PANAGIOTIS TSONIS

Summary

Affiliation: University of Dayton
Country: USA

Publications

  1. pmc miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networking
    Kenta Nakamura
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, United States of America
    PLoS ONE 5:e12058. 2010
  2. pmc Changes in global histone modifications during dedifferentiation in newt lens regeneration
    Nobuyasu Maki
    Department of Biology and Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, OH 45469 2320, USA
    Mol Vis 16:1893-7. 2010
  3. pmc A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice
    Rinako Suetsugu-Maki
    Department of Biology and Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, OH 45469 2320, USA
    Mol Vis 17:949-64. 2011
  4. pmc The other lives of ribosomal proteins
    Rital B Bhavsar
    Department of Biology, University of Dayton, OH 45469 2320, USA
    Hum Genomics 4:327-44. 2010
  5. ncbi request reprint A unique aged human retinal pigmented epithelial cell line useful for studying lens differentiation in vitro
    P A Tsonis
    Department of Biology, University of Dayton, Ohio 45469 2320, USA
    Int J Dev Biol 45:753-8. 2001
  6. ncbi request reprint A "small-world" network hypothesis for memory and dreams
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Perspect Biol Med 47:176-80. 2004
  7. ncbi request reprint A newt's eye view of lens regeneration
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH, USA
    Int J Dev Biol 48:975-80. 2004
  8. ncbi request reprint Molecular mimicry: structural camouflage of proteins and nucleic acids
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Biochim Biophys Acta 1783:177-87. 2008
  9. ncbi request reprint On dorsal/ventral-specific genes in the iris during lens regeneration
    P A Tsonis
    Laboratory of Molecular Biology, Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, 300 College Park, Dayton, Ohio, 45469 2320, USA
    Cell Mol Life Sci 65:41-4. 2008
  10. ncbi request reprint Focus on molecules: Pax-6, the eye master
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Exp Eye Res 83:233-4. 2006

Research Grants

  1. Gene Discovery in Mouse Models for Secondary Cataracts
    Panagiotis A Tsonis; Fiscal Year: 2010
  2. Gene Discovery in Mouse Models for Secondary Cataracts
    PANAGIOTIS TSONIS; Fiscal Year: 2009
  3. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2009
  4. Gene Discovery in Mouse Models for Secondary Cataracts
    PANAGIOTIS TSONIS; Fiscal Year: 2007
  5. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2007
  6. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2006
  7. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2005
  8. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2004
  9. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2002
  10. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2001

