Matthias H Tschop

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. doi request reprint Ghrelin acylation and metabolic control
    O Al Massadi
    Division of Endocrinology, Department of Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Peptides 32:2301-8. 2011
  2. ncbi request reprint Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
    M Tschop
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA
    Nature 430:1 p following 165; discussion 2 p following 165. 2004
  3. ncbi request reprint Diet-induced leptin resistance: the heart of the matter
    Matthias H Tschop
    University of Cincinnati Genome Research Institute, Department of Psychiatry, Obesity Research Center, 2170 East Galbraith Road, Cincinnati, OH 45327, USA
    Endocrinology 148:921-3. 2007
  4. doi request reprint Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
  5. pmc Melanocortin signaling in the CNS directly regulates circulating cholesterol
    Diego Perez-Tilve
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Neurosci 13:877-82. 2010
  6. pmc Acylation type determines ghrelin's effects on energy homeostasis in rodents
    Kristy M Heppner
    Metabolic Diseases Institute, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 153:4687-95. 2012
  7. pmc Caloric restriction chronically impairs metabolic programming in mice
    Henriette Kirchner
    Department of Internal Medicine, Metabolic Diseases Institute, Division of Endocrinology, University of Cincinnati, Cincinnati, OH, USA
    Diabetes 61:2734-42. 2012
  8. pmc Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice
    Susanna M Hofmann
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3271-82. 2007
  9. doi request reprint Mice with chronically increased circulating ghrelin develop age-related glucose intolerance
    Jacquelyn A Reed
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 294:E752-60. 2008
  10. pmc Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    Sarah H Lockie
    Department of Internal Medicine, Metabolic Disease Institute, University of Cincinnati, Cincinnati, OH, USA
    Diabetes 61:2753-62. 2012

Detail Information

Publications62

  1. doi request reprint Ghrelin acylation and metabolic control
    O Al Massadi
    Division of Endocrinology, Department of Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Peptides 32:2301-8. 2011
    ..In addition, we summarized the recent literature on the metabolic effects of GOAT specific inhibitors and shared our view on the potential of targeting GOAT for the treatment of metabolic disorders such as obesity and type 2 diabetes...
  2. ncbi request reprint Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
    M Tschop
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA
    Nature 430:1 p following 165; discussion 2 p following 165. 2004
    ..The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36...
  3. ncbi request reprint Diet-induced leptin resistance: the heart of the matter
    Matthias H Tschop
    University of Cincinnati Genome Research Institute, Department of Psychiatry, Obesity Research Center, 2170 East Galbraith Road, Cincinnati, OH 45327, USA
    Endocrinology 148:921-3. 2007
  4. doi request reprint Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  5. pmc Melanocortin signaling in the CNS directly regulates circulating cholesterol
    Diego Perez-Tilve
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Neurosci 13:877-82. 2010
    ..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver...
  6. pmc Acylation type determines ghrelin's effects on energy homeostasis in rodents
    Kristy M Heppner
    Metabolic Diseases Institute, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 153:4687-95. 2012
    ..Together our data suggest that modification of the FA side-chain length can be a novel approach to modulate the efficacy of pharmacologically administered ghrelin...
  7. pmc Caloric restriction chronically impairs metabolic programming in mice
    Henriette Kirchner
    Department of Internal Medicine, Metabolic Diseases Institute, Division of Endocrinology, University of Cincinnati, Cincinnati, OH, USA
    Diabetes 61:2734-42. 2012
    ..These results suggest that although caloric restriction on a HFD provides metabolic benefits, maintaining those benefits may require lifelong continuation, at least in individuals with a history of obesity...
  8. pmc Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice
    Susanna M Hofmann
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3271-82. 2007
    ..These findings identify LRP1 as a critical regulator of adipocyte energy homeostasis, where functional disruption leads to reduced lipid transport, increased insulin sensitivity, and muscular energy expenditure...
  9. doi request reprint Mice with chronically increased circulating ghrelin develop age-related glucose intolerance
    Jacquelyn A Reed
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 294:E752-60. 2008
    ..Despite the impaired glucose tolerance in L43 mice, insulin levels did not differ from those of wild-type mice. These findings suggest a role for ghrelin in age-associated impairments of glucose homeostasis...
  10. pmc Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    Sarah H Lockie
    Department of Internal Medicine, Metabolic Disease Institute, University of Cincinnati, Cincinnati, OH, USA
    Diabetes 61:2753-62. 2012
    ..Our data suggest that the increase in BAT thermogenesis may be an additional mechanism whereby pharmacological GLP-1R activation controls energy balance...
