Rubin Tuder

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Development and pathology of pulmonary hypertension
    Rubin M Tuder
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Colorado 80045, USA
    J Am Coll Cardiol 54:S3-9. 2009
  2. doi request reprint Relevant issues in the pathology and pathobiology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado Electronic address
    J Am Coll Cardiol 62:D4-12. 2013
  3. doi request reprint Pathology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, Research Complex 2, room 9001, Aurora, CO 80045, USA Electronic address
    Clin Chest Med 34:639-50. 2013
  4. pmc Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease
    James M Hunt
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Denver, Anschutz Medical Campus, Research 2 9th Floor, Rm 9001 Mail stop C 272, 12700 East 19th Ave, Aurora, CO 80045
    Am J Physiol Lung Cell Mol Physiol 305:L725-36. 2013
  5. pmc Pathogenesis of chronic obstructive pulmonary disease
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, School of Medicine, Denver, CO, USA
    J Clin Invest 122:2749-55. 2012
  6. pmc Modern age pathology of pulmonary arterial hypertension
    Elvira Stacher
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Respir Crit Care Med 186:261-72. 2012
  7. pmc Senescence in chronic obstructive pulmonary disease
    Rubin M Tuder
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Proc Am Thorac Soc 9:62-3. 2012
  8. pmc Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, USA
    Am J Respir Crit Care Med 185:260-6. 2012
  9. pmc Stress responses affecting homeostasis of the alveolar capillary unit
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Proc Am Thorac Soc 8:485-91. 2011
  10. doi request reprint Pathology of pulmonary arterial hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
    Semin Respir Crit Care Med 30:376-85. 2009