Collaborators

Detail Information

Publications47

  1. pmc miRNAs in newt lens regeneration: specific control of proliferation and evidence for miRNA networking
    Kenta Nakamura
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, United States of America
    PLoS ONE 5:e12058. 2010
    ..Among several miRNAs we have found that mir-148 shows an up-regulation in the ventral iris, while members of the let-7 family showed down-regulation in dorsal iris during dedifferentiation...
  2. pmc Changes in global histone modifications during dedifferentiation in newt lens regeneration
    Nobuyasu Maki
    Department of Biology and Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, OH 45469 2320, USA
    Mol Vis 16:1893-7. 2010
    ..After lens removal PECs in dorsal iris dedifferentiate and revert to stem cell-like cells, and transdifferentiate into lens cells. Our purpose is to know how global histone modifications are regulated in the reprogramming of PECs...
  3. pmc A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice
    Rinako Suetsugu-Maki
    Department of Biology and Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, OH 45469 2320, USA
    Mol Vis 17:949-64. 2011
    ..To evaluate the effects of complement employing a mouse model for secondary cataract...
  4. pmc The other lives of ribosomal proteins
    Rital B Bhavsar
    Department of Biology, University of Dayton, OH 45469 2320, USA
    Hum Genomics 4:327-44. 2010
    ..This review provides a comprehensive summary of these important aspects...
  5. ncbi request reprint A unique aged human retinal pigmented epithelial cell line useful for studying lens differentiation in vitro
    P A Tsonis
    Department of Biology, University of Dayton, Ohio 45469 2320, USA
    Int J Dev Biol 45:753-8. 2001
    ..Gene expression studies also provided important insights into the role of key genes. This human cell line can be used for detailed genetic studies in order to identify the key factors involved in lens transdifferentiation from PECs...
  6. ncbi request reprint A "small-world" network hypothesis for memory and dreams
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Perspect Biol Med 47:176-80. 2004
  7. ncbi request reprint A newt's eye view of lens regeneration
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH, USA
    Int J Dev Biol 48:975-80. 2004
    ..The ability of the dorsal iris to contribute to lens regeneration is discussed in light of iris-specific gene expression as well as in relation to factors present in the eye...
  8. ncbi request reprint Molecular mimicry: structural camouflage of proteins and nucleic acids
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Biochim Biophys Acta 1783:177-87. 2008
    ..This comprehensive review outlines this important area and aims to emphasize that molecular mimicry could in fact be more widespread than initially thought and eventually adds a new layer of genetic regulation...
  9. ncbi request reprint On dorsal/ventral-specific genes in the iris during lens regeneration
    P A Tsonis
    Laboratory of Molecular Biology, Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, 300 College Park, Dayton, Ohio, 45469 2320, USA
    Cell Mol Life Sci 65:41-4. 2008
    ..In this paper we outline some of the issues pertaining to this dorsal/ventral specificity and identity...
  10. ncbi request reprint Focus on molecules: Pax-6, the eye master
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Exp Eye Res 83:233-4. 2006
  11. ncbi request reprint Bridging knowledge gaps on the long road to regeneration: classical models meet stem cell manipulation and bioengineering
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, The University of Dayton, Dayton, OH 45469 2320, USA
    Mol Interv 7:249-50. 2007
    ..But this interface may make a reality of medicine's long-held dreams for tissue regeneration and organ replacement...
  12. pmc MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469 2320, USA
    Biochem Biophys Res Commun 362:940-5. 2007
    ..This is the first report to correlate expression of miRNAs as novel regulators of vertebrate regeneration, alluding to a novel mechanism whereby transdifferentiation occurs...
  13. ncbi request reprint Regeneration via transdifferentiation: the lens and hair cells
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, 300 College Park, Dayton, OH 45469 2320, USA
    Hear Res 227:28-31. 2007
    ..In this mini-review some issues of transdifferentiation will be presented, especially as they pertain to regeneration and induction of lens and hair cells in several animal models...
  14. ncbi request reprint Stem cells and blastema cells
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469 2320, USA
    Curr Stem Cell Res Ther 3:53-4. 2008
    ..This mini review will discuss these issues and ideas that could unite the stem cell biology with the classical regeneration models...
  15. ncbi request reprint A novel role of the hedgehog pathway in lens regeneration
    Panagiotis A Tsonis
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Dev Biol 267:450-61. 2004
    ..Down-regulation of ptc-1 was also observed when inhibiting the pathway. These results provide the first evidence of a novel role for the hedgehog pathway in specific regulation of the regenerating lens...
  16. ncbi request reprint Effects of a CDK inhibitor on lens regeneration
    Panagiotis A Tsonis
