S Tsimikas

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Am Coll Cardiol 60:2218-29. 2012
  2. doi request reprint Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Am Coll Cardiol 60:716-21. 2012
  3. pmc Spontaneous recanalization of a completely occluded saphenous vein graft two months following acute myocardial infarction with persistent one year patency
    Patrick P Hu
    Division of Cardiovascular Diseases, University of California, San Diego, CA 92093 0682, USA
    J Thromb Thrombolysis 28:101-5. 2009
  4. pmc Estrogen-eluting stents
    Sung Kee Ryu
    Division of Cardiology, Department of Internal Medicine, Seoul Eulji Hospital, School of Medicine, Eulji University, Seoul, Republic of Korea
    J Cardiovasc Transl Res 2:240-4. 2009
  5. ncbi request reprint Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, University of California, San Diego, CA, USA
    J Lipid Res 48:425-33. 2007
  6. ncbi request reprint C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients
    Sotirios Tsimikas
    Department of Medicine, Division of Cardiology, University of California, San Diego, San Diego, California 92093 0682, USA
    J Am Coll Cardiol 47:C19-31. 2006
  7. ncbi request reprint Oxidized low-density lipoprotein biomarkers in atherosclerosis
    Sotirios Tsimikas
    Vascular Medicine Program, University of California San Diego, La Jolla 92037 0975, USA
    Curr Atheroscler Rep 8:55-61. 2006
  8. ncbi request reprint Measures of oxidative stress
    Sotirios Tsimikas
    Department of Vascular Medicine, University of California, San Diego, 9350 Campus Point Drive, Cardiovascular Diseases, La Jolla, CA 92037 0975, USA
    Clin Lab Med 26:571-90, v-vi. 2006
  9. ncbi request reprint Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, USA
    Arterioscler Thromb Vasc Biol 27:175-81. 2007
  10. ncbi request reprint Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes
    Sotirios Tsimikas
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, BSB 1080, La Jolla, CA 92093 0682, USA
    J Am Coll Cardiol 41:360-70. 2003

Detail Information

Publications86

  1. doi request reprint Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Am Coll Cardiol 60:2218-29. 2012
    ..This study sought to assess the long-term predictive value and net reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation-specific epitopes (OSEs)...
  2. doi request reprint Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    J Am Coll Cardiol 60:716-21. 2012
    ..A convergence of academic, scientific, pharmaceutical, and National Institutes of Health priorities and efforts can make this a reality in the next decade...
  3. pmc Spontaneous recanalization of a completely occluded saphenous vein graft two months following acute myocardial infarction with persistent one year patency
    Patrick P Hu
    Division of Cardiovascular Diseases, University of California, San Diego, CA 92093 0682, USA
    J Thromb Thrombolysis 28:101-5. 2009
    ..Following drug eluting stent placement, a favorable clinical course has ensued and patency confirmed on follow up angiography at 1 year...
  4. pmc Estrogen-eluting stents
    Sung Kee Ryu
    Division of Cardiology, Department of Internal Medicine, Seoul Eulji Hospital, School of Medicine, Eulji University, Seoul, Republic of Korea
    J Cardiovasc Transl Res 2:240-4. 2009
    ..Further studies are required to determine optimal dose and method of estrogen delivery with coronary stenting and whether this approach will be a viable alternative to the current DES armamentarium...
  5. ncbi request reprint Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, University of California, San Diego, CA, USA
    J Lipid Res 48:425-33. 2007
    ..In conclusion, IgG and IgM OxLDL biomarkers have divergent associations with CAD in univariate analysis but are not independent predictors of CAD or clinical events...
  6. ncbi request reprint C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients
    Sotirios Tsimikas
    Department of Medicine, Division of Cardiology, University of California, San Diego, San Diego, California 92093 0682, USA
    J Am Coll Cardiol 47:C19-31. 2006
    ....
  7. ncbi request reprint Oxidized low-density lipoprotein biomarkers in atherosclerosis
    Sotirios Tsimikas
    Vascular Medicine Program, University of California San Diego, La Jolla 92037 0975, USA
    Curr Atheroscler Rep 8:55-61. 2006
    ..This has led to a rapidly accelerating pace of new reports on the relationship of circulating oxidized LDL and various cardiovascular pathologic processes, which are the focus of this review...
