- Kinetic models for the coordinated stepping of cytoplasmic dyneinDenis Tsygankov
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Chem Phys 130:025101. 2009..Finally, we use the results of these investigations to develop a full model for dimeric dynein's chemomechanical cycle and analyze this model to make experimentally testable predictions...
- Multiscale approaches for studying energy transduction in dyneinAdrian W R Serohijos
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA
Phys Chem Chem Phys 11:4840-50. 2009..Third, we present a kinetic model of the coordination between the two dynein heads. Lastly, we investigate the various potential geometries of the dimer during its hydrolytic and stepping cycle...
- A physical model reveals the mechanochemistry responsible for dynein's processive motionDenis Tsygankov
Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Biophys J 101:144-50. 2011....
- A quantitative model for age-dependent expression of the p16INK4a tumor suppressorDenis Tsygankov
Departments of Pharmacology, Medicine, and Genetics, and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 106:16562-7. 2009..This analysis is most consistent with the model that p16(INK4a) expression monotonically increases with age, and higher expression is associated with increased subject attrition...