A G Tsai

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine
    Barbara E Friesenecker
    Division of General and Surgical Intensive Care Medicine, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Crit Care 10:R75. 2006
  2. pmc Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective
    Judith Martini
    Department of Bioengineering, University of California, San Diego, Gilman Dr, La Jolla, California 92093, USA
    Crit Care 12:R54. 2008
  3. pmc Microvascular and tissue oxygen gradients in the rat mesentery
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Proc Natl Acad Sci U S A 95:6590-5. 1998
  4. ncbi request reprint Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions
    Amy G Tsai
    Department of Bioengineering, University of California at San Diego, La Jolla 92093 0412, USA
    Transfusion 44:1626-34. 2004
  5. ncbi request reprint Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
    Amy G Tsai
    Dept of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1730-9. 2005
  6. ncbi request reprint The vascular wall as a regulator of tissue oxygenation
    Amy G Tsai
    Department of Bioengineering 0412, University of California San Diego, La Jolla, CA 92093, USA
    Curr Opin Nephrol Hypertens 15:67-71. 2006
  7. pmc Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Blood 108:3603-10. 2006
  8. ncbi request reprint Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 285:H1537-45. 2003
  9. ncbi request reprint Oxygen-carrying blood substitutes: a microvascular perspective
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Expert Opin Biol Ther 4:1147-57. 2004
  10. ncbi request reprint High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 38:229-37. 2001