  8. ncbi request reprint Measures of oxidative stress
    Sotirios Tsimikas
    Department of Vascular Medicine, University of California, San Diego, 9350 Campus Point Drive, Cardiovascular Diseases, La Jolla, CA 92037 0975, USA
    Clin Lab Med 26:571-90, v-vi. 2006
    ..Clinical investigations consisting of epidemiological, case-control, and prospective studies are reviewed to elucidate the role of these biomarkers in reflecting pathophysiology and risk prediction...
  9. ncbi request reprint Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, USA
    Arterioscler Thromb Vasc Biol 27:175-81. 2007
    ..We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression...
  10. ncbi request reprint Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes
    Sotirios Tsimikas
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, BSB 1080, La Jolla, CA 92093 0682, USA
    J Am Coll Cardiol 41:360-70. 2003
    ..This study was conducted to test the hypothesis that plasma markers of oxidized low-density lipoprotein (OxLDL) reflect acute coronary syndromes (ACS)...
  11. ncbi request reprint Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0682, USA
    J Am Coll Cardiol 47:2219-28. 2006
    ..The purpose of this work was to determine the predictive value of oxidized phospholipids (OxPLs) present on apolipoprotein B-100 particles (apoB) in carotid and femoral atherosclerosis...
  12. ncbi request reprint Oxidative biomarkers in the diagnosis and prognosis of cardiovascular disease
    Sotirios Tsimikas
    Interventional Cardiology Program, Section of Vascular Medicine, Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, La Jolla, California, USA
    Am J Cardiol 98:9P-17P. 2006
    ..Future studies are expected to clarify the role of oxidative biomarkers in the diagnosis and prognosis of CVD and to determine their value in specific clinical populations...
  13. doi request reprint In vivo markers of oxidative stress and therapeutic interventions
    Sotirios Tsimikas
    Division of Cardiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Cardiol 101:34D-42D. 2008
    ..This article reviews the latest data on MPO, isoprostanes, oxidized low-density lipoprotein, oxidized phospholipids, and Lp-PLA2 biomarker assays, and it assesses their role in reflecting therapeutic interventions to treat CVD...
  14. doi request reprint The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity
    Sotirios Tsimikas
    Vascular Medicine Program, Department of Medicine, University of California San Diego, Cardiovascular Diseases, La Jolla, CA 92037 0975, USA
    Curr Opin Lipidol 19:369-77. 2008
    ..To review emerging data on the relationship between lipoprotein(a) and oxidized phospholipids...
  15. pmc Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study
    Sotirios Tsimikas
    Vascular Medicine Program, Department of Medicine, University of California San Diego, 9500 Gilman Dr, BSB 1080, La Jolla, CA 92093 0682, USA
    Circulation 119:1711-9. 2009
    ..The relationship of OxPL/apoB levels to race/ethnicity, cardiovascular risk factors, and apo(a) isoforms is not established...
  16. doi request reprint Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events
    Sotirios Tsimikas
    Vascular Medicine Program, University of California San Diego, La Jolla, California 92993 0682, USA
    J Am Coll Cardiol 56:946-55. 2010
    ..This study sought to assess whether oxidation-specific biomarkers are associated with an increased risk of coronary artery disease (CAD) events...
  17. ncbi request reprint Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease
    Sotirios Tsimikas
    Vascular Medicine Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92993 0682, USA
    Curr Pharm Des 17:27-37. 2011
    ..Further understanding of the role of oxidation of lipoproteins may allow more rational targeted diagnostic and therapeutic modalities in clinical applications...
  18. pmc Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0682, USA
    J Am Coll Cardiol 58:1715-27. 2011
    ....
  19. ncbi request reprint Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, University of California, San Diego, La Jolla, CA 92093 0682, USA
    N Engl J Med 353:46-57. 2005
    ....
  20. ncbi request reprint Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo
    S Tsimikas
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Nucl Cardiol 6:41-53. 1999
    ..We describe the in vivo characteristics of MDA2 and initial noninvasive imaging studies of atherosclerosis in rabbits...
  21. ncbi request reprint High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial
    Sotirios Tsimikas
    Vascular Medicine Program, Department of Medicine, University of California San Diego, 9500 Gilman Dr, BSB 1080, La Jolla, CA 92093 0682, USA
    Circulation 110:1406-12. 2004
    ..This study evaluated the impact of atorvastatin on oxidized LDL (OxLDL) in patients with acute coronary syndromes (ACS)...
