Research Topics
Genomes and Genes | Rubin TuderSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Publications
Development and pathology of pulmonary hypertensionRubin M Tuder
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Colorado 80045, USA
J Am Coll Cardiol 54:S3-9. 2009..These important goals provide a blueprint for future research that may significantly impact our present and future understanding of pulmonary hypertension...
Pathogenesis of chronic obstructive pulmonary diseaseRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, School of Medicine, Denver, CO, USA
J Clin Invest 122:2749-55. 2012..Lung damage by cigarette smoke ultimately leads to self-propagating processes, resulting in macromolecular and structural alterations - features similar to those seen in aging...- Modern age pathology of pulmonary arterial hypertensionElvira Stacher
Institute of Pathology, Medical University of Graz, Graz, Austria
Am J Respir Crit Care Med 186:261-72. 2012..The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown... - Senescence in chronic obstructive pulmonary diseaseRubin M Tuder
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
Proc Am Thorac Soc 9:62-3. 2012..This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung Conference... - Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertensionRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, USA
Am J Respir Crit Care Med 185:260-6. 2012..These investigations have led to novel approaches in the diagnosis and therapy of pulmonary hypertension... - Stress responses affecting homeostasis of the alveolar capillary unitRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
Proc Am Thorac Soc 8:485-91. 2011..These alterations may impose significant challenges to cell-based regenerative or pharmacological therapies... - Pathology of pulmonary arterial hypertensionRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
Semin Respir Crit Care Med 30:376-85. 2009..We also highlight the pulmonary vascular pathology in schistosomiasis-associated pulmonary arterial hypertension, possibly the most frequent cause of pulmonary hypertension worldwide... - Lung disease associated with alpha1-antitrypsin deficiencyRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, Colorado, USA
Proc Am Thorac Soc 7:381-6. 2010.... - Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lungEnid R Neptune
Division of Pulmonary and Critical Care Medicine, Institute of Genetic Medicine, Howard Hughes Medical Institute, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
J Biol Chem 283:21160-9. 2008..These results support an unanticipated role for NeuroD in the regulation of pulmonary neuroendocrine and alveolar morphogenesis and suggest an intimate connection between the neuroendocrine compartment and distal lung development... - Genomics of pulmonary arterial hypertension: implications for therapyMark W Geraci
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, AMC, MS C272, RC2, 12700 East 19th Avenue, Aurora, CO 80045, USA
Heart Fail Clin 6:101-14. 2010..This article addresses the advances in the genetics of PAH, including the identification of genetic etiologies and modulators, and the role of genetics in predicting disease progression and targeting therapeutics... 
Hypoxia induces different genes in the lungs of rats compared with miceYasushi Hoshikawa
Pulmonary Hypertension Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Physiol Genomics 12:209-19. 2003....- Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signalingBrian B Graham
Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
Am J Pathol 177:1549-61. 2010..Our data indicate that experimental schistosomiasis causes PH and potentially relies on up-regulated IL-13 signaling... - Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injuryJeffrey R Jacobson
Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Physiol Lung Cell Mol Physiol 288:L1026-32. 2005..g., IL-6, Toll-like receptor 4). Together, these findings confirm significant protection by simvastatin on LPS-induced lung vascular leak and inflammation and implicate a potential role for statins in the management of ALI... - Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in miceMegan Podowski
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Clin Invest 122:229-40. 2012..More importantly, our findings provide a preclinical platform for the development of other TGF-β-targeted therapies for patients with COPD... - Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscleJames West
University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine and Department of Anesthesia, Denver, Colo 80262, USA
Circ Res 94:1109-14. 2004..Studies with SM22-tet-BMPRII(delx4+) mice support the hypothesis that loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype... - Endothelial dysfunction in pulmonary hypertensionRohit Budhiraja
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
Circulation 109:159-65. 2004 - Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertensionLaimute Taraseviciene-Stewart
Division of Pulmonary Sciences and Critical Care Medicine, Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Physiol Lung Cell Mol Physiol 291:L668-76. 2006..We conclude that simvastatin is effective in inducing apoptosis in hyperproliferative pulmonary vascular lesions and could be considered as a potential drug for treatment of human SPH... - Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathwaysRaja Elie E Abdulnour
Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006..We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI... - Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injurySimone Filosto
Genome and Biomedical Sciences Facility, Division of Pulmonary and Critical Care Medicine, University of California Davis, School of Medicine, USA
Am J Respir Cell Mol Biol 44:350-60. 2011.... - Gene expression profiles in pulmonary hypertensionMark W Geraci
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Chest 121:104S-105S. 2002 - Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injuryAnne Le
Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Appl Physiol 105:1282-90. 2008.... - Vascular endothelial growth factor in the lungNorbert F Voelkel
University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006..Here we provide a comprehensive overview of the rapidly expanding literature... - alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosisIrina Petrache
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Pathol 169:1155-66. 2006.... - CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injuryFranco R D'Alessio
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
J Clin Invest 119:2898-913. 2009..These results indicate that Tregs modify innate immune responses during resolution of lung injury and suggest potential targets for treating ALI, for which there are no specific therapies currently available... - Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in miceIrina Petrache
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
Nat Med 11:491-8. 2005..Finally, increased lung ceramides in individuals with smoking-induced emphysema suggests that ceramide upregulation may be a crucial pathogenic element and a promising target in this disease that currently lacks effective therapies... - Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertensionNorbert F Voelkel
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Crit Care Med 30:S251-6. 2002..Chemotherapy strategies can now be employed in the animal model in an attempt to treat established vascular-obliterative lung disease... - Inducible nitric oxide synthase contributes to ventilator-induced lung injuryXinqi Peng
Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 172:470-9. 2005..Inducible nitric oxide synthase (iNOS) has been implicated in the development of acute lung injury. Recent studies indicate a role for mechanical stress in iNOS and endothelial NOS (eNOS) regulation... - Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspectiveBrian B Graham
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, USA
Chest 137:20S-29S. 2010..Further research is needed into the pathogenic mechanism by which this parasitic infection results in pulmonary vascular remodeling and PH, which also may be informative regarding the etiology of other types of PH... - Circulating endothelial cells in pulmonary hypertensionTodd M Bull
Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, CO 80262, USA
Thromb Haemost 90:698-703. 2003..CECs may provide a non-invasive mean of accessing cells important to the pathobiology of severe pulmonary hypertension... - Attenuation of chronic hypoxic pulmonary hypertension by simvastatinReda E Girgis
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1830 E Monument, 5th Floor, Baltimore, MD 21205, USA
Am J Physiol Heart Circ Physiol 285:H938-45. 2003..Enhancement of lung eNOS expression does not appear to be involved in mediating this effect... - Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expressionTirumalai Rangasamy
Division of Pulmonary and Critical Care Medicine, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8692, USA
Am J Physiol Lung Cell Mol Physiol 296:L888-900. 2009..Many of the genes discovered in this study could rationally play an important role in the susceptibility to CS-induced emphysema... - Microsatellite mutational analysis of endothelial cells within plexiform lesions from patients with familial, pediatric, and sporadic pulmonary hypertensionMichael E Yeager
Pulmonary Hypertension Center, Division of Pulmonary Sciences, Department of Medicine, University of Colorado Health Sciences Center, Denver CO 80262, USA
Chest 121:61S. 2002 - It takes two to tango: cigarette smoke partners with viruses to promote emphysemaRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Denver, Colorado 80262, USA
J Clin Invest 118:2689-93. 2008..This novel paradigm may aid related genetic, biomarker, and therapeutic developments and provides important insights into the pathogenesis of emphysematous lung destruction... - Vascular endothelial growth factor of the lung: friend or foeRubin M Tuder
Program in Translational Lung Research, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Denver, School of Medicine, Denver, CO 80262, United States
Curr Opin Pharmacol 8:255-60. 2008..The beneficial and detrimental actions of VEGF underscore that therapeutic targeting of VEGF in disease has to carefully consider the lung biology of VEGF... - Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2Edward S Chen
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Crit Care Med 181:360-73. 2010.... - Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lungRubin M Tuder
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, School of Medicine, 4200 East 9th Avenue, Campus Box C272, Denver, CO 80262, USA
Am J Respir Cell Mol Biol 39:1-6. 2008..Molecular switches, ontologically designed for the protection of the host, are now hijacked by injurious stresses (such as cigarette smoke), leading to organ damage... - Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cellsAigul Moldobaeva
