Chia Ling Tu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function
    Chia Ling Tu
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 132:2350-9. 2012
  2. ncbi The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 131:1119-28. 2011
  3. ncbi Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
  4. ncbi Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
    Laszlo Komuves
    Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
    J Cell Physiol 192:45-54. 2002
  5. ncbi SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
  6. ncbi Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
  7. ncbi The role of the calcium-sensing receptor in epidermal differentiation
    Chia Ling Tu
    Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
    Cell Calcium 35:265-73. 2004
  8. ncbi The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:1074-83. 2007
  9. ncbi Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 124:187-97. 2005
  10. ncbi Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003

Research Grants

  1. Calcium-sensing Receptor and Keratinocyte Differentiation
    Chia Ling Tu; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function
    Chia Ling Tu
    Endocrine Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 132:2350-9. 2012
    ..3%) diet. Deleting CaR perturbs the epidermal Ca(2+) gradient and impairs keratinocyte differentiation and permeability barrier homeostasis, indicating a key role for the CaR in normal epidermal development...
  2. ncbi The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 131:1119-28. 2011
    ..These results indicate that Rho is a downstream mediator of CaR in the regulation of Ca(2+)(o)-induced E-cadherin-mediated cell-cell adhesion and keratinocyte differentiation...
  3. ncbi Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center, University of California, San Francisco, California 94121, USA
    J Biol Chem 283:3519-28. 2008
    ..Our results indicate that the CaR regulates cell survival and Ca(2+)(o)-induced differentiation in keratinocytes at least in part by activating the E-cadherin/PI3K pathway through a Src family tyrosine kinase-mediated signaling...
  4. ncbi Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation
    Laszlo Komuves
    Department of Dermatology, Veterans Affairs Medical Center and the University of California, San Francisco School of Medicine, San Francisco, California 94121, USA
    J Cell Physiol 192:45-54. 2002
    ..Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes...
  5. ncbi SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
    ....
  6. ncbi Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
    ..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes...
  7. ncbi The role of the calcium-sensing receptor in epidermal differentiation
    Chia Ling Tu
    Department of Medicine, Veteran Affairs Medical Center, University of California and Endocrine Unit, San Francisco, CA 94121, USA
    Cell Calcium 35:265-73. 2004
    ..These concepts derived from in vitro experiments have been tested and confirmed in two mouse models...
  8. ncbi The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes
    Chia Ling Tu
    Endocrine Unit, Department of Medicine, Veteran Affairs Medical Center and University of California, San Francisco, California 94121, USA
    J Invest Dermatol 127:1074-83. 2007
    ..Our results indicate that CaR regulates keratinocyte differentiation in part by modulating Ca2+(i) stores via interactions with Ca2+ pumps and channels that regulate those stores...
  9. ncbi Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes
    Chia Ling Tu
    Endocrine Unit, Veteran Affairs Medical Center and Department of Medicine, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 124:187-97. 2005
    ..Our results indicate that the activation of SOC in keratinocytes depends, at least partly, on the interaction of TRPC with PLCgamma1 and IP3R...
  10. ncbi Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
    Daniel D Bikle
    Veterans Affairs Medical Center 111 N, University of California, 4150 Clement Street, San Francisco, CA 94121, USA
    Recent Results Cancer Res 164:111-22. 2003
    ....

Research Grants1

  1. Calcium-sensing Receptor and Keratinocyte Differentiation
    Chia Ling Tu; Fiscal Year: 2010
    ..Successful completion of this project will greatly advance our knowledge of skin cell differentiation and help understanding the pathogenesis of various skin disorders manifesting abnormal differentiation. ..