Robert Tukey

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha
    Mei Fei Yueh
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e37705. 2012
  2. pmc Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice
    Shujuan Chen
    Department of Pharmacology, Laboratory of Environmental Toxicology, University of California, San Diego, La Jolla, CA 92093 0722, USA
    Hepatology 56:658-67. 2012
  3. ncbi request reprint Human UDP-glucuronosyltransferases: metabolism, expression, and disease
    R H Tukey
    Department of Chemistry and Biochemistry, Cancer Center, University of California, San Diego, La Jolla 92093, USA
    Annu Rev Pharmacol Toxicol 40:581-616. 2000
  4. ncbi request reprint Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
    R H Tukey
    Department of Pharmacology, University of California, San Diego, La Jolla, California, USA
    Mol Pharmacol 59:405-14. 2001
  5. pmc The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities
    Keith Pezzoli
    Urban Studies and Planning Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Environ Health Perspect 115:564-71. 2007
  6. ncbi request reprint Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity
    Robert H Tukey
    Department of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Mol Pharmacol 62:446-50. 2002
  7. ncbi request reprint The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice
    Jessica A Bonzo
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 0722, USA
    Hepatology 45:349-60. 2007
  8. pmc Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor
    M F Yueh
    Laboratory of Environmental Toxicology, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
    Mol Pharmacol 79:1053-60. 2011
  9. pmc Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus
    Ryoichi Fujiwara
    Laboratory of Environmental Toxicology, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:5024-9. 2010
  10. doi request reprint Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease
    Nghia Nguyen
    Laboratory of Environmental Toxicology, Departments of Chemistry and Biochemistry and Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7901-11. 2008

