Ming Tsuang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093, USA
    Am J Med Genet B Neuropsychiatr Genet 144:113-6. 2007
  2. doi request reprint Genetics of smoking and depression
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92039, USA
    Hum Genet 131:905-15. 2012
  3. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
  4. ncbi request reprint Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report
    Ming T Tsuang
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 133:1-5. 2005
  5. doi request reprint Prevention of schizophrenia
    Ming T Tsuang
    University of California San Diego, CA, USA
    Expert Rev Neurother 10:1165-74. 2010
  6. ncbi request reprint Spiritual well-being and health
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego 92037, and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Nerv Ment Dis 195:673-80. 2007
  7. doi request reprint Commentary on Koenig (2008): "Concerns about measuring 'spirituality' in research"
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92037, USA
    J Nerv Ment Dis 196:647-9. 2008
  8. ncbi request reprint Posttraumatic stress disorder and late-onset smoking in the Vietnam era twin registry
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, and The Miriam Hospital, Providence, RI, USA
    J Consult Clin Psychol 74:186-90. 2006
  9. ncbi request reprint Specificity of familial vulnerability for alcoholism versus major depression in men
    Michael J Lyons
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Nerv Ment Dis 194:809-17. 2006
  10. doi request reprint Genetic and environmental multidimensionality of well- and ill-being in middle aged twin men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, MC0738, La Jolla, CA 92093, USA
    Behav Genet 42:579-91. 2012

Detail Information

Publications91

  1. ncbi request reprint Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093, USA
    Am J Med Genet B Neuropsychiatr Genet 144:113-6. 2007
    ..However, our failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself...
  2. doi request reprint Genetics of smoking and depression
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92039, USA
    Hum Genet 131:905-15. 2012
    ..The search for underlying genes and genetic mechanisms is at an early stage, but shows promising candidate genes and genetic approaches for future studies...
  3. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  4. ncbi request reprint Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report
    Ming T Tsuang
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 133:1-5. 2005
    ..We therefore propose that blood cell-derived RNA may have significant value for performing diagnostic functions and identifying disease biomarkers in schizophrenia and BPD...
  5. doi request reprint Prevention of schizophrenia
    Ming T Tsuang
    University of California San Diego, CA, USA
    Expert Rev Neurother 10:1165-74. 2010
    ..This strategy will then allow the formation of more homogenous treatment groups to use in developing early intervention and prevention strategies in the not-too-distant future...
  6. ncbi request reprint Spiritual well-being and health
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego 92037, and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Nerv Ment Dis 195:673-80. 2007
    ..quot; We concluded that studies of SWB and health should continue to distinguish between explicitly religious variables and others that more closely approximate the psychological construct of personal well-being...
  7. doi request reprint Commentary on Koenig (2008): "Concerns about measuring 'spirituality' in research"
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92037, USA
    J Nerv Ment Dis 196:647-9. 2008
  8. ncbi request reprint Posttraumatic stress disorder and late-onset smoking in the Vietnam era twin registry
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, and The Miriam Hospital, Providence, RI, USA
    J Consult Clin Psychol 74:186-90. 2006
    ..If replicated, these results identify PTSD as a risk factor for smoking that should lead to early tobacco control treatment in this population...
  9. ncbi request reprint Specificity of familial vulnerability for alcoholism versus major depression in men
    Michael J Lyons
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Nerv Ment Dis 194:809-17. 2006
    ..Our data are most consistent with a mechanism of reciprocal causation, whereby MD increases risk for AD and AD increases risk of MD...
  10. doi request reprint Genetic and environmental multidimensionality of well- and ill-being in middle aged twin men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, MC0738, La Jolla, CA 92093, USA
    Behav Genet 42:579-91. 2012
    ..All measures had specific unique environmental influences. Results indicate that well-being is genetically and environmentally multidimensional and that ill-being has partial overlap with both latent factors...
  11. ncbi request reprint Juvenile conduct disorder as a risk factor for trauma exposure and posttraumatic stress disorder
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Trauma Stress 18:23-32. 2005
    ..The findings suggest CD increases risk for trauma exposure and PTSD among male veterans through direct and indirect mechanisms. Veterans who have a history of CD are at high risk for trauma exposure and development of PTSD...
  12. ncbi request reprint Pilot study of spirituality and mental health in twins
    Ming T Tsuang
    Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, 02115, USA
    Am J Psychiatry 159:486-8. 2002
    ..The goal of this study was to investigate associations between empirically defined dimensions of spirituality, personality variables, and psychiatric disorders in Vietnam era veterans...
