Karen D Tsuchiya

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse
    Karen D Tsuchiya
    Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genome Res 14:1275-84. 2004
  2. doi request reprint Variability in interpreting and reporting copy number changes detected by array-based technology in clinical laboratories
    Karen D Tsuchiya
    Department of Laboratories, Seattle Children s Hospital, Seattle, Washington, USA
    Genet Med 11:866-73. 2009
  3. pmc Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer
    Yajun Yi
    Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Laboratories, Seattle Children s Hospital, WA, USA
    Mol Cytogenet 2:18. 2009
  4. doi request reprint Fluorescence in situ hybridization
    Karen D Tsuchiya
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357110, Seattle, WA 98195, USA
    Clin Lab Med 31:525-42, vii-viii. 2011
  5. pmc Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization
    Karen D Tsuchiya
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, WA, USA
    Mol Cytogenet 1:7. 2008
  6. ncbi request reprint Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development
    Galina N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 8:31-42. 2005
  7. pmc TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway
    Patty Trobridge
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Gastroenterology 136:1680-8.e7. 2009
  8. doi request reprint The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Res 68:1768-76. 2008
  9. doi request reprint Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity
    Ruxandra Bachmann-Gagescu
    Division of Genetic Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Genet Med 12:641-7. 2010
  10. doi request reprint Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA
    Christoph Ausch
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Clin Chem 55:1559-63. 2009

Collaborators

Detail Information

Publications10

  1. pmc Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse
    Karen D Tsuchiya
    Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genome Res 14:1275-84. 2004
    ..Our findings indicate that genomic context, as well as gene-specific regulatory elements, interact to determine expression of a gene from the inactive X-chromosome...
  2. doi request reprint Variability in interpreting and reporting copy number changes detected by array-based technology in clinical laboratories
    Karen D Tsuchiya
    Department of Laboratories, Seattle Children s Hospital, Seattle, Washington, USA
    Genet Med 11:866-73. 2009
    ..The purpose of this study was to assess the variability in interpretation and reporting of copy number changes that are detected by array-based technology in the clinical laboratory...
  3. pmc Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer
    Yajun Yi
    Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Laboratories, Seattle Children s Hospital, WA, USA
    Mol Cytogenet 2:18. 2009
    ..We performed high resolution array comparative genomic hybridization on the metastasizing and non-metastasizing allografts to identify chromosome imbalances that differed between the two groups of tumors...
  4. doi request reprint Fluorescence in situ hybridization
    Karen D Tsuchiya
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357110, Seattle, WA 98195, USA
    Clin Lab Med 31:525-42, vii-viii. 2011
    ..FISH also continues to be widely used in conjunction with banded chromosome analysis, and as a stand-alone technique for the detection of genomic alterations in neoplastic disorders...
  5. pmc Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization
    Karen D Tsuchiya
    Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, WA, USA
    Mol Cytogenet 1:7. 2008
    ..In this study, we describe four patients who possess one or more SMCs (a total of eight SMCs in all four patients) that were characterized by microarray comparative genomic hybridization (array CGH)...
  6. ncbi request reprint Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development
    Galina N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 8:31-42. 2005
    ..Furthermore, the evolution of X chromosome domains appears to be associated with repositioning of chromatin boundary elements...
  7. pmc TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway
    Patty Trobridge
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Gastroenterology 136:1680-8.e7. 2009
    ..The RAS-RAF-ERK pathway is frequently up-regulated in colon cancer via mutational activation of KRAS or BRAF. We assessed how these pathways interact in vivo and affect formation of colorectal tumors...
  8. doi request reprint The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA
    Cancer Res 68:1768-76. 2008
    ..The Smo/Smo model is the first mouse medulloblastoma model to show leptomeningeal spread. The adherence to human pathology, high incidence, and early onset of tumors thus make Smo/Smo mice an efficient model for preclinical studies...
  9. doi request reprint Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity
    Ruxandra Bachmann-Gagescu
    Division of Genetic Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Genet Med 12:641-7. 2010
    ..The purpose of this study was to better define the phenotype of this recurrent SH2B1-containing microdeletion in a cohort of phenotypically abnormal patients not selected for obesity...
  10. doi request reprint Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA
    Christoph Ausch
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Clin Chem 55:1559-63. 2009
    ..Aberrantly methylated genes are promising biomarkers for the detection of colon adenomas and colorectal cancers (CRCs). The optimal assay type and specific methylated genes for these assays remain to be determined...