Benjamin P Tu

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint Driving the cell cycle through metabolism
    Ling Cai
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Annu Rev Cell Dev Biol 28:59-87. 2012
  2. pmc Cyclic changes in metabolic state during the life of a yeast cell
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 104:16886-91. 2007
  3. pmc Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 106:14293-6. 2009
  4. pmc Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
    Lei Shi
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:7318-23. 2013
  5. ncbi request reprint Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity
    Zheng Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 316:1916-9. 2007
  6. pmc High-resolution timing of cell cycle-regulated gene expression
    Maga Rowicka
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:16892-7. 2007
  7. pmc Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    Ling Cai
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Mol Cell 42:426-37. 2011
  8. pmc Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae
    Sunil Laxman
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e26081. 2011
  9. pmc Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
    Xi Wu
    Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Biol Cell 22:4124-33. 2011
  10. pmc Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A
    Benjamin M Sutter
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Cell 154:403-15. 2013

Research Grants

Collaborators

Detail Information

Publications22

  1. doi request reprint Driving the cell cycle through metabolism
    Ling Cai
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Annu Rev Cell Dev Biol 28:59-87. 2012
    ....
  2. pmc Cyclic changes in metabolic state during the life of a yeast cell
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 104:16886-91. 2007
    ..Such oscillations in metabolic state might occur during the course of other biological cycles...
  3. pmc Evidence of carbon monoxide-mediated phase advancement of the yeast metabolic cycle
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 106:14293-6. 2009
    ..These observations provide evidence that gaseous CO may function as a cellular signaling molecule that helps cue metabolic cycling...
  4. pmc Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
    Lei Shi
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:7318-23. 2013
    ....
  5. ncbi request reprint Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity
    Zheng Chen
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 316:1916-9. 2007
    ..Thus, circadian, metabolic, and cell division cycles may be coordinated similarly as an evolutionarily conserved means of preserving genome integrity...
  6. pmc High-resolution timing of cell cycle-regulated gene expression
    Maga Rowicka
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:16892-7. 2007
    ..Our results reveal distinct subphases of the cell cycle undetectable by morphological observation, as well as the precise timeline of macromolecular complex assembly during key cell cycle events...
  7. pmc Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    Ling Cai
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Mol Cell 42:426-37. 2011
    ..Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes...
  8. pmc Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae
    Sunil Laxman
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 6:e26081. 2011
    ....
  9. pmc Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
    Xi Wu
    Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Biol Cell 22:4124-33. 2011
    ..Collectively, our findings have revealed the existence of additional mechanisms that regulate autophagy under previously unrecognized conditions, in response to relatively more subtle changes in metabolic and nutritional state...
  10. pmc Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A
    Benjamin M Sutter
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Cell 154:403-15. 2013
    ..Thus, methionine and SAM levels represent a critical gauge of amino acid availability that is sensed via the methylation of PP2A to reciprocally regulate cell growth and autophagy. ..
  11. pmc Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation
    Sunil Laxman
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Cell 154:416-29. 2013
    ..Thus, tRNA thiolation enables cells to modulate translational capacity according to the availability of sulfur amino acids, establishing a functional significance for this conserved tRNA nucleotide modification in cell growth control...
  12. pmc Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
    Isaac Marin-Valencia
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 15:827-37. 2012
    ..Many of these same activities were conserved in cells cultured ex vivo from the tumors. Thus GBM cells utilize mitochondrial glucose oxidation during aggressive tumor growth in vivo...
  13. ncbi request reprint Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, L3 124, Dallas, TX 75390, USA
    Science 310:1152-8. 2005
    ..Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time...
  14. pmc Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth
    Lei Shi
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9038, USA
    Mol Biol Cell 21:1982-90. 2010
    ..Together, our results support the view that trehalose, which is more stable than other carbohydrates, provides an enduring source of energy that helps drive cell cycle progression upon return to growth...
  15. pmc Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters
    Sunil Laxman
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    PLoS ONE 5:e12595. 2010
    ....
  16. pmc Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
    Shih Chia Tso
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:9728-33. 2013
    ..The results buttress the concept of targeting mitochondrial BDK as a pharmacological approach to mitigate BCAA accumulation in metabolic diseases and heart failure...
  17. ncbi request reprint Metabolic cycles as an underlying basis of biological oscillations
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Rev Mol Cell Biol 7:696-701. 2006
    ..We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations...
  18. pmc Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression
    Salma Kaochar
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, USA
    Trends Biochem Sci 37:477-83. 2012
    ..Herein, we highlight recent developments that have begun to reveal particular cellular metabolites that might in fact be underappreciated regulators of gene expression through their ability to modulate particular histone modifications...
  19. pmc Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export
    Liang Zhang
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 196:315-26. 2012
    ..This reversal of mRNA export block allowed expression of antiviral factors. Thus, pyrimidines play a necessary role in the inhibition of mRNA nuclear export by virulence factors...
  20. doi request reprint Ultradian metabolic cycles in yeast
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 470:857-66. 2010
    ..These ultradian metabolic cycles offer a view of the life of yeast cells under a challenging, nutrient-poor growth environment and might represent useful systems to interrogate a variety of fundamental metabolic and regulatory processes...
  21. pmc Systems approaches for the study of metabolic cycles in yeast
    Sunil Laxman
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9038, United States
    Curr Opin Genet Dev 20:599-604. 2010
    ....
  22. pmc Identification and evaluation of cycling yeast metabolites in two-dimensional comprehensive gas chromatography-time-of-flight-mass spectrometry data
    Rachel E Mohler
    University of Washington, Department of Chemistry, Box 351700, Seattle, WA 98195, USA
    J Chromatogr A 1186:401-11. 2008
    ..The phase delay of the cycling metabolites ranged widely in relation to the oxygen consumption cycling pattern...

Research Grants1

  1. Metabolic signals driving cell growth and proliferation
    Benjamin P Tu; Fiscal Year: 2010
    ..We hope these studies will provide novel insights into the mechanisms of cell growth control and contribute towards our understanding of complex metabolic diseases such as cancer. ..