Research Grants

Detail Information

Publications58

  1. doi request reprint Development and pathology of pulmonary hypertension
    Rubin M Tuder
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Colorado 80045, USA
    J Am Coll Cardiol 54:S3-9. 2009
    ..These important goals provide a blueprint for future research that may significantly impact our present and future understanding of pulmonary hypertension...
  2. doi request reprint Relevant issues in the pathology and pathobiology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado Electronic address
    J Am Coll Cardiol 62:D4-12. 2013
    ..Continued interest in the interface of the genetic basis of PH and cellular and molecular pathogenetic links should further expand our understanding of the disease. ..
  3. doi request reprint Pathology of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, 12700 East 19th Avenue, Research Complex 2, room 9001, Aurora, CO 80045, USA Electronic address
    Clin Chest Med 34:639-50. 2013
    ..There was correlation between perivascular inflammation, remodeling, and hemodynamics. This article summarizes the pathologic features of the normal and abnormal pulmonary circulation, and correlations with animal models. ..
  4. pmc Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease
    James M Hunt
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Denver, Anschutz Medical Campus, Research 2 9th Floor, Rm 9001 Mail stop C 272, 12700 East 19th Ave, Aurora, CO 80045
    Am J Physiol Lung Cell Mol Physiol 305:L725-36. 2013
    ..Our data indicate that remodeling of pulmonary veins is an integral part of PH-LHD and that pulmonary veins share some key features present in remodeled yet not normotensive pulmonary arteries...
  5. pmc Pathogenesis of chronic obstructive pulmonary disease
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, School of Medicine, Denver, CO, USA
    J Clin Invest 122:2749-55. 2012
    ..Lung damage by cigarette smoke ultimately leads to self-propagating processes, resulting in macromolecular and structural alterations - features similar to those seen in aging...
  6. pmc Modern age pathology of pulmonary arterial hypertension
    Elvira Stacher
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Am J Respir Crit Care Med 186:261-72. 2012
    ..The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown...
  7. pmc Senescence in chronic obstructive pulmonary disease
    Rubin M Tuder
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Proc Am Thorac Soc 9:62-3. 2012
    ..This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung Conference...
  8. pmc Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, USA
    Am J Respir Crit Care Med 185:260-6. 2012
    ..These investigations have led to novel approaches in the diagnosis and therapy of pulmonary hypertension...
  9. pmc Stress responses affecting homeostasis of the alveolar capillary unit
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
    Proc Am Thorac Soc 8:485-91. 2011
    ..These alterations may impose significant challenges to cell-based regenerative or pharmacological therapies...
  10. doi request reprint Pathology of pulmonary arterial hypertension
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, School of Medicine, Denver, Colorado 80045, USA
    Semin Respir Crit Care Med 30:376-85. 2009
    ..We also highlight the pulmonary vascular pathology in schistosomiasis-associated pulmonary arterial hypertension, possibly the most frequent cause of pulmonary hypertension worldwide...
  11. pmc Lung disease associated with alpha1-antitrypsin deficiency
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, Colorado, USA
    Proc Am Thorac Soc 7:381-6. 2010
    ....
  12. pmc Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung
    Enid R Neptune
    Division of Pulmonary and Critical Care Medicine, Institute of Genetic Medicine, Howard Hughes Medical Institute, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Biol Chem 283:21160-9. 2008
    ..These results support an unanticipated role for NeuroD in the regulation of pulmonary neuroendocrine and alveolar morphogenesis and suggest an intimate connection between the neuroendocrine compartment and distal lung development...
  13. pmc Genomics of pulmonary arterial hypertension: implications for therapy
    Mark W Geraci
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, AMC, MS C272, RC2, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Heart Fail Clin 6:101-14. 2010
    ..This article addresses the advances in the genetics of PAH, including the identification of genetic etiologies and modulators, and the role of genetics in predicting disease progression and targeting therapeutics...
  14. ncbi request reprint Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury
    Jeffrey R Jacobson
    Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1026-32. 2005
    ..g., IL-6, Toll-like receptor 4). Together, these findings confirm significant protection by simvastatin on LPS-induced lung vascular leak and inflammation and implicate a potential role for statins in the management of ALI...
  15. pmc Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling
    Brian B Graham
    Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
    Am J Pathol 177:1549-61. 2010
    ..Our data indicate that experimental schistosomiasis causes PH and potentially relies on up-regulated IL-13 signaling...
  16. ncbi request reprint Hypoxia induces different genes in the lungs of rats compared with mice
    Yasushi Hoshikawa
    Pulmonary Hypertension Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Physiol Genomics 12:209-19. 2003
    ....
  17. pmc Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice
    Megan Podowski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 122:229-40. 2012
    ..More importantly, our findings provide a preclinical platform for the development of other TGF-β-targeted therapies for patients with COPD...
  18. ncbi request reprint Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    James West
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine and Department of Anesthesia, Denver, Colo 80262, USA
    Circ Res 94:1109-14. 2004