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Wound Repair Regen 12:24-9. 2004
    ..The inhibitor significantly reduced cell proliferation and enhanced apoptosis of pigment epithelial cells both in vitro and in vivo and of the regenerating lens in vivo...
  17. ncbi request reprint Regenerative biology: the emerging field of tissue repair and restoration
    Panagiotis A Tsonis
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Differentiation 70:397-409. 2002
    ..This review will present an overview of the potential of all vertebrate organs to regenerate and of the basic mechanisms involved...
  18. ncbi request reprint Expression and role of retinoic acid receptor alpha in lens regeneration
    Panagiotis A Tsonis
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Dev Growth Differ 44:391-4. 2002
    ..It was also shown that RAR-alpha is expressed in the lens during the process of regeneration. These results indicate that different RAR might have unique as well as redundant effects and patterns of expression in the regenerating lens...
  19. doi request reprint Controlling gene loss of function in newts with emphasis on lens regeneration
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, Ohio, USA
    Nat Protoc 6:593-9. 2011
    ..The protocol can take a few days or up to 20 d to complete, depending on the duration of the experiment...
  20. ncbi request reprint Lens and retina regeneration: transdifferentiation, stem cells and clinical applications
    Panagiotis A Tsonis
    University of Dayton, Laboratory of Molecular Biology, Department of Biology, Dayton, OH 45469 2320, USA
    Exp Eye Res 78:161-72. 2004
    ..Furthermore, we elaborate on specific clinical applications as the outcome of regeneration-based research...
  21. ncbi request reprint Regeneration according to Spallanzani
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering at Dayton, University of Dayton, Dayton, Ohio 45469 2320, USA
    Dev Dyn 238:2357-63. 2009
    ..This letter reflects the way of thinking in the 18(th) century that shaped the important scientific fields of regeneration and reproduction...
  22. pmc How to build and rebuild a lens
    Panagiotis A Tsonis
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Ohio 45469 2320, USA
    J Anat 209:433-7. 2006
    ..This review outlines the basic mechanisms of lens regeneration and its induction and the possibility of creating lenses by transdifferentiation of the pigment epithelial cells, by stem cells or by bioengineering...
  23. ncbi request reprint Role of retinoic acid in lens regeneration
    P A Tsonis
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Dev Dyn 219:588-93. 2000
    ..Therefore, it seems that this receptor is specific for the regeneration process and consequently such expression correlates well with the effects of RAR inhibition observed in our studies...
  24. ncbi request reprint Expression of the third component of complement, C3, in regenerating limb blastema cells of urodeles
    K Del Rio-Tsonis
    Department of Biology, University of Dayton, OH 45469, USA
    J Immunol 161:6819-24. 1998
    ..All these findings implicate C3 in the dedifferentiation process and may indicate a new role for this molecule in muscle differentiation...
  25. ncbi request reprint 9-cis retinoic acid antagonizes the stimulatory effect of 1,25 dihydroxyvitamin D3 on chondrogenesis of chick limb bud mesenchymal cells: interactions of their receptors
    P A Tsonis
    Department of Biology, University of Dayton, OH 45469 2320, USA
    Int J Dev Biol 40:1053-9. 1996
    ..The receptors for 9-cis RA (RXR) and vitamin D (VDR) were also shown to be present in the mesenchymal cells and to form heterodimers. These results implicate these receptors in cartilage differentiation during limb development...
  26. ncbi request reprint Can insights into urodele limb regeneration be achieved with cell cultures and retroviruses?
    P A Tsonis
    Department of Biology, University of Dayton 45469 2320, USA
    Int J Dev Biol 40:813-6. 1996
    ..In addition, the availability of suitable retroviral vectors for salamanders is discussed for it has opened new avenues for experimentation at the molecular level...
  27. ncbi request reprint Protein separation techniques in the study of tissue regeneration
    P A Tsonis
    Department of Biology, University of Dayton, OH 45469-2320, USA
    J Chromatogr A 698:361-7. 1995
    ..Such an approach is more realistic than other methods employing gene cloning or generation of antibodies and can lead to the actual identification and characterization of factors that are involved in these phenomena...
  28. pmc The role of Pax-6 in lens regeneration
    Mayur Madhavan
    Department of Zoology, Miami University, Oxford, OH 45056, USA
    Proc Natl Acad Sci U S A 103:14848-53. 2006
    ..These results conclusively show that Pax-6 is associated with distinct early events during lens regeneration, namely control of cell proliferation and subsequent lens fiber differentiation...
  29. ncbi request reprint Stem cells from differentiated cells
    Panagiotis A Tsonis
    Department of Biology, 300 College Park, University of Dayton, Dayton, OH 45469 2320, USA
    Mol Interv 4:81-3. 2004
  30. doi request reprint A novel approach to control growth, orientation, and shape of human osteoblasts
    Jarema S Czarnecki
    University of Dayton, Dayton, Ohio, USA
    Tissue Eng Part A 14:255-65. 2008