  22. ncbi request reprint Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies
    Sotirios Tsimikas
    Department of Medicine, Division of Cardiovascular Diseases, University of California, San Diego, La Jolla, California, USA
    J Cell Biochem Suppl 39:138-46. 2002
    ....
  23. ncbi request reprint Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein
    Sotirios Tsimikas
    Vascular Medicine Program, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 1080, La Jolla, CA 92093 0682, USA
    Circulation 109:3164-70. 2004
    ..This study was performed to assess whether oxidized low-density lipoprotein (OxLDL) levels are elevated after percutaneous coronary intervention (PCI)...
  24. ncbi request reprint Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient mice
    S Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California, San Diego, USA
    Arterioscler Thromb Vasc Biol 21:95-100. 2001
    ..Whether autoantibody titers to OxLDL will provide similar valuable insights into the extent of human atherosclerosis, particularly anatomic measurements of plaque burden and OxLDL content, remains to be determined...
  25. ncbi request reprint In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression
    S Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0682, USA
    Arterioscler Thromb Vasc Biol 20:689-97. 2000
    ..Thus, the uptake of (125)I-MDA2 correlates well with traditional measures of atherosclerosis but also reflects reduced plaque OxLDL content after hypocholesterolemic intervention...
  26. ncbi request reprint Noninvasive imaging of oxidized low-density lipoprotein in atherosclerotic plaques with tagged oxidation-specific antibodies
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Am J Cardiol 90:22L-27L. 2002
    ....
  27. ncbi request reprint Relationship between the heparin management test and the HemoTec activated clotting time in patients undergoing percutaneous coronary intervention
    S Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, 9500 Gilman Drive, BSB 1080, La Jolla, CA 92093 0682, USA
    J Thromb Thrombolysis 11:217-21. 2001
    ..The HMT, therefore, appears to be more sensitive to heparin anticoagulation that the HemoTec ACT and correlates well with it in the range required for percutaneous coronary intervention...
  28. ncbi request reprint Antibodies to oxidized low density lipoprotein: epidemiological studies and potential clinical applications in cardiovascular disease
    P Gounopoulos
    Division of Cardiovascular Diseases, University of California, San Diego, San Diego, La Jolla, CA 92093 0682, USA
    Minerva Cardioangiol 55:821-37. 2007
    ..Although these investigation are at an early stage, they show promise that immune modulation may lead to novel approaches to treat atherosclerosis and cardiovascular disease...
  29. doi request reprint Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardia
    Alexander E Fraley
    University of California San Diego, 92093 0682, USA
    J Am Coll Cardiol 53:2186-96. 2009
    ..This study sought to define the relationship between oxidative biomarkers, cardiovascular disease (CVD) risk factors, and inflammatory and thrombosis biomarkers...
  30. ncbi request reprint Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo
    P X Shaw
    Department of Medicine, University of California, San Diego, La Jolla 92093-0682, USA
    Arterioscler Thromb Vasc Biol 21:1333-9. 2001
    ..Human autoantibodies to OxLDL have important biological properties that could influence the natural course of atherogenesis...
  31. doi request reprint Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium
    Naser Ahmadi
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA
    Am J Cardiol 105:459-66. 2010
    ..Increases in OxPL/apoB and lipoprotein(a) correlated strongly with increases in vascular function and predicted a lack of progression of CAC...
  32. ncbi request reprint Clinical applications of circulating oxidized low-density lipoprotein biomarkers in cardiovascular disease
    Alexander E Fraley
    Division of Cardiology, University of California San Diego, 9350 Campus Point Drive, La Jolla, CA 92037, USA
    Curr Opin Lipidol 17:502-9. 2006
    ..The aim of this article is to review, analyze and interpret the growing body of evidence on circulating oxidized low-density lipoprotein and its relationship to diagnosis and prognosis of cardiovascular disease...
  33. doi request reprint Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice
    Esther Merki
    University of California San Diego, La Jolla, CA 92093 0682, USA
    Circulation 118:743-53. 2008
    ..Lipoprotein (a) [Lp(a)] is a genetic cardiovascular risk factor that preferentially binds oxidized phospholipids (OxPL) in plasma. There is a lack of therapeutic agents that reduce plasma Lp(a) levels...
