Michael Y Tsai

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Epistatic study reveals two genetic interactions in blood pressure regulation
    Ndeye Coumba Ndiaye
    Cardiovascular Genetics Research Unit, EA 4373, University of Lorraine, 30 rue Lionnois 54000, Nancy, France
    BMC Med Genet 14:2. 2013
  2. pmc High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an interventional study
    Mary K Wojczynski
    Department of Biostatistics, University of Alabama at Birmingham, Brimingham, AL, USA
    Lipids Health Dis 10:181. 2011
  3. pmc TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
    Edmond K Kabagambe
    Department of Epidemiology, School of Public Health and Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294, USA
    Diabetol Metab Syndr 1:16. 2009
  4. pmc The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis
    Aydin Nazmi
    Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Room 3659, Ann Arbor, MI 48109, USA
    BMC Public Health 10:706. 2010
  5. pmc Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet Network
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Mol Genet Metab 100:118-22. 2010
  6. doi request reprint Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Clin Chem 55:481-8. 2009
  7. pmc Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
    Atherosclerosis 200:359-67. 2008
  8. pmc Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1 levels in a subcohort of hypertriglyceridemic GOLDN participants
    Alexander K Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Transl Res 158:99-105. 2011
  9. ncbi request reprint Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am J Hematol 72:192-200. 2003
  10. doi request reprint Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population
    Alexander K Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Atherosclerosis 207:487-91. 2009

