Zhengkun Tu

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint HCV core and NS3 proteins manipulate human blood-derived dendritic cell development and promote Th 17 differentiation
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int Immunol 24:97-106. 2012
  2. doi request reprint Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Immunol 271:286-91. 2011
  3. doi request reprint Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    Gastroenterology 138:305-14. 2010
  4. pmc TLR-dependent cross talk between human Kupffer cells and NK cells
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Exp Med 205:233-44. 2008

Detail Information

Publications4

  1. doi request reprint HCV core and NS3 proteins manipulate human blood-derived dendritic cell development and promote Th 17 differentiation
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int Immunol 24:97-106. 2012
    ..Since T(h) 17 cells are active in many examples of immunopathology, these effects may contribute to HCV autoimmune responses in chronically infected patients...
  2. doi request reprint Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Immunol 271:286-91. 2011
    ..A better understanding of the intra-hepatic NK cell activation against viral infection may help in the design of therapies and vaccines for the control of viral hepatitis...
  3. doi request reprint Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    Gastroenterology 138:305-14. 2010
    ..The hepatitis C virus core protein (HCVc) engages TLR2 on peripheral blood monocytes and induces production of multiple inflammatory cytokines. We examined the effects of HCVc on human primary KC functions...
  4. pmc TLR-dependent cross talk between human Kupffer cells and NK cells
    Zhengkun Tu
    Department of Surgery, Division of Solid Organ Transplantation and Hepatobiliary Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Exp Med 205:233-44. 2008
    ..Subversion of cellular mechanisms of innate immune response against viruses may be important for hepatotropic viruses (e.g., hepatitis B and C) to develop persistence...