  34. ncbi request reprint Highlights of the Year in JACC 2006
    Anthony N Demaria
    Cardiology Division, University of California San Diego, 92103 9000, USA
    J Am Coll Cardiol 49:509-27. 2007
  35. doi request reprint Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study
    Sotirios Tsimikas
    Division of Cardiology, University of California San Diego, La Jolla, CA, USA
    Eur Heart J 30:107-15. 2009
    ....
  36. ncbi request reprint Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis
    Wulf Palinski
    Department of Medicine 0682, University of California San Diego, La Jolla, California 92093 0682, USA
    J Am Soc Nephrol 13:1673-81. 2002
    ....
  37. ncbi request reprint Elevated plasma fibrinogen level predicts suboptimal response to therapy with both single- and double-bolus eptifibatide during percutaneous coronary intervention
    Ehtisham Mahmud
    Division of Cardiology, University of California at San Diego, San Diego, California 92103 8784, USA
    J Am Coll Cardiol 49:2163-71. 2007
    ..This study sought to determine the factors associated with suboptimal platelet inhibition (PI) with single- and double-bolus eptifibatide during percutaneous coronary intervention (PCI)...
  38. doi request reprint Highlights of the year in JACC 2007
    Anthony N Demaria
    Cardiology Division, University of California San Diego, San Diego, California 92103 8411, USA
    J Am Coll Cardiol 51:490-512. 2008
  39. ncbi request reprint Severe ostial saphenous vein graft disease leading to acute coronary syndromes following proximal aorto-saphenous anastomoses with the symmetry bypass connector device: is it a suture device or a "stent"?
    Jeffrey J Cavendish
    Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, California, USA
    J Am Coll Cardiol 43:133-9. 2004
    ..Dual antiplatelet agents, evaluation for ischemia, and close follow-up are warranted in patients that have already received the device...
  40. ncbi request reprint Statin-associated pleiotropy: possible beneficial effects beyond cholesterol reduction
    Matthew K Ito
    University of California, San Diego School of Medicine, La Jolla, California, USA
    Pharmacotherapy 26:85S-97S; discussion 98S-101S; quiz 106S-108S. 2006
    ....
  41. ncbi request reprint Expanded applications of rotational atherectomy in contemporary coronary and peripheral interventional practice
    Ehtisham Mahmud
    Cardiac Catheterization Laboratory, Division of Cardiology, University of California, San Diego, UCSD Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8784, USA
    J Invasive Cardiol 17:207-10. 2005
    ..We identify and present three novel uses for this device in percutaneous coronary and peripheral interventional procedures, which further expands the applications of rotational atherectomy...
  42. ncbi request reprint Highlights of the year in JACC 2003
    Anthony N Demaria
    Cardiology Division, University of California San Diego Medical Center, San Diego, California 92103, USA
    J Am Coll Cardiol 42:2156-66. 2003
  43. pmc Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity
    Yury I Miller
    Department of Medicine MC0682, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Circ Res 108:235-48. 2011
    ..These insights may lead to improved understanding of inflammation and atherogenesis and suggest new approaches to diagnosis and therapy...
  44. pmc Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation
    Longhou Fang
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:32343-51. 2010
    ....
  45. ncbi request reprint Fibromuscular dysplasia of renal arteries: percutaneous revascularization based on hemodynamic assessment with a pressure measurement guidewire
    Ehtisham Mahmud
    Division of Cardiovascular Medicine, San Diego School of Medicine, University of California, San Diego, California 92103 8784, USA
    Catheter Cardiovasc Interv 67:434-7. 2006
    ....
  46. ncbi request reprint Imaging vulnerable plaque by ultrasound
    Anthony N Demaria
    Division of Cardiology, University of California San Diego, San Diego, California, USA
    J Am Coll Cardiol 47:C32-9. 2006
    ..These advances pave the way for future clinical trials in assessing the ability of such techniques to diagnose vulnerable plaques and to assess the effects of both pharmacologic and mechanical therapies on plaque characteristics...
  47. doi request reprint Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in atherogenesis
    Yury I Miller
    Department of Medicine, University of California, San Diego, La Jolla, CA 92037 0682, USA
    Subcell Biochem 51:229-51. 2010
    ..Future directions in studying foam cell formation may include introducing novel animal models, such as hypercholesterolemic zebrafish, enabling dynamic in vivo observation of macrophage lipid uptake...