  13. ncbi request reprint A twin registry study of the relationship between posttraumatic stress disorder and nicotine dependence in men
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Avenue, Kresge 613, Boston, MA 02115, USA
    Arch Gen Psychiatry 62:1258-65. 2005
    ..Recent studies indicate a strong association between posttraumatic stress disorder (PTSD) and nicotine dependence (ND). However, the explanation for the association remains unclear...
  14. ncbi request reprint Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples
    Sakae Takahashi
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Psychiatry 54:129-35. 2003
    ..A family based association study in a British sample found the NOTCH4 gene to be associated with schizophrenia; however, all six replication studies failed to confirm the finding...
  15. ncbi request reprint Shared genetic risk of major depression, alcohol dependence, and marijuana dependence: contribution of antisocial personality disorder in men
    Qiang Fu
    Missouri Alcoholism Research Center at Washington University, Department of Psychiatry, Washington University School of Medicine, 40 N Kingshighway Blvd, Suite 2, St Louis, MO 63108, USA
    Arch Gen Psychiatry 59:1125-32. 2002
    ..We examined the contribution of genetic effects associated with ASPD to the comorbidity of MD and substance use disorders...
  16. doi request reprint Between-site reliability of startle prepulse inhibition across two early psychosis consortia
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0810, USA
    Neuroreport 24:626-30. 2013
    ..In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites. ..
  17. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  18. ncbi request reprint A twin study of the neuropsychological consequences of stimulant abuse
    Rosemary Toomey
    Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 02129, USA
    Arch Gen Psychiatry 60:303-10. 2003
    ..Previous studies document neuropsychological deficits associated with stimulant abuse, but findings are inconsistent...
  19. pmc Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study
    Scott W Woods
    PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Bull 35:894-908. 2009
    ..The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)...
  20. ncbi request reprint Meta-analysis shows schizophrenia is not associated with the 40-base-pair repeat polymorphism of the dopamine transporter gene
    F Gamma
    Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 73:55-8. 2005
    ..The results of these studies have been equivocal due to small sample size and low power. This meta-analysis has the aim to evaluate the collective evidence for an association between the VTNR polymorphism and schizophrenia...
  21. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  22. pmc Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 15:3132-45. 2006
    ....
  23. ncbi request reprint Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Psychiatry 163:1760-6. 2006
    ..To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members...
  24. ncbi request reprint Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center and Massachusetts General Hospital, Boston 02115, USA
    Am J Psychiatry 160:469-76. 2003
    ..The authors' goal was to evaluate the collective evidence for an association between the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophrenia...
  25. ncbi request reprint Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI
    Heidi W Thermenos
    Harvard Medical School, Massachusetts Mental Health Center in the Division of Public Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Biol Psychiatry 61:564-74. 2007
    ..We used functional magnetic resonance imaging (fMRI) to assess brain activity in the MTL during novel and repeated word-pair encoding...
  26. ncbi request reprint Co-occurrence of binge eating disorder with psychiatric and medical disorders
    Kristin N Javaras
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass, USA
    J Clin Psychiatry 69:266-73. 2008
    ..We used data from that type of study to assess the co-occurrence of various psychiatric and medical disorders with DSM-IV BED and with subthreshold BED...
  27. ncbi request reprint Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study
    Heidi W Thermenos
    Department of Psychology and Brain Research Institute RP, University of California, Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 55:490-500. 2004
    ....
  28. ncbi request reprint Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness
    Larry J Seidman
    Harvard Medical, School Department of Psychiatry at Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    J Clin Exp Neuropsychol 25:949-64. 2003
    ..Further research is required to determine whether similar mechanisms underlie the neurocognitive deficits in these psychotic disorders...
  29. pmc Posttraumatic stress disorder and the genetic structure of comorbidity
    Erika J Wolf
    National Center for PTSD, VA Boston Healthcare System and Department of Psychology, Boston University, Boston, MA, USA
    J Abnorm Psychol 119:320-30. 2010
    ..Shared genetic variance across the 2 dimensions explained 67% of their phenotypic correlation (r = .52). These findings have implications for conceptualizations of the etiology of PTSD and its location in an empirically based nosology...
  30. ncbi request reprint Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  31. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  32. ncbi request reprint A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses
    Larry J Seidman
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, and Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 53:31-44. 2002
    ..Further research is required to determine whether similar mechanisms underly the neurocognitive deficits in these disorders...
