Betty Tsao

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression
    Daisuke Sakurai
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 9:e1003870. 2013
  2. pmc MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
    Yun Deng
    Division of Rheumatology, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 9:e1003336. 2013
  3. pmc Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility
    Jian Zhao
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1002079. 2011
  4. pmc Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus
    Xuebing Feng
    Department of Rheumatology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, PR China
    Arthritis Res Ther 12:R59. 2010
  5. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
  6. ncbi request reprint Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort
    Hui Wu
    University of California, Los Angeles90095 1670, USA
    Arthritis Rheum 50:3093-103. 2004
  7. ncbi request reprint Update on human systemic lupus erythematosus genetics
    Betty P Tsao
    Department of Medicine, Division of Rheumatology, UCLA School of Medicine, Los Angeles, California 90095 1670, USA
    Curr Opin Rheumatol 16:513-21. 2004
  8. ncbi request reprint The genetics of human systemic lupus erythematosus
    Betty P Tsao
    UCLA School of Medicine, Department of Medicine, Division of Rheumatology, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095 1670, USA
    Trends Immunol 24:595-602. 2003
  9. ncbi request reprint Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus
    Betty P Tsao
    Department of Medicine, Rehabilitation Center, Room 32 59, 1000 Veteran Avenue, UCLA School of Medicine, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2928-36. 2002
  10. ncbi request reprint Familiality and co-occurrence of clinical features of systemic lupus erythematosus
    Betty P Tsao
    Division of Rheumatology, Department of Medicine, Rehabilitation Center, Room 32 59, University of California Los Angeles School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2678-85. 2002