    ..In conclusion, osteoblast (bone-forming cells) attachment and overall growth is a function of crystallite size, graphene orientation, and carbon graphitization...
  31. ncbi request reprint Lens regeneration in mice: implications in cataracts
    Mindy K Call
    Exp Eye Res 78:297-9. 2004
    ..Epithelial to mesenchymal cell transformation is also seen during the early stages. The mouse, therefore, can become an indispensable animal model for cataract research, surgery and therapy...
  32. ncbi request reprint Gene expression and discovery during lens regeneration in mouse: regulation of epithelial to mesenchymal transition and lens differentiation
    Mario Medvedovic
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical School, Cincinnati, OH, USA
    Mol Vis 12:422-40. 2006
    ..This study, using a unique mouse model, was undertaken to identify novel regulators and networks in order to more clearly understand secondary cataracts at the molecular level...
  33. ncbi request reprint Expression of complement 3 and complement 5 in newt limb and lens regeneration
    Yuko Kimura
    Protein Chemistry Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 170:2331-9. 2003
    ....
  34. ncbi request reprint Eye regeneration at the molecular age
    Katia Del Rio-Tsonis
    Department of Zoology, Miami University, Oxford, Ohio 45469, USA
    Dev Dyn 226:211-24. 2003
    ..In addition, we stress the place of this field at the molecular age and the importance of the recent technologic advances...
  35. ncbi request reprint Unique expression patterns of the retinoblastoma (Rb) gene in intact and lens regeneration-undergoing newt eyes
    Angela R Thitoff
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Anat Rec A Discov Mol Cell Evol Biol 271:185-8. 2003
    ..These distinct patterns might be related to the regenerative potential of the lens in the newt...
  36. pmc BMP signaling mediates stem/progenitor cell-induced retina regeneration
    Tracy Haynes
    Department of Zoology, Miami University, Oxford, OH 45056, USA
    Proc Natl Acad Sci U S A 104:20380-5. 2007
    ..Retina stem/progenitor cells exist in other species, including humans. Thus, our findings provide insights on how retinal stem cells can be activated for possible regenerative therapies...
  37. ncbi request reprint Regeneration of retinotectal projections after optic tectum removal in adult newts
    Mitsumasa Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    Mol Vis 13:2112-8. 2007
    ..We wanted to examine how the retinotectal projections regenerate after removal of the brain's optic tectum and establish this animal as a model for retinal projection as well as a central nervous system regeneration model...
  38. pmc Eye on regeneration
    Mindy K Call
    University of Dayton, Ohio 45469, USA
    Anat Rec B New Anat 287:42-8. 2005
    ....
  39. pmc BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration
    Matthew W Grogg
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, Ohio 45469 2320, USA
    Nature 438:858-62. 2005
    ....
  40. ncbi request reprint To regeneration...with complement
    Panagiotis A Tsonis
    Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Adv Exp Med Biol 586:63-70. 2006
  41. pmc Gene expression signatures in the newt irises during lens regeneration
    Evgeny Makarev
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469 2320, USA
    FEBS Lett 581:1865-70. 2007
    ..Such transcriptional activity in the regeneration-incompetent ventral iris was unexpected and calls for a revision of our views about mechanisms of lens regeneration induction...
  42. ncbi request reprint Bridging the regeneration gap: genetic insights from diverse animal models
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, University of Utah School of Medicine, Deptartment of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA
    Nat Rev Genet 7:873-84. 2006
    ..Our expanding knowledge in these areas not only provides insights into animal biology in general, but also has important implications for regenerative medicine and stem-cell biology...
  43. ncbi request reprint Identification of microRNAs and other small RNAs from the adult newt eye
    Evgeny Makarev
    Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH 45469 2320, USA
    Mol Vis 12:1386-91. 2006
    ..miRNAs have been found in all animals from Drosophila to human and they are highly conserved. This work was undertaken in order to identify such RNAs in the newt eye...
  44. pmc Signaling during lens regeneration
    Matthew W Grogg
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Semin Cell Dev Biol 17:753-8. 2006
    ..In addition to outlining the current research involved in elucidating the key signaling molecules in lens regeneration, we will also highlight some of the similarities and differences between lens regeneration and development...
  45. ncbi request reprint Three novel spermatogenesis-specific zinc finger genes
    Helge Weissig
    The Burnham Institute, La Jolla, CA 92037, USA
    FEBS Lett 547:61-8. 2003
    ....
  46. ncbi request reprint Vertebrate limb regeneration
    Mindy K Call
    Laboratory of Molecular Biology, Department of Biology, University of Dayton, Dayton, OH 45469 2320, USA
    Adv Biochem Eng Biotechnol 93:67-81. 2005
    ..Our synthesis incorporates recent advances in molecular biology, which has revealed some important factors related to the initiation, induction and patterning in limb regeneration...