  33. pmc Treatment history in the psychosis prodrome: characteristics of the North American Prodrome Longitudinal Study Cohort
    Kristin S Cadenhead
    Department of Psychiatry and Biobehavioral Sciences, UCSD, San Diego, California 92093 0810, USA
    Early Interv Psychiatry 4:220-6. 2010
    ..The primary aim of this manuscript is to describe the treatment histories of a large cohort of individuals who entered into one of seven prodromal research programs in a North American Prodrome Longitudinal Study consortium...
  34. doi request reprint A twin study of smoking, nicotine dependence, and major depression in men
    Michael Lyons
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Nicotine Tob Res 10:97-108. 2008
    ..Findings extend Kendler and colleague's (1993) study of female twins by demonstrating in men that shared genetic factors predispose not only to major depression and daily smoking but also to major depression and nicotine dependence...
  35. ncbi request reprint CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 121:14-20. 2003
    ..Further, it remains unknown if this polymorphism, or one in linkage disequilibrium with it, contributes to some distinct feature of the disorder, such as symptom severity or anticipation...
  36. ncbi request reprint Schizotaxia: current status and future directions
    Ming T Tsuang
    Department of Psychiatry at the Massachusetts Mental Health Center, Harvard Medical School, 74 Fernwood Road, Boston, MA 02115, USA
    Curr Psychiatry Rep 5:128-34. 2003
    ..In this review, the authors update the conceptual basis of schizotaxia, consider evidence for its validity, and look toward its likely evolution in the future...
  37. ncbi request reprint Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Schizophr Res 67:53-62. 2004
    ..The effects of other genes, environmental effects on DNA methylation, or different methods of classification may be the causes for such heterogeneity, but more study in this area is needed...
  38. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  39. ncbi request reprint Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin study
    William S Kremen
    Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 64:361-8. 2007
    ..Cognitive deficits are associated with posttraumatic stress disorder (PTSD), but whether such deficits reflect sequelae or risk factors is not fully resolved...
  40. pmc Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
    Neuroimage 49:1213-23. 2010
    ..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life...
  41. ncbi request reprint Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, California 92093, USA
    Psychiatr Genet 17:165-70. 2007
    ..Many case-control association studies have been performed to see if BDNF could serve as a useful clinical diagnostic biomarker for schizophrenia or bipolar disorder, but results have been equivocal...
  42. ncbi request reprint Is the Wisconsin Card Sorting Test a useful neurocognitive endophenotype?
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093 0738, USA
    Am J Med Genet B Neuropsychiatr Genet 144:403-6. 2007
    ..Rather, we believe that our results suggest that some properties of this particular test make it undesirable for use as an endophenotype...
  43. ncbi request reprint Family study of affective spectrum disorder
    James I Hudson
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Arch Gen Psychiatry 60:170-7. 2003
    ..Two predictions of the ASD hypothesis were tested: that ASD, taken as a single entity, would aggregate in families and that MDD would coaggregate with other forms of ASD in families...
  44. ncbi request reprint Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?
    William S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, 2230 Stockton Blvd, Sacramento, CA 95817, USA
    J Int Neuropsychol Soc 9:79-88. 2003
    ..48 < rs < .79). These results mirror a literature that overall suggests a small degree of disproportionate semantic fluency impairment in schizophrenia, but also some heterogeneity in fluency deficits...
  45. ncbi request reprint Genetics of verbal working memory processes: a twin study of middle-aged men
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
    Neuropsychology 21:569-80. 2007
    ..The genetic influences that were specific to reading span were concluded to most likely reflect an executive function component. Implications for genetic studies of aging and prefrontal brain function are discussed...
  46. doi request reprint IQ decline in cross-sectional studies of schizophrenia: methodology and interpretation
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
    Psychiatry Res 158:181-94. 2008
    ..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time...
  47. ncbi request reprint An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention
    Ming T Tsuang
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center MMHC, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 54:169-75. 2002
    ..25-2.0 mg). Thus, clinical deficits in schizotaxia may be identifiable, and to a significant extent, reversible. Implications for the conception of schizotypy and the prevention of schizophrenia will be discussed...
  48. doi request reprint The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: replication in schizophrenia and extension to bipolar disorder with psychosis
    Tetsufumi Kanazawa
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 147:686-9. 2008
    ..Future studies should exploit DNA-based methods and molecular investigations on the role of SELENBP1 in order to gain insights into the nature of its influence on schizophrenia and psychotic symptoms...