    ..Studies with SM22-tet-BMPRII(delx4+) mice support the hypothesis that loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype...
  19. ncbi request reprint Endothelial dysfunction in pulmonary hypertension
    Rohit Budhiraja
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 109:159-65. 2004
  20. ncbi request reprint Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension
    Laimute Taraseviciene-Stewart
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L668-76. 2006
    ..We conclude that simvastatin is effective in inducing apoptosis in hyperproliferative pulmonary vascular lesions and could be considered as a potential drug for treatment of human SPH...
  21. ncbi request reprint Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
    ..We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI...
  22. pmc Inducible nitric oxide synthase contributes to ventilator-induced lung injury
    Xinqi Peng
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 172:470-9. 2005
    ..Inducible nitric oxide synthase (iNOS) has been implicated in the development of acute lung injury. Recent studies indicate a role for mechanical stress in iNOS and endothelial NOS (eNOS) regulation...
  23. pmc Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury
    Simone Filosto
    Genome and Biomedical Sciences Facility, Division of Pulmonary and Critical Care Medicine, University of California Davis, School of Medicine, USA
    Am J Respir Cell Mol Biol 44:350-60. 2011
    ....
  24. pmc CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury
    Franco R D'Alessio
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    J Clin Invest 119:2898-913. 2009
    ..These results indicate that Tregs modify innate immune responses during resolution of lung injury and suggest potential targets for treating ALI, for which there are no specific therapies currently available...
  25. pmc Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
    Anne Le
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 105:1282-90. 2008
    ....
  26. pmc alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis
    Irina Petrache
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Pathol 169:1155-66. 2006
    ....
  27. pmc Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
    ..Finally, increased lung ceramides in individuals with smoking-induced emphysema suggests that ceramide upregulation may be a crucial pathogenic element and a promising target in this disease that currently lacks effective therapies...
  28. ncbi request reprint Gene expression profiles in pulmonary hypertension
    Mark W Geraci
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:104S-105S. 2002
  29. ncbi request reprint Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Crit Care Med 30:S251-6. 2002
    ..Chemotherapy strategies can now be employed in the animal model in an attempt to treat established vascular-obliterative lung disease...
  30. ncbi request reprint Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
    ..Here we provide a comprehensive overview of the rapidly expanding literature...
  31. pmc It takes two to tango: cigarette smoke partners with viruses to promote emphysema
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 118:2689-93. 2008
    ..This novel paradigm may aid related genetic, biomarker, and therapeutic developments and provides important insights into the pathogenesis of emphysematous lung destruction...
  32. pmc Vascular endothelial growth factor of the lung: friend or foe
    Rubin M Tuder
    Program in Translational Lung Research, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Denver, School of Medicine, Denver, CO 80262, United States
    Curr Opin Pharmacol 8:255-60. 2008
    ..The beneficial and detrimental actions of VEGF underscore that therapeutic targeting of VEGF in disease has to carefully consider the lung biology of VEGF...
  33. pmc Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression
    Tirumalai Rangasamy
    Division of Pulmonary and Critical Care Medicine, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8692, USA
    Am J Physiol Lung Cell Mol Physiol 296:L888-900. 2009
    ..Many of the genes discovered in this study could rationally play an important role in the susceptibility to CS-induced emphysema...
  34. ncbi request reprint Circulating endothelial cells in pulmonary hypertension
    Todd M Bull
    Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, CO 80262, USA
    Thromb Haemost 90:698-703. 2003
    ..CECs may provide a non-invasive mean of accessing cells important to the pathobiology of severe pulmonary hypertension...
  35. ncbi request reprint Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
    Reda E Girgis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1830 E Monument, 5th Floor, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 285:H938-45. 2003
    ..Enhancement of lung eNOS expression does not appear to be involved in mediating this effect...
  36. ncbi request reprint Microsatellite mutational analysis of endothelial cells within plexiform lesions from patients with familial, pediatric, and sporadic pulmonary hypertension
    Michael E Yeager
    Pulmonary Hypertension Center, Division of Pulmonary Sciences, Department of Medicine, University of Colorado Health Sciences Center, Denver CO 80262, USA
    Chest 121:61S. 2002
  37. doi request reprint Schistosomiasis-associated pulmonary hypertension: pulmonary vascular disease: the global perspective
    Brian B Graham
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, USA
    Chest 137:20S-29S. 2010
    ..Further research is needed into the pathogenic mechanism by which this parasitic infection results in pulmonary vascular remodeling and PH, which also may be informative regarding the etiology of other types of PH...
  38. pmc Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2
    Edward S Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 181:360-73. 2010
    ....
  39. ncbi request reprint Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury
    Shui Q Ye
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building Center Tower 664, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 171:361-70. 2005
