Benjamin P Tu

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Driving the cell cycle through metabolism
    Ling Cai
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Annu Rev Cell Dev Biol 28:59-87. 2012
  2. ncbi Cyclic changes in metabolic state during the life of a yeast cell
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 104:16886-91. 2007
  3. ncbi Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 106:14293-6. 2009
  4. ncbi Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity
    Zheng Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 316:1916-9. 2007
  5. ncbi High-resolution timing of cell cycle-regulated gene expression
    Maga Rowicka
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:16892-7. 2007
  6. ncbi Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    Ling Cai
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Mol Cell 42:426-37. 2011
  7. ncbi Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae
    Sunil Laxman
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e26081. 2011
  8. ncbi Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
    Xi Wu
    Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Biol Cell 22:4124-33. 2011
  9. ncbi Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
    Isaac Marin-Valencia
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 15:827-37. 2012
  10. ncbi Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters
    Sunil Laxman
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    PLoS ONE 5:e12595. 2010

Research Grants

  1. Metabolic signals driving cell growth and proliferation
    Benjamin P Tu; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi Driving the cell cycle through metabolism
    Ling Cai
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Annu Rev Cell Dev Biol 28:59-87. 2012
    ....
  2. ncbi Cyclic changes in metabolic state during the life of a yeast cell
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 104:16886-91. 2007
    ..Such oscillations in metabolic state might occur during the course of other biological cycles...
  3. ncbi Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 106:14293-6. 2009
    ..These observations provide evidence that gaseous CO may function as a cellular signaling molecule that helps cue metabolic cycling...
  4. ncbi Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity
    Zheng Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 316:1916-9. 2007
    ..Thus, circadian, metabolic, and cell division cycles may be coordinated similarly as an evolutionarily conserved means of preserving genome integrity...
  5. ncbi High-resolution timing of cell cycle-regulated gene expression
    Maga Rowicka
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:16892-7. 2007
    ..Our results reveal distinct subphases of the cell cycle undetectable by morphological observation, as well as the precise timeline of macromolecular complex assembly during key cell cycle events...
  6. ncbi Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    Ling Cai
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Mol Cell 42:426-37. 2011
    ..Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes...
  7. ncbi Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae
    Sunil Laxman
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e26081. 2011
    ....
  8. ncbi Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
    Xi Wu
    Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Biol Cell 22:4124-33. 2011
    ..Collectively, our findings have revealed the existence of additional mechanisms that regulate autophagy under previously unrecognized conditions, in response to relatively more subtle changes in metabolic and nutritional state...
  9. ncbi Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
    Isaac Marin-Valencia
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 15:827-37. 2012
    ..Many of these same activities were conserved in cells cultured ex vivo from the tumors. Thus GBM cells utilize mitochondrial glucose oxidation during aggressive tumor growth in vivo...
  10. ncbi Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters
    Sunil Laxman
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    PLoS ONE 5:e12595. 2010
    ....
  11. ncbi Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth
    Lei Shi
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Mol Biol Cell 21:1982-90. 2010
    ..Together, our results support the view that trehalose, which is more stable than other carbohydrates, provides an enduring source of energy that helps drive cell cycle progression upon return to growth...
  12. ncbi Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, L3.124, Dallas, TX 75390, USA
    Science 310:1152-8. 2005
    ..Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time...
  13. ncbi Metabolic cycles as an underlying basis of biological oscillations
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Rev Mol Cell Biol 7:696-701. 2006
    ..We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations...
  14. ncbi Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
    Liang Zhang
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 196:315-26. 2012
    ..This reversal of mRNA export block allowed expression of antiviral factors. Thus, pyrimidines play a necessary role in the inhibition of mRNA nuclear export by virulence factors...
  15. ncbi Ultradian metabolic cycles in yeast
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 470:857-66. 2010
    ..These ultradian metabolic cycles offer a view of the life of yeast cells under a challenging, nutrient-poor growth environment and might represent useful systems to interrogate a variety of fundamental metabolic and regulatory processes...
  16. ncbi Systems approaches for the study of metabolic cycles in yeast
    Sunil Laxman
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, United States
    Curr Opin Genet Dev 20:599-604. 2010
    ....
  17. ncbi Identification and evaluation of cycling yeast metabolites in two-dimensional comprehensive gas chromatography-time-of-flight-mass spectrometry data
    Rachel E Mohler
    University of Washington, Department of Chemistry, Box 351700, Seattle, WA 98195, USA
    J Chromatogr A 1186:401-11. 2008
    ..The phase delay of the cycling metabolites ranged widely in relation to the oxygen consumption cycling pattern...

Research Grants1

  1. Metabolic signals driving cell growth and proliferation
    Benjamin P Tu; Fiscal Year: 2010
    ..We hope these studies will provide novel insights into the mechanisms of cell growth control and contribute towards our understanding of complex metabolic diseases such as cancer. ..