  48. doi request reprint Renal frame count and renal blush grade: quantitative measures that predict the success of renal stenting in hypertensive patients with renal artery stenosis
    Ehtisham Mahmud
    Division of Cardiovascular Medicine, School of Medicine, University of California, San Diego, California 92103 8784, USA
    JACC Cardiovasc Interv 1:286-92. 2008
    ..This study sought to identify angiographic parameters of favorable clinical response to renal artery stenting...
  49. ncbi request reprint Common femoral artery anatomy is influenced by demographics and comorbidity: implications for cardiac and peripheral invasive studies
    G Schnyder
    Division of Cardiology, UCSD Medical Center, University of California, 200 West Arbor Drive, San Diego, CA 92103, USA
    Catheter Cardiovasc Interv 53:289-95. 2001
    ..Puncture above the femoral head center and below the superior margin of the acetabulum accurately predicts an ideal puncture site. Thus, routine fluoroscopic guidance should be considered. Cathet Cardiovasc Intervent 2001;53:289-295...
  50. ncbi request reprint High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins
    Matthias Schneider
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA
    J Lipid Res 46:769-78. 2005
    ..The increase in oxidized lipids specific to Lp[a] in high-level apo[a]-expressing mice suggests a mechanism by which increased circulating levels of Lp[a] could contribute to atherogenesis...
  51. ncbi request reprint Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5
    Satoshi Isobe
    Division of Cardiology, University of California, Irvine School of Medicine, 92697, USA
    J Nucl Med 47:1497-505. 2006
    ..We evaluated the feasibility of annexin A5 imaging in transgenic apoE(-/-) and LDLR(-/-) mice with or without a cholesterol diet...
  52. doi request reprint The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles
    Kiyohito Arai
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0682, United States
    Atherosclerosis 209:498-503. 2010
    ..We hypothesized that carriers of the Met allele of the I4399M SNP would also have elevated levels of oxidized phospholipids (OxPL) on apoB (OxPL/apoB) particles...
  53. ncbi request reprint Rapid progression of common femoral artery stenosis leading to development of ischemic foot ulcer following repeated ipsilateral arterial access
    Paulo Guillinta
    Division of Cardiology, University of California, San Diego, La Jolla, California 92093 0682, USA
    Catheter Cardiovasc Interv 66:487-90. 2005
    ..We hypothesize that recurrent arterial injury in a setting of diabetes resulted in progressive critical common femoral artery stenosis...
  54. ncbi request reprint New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease
    Sotirios Tsimikas
    Department of Medicine, University of California San Diego, La Jolla, Calif, USA
    Arterioscler Thromb Vasc Biol 27:2094-9. 2007
    ....
  55. pmc Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice
    Galina K Sukhova
    the Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:897-906. 2003
    ..CatS(-/-)LDLR(-/-) monocytes showed impaired subendothelial basement membrane transmigration, and aortas from CatS(-/-)LDLR(-/-) mice had preserved elastic laminae. These findings establish a pivotal role for Cat S in atherogenesis...
  56. doi request reprint Recent advances in hemodynamics: noncoronary applications of a pressure sensor angioplasty guidewire
    Jeffrey J Cavendish
    Department of Cardiology, Naval Medical Center San Diego, San Diego, California, USA
    Catheter Cardiovasc Interv 71:748-58. 2008
    ....
  57. pmc The role of oxidized phospholipids in atherosclerosis
    Judith A Berliner
    Department of Pathology, University of California, Los Angeles, CA, USA
    J Lipid Res 50:S207-12. 2009
    ..Levels of OxPL in plasma have been shown to be correlated with platelet activation. The results of these studies suggest an important role for OxPL in all stages of atherosclerosis...
  58. ncbi request reprint Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a)
    Celina Edelstein
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:52841-7. 2003
    ....
  59. ncbi request reprint Treatment of recurrent pulmonary vein stenoses with endovascular stenting and adjuvant oral sirolimus
    Guilherme Bromberg-Marin
    Division of Cardiovascular Disease, University of California San Diego, UCSD Medical Center, 200 West Arbor Drive, San Diego, CA 92103, USA
    Catheter Cardiovasc Interv 69:362-8. 2007
    ..Both patients remain asymptomatic at 1 year follow-up without evidence of restenosis...