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Physiol Lung Cell Mol Physiol 290:L919-30. 2006.... - Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injuryShui Q Ye
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building Center Tower 664, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 171:361-70. 2005..Together, these results strongly indicate that PBEF is a potential novel biomarker in ALI and demonstrate the successful application of robust genomic technologies in the identification of candidate genes in complex lung disease... - Regression of chronic hypoxic pulmonary hypertension by simvastatinReda E Girgis
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Physiol Lung Cell Mol Physiol 292:L1105-10. 2007..001). We conclude that simvastatin attenuates and induces regression of established CHPH through inhibition of HMG-CoA reductase. Inhibition of ROCK expression and activity may be an important mechanism of statin effect... - Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associationsLi Gao
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Transl Res 150:18-29. 2007..These data, generated via functional genomic and genetic approaches, suggest that MIF is a relevant molecular target in ALI... - Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injuryXinqi Peng
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Crit Care Med 169:1245-51. 2004.... - Emphysema lung tissue gene expression profilingHeiko A Golpon
Division of Pulmonary Sciences and Critical Care Medicine, 4200 East Ninth Avenue, C272, Denver, CO 80262, USA
Am J Respir Cell Mol Biol 31:595-600. 2004.... - Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlationJai Soung Park
Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Comput Assist Tomogr 26:13-20. 2002..These radiologic features, in patients with a history of heavy cigarette smoking, may differentiate RB-ILD from other interstitial lung diseases... - Methylprednisolone causes matrix metalloproteinase-dependent emphysema in adult ratsKang-Hyeon Choe
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C 272, 4200 E. Ninth Avenue, Denver, CO 80262, USA
Am J Respir Crit Care Med 167:1516-21. 2003..We conclude that systemic treatment of adult rats with the antiinflammatory steroid methylprednisolone increases the activity of matrix metalloproteinases in the lung and causes emphysema... - Pulmonary eosinophilia following lung transplantation for sarcoidosis in two patientsSusan G Gerhardt
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
Chest 123:629-32. 2003..It is known that peripheral eosinophilia is a marker for pulmonary allograft rejection, but its potential in the pathogenesis of BOS is unclear... - Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic miceJames West
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Chest 128:553S. 2005 - HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaquesJohn C Marecki
Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C272, Denver, CO 80262, USA
Am J Respir Crit Care Med 174:437-45. 2006.... - Mechanisms of autoimmune emphysemaLaimute Taraseviciene-Stewart
Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, USA
Proc Am Thorac Soc 3:486-7. 2006 - N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysemaYoshiki Demura
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, Colorado 80262, USA
COPD 1:25-32. 2004.... - Pathobiology of cigarette smoke-induced chronic obstructive pulmonary diseaseToshinori Yoshida
Division of Cardiopulmonary Pathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Physiol Rev 87:1047-82. 2007..The authors provide an updated insight into the molecular and cellular pathobiology of COPD based on human and/or animal data... - Apoptotic sphingolipid signaling by ceramides in lung endothelial cellsTerry R Medler
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 38:639-46. 2008..The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides... - Short telomeres are a risk factor for idiopathic pulmonary fibrosisJonathan K Alder
Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 105:13051-6. 2008..The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver... - Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertensionAri L Zaiman
Johns Hopkins School of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
Am J Respir Crit Care Med 177:896-905. 2008..However, the role of TGF-beta family signaling in PH and pulmonary vascular remodeling remains unclear... - Nonspecific interstitial pneumonitis as the sole histologic expression of hypersensitivity pneumonitisJason S Vourlekis
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Med 112:490-3. 2002 - Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cellsIwona Fijalkowska
Department of Pathology, Johns Hopkins Univesity School of Medicine, Baltimore, MD, USA
Am J Pathol 176:1130-8. 2010..These findings indicate that alterations of nitric oxide and MnSOD contribute to pathological HIF-1alpha expression and account for lower numbers of mitochondria in IPAH-ECs...
Research Grants
- ENDOTHELIAL CELL DEATH AND INFLAMMATION IN EMPHYSEMARubin Tuder; Fiscal Year: 2003..The experimental results may point the way towards a new treatment/prevention strategy, i.e., inhibition of lung alveolar septal endothelial cell apoptosis and oxidant stress. ..
- Endothelial Cell Death in EmphysemaRubin Tuder; Fiscal Year: 2007..abstract_text> ..
- VEGF PROTECTS AGAINST PULMONARY VASCULAR REMODELINGRubin Tuder; Fiscal Year: 2001....