Research Grants17

  1. Gene Discovery in Mouse Models for Secondary Cataracts
    Panagiotis A Tsonis; Fiscal Year: 2010
    ..Also, this research will address the bipotency of lens epithelial cells to undergo EMT, which results in secondary cataracts, or lens fiber differentiation, which is a normal repair process. ..
  2. Gene Discovery in Mouse Models for Secondary Cataracts
    PANAGIOTIS TSONIS; Fiscal Year: 2009
    ..Also, this research will address the bipotency of lens epithelial cells to undergo EMT, which results in secondary cataracts, or lens fiber differentiation, which is a normal repair process. ..
  3. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2009
    ..In the long run understanding of the mechanism whereby the salamanders regenerate their tissues will eventually impact the field of regenerative medicine as a whole. ..
  4. Gene Discovery in Mouse Models for Secondary Cataracts
    PANAGIOTIS TSONIS; Fiscal Year: 2007
    ..Also, this research will address the bipotency of lens epithelial cells to undergo EMT, which results in secondary cataracts, or lens fiber differentiation, which is a normal repair process. ..
  5. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2007
    ..This might lead to experimentation with established animal models, which eventually can be used more efficiently in clinical applications. ..
  6. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2006
    ..This might lead to experimentation with established animal models, which eventually can be used more efficiently in clinical applications. ..
  7. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2005
    ..This might lead to experimentation with established animal models, which eventually can be used more efficiently in clinical applications. ..
  8. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2004
    ..This might lead to experimentation with established animal models, which eventually can be used more efficiently in clinical applications. ..
  9. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2002
    ..Understanding induction of lens regeneration would be of enormous importance in pathological states where the lens must be removed. ..
  10. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2001
    ..Understanding induction of lens regeneration would be of enormous importance in pathological states where the lens must be removed. ..
  11. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 2000
    ..Understanding induction of lens regeneration would be of enormous importance in pathological states where the lens must be removed. ..
  12. GENE REGULATION IN LENS REGENERATION
    PANAGIOTIS TSONIS; Fiscal Year: 1999
    ..Understanding induction of lens regeneration would be of enormous importance in pathological states where the lens must be removed. ..
  13. GENE REGULATION IN LENS REGENERATION
    Panagiotis A Tsonis; Fiscal Year: 2010
    ..In the long run understanding of the mechanism whereby the salamanders regenerate their tissues will eventually impact the field of regenerative medicine as a whole. ..