  49. pmc Factor structure of planning and problem-solving: a behavioral genetic analysis of the Tower of London task in middle-aged twins
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
    Behav Genet 39:133-44. 2009
    ..The different phenotypic and genetic factor results suggest that relying solely on the former could obscure genetic associations...
  50. ncbi request reprint Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia
    Stephen J Glatt
    Center for Behavioral Genomics, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 920923, USA
    Br J Psychiatry 189:337-45. 2006
    ..Evaluation of individuals at high genetic risk of schizophrenia is a powerful method for identifying precursors of the illness...
  51. ncbi request reprint Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses
    Stephen J Glatt
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States
    Schizophr Res 73:281-90. 2005
    ....
  52. pmc Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Hum Brain Mapp 32:641-53. 2011
    ....
  53. doi request reprint Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood
    Chad A Bousman
    Department of Psychiatry, University of California, San Diego, California, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1336-41. 2010
    ..Our findings suggest that dysregulation of the UPS, specifically ubiquitin conjugation and deubiquitination, may point to a possible underlying biological mechanism for severity of positive but not negative symptoms...
  54. ncbi request reprint The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 57:1485-92. 2005
    ..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
  55. ncbi request reprint Heritability of word recognition in middle-aged men varies as a function of parental education
    William S Kremen
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Behav Genet 35:417-33. 2005
    ..Our results suggest that shared environmental factors in families with low parental education have long-lasting effects on word recognition ability, well beyond any critical period for developing reading proficiency...
  56. ncbi request reprint Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 161:625-30. 2004
    ..Because age at onset may have utility in resolving the complexity and heterogeneity of the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this trait...
  57. ncbi request reprint Heterogeneity of schizophrenia: a study of individual neuropsychological profiles
    William S Kremen
    Department of Psychiatry and Behavioral Sciences, University of California, Davis School of Medicine, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    Schizophr Res 71:307-21. 2004
    ..Further research-probably including neuroimaging and genetic studies-will also be needed to determine the validity and the utility of this strategy for identifying neuropsychological profile types...
  58. ncbi request reprint Early and late neurodevelopmental influences in the prodrome to schizophrenia: contributions of genes, environment, and their interactions
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, 90095, USA
    Schizophr Bull 29:653-69. 2003
    ....
  59. ncbi request reprint A discordant twin study of premorbid cognitive ability in schizophrenia
    William S Kremen
    Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
    J Clin Exp Neuropsychol 28:208-24. 2006
    ..Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment...
  60. ncbi request reprint Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders
    Jessica A Lasky-Su
    Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 133:110-5. 2005
    ..The small but significant effects of the 44-bp insertion/deletion polymorphism for BP is consistent with being one of many genes that contributes to the multi-factorial nature of these psychiatric disorders...
  61. doi request reprint Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  62. pmc Genome-wide linkage analysis of heroin dependence in Han Chinese: results from wave one of a multi-stage study
    Stephen J Glatt
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, Gilman Drive, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 141:648-52. 2006
    ....
  63. pmc Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies
    Larry J Seidman
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, USA
    Schizophr Bull 32:507-24. 2006
    ..Ascertainment criteria for controls may markedly influence results and interpretation of group differences...
  64. pmc Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England family study's high-risk design
    Jill M Goldstein
    Division of Women s Health, Mary Horrigan Connors Center for Women s Health and Gender Biology, and Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Arch Gen Psychiatry 67:458-67. 2010
    ..However, few studies have investigated the specificity of the transmission of schizophrenia-psychosis spectrum (SPS) disorders and affective psychoses (APs) or observed high-risk offspring into mid-adulthood...
  65. pmc Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence
    Chad A Bousman
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
    Psychiatry Res 178:295-8. 2010
    ..Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups...
  66. pmc Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  67. pmc Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical
    Brandon Abbs
    Brigham and Women s Hospital, Connors Center for Women s Health and Gender Biology, 1620 Tremont St BC 3 34, Boston, MA 02120, USA
    Neuroimage 56:1865-74. 2011
    ..These results illustrate the utility of a unique covariance structure modeling approach that yields important new knowledge for understanding the nature of schizophrenia...
  68. doi request reprint Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples
    Chad A Bousman
    Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92039, USA
    Am J Med Genet B Neuropsychiatr Genet 153:494-502. 2010
    ..Findings provide preliminary evidence of UPS dysregulation in BPD and psychosis as well as support further investigation of the UPS and other molecular and cellular pathways for potential biomarkers for SCZ, BPD, and/or psychosis...