  60. ncbi request reprint Catheter-induced vasospasm of both the right external iliac and right coronary arteries during coronary angiography
    Brian P Shortal
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, BSB, La Jolla 92093 0682, USA
    Int J Cardiovasc Imaging 21:481-5. 2005
    ..This case illustrates the potential challenges in diagnosing catheter-induced vasospasm from fixed obstructive atherosclerotic lesions in peripheral vessels...
  61. ncbi request reprint Treatment of ischemic stroke complicating cardiac catheterization with systemic thrombolytic therapy
    Rod Serry
    Division of Cardiology, University of California, San Diego School of Medicine, San Diego, California, USA
    Catheter Cardiovasc Interv 66:364-8. 2005
    ..As the consequences of this rare complication are severe, systemic thrombolytic therapy should be considered for patients suffering an acute ischemic stroke during cardiac catheterization or percutaneous coronary intervention...
  62. doi request reprint Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel
    Lawrence Ang
    Division of Cardiovascular Medicine, University of California, San Diego School of Medicine, San Diego, California, USA
    J Am Coll Cardiol 52:1052-9. 2008
    ..The goal of this study was to identify factors associated with lower platelet inhibition (PI) with clopidogrel in subjects with cardiovascular disease (CVD)...
  63. doi request reprint Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor
    Satoru Ohshima
    Division of Cardiology, University of California, Irvine School of Medicine, Irvine, California, USA
    J Nucl Med 50:612-7. 2009
    ..Matrix metalloproteinases (MMPs) are expressed in atherosclerotic plaques and play an important role in plaque instability...
  64. doi request reprint Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, USA
    Prev Med 49:101-7. 2009
    ..This study was designed to assess whether aged garlic extract therapy with supplements (AGE+S) favorably affects inflammatory and oxidation biomarkers, vascular function and progression of atherosclerosis as compared to placebo...
  65. ncbi request reprint Successful utilization of a novel aspiration thrombectomy catheter (Pronto) for the treatment of patients with stent thrombosis
    Danish S Siddiqui
    Division of Cardiology, University of California, San Diego School of Medicine, San Diego, California 92103 8784, USA
    Catheter Cardiovasc Interv 67:894-9. 2006
    ..We present three patients with stent thrombosis successfully treated with the adjunctive use of a novel and new aspiration thrombectomy device (Pronto)...
  66. ncbi request reprint Concomitant coronary and multiple arch vessel stenoses in patients treated with external beam radiation: pathophysiological basis and endovascular treatment
    Jeffrey J Cavendish
    Division of Cardiology, University of California, San Diego, California, USA
    Catheter Cardiovasc Interv 62:385-90. 2004
    ..We review the pathophysiology, discuss the treatment options and describe the percutaneous treatment of coronary, carotid, subclavian, and axillary stenoses related to this rare but likely underdiagnosed disorder...
  67. ncbi request reprint Highlights of the Year in JACC 2005
    Anthony N Demaria
    Cardiology Division, University of California San Diego, San Diego, California
    J Am Coll Cardiol 47:184-202. 2006
  68. ncbi request reprint Highlights of the year in JACC 2004
    Anthony N Demaria
    Cardiology Division, University of California San Diego, San Diego, California
    J Am Coll Cardiol 45:137-53. 2005
  69. ncbi request reprint Emerging approaches for imaging vulnerable plaques in patients
    Seung Hyuk Choi
    Division of Cardiology, University of California San Diego, La Jolla, USA
    Curr Opin Biotechnol 18:73-82. 2007
    ..Natural history and intervention studies will need to be performed to determine whether identifying and treating vulnerable plaques will lead to improved clinical outcomes...
  70. pmc The role of innate immunity in atherogenesis
    Karsten Hartvigsen
    Department of Medicine, University of California, San Diego, CA, USA
    J Lipid Res 50:S388-93. 2009
    ..We discuss the evidence for this hypothesis and the consequences of such responses in health and disease, such as atherosclerosis...
  71. ncbi request reprint Spontaneous multivessel coronary vasospasm leading to cardiogenic shock
    Guilherme Bromberg-Marin
    Division of Cardiovascular Diseases, University of California San Diego, La Jolla, CA 92093 0682, USA
    J Invasive Cardiol 19:E85-8. 2007
    ..We review the diagnosis and treatment of coronary vasospasm and the implications of coronary vasoreactivity in the pathophysiology of myocardial infarction...