Collaborators

Detail Information

Publications33

  1. pmc Epistatic study reveals two genetic interactions in blood pressure regulation
    Ndeye Coumba Ndiaye
    Cardiovascular Genetics Research Unit, EA 4373, University of Lorraine, 30 rue Lionnois 54000, Nancy, France
    BMC Med Genet 14:2. 2013
    ..This phenomenon can partially be explained by possible gene-gene/epistasis interactions that were little investigated so far...
  2. pmc High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN): an interventional study
    Mary K Wojczynski
    Department of Biostatistics, University of Alabama at Birmingham, Brimingham, AL, USA
    Lipids Health Dis 10:181. 2011
    ..Analyses were stratified by baseline triglycerides (normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein subclasses was assessed using repeated measures ANOVA...
  3. pmc TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate
    Edmond K Kabagambe
    Department of Epidemiology, School of Public Health and Clinical Nutrition Research Center, University of Alabama, Birmingham, AL 35294, USA
    Diabetol Metab Syndr 1:16. 2009
    ....
  4. pmc The influence of persistent pathogens on circulating levels of inflammatory markers: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis
    Aydin Nazmi
    Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Room 3659, Ann Arbor, MI 48109, USA
    BMC Public Health 10:706. 2010
    ..Antibody levels of pathogens have not been examined in relation to inflammation...
  5. pmc Effect of fenofibrate therapy and ABCA1 polymorphisms on high-density lipoprotein subclasses in the Genetics of Lipid Lowering Drugs and Diet Network
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Mol Genet Metab 100:118-22. 2010
    ....
  6. doi request reprint Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Clin Chem 55:481-8. 2009
    ..The associations of ABCA1 and CETP polymorphisms with lipoprotein subclasses have not been extensively studied...
  7. pmc Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
    Atherosclerosis 200:359-67. 2008
    ..8%, 19.8%, and 18.4%, respectively; p<0.001) and higher HDL-C concentration (9.7%, 11.5%, and 10.4%, respectively; p<0.01). However, we did not find any associations between these non-coding polymorphisms and subclinical CVD...
  8. pmc Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1 levels in a subcohort of hypertriglyceridemic GOLDN participants
    Alexander K Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Transl Res 158:99-105. 2011
    ..The greatest reductions in Lp-PLA(2) levels were observed in individuals with Lp-PLA(2) concentrations indicative of increased cardiovascular disease risk (>200 ng/mL)...
  9. ncbi request reprint Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am J Hematol 72:192-200. 2003
    ..74, 95% CI = 0.56-0.98). Our prospective data showed, at most, a weak relationship between homocysteine and VTE risk, with associations larger among younger participants. MTHFR C677T was not a risk factor for VTE...
  10. doi request reprint Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population
    Alexander K Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Atherosclerosis 207:487-91. 2009
    ..To examine whether genetic polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) confer an increased risk to angiographically proven coronary artery disease (CAD) in a case-control study of a Midwestern population in the US...
  11. pmc Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Nutr 139:33-7. 2009
    ..We conclude that after folic acid fortification in the US, measurement of tHcy rather than genotyping of MTHFR 677TT should be used as the primary assay for the diagnosis and monitoring of moderate hyperhomocysteinemia...
  12. pmc Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participants
    Yan Dong
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
    Atherosclerosis 214:422-5. 2011
    ....
  13. ncbi request reprint Discordance between N-acetyltransferase 2 phenotype and genotype in a population of Hmong subjects
    Robert J Straka
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455 0353, USA
    J Clin Pharmacol 46:802-11. 2006
    ..Environmental, genetic, or phenotypic anomalies that may contribute to this discordance should be considered and evaluated in future studies within this unique population...
  14. pmc Polygenic association with total homocysteine in the post-folic acid fortification era: the CARDIA study
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Mol Genet Metab 98:181-6. 2009
    ....
  15. pmc The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St Suite 300, Minneapolis, MN 55454, USA
    Thromb Res 121:1-7. 2007
    ..However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study...
  16. ncbi request reprint Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
    Am J Hematol 71:285-90. 2002
    ..38). There was no association between venous thromboembolism and plasma prothrombin antigen level. We estimated that the G20210A polymorphism may account for approximately 2.5% of venous thromboembolism events in United States whites...
  17. pmc Suggestion for linkage of chromosome 1p35.2 and 3q28 to plasma adiponectin concentrations in the GOLDN Study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
    BMC Med Genet 10:39. 2009
    ..Variance components analysis was used to estimate heritability and to perform genome-wide scans. Adiponectin was adjusted for age, sex, and field center. Additional models also included BMI adjustment...
  18. pmc Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study
    Kazumasa Yamagishi
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
    Br J Haematol 145:221-6. 2009
    ..51[1.01-2.26]). The 6963A/G polymorphism was not associated with VTE risk (OR = 0.93[0.70-1.25]). In conclusion, sEPCR levels and the PROCR 6963A/G polymorphism were not associated overall with increased risk of VTE...
  19. ncbi request reprint Effect of influenza vaccine on markers of inflammation and lipid profile
    Michael Y Tsai
    Laboratory of Medicine and Pathology, University of Minnesota, Minneapolis, USA
    J Lab Clin Med 145:323-7. 2005
    ..Consequently, clinical and epidemiologic interpretation of the biomarkers affected should take into account the possible effects of influenza vaccination...
  20. pmc APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Shuang Liang
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Atherosclerosis 228:181-7. 2013
    ..We aimed to determine whether APOE genotype modifies the association of lipid profile characteristics with plasma EPA and DHA levels...
  21. ncbi request reprint Effect of two common polymorphisms in the ATP binding cassette transporter A1 gene on HDL-cholesterol concentration
    Petter S Woll
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455 0392, USA
    Clin Chem 51:907-9. 2005
  22. ncbi request reprint Anticardiolipin antibodies as a risk factor for venous thromboembolism in a population-based prospective study
    Shauna S Runchey
    Division of Epidemiology, School of Public Health, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Br J Haematol 119:1005-10. 2002
    ..43, 1.78) for greater than versus less than the 95th percentile of anticardiolipin IgG. In conclusion, in this general population sample, an elevated anticardiolipin antibody level was not a risk factor for venous thromboembolism...
  23. doi request reprint n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis
    Brian T Steffen
    Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street, SE, Mayo Mail Code 609, Minneapolis, MN 55455 0392, USA
    Br J Nutr 110:1664-71. 2013
    ..Intervention studies are warranted to assess whether these macronutrients may directly influence Lp-PLA2 expression or activity...
  24. pmc Plasma phospholipid trans fatty acids and risk of heart failure
    Oluwabunmi A Tokede
    Divisions of Aging and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Am J Clin Nutr 97:698-705. 2013
    ..Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF)...
  25. ncbi request reprint Comparison of ultracentrifugation and nuclear magnetic resonance spectroscopy in the quantification of triglyceride-rich lipoproteins after an oral fat load
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Clin Chem 50:1201-4. 2004
    ....
  26. ncbi request reprint Plasma homocysteine levels in living kidney donors before and after uninephrectomy
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, 55455 0392, USA
    J Lab Clin Med 143:340-3. 2004
    ..Our results, the first to be obtained from living kidney donors, support the hypothesis that renal metabolism of tHcy is the mechanism responsible for the correlation between renal function and plasma tHcy level...
  27. ncbi request reprint Polymorphisms in the fatty acid-binding protein 2 and apolipoprotein C-III genes are associated with the metabolic syndrome and dyslipidemia in a South Indian population
    Jean Marc Guettier
    Division of Endocrinology, Metabolism, and Nutrition, One Veteran s Drive, Mail Code 111G, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 90:1705-11. 2005
    ..The polymorphisms were not associated with MS in patients with diabetes. The association of the polymorphisms with MS and dyslipidemia could contribute to the high cardiovascular disease prevalence in this population...
  28. doi request reprint N-terminal pro B-type natriuretic peptide predicts mortality in patients with left ventricular hypertrophy
    Santiago Garcia
    Department of Medicine, Cardiology Section, University of Minnesota, Minneapolis, Minnesota, United States
    Int J Cardiol 143:349-52. 2010
    ..We aimed to study the prognostic value of NT-proBNP in hypertensive patients with LVH...
  29. ncbi request reprint Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota
    Robert J Straka
    University of Minnesota, Department of Experimental and Clinical Pharmacology, 7 109 Weaver Densford Hall, Minneapolis, MN 55455 0353, USA
    Biopharm Drug Dispos 27:299-304. 2006
    ..The predominance of the SA phenotype within Minnesota Hmong is confirmed. Further studies evaluating this unexpected prevalence, its genetic basis and potential clinical relevance to drug toxicity and disease are warranted...
  30. ncbi request reprint Interlaboratory variation of plasma total homocysteine measurements: results of three successive homocysteine proficiency testing surveys
    Naomi Q Hanson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455 0392, USA
    Clin Chem 48:1539-45. 2002
    ..However, little information is available regarding interlaboratory variation of tHcy measurements, especially at the increased tHcy concentrations observed after loading...
  31. ncbi request reprint Unlike type 2 diabetes, type 1 does not interact with the codon 54 polymorphism of the fatty acid binding protein 2 gene
    Angeliki Georgopoulos
    Minneapolis Veterans Affairs Medical Center, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55417, USA
    J Clin Endocrinol Metab 87:3735-9. 2002
    ..Insulin resistance could account possibly for this difference...
  32. ncbi request reprint Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids
    Jing Cao
    University of Minnesota, Minneapolis, MN 55455, USA
    Clin Chem 52:2265-72. 2006
    ..To study the effects of fatty acid supplementation, we investigated the rate of incorporation and clearance of these fatty acids in erythrocyte membranes and plasma after intake of supplements...
  33. ncbi request reprint A prospective study of venous thromboembolism in relation to factor V Leiden and related factors
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Blood 99:2720-5. 2002
    ....