  69. ncbi request reprint Sex differences in language dysfunction in schizophrenia
    Deborah J Walder
    Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Psychiatry 163:470-7. 2006
    ..The current study investigated this issue in the domains of phonology, semantics, and grammar, which have been closely linked with neuroanatomic regions for which sex differences have been identified...
  70. ncbi request reprint An overview of the genetics of psychotic mood disorders
    Ming T Tsuang
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA, USA
    J Psychiatr Res 38:3-15. 2004
    ..Future research should continue to examine psychotic forms of mood disorder using both epidemiological and molecular approaches...
  71. ncbi request reprint Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior
    Brett M Kia-Keating
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1048-53. 2007
    ..Given that in the United States a higher proportion of females attempt suicide, and the higher proportion of males successfully commit suicide, it is possible that COMT is related to the lethality of suicide attempts...
  72. pmc An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder
    Heidi W Thermenos
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:120-31. 2010
    ..Persons with BD and RELs exhibit altered activity in the frontopolar cortex and insula, which may represent biomarkers of genetic risk for BD...
  73. pmc A pilot study exploring the effects of a 12-week t'ai chi intervention on somatic symptoms of depression in patients with heart failure
    Laura S Redwine
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    J Altern Complement Med 18:744-8. 2012
    ..T'ai chi practice is related to increased emotional well-being in various clinical populations; however, relatively little is known about t'ai chi's effects on somatic versus cognitive symptom dimensions of depression in HF...
  74. pmc Distinct genetic influences on cortical surface area and cortical thickness
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 19:2728-35. 2009
    ..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure...
  75. ncbi request reprint The effect of working memory performance on functional MRI in schizophrenia
    Heidi W Thermenos
    Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Schizophr Res 74:179-94. 2005
    ..We report functional magnetic resonance imaging (fMRI) data comparing subjects with schizophrenia and healthy controls performing a 2-back working memory (WM) task, addressing the effects of task performance...
  76. ncbi request reprint Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 134:60-6. 2005
    ..Further studies with a larger sample set would be required to validate these preliminary observations...
  77. ncbi request reprint Mapping genes of complex psychiatric diseases in Daghestan genetic isolates
    Kazima B Bulayeva
    Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 117809 Russia
    Am J Med Genet B Neuropsychiatr Genet 132:76-84. 2005
    ..While the analyses are ongoing, the most positive findings were made in different isolated pedigrees on chromosomes 17p11, 3q24, and 22q for schizophrenia and on chromosome 12q for nonspecific mental retardation...
  78. ncbi request reprint Genetic and environmental contributions to the development of alcohol dependence in male twins
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
    Arch Gen Psychiatry 61:897-903. 2004
    ..Information on the heritability of the development of alcohol dependence could provide a better understanding of the importance of genetic components in disease transition...
  79. ncbi request reprint A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families
    Stephen V Faraone
    Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School, 37 Shields Avenue, Boston, MA 02301, USA
    Hum Hered 57:59-68. 2004
    ..Such findings help prioritize genes for future case control studies. In addition, we provide a novel permutation method that is useful in future analyses involving a single hypothesis, with multiple candidate genes...
  80. ncbi request reprint A high risk twin study of combat-related PTSD comorbidity
    Karestan C Koenen
    Women s Health Sciences Division 116B 3, National Center for PTSD, VA Boston Healthcare System, MA 02130, USA
    Twin Res 6:218-26. 2003
    ....
  81. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  82. ncbi request reprint Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study
    Larry J Seidman
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston, USA
    J Clin Exp Neuropsychol 28:225-42. 2006
    ..Future research on this sample will evaluate the prospective roles of family history and perinatal complications on cognition, and assess the specificity of these findings...
  83. ncbi request reprint The genetics of pediatric-onset bipolar disorder
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:970-7. 2003
    ....
  84. ncbi request reprint Evaluation of RGS4 as a candidate gene for schizophrenia
    Yu Li Liu
    Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Med Genet B Neuropsychiatr Genet 141:418-20. 2006
    ..Our results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated from these three SNP markers...
  85. ncbi request reprint Genome-wide linkage scan of schizophrenia: a cross-isolate study
    Kazima B Bulayeva
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin Street 3, Moscow 117809, Russia
    Genomics 89:167-77. 2007
    ..A study at higher genotyping density across the regions of interest and fluorescence in situ hybridization analyses are currently underway...
  86. pmc Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 90:159-65. 2007
    ....