Detail Information

Publications35

  1. pmc Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression
    Daisuke Sakurai
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 9:e1003870. 2013
    ..Taken together, our data suggest that preferential binding of activated Elk-1 to the IL10 rs3122605-G allele upregulates IL10 expression and confers increased risk for SLE in European Americans...
  2. pmc MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
    Yun Deng
    Division of Rheumatology, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 9:e1003336. 2013
    ..0×10(-19), OR = 1.25 [1.20-1.32]), which confers allelic effect on transcript turnover via differential binding to the epigenetic factor miR-3148...
  3. pmc Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility
    Jian Zhao
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1002079. 2011
    ....
  4. pmc Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus
    Xuebing Feng
    Department of Rheumatology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, PR China
    Arthritis Res Ther 12:R59. 2010
    ....
  5. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
    ....
  6. ncbi request reprint Interaction between RANKL and HLA-DRB1 genotypes may contribute to younger age at onset of seropositive rheumatoid arthritis in an inception cohort
    Hui Wu
    University of California, Los Angeles90095 1670, USA
    Arthritis Rheum 50:3093-103. 2004
    ..To determine whether the RANKL and HLA-DRB1 "shared epitope" (SE) genotypes contribute to the development of rheumatoid arthritis (RA)...
  7. ncbi request reprint Update on human systemic lupus erythematosus genetics
    Betty P Tsao
    Department of Medicine, Division of Rheumatology, UCLA School of Medicine, Los Angeles, California 90095 1670, USA
    Curr Opin Rheumatol 16:513-21. 2004
    ..This review highlights recent findings that may lead to the identification of putative genes and new insights in the pathogenesis of SLE...
  8. ncbi request reprint The genetics of human systemic lupus erythematosus
    Betty P Tsao
    UCLA School of Medicine, Department of Medicine, Division of Rheumatology, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095 1670, USA
    Trends Immunol 24:595-602. 2003
    ..An overview of our current understanding of the genetic basis of SLE and a brief review of findings of linkage and association studies are described here...
  9. ncbi request reprint Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus
    Betty P Tsao
    Department of Medicine, Rehabilitation Center, Room 32 59, 1000 Veteran Avenue, UCLA School of Medicine, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2928-36. 2002
    ....
  10. ncbi request reprint Familiality and co-occurrence of clinical features of systemic lupus erythematosus
    Betty P Tsao
    Division of Rheumatology, Department of Medicine, Rehabilitation Center, Room 32 59, University of California Los Angeles School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 46:2678-85. 2002
    ..To evaluate familiality of 15 clinical and laboratory features in systemic lupus erythematosus (SLE)-affected sibpairs, and to estimate correlations with the age at SLE diagnosis in affected sibpairs and parent-offspring pairs...
  11. ncbi request reprint An update on genetic studies of systemic lupus erythematosus
    Betty P Tsao
    UCLA School of Medicine, Department of Medicine, Division of Rheumatology, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095 1670, USA
    Curr Rheumatol Rep 4:359-67. 2002
    ..Studies are underway to fine map these linked regions and to identify the genes in the susceptibility regions. An understanding of the genes involved in the development of lupus should provide targets for more focused therapy in lupus...
  12. ncbi request reprint Genetics and systemic lupus erythematosus
    B P Tsao
    UCLA School of Medicine, Department of Medicine, Division of Rheumatology, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095 1670, USA
    Curr Rheumatol Rep 3:183-90. 2001
    ..Studies to identify the genes in the susceptibility regions are underway. An understanding of the genes involved in the development of lupus should provide targets for more focused therapy in lupus...
  13. ncbi request reprint Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus
    B H Hahn
    University of California, Los Angeles, USA
    Arthritis Rheum 44:432-41. 2001
    ..A striking effect is the ability of the peptide to tolerize T cell help for anti-DNA that is induced by multiple, structurally unrelated self antigens...
  14. pmc Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus
    R R Singh
    Autoimmunity and Tolerance Laboratory, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 102:1841-9. 1998
    ..Thus, determinant spreading and degenerate recognition in T cells coupled with recurring use of T cell determinant sequences among autoantibodies result in polyclonality that is restricted to certain autoantigens...
  15. pmc PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus
    B P Tsao
    Division of Rheumatology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1670
    J Clin Invest 103:1135-40. 1999
    ..004). Similar TDT analyses of TGFB2 and HLX1 polymorphisms yielded no evidence for association with SLE. These results suggest that PARP may be (or is close to) the susceptibility gene within the chromosome 1q41-q42 region linked to SLE...
  16. ncbi request reprint Genetics and systemic lupus erythematosus
    J M Grossman
    UCLA School of Medicine, Department of Medicine, Division of Rheumatology, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095, USA jgrossm
    Curr Rheumatol Rep 2:13-8. 2000
    ..Studies to identify the genes in the susceptibility regions are underway. An understanding of the genes involved in the development of lupus should provide targets for more focused therapy...
  17. pmc Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus
    B P Tsao
    University of California, Los Angeles, USA
    J Clin Invest 99:725-31. 1997
    ..01). We concluded that this candidate 1q41-q42 region probably contains a susceptibility gene(s) that confers risk for SLE in multiple ethnic groups...
  18. pmc Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients
    G J Silverman
    Rheumatic Diseases Core Center and the Laboratory of B cell Immunobiology, University of California, San Diego, CA 92093 0663, USA
    Clin Exp Immunol 153:102-16. 2008
    ..In contrast, the sharing of IgG autoantibody fingerprints by monozygotic twins suggests that lupus IgG autoantibodies can arise in predisposed individuals in genetically determined patterns...
  19. ncbi request reprint CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B
    Yuki Hitomi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan
    Hum Mol Genet 13:2907-17. 2004
    ..These results indicated that the presence of CD72-*2 allele decreases risk for human SLE conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72...
  20. ncbi request reprint Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies
    Gabriela Riemekasten
    University of California, Los Angeles, USA
    Arthritis Rheum 48:475-85. 2003
    ..This study was undertaken to test the hypothesis that SmD1(83-119)-reactive T cells play a crucial role in the generation of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies...
  21. ncbi request reprint Association of Fcgamma receptor IIA, but not IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family-based association study in Caucasians
    Chieko Kyogoku
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:671-3. 2004
  22. ncbi request reprint Fcgamma receptor IIIA polymorphism in Korean patients with systemic lupus erythematosus
    Eun Bong Lee
    Department of Internal Medicine, Clinical Research Institute, Seoul National University College of Medicine, Korea
    Rheumatol Int 21:222-6. 2002
    ..In conclusion, FcgammaRIIIA-176F/V polymorphism is not associated with SLE in Koreans...
  23. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  24. pmc Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European America
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 80:1037-54. 2007
    ..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease...
  25. pmc Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus
    Hui Wu
    Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:3961-6. 2007
    ..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus...
  26. ncbi request reprint Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort
    Dinesh Khanna
    David Geffen School of Medicine at the University of California, Los Angeles, and the Veterans Affairs Medical Center, Cincinnati, Ohio 45267 0563, USA
    Arthritis Rheum 54:1105-16. 2006
    ..To determine whether the tumor necrosis factor alpha (TNFA) -308 guanine-to-adenosine polymorphism and/or the shared epitope (SE) is associated with radiographic damage in patients with early rheumatoid arthritis (RA)...
  27. ncbi request reprint Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23
    Rita M Cantor
    David Geffen School of Medicine, University of California, Los Angeles, 90095 7088, USA
    Arthritis Rheum 50:3203-10. 2004
    ..To identify chromosome regions likely to harbor genes that predispose to the development of systemic lupus erythematosus (SLE) by analyzing a full genome scan in nuclear families ascertained for siblings with SLE...
  28. pmc A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 102:10593-7. 2005
    ..These data support a role for flagellated bacteria and the innate immune response in the development of SLE with implications for novel immunomodulatory treatment strategies...
  29. ncbi request reprint Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease
    Hui Wu
    David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 52:2396-402. 2005
    ..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members...
  30. ncbi request reprint Maternal HLA class II compatibility in men with systemic lupus erythematosus
    Anne M Stevens
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Arthritis Rheum 52:2768-73. 2005
    ..Male subjects were selected in order to avoid confounding due to fetal microchimerism, which may occur in women...
  31. ncbi request reprint Current advances in the human lupus genetics
    Nan Shen
    Division of Rheumatology, Department of Medicine, Rehabilitation Center, Room 32 59, 1000 Veteran Avenue, UCLA School of Medicine, Los Angeles, CA 90095 1670, USA
    Curr Rheumatol Rep 6:391-8. 2004
    ..In the coming years, susceptibility genes responsible for the observed linkage will be identified, and will lead to further delineating genetic pathways involved in susceptibility to SLE...
  32. ncbi request reprint Current topics in human SLE genetics
    Maida Wong
    Division of Rheumatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1670, USA
    Springer Semin Immunopathol 28:97-107. 2006
    ..Copy polymorphisms in susceptibility genes provide evidence in how genetic plasticity affects complex phenotypes as seen in SLE...
  33. pmc Identification and characterization of a peptide mimetic that may detect a species of disease-associated anticardiolipin antibodies in patients with the antiphospholipid syndrome
    Sudha Visvanathan
    University of California at Los Angeles, 90095, USA
    Arthritis Rheum 48:737-45. 2003
    ..To test the feasibility of applying a mimetic (specific for a patient-derived prothrombotic anticardiolipin antibody [aCL]) to study the homologous, disease-associated aCL in patients with antiphospholipid syndrome (APS)...
  34. ncbi request reprint Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
    Xuebing Feng
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 54:2951-62. 2006
    ..To study 5 type I interferon (IFN)-inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) in patients with systemic lupus erythematosus (SLE) and to correlate expression levels with disease activity and/or clinical manifestations...
  35. ncbi request reprint ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia
    Xuebing Feng
    Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA, USA
    J Lipid Res 48:794-805. 2007
    ..Correlations of IgG anti-OxPL with lupus-like disease, atherosclerosis, and bone loss suggested a shared pathway of these disease processes...