  72. doi request reprint Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes
    Karen C Briley-Saebo
    Imaging Science Laboratory, Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 117:3206-15. 2008
    ....
  73. doi request reprint Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study
    Seung Hyuk Choi
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Am Coll Cardiol 52:24-32. 2008
    ..This study was designed to test the hypothesis that circulating biomarkers of oxidized low-density lipoprotein (OxLDL) are affected by statin therapy and predict changes in atheroma volume...
  74. ncbi request reprint Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, University of Mainz, Germany
    Arterioscler Thromb Vasc Biol 24:2307-12. 2004
    ..Labeled oxidation-specific antibodies (Ox-AB) detect, quantify, and noninvasively image lipid-rich atherosclerotic lesions. However, it is unknown whether Ox-AB detect plaque stabilization...
  75. ncbi request reprint Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina
    Amit Segev
    Ann and Roy Foss Interventional Research Program, Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 150:1007-14. 2005
    ..OxLDL induces up-regulation of inflammatory genes and cytokines and recruits monocytes to the vessel wall. Elevated levels of monocytes post-percutaneous coronary intervention (PCI) are associated with in-stent restenosis...
  76. ncbi request reprint Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin
    Jessica Rodenburg
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 47:1803-10. 2006
    ..To assess the role of oxidized phospholipids (OxPLs) in children with familial hypercholesterolemia (FH) and the effect of pravastatin...
  77. ncbi request reprint Oxidized low-density lipoprotein biomarkers in patients with end-stage renal failure: acute effects of hemodialysis
    Maurizio Bossola
    Istituto di Clinica Chirurgica, Universita Cattolica del Sacro Cuore, Roma, Italia
    Blood Purif 25:457-65. 2007
    ..Patients with end-stage renal failure have increased oxidative stress and are at significantly increased risk of cardiovascular disease...
  78. ncbi request reprint Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Arterioscler Thromb Vasc Biol 27:850-7. 2007
    ..The present study analyzed the effect of glutathione peroxidase-1 deficiency on atherogenesis in the apolipoprotein E-deficient mouse...
  79. ncbi request reprint Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study
    Manuel Mayr
    Department of Cardiac and Vascular Sciences, St George s, University of London, London, United Kingdom
    J Am Coll Cardiol 47:2436-43. 2006
    ..We investigated whether associations exist between immune reactions to oxidized low-density lipoproteins (OxLDLs), chronic infections, and carotid atherosclerosis as quantified by ultrasound...
  80. ncbi request reprint Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study
    Stefan Kiechl
    Department of Neurology, Medical University of Innsbruck, Austria
    Arterioscler Thromb Vasc Biol 27:1788-95. 2007
    ..Oxidized phospholipids (OxPL) circulate on apolipoprotein B-100 particles (OxPL/apoB), and primarily on Lp(a) lipoprotein (a) [Lp(a)]. The relationship of OxPL/apoB levels to future cardiovascular events is not known...
  81. doi request reprint The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans
    Bonnie Ky
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Am Coll Cardiol 51:1653-62. 2008
    ..The aim of this study was to determine the effects of pravastatin and atorvastatin on markers of oxidative stress in plasma...
  82. ncbi request reprint Drug-eluting stents and late adverse clinical outcomes lessons learned, lessons awaited
    Sotirios Tsimikas
    J Am Coll Cardiol 47:2112-5. 2006
  83. doi request reprint A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma
    Claes Bergmark
    Department of Vascular Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Lipid Res 49:2230-9. 2008
    ..These data demonstrate that Lp[a] is the preferential carrier of PC-containing OxPL in human plasma. This unique property of Lp[a] suggests novel insights into its physiological function and mechanisms of atherogenicity...
  84. doi request reprint The evolution of thienopyridine therapy clopidogrel duration, diabetes, and drug-eluting stents
    Seung Hyuk Choi
    J Am Coll Cardiol 51:2228-9. 2008
  85. ncbi request reprint Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia
    Radjesh J Bisoendial
    Arterioscler Thromb Vasc Biol 25:e133-4. 2005
  86. ncbi request reprint Shifting the diagnosis and treatment of atherosclerosis to children and young adults: a new paradigm for the 21st century
    Sotirios Tsimikas
    J Am Coll Cardiol 40:2122-4. 2002