C C Tsai

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species
    Jeannette Philipp-Staheli
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Virol J 3:11. 2006
  2. ncbi request reprint Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection
    C C Tsai
    University of Washington Regional Primate Research Center, Seattle, WA 98195, USA
    J Med Primatol 29:248-58. 2000
  3. ncbi request reprint Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models
    Che Chung Tsai
    Washington National Primate Research Center, University of Washington, Seattle, Washington 98105, USA
    AIDS Res Hum Retroviruses 20:11-8. 2004
  4. pmc Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment
    C C Tsai
    Regional Primate Research Center, University of Washington, Seattle 98195, USA
    J Virol 72:4265-73. 1998
  5. doi request reprint Macaca fascicularis are highly susceptible to an RT-SHIV following intravaginal inoculation: a new model for microbicide evaluation
    Y Jiang
    Washington National Primate Research Center, University of Washington, Seattle, WA 98195 7330, USA
    J Med Primatol 38:39-46. 2009
  6. ncbi request reprint Characterization of infectious type D retrovirus from baboons
    R F Grant
    Regional Primate Research Center, University of Washington, Seattle 98195
    Virology 207:292-6. 1995
  7. ncbi request reprint Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques
    C C Tsai
    Regional Primate Research Center, University of Washington, Seattle
    J Med Primatol 19:203-16. 1990
  8. ncbi request reprint Focal segmental glomerulosclerosis in primates infected with a simian immunodeficiency virus
    C E Alpers
    Department of Pathology, School of Medicine, University of Washington, Seattle 98195, USA
    AIDS Res Hum Retroviruses 13:413-24. 1997
  9. pmc Toxicity and efficacy of 2',3'-dideoxycytidine in clinical trials of pigtailed macaques infected with simian retrovirus type 2
    C C Tsai
    Regional Primate Research Center, University of Washington, Seattle 98195
    Antimicrob Agents Chemother 33:1908-14. 1989
  10. ncbi request reprint Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide
    P Emau
    Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA
    J Med Primatol 36:244-53. 2007

Collaborators

Detail Information

Publications14

  1. pmc Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species
    Jeannette Philipp-Staheli
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Virol J 3:11. 2006
    ....
  2. ncbi request reprint Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection
    C C Tsai
    University of Washington Regional Primate Research Center, Seattle, WA 98195, USA
    J Med Primatol 29:248-58. 2000
    ..Our results indicate that early PECP could activate immune responses to protect against subsequent infection with heterologous challenge virus...
  3. ncbi request reprint Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models
    Che Chung Tsai
    Washington National Primate Research Center, University of Washington, Seattle, Washington 98105, USA
    AIDS Res Hum Retroviruses 20:11-8. 2004
    ..Further, CV-N produced no cytotoxic or clinical adverse effects in either the in vitro or in vivo model systems. Together these studies suggest that CV-N is a good candidate for testing in humans as an anti-HIV topical microbicide...
  4. pmc Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment
    C C Tsai
    Regional Primate Research Center, University of Washington, Seattle 98195, USA
    J Virol 72:4265-73. 1998
    ..These results clearly show that both the time between virus exposure and initiation of PMPA treatment as well as the duration of treatment are crucial factors for prevention of acute SIV infection in the macaque model...
  5. doi request reprint Macaca fascicularis are highly susceptible to an RT-SHIV following intravaginal inoculation: a new model for microbicide evaluation
    Y Jiang
    Washington National Primate Research Center, University of Washington, Seattle, WA 98195 7330, USA
    J Med Primatol 38:39-46. 2009
    ..A suitable RT-SHIV/macaque model is urgently needed for the evaluation of HIV/AIDS therapies and microbicides specifically targeting HIV-1 RT...
  6. ncbi request reprint Characterization of infectious type D retrovirus from baboons
    R F Grant
    Regional Primate Research Center, University of Washington, Seattle 98195
    Virology 207:292-6. 1995
    ..The homologies in the p27 segment were 91-94% and the homologies in the gp20 segment were 72-75%...
  7. ncbi request reprint Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques
    C C Tsai
    Regional Primate Research Center, University of Washington, Seattle
    J Med Primatol 19:203-16. 1990
    ..SRV-2 infection occurred principally in utero by the transplacental route. Infants born to viremic mothers exhibited low birth weight, prematurity, high perinatal death, and increased incidence of SAIDS...
  8. ncbi request reprint Focal segmental glomerulosclerosis in primates infected with a simian immunodeficiency virus
    C E Alpers
    Department of Pathology, School of Medicine, University of Washington, Seattle 98195, USA
    AIDS Res Hum Retroviruses 13:413-24. 1997
    ..They also indicate the variable pathology that can be seen in primate infections of distinct retrovirus types, each of which produces a simian immunodeficiency state that resembles human AIDS...
  9. pmc Toxicity and efficacy of 2',3'-dideoxycytidine in clinical trials of pigtailed macaques infected with simian retrovirus type 2
    C C Tsai
    Regional Primate Research Center, University of Washington, Seattle 98195
    Antimicrob Agents Chemother 33:1908-14. 1989
    ..However, a prophylactic regimen of ddC did have an inhibitory effect on SRV-2. Our findings suggest that ddC may be valuable as a short-term prophylactic treatment rather than as a long-term therapy...
  10. ncbi request reprint Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide
    P Emau
    Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA
    J Med Primatol 36:244-53. 2007
    ..Hence, we evaluated griffithsin (GRFT), a 12.7 kDa carbohydrate-binding protein, both native and recombinant GRFT, potently inhibited both CXCR4-and CCR5-tropic HIV infection and transmission in vitro...
  11. ncbi request reprint PCR amplification and DNA sequencing of SRV-2 from archived tumor tissues
    R F Grant
    Regional Primate Research Center, University of Washington, Seattle 99195, USA
    Virus Res 36:187-200. 1995
    ..nigra). A T-cell activating domain (Env residues 233-249) was 100% conserved in the SRV-2/WA isolates...
  12. pmc Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species
    T M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 71:4138-44. 1997
    ..Our data suggest that KSHV and the putative macaque herpesviruses define a new group within the subfamily Gammaherpesvirinae whose members are implicated in the pathogenesis of KS and KS-like neoplasms in different primate species...
  13. ncbi request reprint Dipyridamole inhibits human peritoneal mesothelial cell proliferation in vitro and attenuates rat peritoneal fibrosis in vivo
    K Y Hung
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
    Kidney Int 59:2316-24. 2001
    ..CONCLUSIONS: This study suggests that dipyridamole may have therapeutic potential in treating peritoneal fibrosis...
  14. ncbi request reprint Prophylactic effect of four prescriptions of traditional Chinese medicine on alpha-naphthylisothiocyanate and carbon tetrachloride induced toxicity in rats
    K J Lin
    Department of Surgery, China Medical College-Hospital, Taichung, Taiwan, China
    Acta Pharmacol Sin 22:1159-67. 2001
    ..Therefore they may be able to exert hepatoprotective effects through more than one mechanism of action because they contained a mixture of anti-hepatotoxic ingredients with mutual reinforcement and assistance...