  87. ncbi request reprint Heritability of SF-36 among middle-age, middle-class, male-male twins
    James C Romeis
    Comparative Aging and Health Status Laboratory, Department of Health Management and Policy, School of Public Health, Saint Louis University, St Louis, MO 63104 1314, USA
    Med Care 43:1147-54. 2005
    ....
  88. pmc Common genetic liability to major depression and posttraumatic stress disorder in men
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, United States
    J Affect Disord 105:109-15. 2008
    ..The degree to which a common genetic liability explains the etiology of the MD-PTSD association has not been quantified and has important implications for research and prevention...
  89. pmc Common genetic risk of major depression and nicotine dependence: the contribution of antisocial traits in a United States veteran male twin cohort
    Qiang Fu
    Department of Community Health, St Louis University School of Public Health, St Louis, Missouri 63104, United States of America
    Twin Res Hum Genet 10:470-8. 2007
    ....
  90. ncbi request reprint Auditory verbal working memory load and thalamic activation in nonpsychotic relatives of persons with schizophrenia: an fMRI replication
    Larry J Seidman
    Division of Public Psychiatry, Harvard Medical School Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, MA 02215, USA
    Neuropsychology 21:599-610. 2007
    ..This replication suggests that altered thalamic activation is a feature of neurobiological risk for schizophrenia...
  91. ncbi request reprint Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies
    Stephen V Faraone
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 60:125-40. 2003
    ....

Research Grants37

  1. NEURODEVELOPMENTAL STUDY OF SCHIZOPHRENIA--PHASE III
    Ming Tsuang; Fiscal Year: 2002
    ..e., in limbic-diencephalic, paralimbic and cortical regions, and white matter tracts). This study has important implications for understand2ing the etiology and development of schizophrenia. ..
  2. Genetics of Endophenotypes and Schizophrenia
    Ming Tsuang; Fiscal Year: 2003
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  3. MOLECULAR GENETICS OF HEROIN DEPENDENCE
    Ming Tsuang; Fiscal Year: 2004
    ..All genotypes will be available one year after they are generated, but no later than a year after the end of the funding period. We are submitting this proposal using the RO1 mechanism. ..
  4. Alternate Phenotypes of Substance Abuse
    Ming Tsuang; Fiscal Year: 2006
    ..The enormous health and financial costs of illicit drug abuse, both to the individual and to society, underscores the pressing need for such research. ..
  5. Schizophrenia Biomarkers: Blood vs Brain Gene Expression
    Ming Tsuang; Fiscal Year: 2006
    ..abstract_text> ..
  6. Translational Studies of Cycling in Bipolar Disorder
    Ming Tsuang; Fiscal Year: 2007
    ..abstract_text> ..
  7. Genetic Predictors of Neuropsychological and Functional Outcomes in Schizophrenia
    Ming Tsuang; Fiscal Year: 2009
    ....
  8. 1/2 Expanding Rapid Ascertainment Networks Of Schizophrenia Families In Taiwan
    Ming Tsuang; Fiscal Year: 2009
    ..Also, by capitalizing on an existing clinical infrastructure and an efficient screening and assessment protocol, we will obtain a well-powered sample in a very rapid and cost-effective manner. ..
  9. Genetic Predictors of Neuropsychological and Functional Outcomes in Schizophrenia
    Ming T Tsuang; Fiscal Year: 2010
    ....
  10. GENETIC LINKAGE STUDY OF SCHIZOPHRENIA
    Ming Tsuang; Fiscal Year: 2001
    ..This, and Millennium's prior genotyping experience shows that the genotyping phase of the work is feasible. ..
  11. NEURODEVELOPMENTAL STUDY OF SCHIZOPHRENIA
    Ming Tsuang; Fiscal Year: 1993
    ..Finally, measures of cerebral laterality will be used to contrast subjects with schizophrenia and subjects with affective disorder...
  12. SCHIZOPHRENIA--PSYCHOPATHOLOGY AND HETEROGENEITY
    Ming Tsuang; Fiscal Year: 2002
    ..Achievement of the second goal will help clarify which brain abnormalities in schizophrenic patients can be attributed to neurodevelop-mental events prior to onset and which are due to neurodegeneration after onset. ..
  13. 1/2 Expanding Rapid Ascertainment Networks Of Schizophrenia Families In Taiwan
    Ming T Tsuang; Fiscal Year: 2010
    ..Also, by capitalizing on an existing clinical infrastructure and an efficient screening and assessment protocol, we will obtain a well-powered sample in a very rapid and cost-effective manner. ..