Hung Tseng

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Complementary oligonucleotides and the origin of the mammalian involucrin gene
    H Tseng
    School of Medicine, University of Pennsylvania, Department of Dermatology, Philadelphia, USA
    Gene 194:87-95. 1997
  2. ncbi request reprint DNA cloning without restriction enzyme and ligase
    H Tseng
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Biotechniques 27:1240-4. 1999
  3. pmc Mouse ribosomal RNA genes contain multiple differentially regulated variants
    Hung Tseng
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1843. 2008
  4. ncbi request reprint Cell-type-specific regulation of RNA polymerase I transcription: a new frontier
    Hung Tseng
    Department of Dermatology, Department of Cell and Developmental Biology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, CRB Room 242B, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Bioessays 28:719-25. 2006
  5. pmc Search for basonuclin target genes
    Junwen Wang
    Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 348:1261-71. 2006
  6. pmc Basonuclin regulates a subset of ribosomal RNA genes in HaCaT cells
    Shengliang Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 2:e902. 2007
  7. pmc Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium
    Xiaohong Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 2:e1087. 2007
  8. ncbi request reprint Basonuclin: a novel mammalian maternal-effect gene
    Jun Ma
    Department of Dermatology, University of Pennsylvania, PA 19104, USA
    Development 133:2053-62. 2006
  9. pmc BNC1 is required for maintaining mouse spermatogenesis
    Xiaohong Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    Genesis 50:517-24. 2012
  10. pmc Mapping ribosomal RNA transcription activity in the mouse eye
    Jiangchao Qian
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 235:1984-93. 2006

Research Grants

  1. Is Basonuclin essential for Oogenesis
    Hung Tseng; Fiscal Year: 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Complementary oligonucleotides and the origin of the mammalian involucrin gene
    H Tseng
    School of Medicine, University of Pennsylvania, Department of Dermatology, Philadelphia, USA
    Gene 194:87-95. 1997
    ..Such a replication mechanism differs from the one that creates tandem repeats by producing short complementary sequence on the same strand of DNA...
  2. ncbi request reprint DNA cloning without restriction enzyme and ligase
    H Tseng
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Biotechniques 27:1240-4. 1999
    ..It also simplifies the planning of a cloning strategy, increases recombinant frequency and is suitable for automation...
  3. pmc Mouse ribosomal RNA genes contain multiple differentially regulated variants
    Hung Tseng
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1843. 2008
    ..Thus, the mouse rDNA array likely consists of genetically distinct variants, and some are regulated tissue-specifically. Our results provide the first molecular evidence for cell-type-specific regulation of a subset of rDNA...
  4. ncbi request reprint Cell-type-specific regulation of RNA polymerase I transcription: a new frontier
    Hung Tseng
    Department of Dermatology, Department of Cell and Developmental Biology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, CRB Room 242B, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Bioessays 28:719-25. 2006
    ..Specifically, issues concerning the cell-type-specific requirement for rRNA production, the universality of Pol I transcription complex and the division of rDNA into regulatory subdomains are discussed...
  5. pmc Search for basonuclin target genes
    Junwen Wang
    Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 348:1261-71. 2006
    ..Our results suggest that basonuclin, like MYC, may coordinate transcriptional activities among the three RNA polymerases. But basonuclin regulates a distinctive set of pathways, which differ from that regulated by MYC...
  6. pmc Basonuclin regulates a subset of ribosomal RNA genes in HaCaT cells
    Shengliang Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 2:e902. 2007
    ..In conclusion, our results demonstrate basonuclin's functional association with rDNA promoters and its interaction with Pol I in vivo. Our data also suggest that basonuclin-Pol I complex transcribes a subset of rDNA...
  7. pmc Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium
    Xiaohong Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 2:e1087. 2007
    ..Basonuclin likely coordinates functions of a subset of ribosomal RNA genes (rDNA) and a group of protein coding genes in cellular processes critical for the regulation of cell proliferation...
  8. ncbi request reprint Basonuclin: a novel mammalian maternal-effect gene
    Jun Ma
    Department of Dermatology, University of Pennsylvania, PA 19104, USA
    Development 133:2053-62. 2006
    ..These results suggest that basonuclin is a new member of the mammalian maternal-effect genes and, interestingly, differs from the previously reported mammalian maternal-effect genes in that it also apparently perturbs oogenesis...
  9. pmc BNC1 is required for maintaining mouse spermatogenesis
    Xiaohong Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    Genesis 50:517-24. 2012
    ..In conclusion, our data demonstrate for the first time BNC1's essential role in maintaining mouse spermatogenesis...
  10. pmc Mapping ribosomal RNA transcription activity in the mouse eye
    Jiangchao Qian
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 235:1984-93. 2006
    ..Interestingly, in some retinal neurons, the high level of 47S pre-rRNA does not correlate with mature rRNA accumulation or protein synthesis, suggesting the existence of unappreciated biochemical needs of these cells...
  11. ncbi request reprint Gli proteins up-regulate the expression of basonuclin in Basal cell carcinoma
    Chunhua Cui
    Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 64:5651-8. 2004
    ..Our data suggest that Hedgehog-Gli pathway enhances rRNA transcription in BCC by increasing basonuclin gene expression...
  12. pmc Expression of variant ribosomal RNA genes in mouse oocytes and preimplantation embryos
    Motomasa Ihara
    Department of Biology, University of Pennsylvania, 433 South University Ave, Philadelphia, PA 19104, USA
    Biol Reprod 84:944-6. 2011
    ..The maternal and embryonic ribosome pools are therefore quite similar, minimizing the likelihood that developmental changes in composition of the ribosome population are critical for preimplantation development...
  13. ncbi request reprint Estimation of ribosomal RNA transcription rate in situ
    Chunhua Cui
    University of Pennsylvania, Philadelphia, PA, USA
    Biotechniques 36:134-8. 2004
    ....
  14. pmc MetaProm: a neural network based meta-predictor for alternative human promoter prediction
    Junwen Wang
    Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Genomics 8:374. 2007
    ..Furthermore, most PPPs are trained and tested on the most-upstream promoters; their performances on alternative promoters have not been assessed...

Research Grants1

  1. Is Basonuclin essential for Oogenesis
    Hung Tseng; Fiscal Year: 2004
    ..Sub aim 1 will use an RNAi approach to reduce the amount of basonuclin in oocytes; Sub aim 2 will use the Cre recombinase to knockout [the] basonuclin gene in oocytes. ..