Collaborators

Detail Information

Publications25

  1. pmc Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha
    Mei Fei Yueh
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e37705. 2012
    ..Activation of these xenobiotic-sensing receptors amplifies gene expression profiles that might represent a mechanistic base for potential human health effects from exposure to TCC...
  2. pmc Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice
    Shujuan Chen
    Department of Pharmacology, Laboratory of Environmental Toxicology, University of California, San Diego, La Jolla, CA 92093 0722, USA
    Hepatology 56:658-67. 2012
    ..Thus, PXR serves to repress UGT1A1 gene expression during development. Transcriptional silencing of the UGT1A1 gene was relieved in neonatal hUGT1 hepatocytes through interruption of PXR by small interfering RNA...
  3. ncbi request reprint Human UDP-glucuronosyltransferases: metabolism, expression, and disease
    R H Tukey
    Department of Chemistry and Biochemistry, Cancer Center, University of California, San Diego, La Jolla 92093, USA
    Annu Rev Pharmacol Toxicol 40:581-616. 2000
    ..The role of the UGTs in metabolism and different disease states in humans is the topic of this review...
  4. ncbi request reprint Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
    R H Tukey
    Department of Pharmacology, University of California, San Diego, La Jolla, California, USA
    Mol Pharmacol 59:405-14. 2001
    ..In addition, tools have now been developed and examples presented to identify the expression patterns of the UGTs in human tissues, paying particular attention to expression patterns of these genes in the hepato-gastrointestinal tract...
  5. pmc The NIEHS Environmental Health Sciences Data Resource Portal: placing advanced technologies in service to vulnerable communities
    Keith Pezzoli
    Urban Studies and Planning Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Environ Health Perspect 115:564-71. 2007
    ..Over 1,300 people died. The projected economic costs for recovery and reconstruction are likely to exceed $125 billion...
  6. ncbi request reprint Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity
    Robert H Tukey
    Department of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Mol Pharmacol 62:446-50. 2002
  7. ncbi request reprint The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice
    Jessica A Bonzo
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093 0722, USA
    Hepatology 45:349-60. 2007
    ....
  8. pmc Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor
    M F Yueh
    Laboratory of Environmental Toxicology, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
    Mol Pharmacol 79:1053-60. 2011
    ..These results suggest that HNF4α plays an important role in the constitutive expression of hepatic UGT2B7, and CAR acts as a negative regulator by interfering with HNF4α binding activity...
  9. pmc Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus
    Ryoichi Fujiwara
    Laboratory of Environmental Toxicology, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:5024-9. 2010
    ..UCB deposition in brain tissue and the ensuing seizures were associated with developmental milestones and can be prevented by enhancing regulation of the UGT1A1 gene in neonatal mice...
  10. doi request reprint Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease
    Nghia Nguyen
    Laboratory of Environmental Toxicology, Departments of Chemistry and Biochemistry and Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7901-11. 2008
    ..Thus, the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans...
  11. ncbi request reprint Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice
    Mei Fei Yueh
    Laboratory of Environmental Toxicology, Department of Chemistry, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:8749-58. 2007
    ....
  12. ncbi request reprint Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation
    Theresa N Operaña
    Department of Chemistry and Biochemistry, Laboratory of Environmental Toxicology, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:4821-9. 2007
    ..These preliminary studies suggest that the UGT1A family of proteins form oligomerized complexes in the membrane, a property that may influence function and substrate selectivity...
  13. ncbi request reprint Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation
    Kathy Senekeo-Effenberger
    Leichtag Biomedical Research Building, University of California, San Diego, La Jolla, CA 92093 0722, USA
    Drug Metab Dispos 35:419-27. 2007
    ....
  14. ncbi request reprint Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure
    Theresa N Operaña
    Laboratory of Environmental Toxicology, Departments of Chemistry and Biochemistry and Pharmacology, University of California, San Diego, La Jolla, California 92093 0722, USA
    Toxicol Sci 95:98-107. 2007
    ..The capability to identify fluorescently labeled CYP1A1 in vivo provides a sensitive measurement of gene response and links exposure to potential environmental toxicants and activation of the AhR...
  15. ncbi request reprint Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3
    Yue Hua Huang
    Laboratory of Environmental Toxicology, Department of Chemistry, Cancer Center, University of California, San Diego, La Jolla, California 92093 0636, USA
    Pharmacogenetics 12:287-97. 2002
    ..Allelic variation leading to singular codon changes could potentially alter drug metabolism in extrahepatic tissues...
  16. ncbi request reprint The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1
    Mei Fei Yueh
    Department of Pharmacology, Chemistry and Biochemistry, Laboratory of Environmental Toxicology, University of California, San Diego, La Jolla, USA
    Methods Enzymol 400:75-91. 2005
    ..Similar to regulation of CYP1A1, the transcriptional activation of UGT1A1 by TCDD is mediated through the aryl hydrocarbon receptor...
  17. ncbi request reprint Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus
    Shujuan Chen
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, 92093 0722, USA
    J Biol Chem 280:37547-57. 2005
    ..With expression of the UGT1 locus confirmed in a variety of mouse tissues, these results suggested that the Tg-UGT1 mice will be a useful model to examine the regulatory and functional properties of human glucuronidation...
  18. ncbi request reprint Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1
    Mei Fei Yueh
    Departments of Pharmacology, Chemistry and Biochemistry, Laboratory of Environmental Toxicology, University of California San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 278:15001-6. 2003
    ..These observations reveal that the Ah receptor is involved in human UGT1A1 induction...
  19. ncbi request reprint ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation
    Shujuan Chen
    Laboratory of Environmental Toxicology, Department of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:4350-9. 2005
    ....
  20. ncbi request reprint The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis
    Shujuan Chen
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 278:19526-33. 2003
    ..These results confirm that the Ah receptor plays a critical role in B[a]P-7,8-dihydrodiol-induced apoptosis while p38 MAP kinase links the actions of an electrophilic metabolite like BPDE-2 to the regulation of programmed cell death...
  21. doi request reprint Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling
    Sarah Chouinard
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec G1V 4G2, Canada
    J Steroid Biochem Mol Biol 109:247-53. 2008
    ..It is also postulated that UGT enzymes protect the tissue from deleteriously high concentrations of active androgen...
  22. pmc Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
    Wen Xie
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 100:4150-5. 2003
    ....
  23. ncbi request reprint The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice
    Alema Galijatovic
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    J Biol Chem 279:23969-76. 2004
    ..Combined these results indicate that tissue-specific and developmental factors are controlling aryl hydrocarbon receptor-mediated induction of human CYP1A1...
  24. ncbi request reprint The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression
    Daniel E W Machemer
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0722, USA
    Toxicol Sci 87:27-37. 2005
    ..The specific PKC inhibitors did not significantly alter cytosolic or nuclear levels of AhR protein, whether alone or in combination with TCDD. These results suggested that PKC was not the sole factor responsible for regulation of CYP1A1...
  25. ncbi request reprint The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice
    Mélanie Verreault
    Molecular Endocrinology and Oncology Research Center, CHUL Research Center and the Faculty of Pharmacy, Laval University, Quebec, Canada
    Hepatology 44:368-78. 2006
    ..LXR agonists may be useful for stimulating both bile acid detoxification and cholesterol removal in cholestatic or hypercholesterolemic patients, respectively...