    ..Together, these results strongly indicate that PBEF is a potential novel biomarker in ALI and demonstrate the successful application of robust genomic technologies in the identification of candidate genes in complex lung disease...
  40. ncbi request reprint Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury
    Xinqi Peng
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 169:1245-51. 2004
    ....
  41. ncbi request reprint Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells
    Aigul Moldobaeva
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 290:L919-30. 2006
    ....
  42. ncbi request reprint Regression of chronic hypoxic pulmonary hypertension by simvastatin
    Reda E Girgis
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1105-10. 2007
    ..001). We conclude that simvastatin attenuates and induces regression of established CHPH through inhibition of HMG-CoA reductase. Inhibition of ROCK expression and activity may be an important mechanism of statin effect...
  43. pmc Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations
    Li Gao
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Transl Res 150:18-29. 2007
    ..These data, generated via functional genomic and genetic approaches, suggest that MIF is a relevant molecular target in ALI...
  44. pmc Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung
    Rubin M Tuder
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, School of Medicine, 4200 East 9th Avenue, Campus Box C272, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 39:1-6. 2008
    ..Molecular switches, ontologically designed for the protection of the host, are now hijacked by injurious stresses (such as cigarette smoke), leading to organ damage...
  45. ncbi request reprint Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic mice
    James West
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 128:553S. 2005
  46. ncbi request reprint Nonspecific interstitial pneumonitis as the sole histologic expression of hypersensitivity pneumonitis
    Jason S Vourlekis
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Med 112:490-3. 2002
  47. pmc Mechanisms of autoimmune emphysema
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, USA
    Proc Am Thorac Soc 3:486-7. 2006
  48. ncbi request reprint Methylprednisolone causes matrix metalloproteinase-dependent emphysema in adult rats
    Kang Hyeon Choe
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C 272, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 167:1516-21. 2003
    ..We conclude that systemic treatment of adult rats with the antiinflammatory steroid methylprednisolone increases the activity of matrix metalloproteinases in the lung and causes emphysema...
  49. pmc Apoptotic sphingolipid signaling by ceramides in lung endothelial cells
    Terry R Medler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:639-46. 2008
    ..The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides...
  50. ncbi request reprint Pulmonary eosinophilia following lung transplantation for sarcoidosis in two patients
    Susan G Gerhardt
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Chest 123:629-32. 2003
    ..It is known that peripheral eosinophilia is a marker for pulmonary allograft rejection, but its potential in the pathogenesis of BOS is unclear...
  51. pmc Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension
    Ari L Zaiman
    Johns Hopkins School of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 177:896-905. 2008
    ..However, the role of TGF-beta family signaling in PH and pulmonary vascular remodeling remains unclear...
  52. pmc HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques
    John C Marecki
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C272, Denver, CO 80262, USA
    Am J Respir Crit Care Med 174:437-45. 2006
    ....
  53. ncbi request reprint Emphysema lung tissue gene expression profiling
    Heiko A Golpon
    Division of Pulmonary Sciences and Critical Care Medicine, 4200 East Ninth Avenue, C272, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 31:595-600. 2004
    ....
  54. ncbi request reprint Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation
    Jai Soung Park
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Comput Assist Tomogr 26:13-20. 2002
    ..The purpose of this work was to describe the radiographic and CT findings in patients with respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) and to correlate them with clinical, physiologic, and pathologic features...
  55. ncbi request reprint Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
    Toshinori Yoshida
    Division of Cardiopulmonary Pathology, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Physiol Rev 87:1047-82. 2007
    ..The authors provide an updated insight into the molecular and cellular pathobiology of COPD based on human and/or animal data...
  56. pmc Short telomeres are a risk factor for idiopathic pulmonary fibrosis
    Jonathan K Alder
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 105:13051-6. 2008
    ..The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver...
  57. ncbi request reprint N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema
    Yoshiki Demura
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, Colorado 80262, USA
    COPD 1:25-32. 2004
    ....
  58. pmc Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells
    Iwona Fijalkowska
    Department of Pathology, Johns Hopkins Univesity School of Medicine, Baltimore, MD, USA
    Am J Pathol 176:1130-8. 2010
    ..These findings indicate that alterations of nitric oxide and MnSOD contribute to pathological HIF-1alpha expression and account for lower numbers of mitochondria in IPAH-ECs...

Research Grants10

  1. ENDOTHELIAL CELL DEATH AND INFLAMMATION IN EMPHYSEMA
    Rubin Tuder; Fiscal Year: 2003
    ..The experimental results may point the way towards a new treatment/prevention strategy, i.e., inhibition of lung alveolar septal endothelial cell apoptosis and oxidant stress. ..
  2. Endothelial Cell Death in Emphysema
    Rubin Tuder; Fiscal Year: 2007
    ..abstract_text> ..
  3. VEGF PROTECTS AGAINST PULMONARY VASCULAR REMODELING
    Rubin Tuder; Fiscal Year: 2001
    ....