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Genomes and Genes | Michael Y TsaiSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an interventional studyMary K Wojczynski
Department of Biostatistics, University of Alabama at Birmingham, Brimingham, AL, USA
Lipids Health Dis 10:181. 2011..Analyses were stratified by baseline triglycerides (normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein subclasses was assessed using repeated measures ANOVA...- TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrateEdmond K Kabagambe
Department of Epidemiology, School of Public Health and Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294, USA
Diabetol Metab Syndr 1:16. 2009.... - The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of AtherosclerosisAydin Nazmi
Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Room 3659, Ann Arbor, MI 48109, USA
BMC Public Health 10:706. 2010..Antibody levels of pathogens have not been examined in relation to inflammation... - Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of AtherosclerosisMichael Y Tsai
Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
Atherosclerosis 200:359-67. 2008..8%, 19.8%, and 18.4%, respectively; p<0.001) and higher HDL-C concentration (9.7%, 11.5%, and 10.4%, respectively; p<0.01). However, we did not find any associations between these non-coding polymorphisms and subclinical CVD... - Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet NetworkMichael Y Tsai
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
Mol Genet Metab 100:118-22. 2010.... 
Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosisMichael Y Tsai
Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
Clin Chem 55:481-8. 2009..The associations of ABCA1 and CETP polymorphisms with lipoprotein subclasses have not been extensively studied...- Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1 levels in a subcohort of hypertriglyceridemic GOLDN participantsAlexander K Tsai
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
Transl Res 158:99-105. 2011..The greatest reductions in Lp-PLA(2) levels were observed in individuals with Lp-PLA(2) concentrations indicative of increased cardiovascular disease risk (>200 ng/mL)... 
Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)Albert W Tsai
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Am J Hematol 72:192-200. 2003..74, 95% CI = 0.56-0.98). Our prospective data showed, at most, a weak relationship between homocysteine and VTE risk, with associations larger among younger participants. MTHFR C677T was not a risk factor for VTE...- Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American populationAlexander K Tsai
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Atherosclerosis 207:487-91. 2009..To examine whether genetic polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) confer an increased risk to angiographically proven coronary artery disease (CAD) in a case-control study of a Midwestern population in the US... - Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification eraMichael Y Tsai
Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
J Nutr 139:33-7. 2009..We conclude that after folic acid fortification in the US, measurement of tHcy rather than genotyping of MTHFR 677TT should be used as the primary assay for the diagnosis and monitoring of moderate hyperhomocysteinemia... - Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participantsYan Dong
Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
Atherosclerosis 214:422-5. 2011.... - Discordance between N-acetyltransferase 2 phenotype and genotype in a population of Hmong subjectsRobert J Straka
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455 0353, USA
J Clin Pharmacol 46:802-11. 2006..Environmental, genetic, or phenotypic anomalies that may contribute to this discordance should be considered and evaluated in future studies within this unique population... - Polygenic association with total homocysteine in the post-folic acid fortification era: the CARDIA studyMichael Y Tsai
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Mol Genet Metab 98:181-6. 2009.... - The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE studyLaura J Rasmussen-Torvik
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St Suite 300, Minneapolis, MN 55454, USA
Thromb Res 121:1-7. 2007..However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study... - Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolismAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
Am J Hematol 71:285-90. 2002..38). There was no association between venous thromboembolism and plasma prothrombin antigen level. We estimated that the G20210A polymorphism may account for approximately 2.5% of venous thromboembolism events in United States whites... - Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN StudyLaura J Rasmussen-Torvik
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
BMC Med Genet 10:39. 2009..Variance components analysis was used to estimate heritability and to perform genome-wide scans. Adiponectin was adjusted for age, sex, and field center. Additional models also included BMI adjustment... - Effect of influenza vaccine on markers of inflammation and lipid profileMichael Y Tsai
Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, USA
J Lab Clin Med 145:323-7. 2005..Consequently, clinical and epidemiologic interpretation of the biomarkers affected should take into account the possible effects of influenza vaccination... - Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective studyKazumasa Yamagishi
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
Br J Haematol 145:221-6. 2009..51[1.01-2.26]). The 6963A/G polymorphism was not associated with VTE risk (OR = 0.93[0.70-1.25]). In conclusion, sEPCR levels and the PROCR 6963A/G polymorphism were not associated overall with increased risk of VTE... - Anticardiolipin antibodies as a risk factor for venous thromboembolism in a population-based prospective studyShauna S Runchey
Division of Epidemiology, School of Public Health, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454-1015, USA
Br J Haematol 119:1005-10. 2002..43, 1.78) for greater than versus less than the 95th percentile of anticardiolipin IgG. In conclusion, in this general population sample, an elevated anticardiolipin antibody level was not a risk factor for venous thromboembolism... - Effect of two common polymorphisms in the ATP binding cassette transporter A1 gene on HDL-cholesterol concentrationPetter S Woll
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455-0392, USA
Clin Chem 51:907-9. 2005 - Plasma phospholipid trans fatty acids and risk of heart failureOluwabunmi A Tokede
Divisions of Aging and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Am J Clin Nutr 97:698-705. 2013..Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF)... - Comparison of ultracentrifugation and nuclear magnetic resonance spectroscopy in the quantification of triglyceride-rich lipoproteins after an oral fat loadMichael Y Tsai
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Clin Chem 50:1201-4. 2004.... - Polymorphisms in the fatty acid-binding protein 2 and apolipoprotein C-III genes are associated with the metabolic syndrome and dyslipidemia in a South Indian populationJean Marc Guettier
Division of Endocrinology, Metabolism, and Nutrition, One Veteran s Drive, Mail Code 111G, VA Medical Center, Minneapolis, Minnesota 55417, USA
J Clin Endocrinol Metab 90:1705-11. 2005..The polymorphisms were not associated with MS in patients with diabetes. The association of the polymorphisms with MS and dyslipidemia could contribute to the high cardiovascular disease prevalence in this population... - Plasma homocysteine levels in living kidney donors before and after uninephrectomyMichael Y Tsai
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, 55455 0392, USA
J Lab Clin Med 143:340-3. 2004..Our results, the first to be obtained from living kidney donors, support the hypothesis that renal metabolism of tHcy is the mechanism responsible for the correlation between renal function and plasma tHcy level... - N-terminal pro B-type natriuretic peptide predicts mortality in patients with left ventricular hypertrophySantiago Garcia
Department of Medicine, Cardiology Section, University of Minnesota, Minneapolis, Minnesota, United States
Int J Cardiol 143:349-52. 2010..We aimed to study the prognostic value of NT-proBNP in hypertensive patients with LVH... - Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in MinnesotaRobert J Straka
University of Minnesota, Department of Experimental and Clinical Pharmacology, 7 109 Weaver Densford Hall, Minneapolis, MN 55455 0353, USA
Biopharm Drug Dispos 27:299-304. 2006..The predominance of the SA phenotype within Minnesota Hmong is confirmed. Further studies evaluating this unexpected prevalence, its genetic basis and potential clinical relevance to drug toxicity and disease are warranted... - Interlaboratory variation of plasma total homocysteine measurements: results of three successive homocysteine proficiency testing surveysNaomi Q Hanson
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455-0392, USA
Clin Chem 48:1539-45. 2002..CONCLUSIONS: Various degrees of imprecision and lack of correlation among tHcy methods indicate that there is a need to improve analytical precision, decrease analytical difference, and standardize tHcy measurements among laboratories... - Unlike type 2 diabetes, type 1 does not interact with the codon 54 polymorphism of the fatty acid binding protein 2 geneAngeliki Georgopoulos
Minneapolis Veterans Affairs Medical Center, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
J Clin Endocrinol Metab 87:3735-9. 2002..Insulin resistance could account possibly for this difference... - APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA)Shuang Liang
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Atherosclerosis 228:181-7. 2013..We aimed to determine whether APOE genotype modifies the association of lipid profile characteristics with plasma EPA and DHA levels... - Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipidsJing Cao
University of Minnesota, Minneapolis, MN 55455, USA
Clin Chem 52:2265-72. 2006..These results may be useful to establish appropriate dosage for omega-3 fatty acid supplementation... - A prospective study of venous thromboembolism in relation to factor V Leiden and related factorsAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Blood 99:2720-5. 2002....