  11. pmc Fibroblast growth factor 21 mediates specific glucagon actions
    Kirk M Habegger
    Metabolic Disease Institute, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 62:1453-63. 2013
    ..Taken together, these data reveal for the first time that glucagon controls glucose, energy, and lipid metabolism at least in part via FGF21-dependent pathways...
  12. pmc The effects of vertical sleeve gastrectomy in rodents are ghrelin independent
    Adam P Chambers
    Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Gastroenterology 144:50-52.e5. 2013
    ..We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG...
  13. doi request reprint Ghrelin in the control of energy, lipid, and glucose metabolism
    Kristy M Heppner
    Metabolic Diseases Institute, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Methods Enzymol 514:249-60. 2012
    ..Together, the literature highlights a predominant role of ghrelin in regulating energy and glucose metabolism...
  14. pmc GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats
    Kirk M Habegger
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Metabolic Disease Institute, University of Cincinnati, Cincinnati, Ohio
    Diabetes 62:3261-7. 2013
    ..These data show that GLP-1R agonism, but not CB1-R antagonism, improves weight loss achieved by AGB and suggest an opportunity to optimize bariatric surgery with adjunctive pharmacotherapy. ..
  15. ncbi request reprint Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
    Paul T Pfluger
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 294:G610-8. 2008
    ....
  16. doi request reprint Action profile of the antiobesity drug candidate oleoyl-estrone in rats
    Sabine Strassburg
    Obesity Research Center, Department of Internal Medicine, University of Cincinnati Metabolic Diseases Institute, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 18:2260-7. 2010
    ..The present data suggest that OE decreases food intake and body weight but also appears to cause a significant impact on the hypothalamus-pituitary-reproductive axis...
  17. pmc Dietary sugars: a fat difference
    Susanna M Hofmann
    Department of Medicine, Obesity Research Center, University of Cincinnati College of Medicine, Ohio, USA
    J Clin Invest 119:1089-92. 2009
    ....
  18. pmc Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity
    Kimberly A Krawczewski Carhuatanta
    Metabolic Disease Institute and Department of Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45237 1625, USA
    Endocrinology 152:2655-64. 2011
    ..These results support the notion that physical exercise directly influences the responsiveness of the CNS circuits involved in energy homeostasis by allowing the defense of a lowered BW...
  19. pmc PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
    Sang Jun Lee
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cell Metab 12:65-77. 2010
    ..These results establish PKCzeta as a critical negative regulator of IL-6 in the control of obesity-induced inflammation in adipocytes...
  20. pmc Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 98:2536-43. 2013
    ..Infusion of ghrelin to supraphysiologic levels inhibits glucose-stimulated insulin secretion, reduces insulin sensitivity, and worsens glucose tolerance in humans...
  21. pmc Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 97:3366-74. 2012
    ..The 20-kDa hGH promotes growth similarly to 22-kDa or total hGH, the predominant form in circulation, but the relative effects of these isoforms on glucose metabolism have been debated...
  22. ncbi request reprint Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity
    Tamara R Castaneda
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA
    J Nutr 135:1314-9. 2005
    ..Despite this, very little is known about the molecular mechanisms by which SPA is regulated. The overview will attempt to summarize available information on neuroendocrine factors regulating SPA...
  23. pmc Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity
    Eric D Labonté
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 2120 E Galbraith Rd, Cincinnati, OH 45237, USA
    FASEB J 24:2516-24. 2010
    ....
  24. pmc Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Center, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 149:3009-15. 2008
    ..Future studies will be necessary to test if Bsx may be involved in the pathogenesis of leptin resistance...
  25. pmc GOAT links dietary lipids with the endocrine control of energy balance
    Henriette Kirchner
    Departments of Psychiatry and Medicine, Obesity Research Centre and Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 15:741-5. 2009
    ..These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted...
  26. pmc Central nervous system regulation of energy metabolism: ghrelin versus leptin
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Ann N Y Acad Sci 1126:14-9. 2008
    ..Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS...
  27. pmc Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 57:2977-91. 2008
    ....
  28. doi request reprint Cooperation between brain and islet in glucose homeostasis and diabetes
    Michael W Schwartz
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 503:59-66. 2013
    ..Consequently, therapies that target the BCGS in addition to conventional approaches based on enhancing insulin effects may have the potential to induce diabetes remission, whereas targeting just one typically does not. ..
  29. doi request reprint CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice
    Sarah Haas Lockie
    Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 152:3661-7. 2011
    ..These results indicate that the endogenous opioid system is involved in modulating both the metabolic and mood effects of rimonabant...
  30. doi request reprint Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants
    Henriette Kirchner
    Obesity Research Centre, Department of Internal Medicine, University of Cincinnati College of Medicine, 2170 E Galbraith Rd, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 298:E909-19. 2010
    ....