Research Grants15

  1. Association of Positional Candidate Gene Variants with SLE
    Betty Tsao; Fiscal Year: 2009
    ..The identification of novel genes common to multiple ethnic groups will yield new insights into the mechanisms underlying the disease, which may lead to the development of specific targets for therapeutic interventions. ..
  2. Fine Mapping and Functional Analysis of RANKL Variants in Early RA Onset
    Betty Tsao; Fiscal Year: 2007
    ..The understanding of molecular mechanisms for the pathogenesis of RA may lead to the development of novel targeted medications. ..
  3. Chromosome 1 Regions Linked to SLE in Multiplex Families
    Betty Tsao; Fiscal Year: 2006
    ..The identification of SLE susceptibility genes can reveal underlying mechanisms in the pathogenesis of autoimmunity and provide potential targets for disease management. ..
  4. CHROMOSOME REGIONS LINKED TO SLE IN MULTIPLEX FAMILIES
    Betty Tsao; Fiscal Year: 2000
    ..Our ultimate goal is to identify individual genes that increase the risk for SLE, then determine how these genes influence immune responses. ..
  5. Association of Positional Candidate Gene Variants with SLE
    Betty P Tsao; Fiscal Year: 2010
    ..The identification of novel genes common to multiple ethnic groups will yield new insights into the mechanisms underlying the disease, which may lead to the development of specific targets for therapeutic interventions. ..