, Turkey Electronic address
    J Surg Res 188:510-6. 2014
    ..Therefore, we investigated the involvement of the sympathoadrenergic and renin-angiotensin system in MV-induced altered cardiovascular responses...
  29. pmc Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72
    Andreas N Kavazis
    Applied Physiology and Kinesiology, University of Florida, USA
    Am J Physiol Heart Circ Physiol 299:H1515-24. 2010
    ..Finally, our data are consistent with the concept that increases in cardiac mitochondrial antioxidant enzymes may contribute to exercise-induced cardioprotection...
  30. pmc Increased temperature and protein oxidation lead to HSP72 mRNA and protein accumulation in the in vivo exercised rat heart
    Jessica L Staib
    Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118225, Gainesville, FL 32611, USA
    Exp Physiol 94:71-80. 2009
    ....