  31. pmc Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats
    Sabine Strassburg
    Department of Psychiatry, Obesity Research Centre Genome Research Institute, Univ of Cincinnati College of Medicine, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 295:E78-84. 2008
    ..These results characterize BIM-28131 as a promising GHS-R agonist with an attractive action profile for the treatment of catabolic disease states such as cachexia...
  32. doi request reprint Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
    Timo D Müller
    Metabolic Disease Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45230, USA
    J Pept Sci 18:383-93. 2012
    ..Our findings provide preclinical evidence that high activity, long-acting leptin analogs are additively efficacious when used in combination with other weight-lowering agents...
  33. pmc High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney
    Kerstin Stemmer
    Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati, Division of Endocrinology and Metabolism, 2170 East Galbraith Road, Building E, Cincinnati, OH 45237, USA
    Dis Model Mech 5:627-35. 2012
    ....
  34. pmc Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat
    Jon F Davis
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Behav Neurosci 122:1257-63. 2008
    ....
  35. pmc A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis
    Sang Jun Lee
    Department of Cancer and Cell Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    EMBO Rep 11:226-32. 2010
    ..These results establish genetically that p62 is a crucial regulator of ERK1 in metabolism...
  36. pmc Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    Jenny Tong
    1Department of Medicine, Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:2145-51. 2010
    ..The goal of this study was to test the hypothesis that circulating ghrelin suppresses glucose-stimulated insulin secretion in healthy subjects...
  37. ncbi request reprint The brain is getting ready for dinner
    Matthias H Tschop
    Department of Psychiatry, Obesity Research Center Genome Research Institute, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45237, USA
    Cell Metab 4:257-8. 2006
    ..2006) provides evidence that in parallel to our learned preparatory behaviors, our central nervous system is going through comparable motions as it gets ready for the anticipated meal...
  38. pmc Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice
    Susanna M Hofmann
    Department of Pathology and Laboratory Medicine, Genome Research Institute ML0507, University of Cincinnati, 2120 E Galbraith Rd, Cincinnati, OH 45237, USA
    Diabetes 57:5-12. 2008
    ..This study tested the impact of modulating lipid delivery to tissues on insulin responsiveness and diet-induced obesity...
  39. pmc Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, ML 0506, Reading, OH 45237, United States
    Physiol Behav 92:924-30. 2007
    ..These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile...
  40. doi request reprint The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism
    Kristy M Heppner
    Department of Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Curr Opin Endocrinol Diabetes Obes 18:50-5. 2011
    ..This review discusses recent findings illustrating the role of acyl ghrelin, des-acyl ghrelin and GOAT in regulating glucose homeostasis...
  41. pmc Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors
    Kristy M Heppner
    Department of Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH
    Diabetes 63:122-31. 2014
    ..Together, these data demonstrate that dAG is an agonist of GHSR and regulates body adiposity and peripheral glucose metabolism through a CNS GHSR-dependent mechanism. ..
  42. pmc Gastric O-acyl transferase activates hunger signal to the brain
    Jenny Tong
    Departments of Psychiatry and Medicine, Obesity Research Centre and Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:6213-4. 2008
  43. pmc The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45219 0547, USA
    Eur J Endocrinol 168:821-8. 2013
    ..However, there is only limited data on the pharmacokinetics of AG and DAG...
  44. pmc Sirt1 protects against high-fat diet-induced metabolic damage
    Paul T Pfluger
    Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:9793-8. 2008
    ..Together, these results provide direct proof of the protective potential of Sirt1 against the metabolic consequences of chronic exposure to a high-fat diet...
  45. ncbi request reprint Cannabinoids, opioids and eating behavior: the molecular face of hedonism?
    Daniela Cota
    Obesity Research Center, Department of Psychiatry, University of Cincinnati Genome Research Institute, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Brain Res Rev 51:85-107. 2006
    ....
  46. pmc The metabolic actions of glucagon revisited
    Kirk M Habegger
    Department of Medicine, University of Cincinnati, Metabolic Diseases Institute, Office E 217, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Nat Rev Endocrinol 6:689-97. 2010
    ..Collectively, these observations challenge us to thoroughly investigate the physiology and therapeutic potential of insulin's long-known opponent...
  47. pmc Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Neurosci 31:5841-6. 2011
    ..This novel role is consistent with ghrelin's overall function as a signal amplifier at the molecular interface between environmental and nutritional cues and neuroendocrine circuits controlling energy homeostasis...