Research Grants19

  1. Xenobiotic sensors PXR and CAR and regulation of the UGT1 locus
    Robert H Tukey; Fiscal Year: 2010
    ..This application is the first attempt to investigate how human UGTs are regulated in mice, and to apply this animal to understand the impact of glucuronidation towards drug-drug interactions, drug metabolism and eventually disease. ..
  2. Xenobiotic sensors PXR and CAR and regulation of the UGT1 locus
    Robert Tukey; Fiscal Year: 2009
    ..This application is the first attempt to investigate how human UGTs are regulated in mice, and to apply this animal to understand the impact of glucuronidation towards drug-drug interactions, drug metabolism and eventually disease. ..
  3. Regulated Properties of the Human UGT1A1 Gene.
    Robert Tukey; Fiscal Year: 2006
    ..Identifying the mechanisms that underlie expression of UGT1A1 may provide us with important clues toward improving expression of this gene and avoiding potential toxicities because of inadequate gene expression. ..
  4. Regulated Properties of the Human UGT1A1 Gene.
    Robert Tukey; Fiscal Year: 2003
    ..Identifying the mechanisms that underlie expression of UGT1A1 may provide us with important clues toward improving expression of this gene and avoiding potential toxicities because of inadequate gene expression. ..
  5. EXTRAHEPATIC EXPRESSION OF UDP GLUCURONOSYLTRANSFERASES
    Robert Tukey; Fiscal Year: 2002
    ..These studies should provide a better understanding for the cellular and molecular events that underlie the tissue specific expression patterns of the UGT1A locus in human tissues. ..
  6. GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    Robert Tukey; Fiscal Year: 2002
    ....
  7. EXTRAHEPATIC EXPRESSION OF UDP GLUCURONOSYLTRANSFERASES
    Robert Tukey; Fiscal Year: 2001
    ..These studies should provide a better understanding for the cellular and molecular events that underlie the tissue specific expression patterns of the UGT1A locus in human tissues. ..
  8. GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    Robert Tukey; Fiscal Year: 2001
    ....
  9. EXTRAHEPATIC EXPRESSION OF UDP GLUCURONOSYLTRANSFERASES
    Robert Tukey; Fiscal Year: 2000
    ..These studies should provide a better understanding for the cellular and molecular events that underlie the tissue specific expression patterns of the UGT1A locus in human tissues. ..
  10. GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    Robert Tukey; Fiscal Year: 2000
    ....
  11. EXTRAHEPATIC EXPRESSION OF UDP GLUCURONOSYLTRANSFERASES
    Robert Tukey; Fiscal Year: 1999
    ..These studies should provide a better understanding for the cellular and molecular events that underlie the tissue specific expression patterns of the UGT1A locus in human tissues. ..
  12. GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    Robert Tukey; Fiscal Year: 1999
    ....