  48. doi request reprint Neural regulation of cholesterol metabolism
    Diego Perez-Tilve
    Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati Cincinnati, OH 45237, USA
    Curr Opin Lipidol 22:283-7. 2011
    ..In this review we summarize and analyze evidence suggesting a specific role of the CNS in the control of systemic cholesterol metabolism and circulating plasma lipids levels...
  49. doi request reprint Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats
    Kerstin Stemmer
    Institute for Diabetes and Obesity, Helmholtz Centre Munich, 85764 Neuherberg, Germany
    Endocrinology 154:2015-24. 2013
    ..These data point toward important similarities and differences between bariatric procedures that should be considered in clinical settings as guidance for which procedure will be best for specific patient populations...
  50. doi request reprint A role for astrocytes in the central control of metabolism
    Chun Xia Yi
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati, Ohio, USA
    Neuroendocrinology 93:143-9. 2011
    ..Finally, potential obstacles and pitfalls for studying the role of astrocytes in metabolic sensing and regulation are discussed...
  51. doi request reprint A sweet spot for the bariatric surgeon
    Diego Perez-Tilve
    Departments of Psychiatry and Medicine, Obesity Research Centre, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
    Cell Metab 8:177-9. 2008
    ..New work in this issue (Troy et al., 2008) suggests intestinal glucose production sensed by afferent nerve fibers surrounding the portal vein may be key...
  52. pmc Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice
    Kirk M Habegger
    Division of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati Cincinnati, OH, USA
    Front Endocrinol (Lausanne) 2:67. 2011
    ....
  53. doi request reprint Central nervous system regulation of adipocyte metabolism
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, OH 45226, USA
    Regul Pept 149:26-31. 2008
    ..In this review, we discuss the central actions of some peptides with an important role in energy balance regulation on adipocyte metabolism and the physiological relevance of these actions...
  54. pmc Uroguanylin: how the gut got another satiety hormone
    Randy J Seeley
    Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 121:3384-6. 2011
    ..This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity...
  55. pmc The intestinal lymph fistula model--a novel approach to study ghrelin secretion
    Jenny Tong
    Departments of Medicine, University of Cincinnati, Ohio, 45267 0547, USA
    Am J Physiol Gastrointest Liver Physiol 298:G474-80. 2010
    ..The postprandial dynamics of ghrelin are slower in lymph than plasma, but the magnitude of change is greater. Assessing ghrelin levels in the lymph may be advantageous for studying its secretion and concentrations in the gastric mucosa...
  56. doi request reprint Ghrelin in eating disorders
    Chun Xia Yi
    Department of Medicine, University of Cincinnati, Cincinnati, OH 45226, USA
    Mol Cell Endocrinol 340:29-34. 2011
    ....
  57. doi request reprint Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa
    Timo D Müller
    Obesity Research Centre, Institute for Metabolic Disease, Division of Endocrinology, Department of Medicine, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    J Psychiatr Res 45:706-11. 2011
    ..031). Based on our results we conclude that genetic variation in GOAT might be implicated in the etiology of AN...
  58. ncbi request reprint The role of ghrelin in the control of energy balance
    Henriette Kirchner
    Department of Internal Medicine and Endocrinology, Metabolic Diseases Institute, Obesity Research Center, University of Cincinnati, 2180 E Galbraith Rd, Cincinnati, OH, 54237, USA
    Handb Exp Pharmacol 209:161-84. 2012
    ..Thus, agents antagonizing the action of ghrelin may have therapeutic potential in the therapy of obesity...
  59. ncbi request reprint Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity
    Karine Proulx
    Genome Research Institute, ML 0506, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 289:R729-37. 2005
    ..Despite that OEA-induced anorexia is unlikely to be due to impaired motor activity, our data raise a cautionary note in how specific behavioral and metabolic effects of OEA should be interpreted...
  60. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  61. doi request reprint Hormones and diet, but not body weight, control hypothalamic microglial activity
    Yuanqing Gao
    Institute for Diabetes and Obesity, Helmholtz Centre for Health and Environment and Technische Universität München, Munich, Germany Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio
    Glia 62:17-25. 2014
    ..Our results show that diet type, adipokines, and gut signals, but not body weight, affect the presence and activity levels of hypothalamic microglia in obesity...
  62. ncbi request reprint Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy
    Thomas H Inge
    Division of Pediatric General and Thoracic Surgery, ML 2023, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Nat Clin Pract Endocrinol Metab 3:606-9. 2007
    ..Extreme obesity (BMI >60 kg/m(2)) and hyperinsulinemia followed tumor resection and cranial irradiation. Dietary interventions were unsuccessful, and pharmacologic intervention (i.e. octreotide) only slowed the rate of weight gain...