Collaborators

Detail Information

Publications77

  1. pmc Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine
    Barbara E Friesenecker
    Division of General and Surgical Intensive Care Medicine, Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Crit Care 10:R75. 2006
    ..It is known from patients with advanced vasodilatory shock that AVP exerts strong additional vasoconstriction when incremental dosage increases of NE have no further effect on mean arterial blood pressure (MAP)...
  2. pmc Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective
    Judith Martini
    Department of Bioengineering, University of California, San Diego, Gilman Dr, La Jolla, California 92093, USA
    Crit Care 12:R54. 2008
    ....
  3. pmc Microvascular and tissue oxygen gradients in the rat mesentery
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Proc Natl Acad Sci U S A 95:6590-5. 1998
    ....
  4. ncbi request reprint Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions
    Amy G Tsai
    Department of Bioengineering, University of California at San Diego, La Jolla 92093 0412, USA
    Transfusion 44:1626-34. 2004
    ..Transfusions are intended to augment oxygen-carrying capacity. The ability of fresh and stored red blood cells (RBCs) to maintain microvascular perfusion and oxygen delivery to the tissue has not been directly measured...
  5. ncbi request reprint Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion
    Amy G Tsai
    Dept of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1730-9. 2005
    ..Results support the concept that in extreme hemodilution HV plasma maintains functional capillary density through a NO-mediated vasodilatation...
  6. ncbi request reprint The vascular wall as a regulator of tissue oxygenation
    Amy G Tsai
    Department of Bioengineering 0412, University of California San Diego, La Jolla, CA 92093, USA
    Curr Opin Nephrol Hypertens 15:67-71. 2006
    ..This review presents the current status of in-vivo studies on the partitioning of oxygen between blood, the vascular wall and the surrounding tissue, thereby positioning an oxygen sink between blood and tissue regulating oxygen release...
  7. pmc Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Blood 108:3603-10. 2006
    ....
  8. ncbi request reprint Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 285:H1537-45. 2003
    ....
  9. ncbi request reprint Oxygen-carrying blood substitutes: a microvascular perspective
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Expert Opin Biol Ther 4:1147-57. 2004
    ....
  10. ncbi request reprint High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 38:229-37. 2001
    ..In this condition increasing plasma viscosity is beneficial and extends the transfusion trigger reducing the use of blood transfusions...
  11. ncbi request reprint Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Transfusion 41:1290-8. 2001
    ..Their ability to maintain microvascular perfusion and to deliver oxygen to tissue when they replace the RBCs as oxygen carriers has not been directly measured...
  12. ncbi request reprint Is the distribution of tissue pO(2) homogeneous?
    Amy G Tsai
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Antioxid Redox Signal 9:979-84. 2007
    ....
  13. ncbi request reprint Improving microcirculation is more effective than substitution of red blood cells to correct metabolic disorder in experimental hemorrhagic shock
    Reto Wettstein
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
    Shock 21:235-40. 2004
    ..Our results suggest that the transfusion trigger in hemorrhagic shock may be shifted toward lower hemoglobin concentrations if highly viscous and oncotic solutions are used...
  14. ncbi request reprint Perfluorocarbon in microcirculation during ischemia reperfusion
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    J Am Coll Surg 204:225-35. 2007
    ....
  15. ncbi request reprint Rapid restoration of microcirculatory blood flow with hyperviscous and hyperoncotic solutions lowers the transfusion trigger in resuscitation from hemorrhagic shock
    Reto Wettstein
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Shock 25:641-6. 2006
    ....
  16. ncbi request reprint Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics
    Amy G Tsai
    Department of Bioeengineering, University of California, San Diego, La Jolla 92023, USA
    Am J Physiol Heart Circ Physiol 285:H1411-9. 2003
    ..Higher O2 extraction of both red blood cell and plasma hemoglobin in capillaries represents a new mechanism of action of cell-free hemoglobin. High O2 affinity appears to be an important property for cell-free hemoglobin solutions...
  17. ncbi request reprint Beneficial effects due to increasing blood and plasma viscosity
    J Martini
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Clin Hemorheol Microcirc 35:51-7. 2006
    ..These results show that the rheological properties of plasma affect vessel diameter in the microcirculation leading to counterintuitive responses to the increase in viscosity...
  18. ncbi request reprint Role of endothelial nitric oxide in microvascular oxygen delivery and consumption
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Free Radic Biol Med 39:1229-37. 2005
    ..Finally, the findings of the study support the argument that NO availability limits oxygen consumption by the tissue...
  19. ncbi request reprint Early resuscitation with polymerized bovine hemoglobin reverses acidosis, but not peripheral tissue oxygenation, in a severe hamster shock model
    Reto Wettstein
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive 0412, La Jolla, CA 92093, USA
    Shock 26:496-503. 2006
    ..However, oxygenation of the peripheral tissue was inferior with PBH. This was attributed to its negative impact on the peripheral microcirculation caused by arteriolar vasoconstriction...
  20. ncbi request reprint Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin
    Reto Wettstein
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412 USA
    Shock 22:351-7. 2004
    ..7 cP (vs. 2.5 cP for MalPEG-Hb). The present results show that both solutions are efficacious plasma expanders and that the hemoglobin-based solution provides improved oxygen distribution and tissue Po2 in the hamster chamber model...
  21. ncbi request reprint Microcirculatory changes during chronic adaptation to hypoxia
    ENRIQUE SALDIVAR
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 285:H2064-71. 2003
    ..5 +/- 0.07 g/dl at control to 21.04 +/- 1.24 g/dl in the adapted animals (P < 0.05)...
  22. ncbi request reprint Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia
    Nanae Hangai-Hoger
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Crit Care Med 34:108-17. 2006
    ..5% weight/volume) infused at 16 mL/kg/hr (PEG-BSA-16) or at 24 mL/kg/hr (PEG-BSA-24) for 1 hr improves microcirculatory conditions in endotoxemia compared with dextran 70 (6% weight/volume) infused at 24 mL/kg/hr (Dex)...
  23. doi request reprint Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model
    Nivaldo R Villela
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0412, USA
    Shock 31:645-52. 2009
    ..These results suggest that lowering blood P50 in resuscitation provides improved microvascular function in comparison with higher P50...
  24. ncbi request reprint Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile
    Juan Carlos Briceno
    Dept of Bioengineering, 0412, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 286:H1223-8. 2004
    ..Po(2) profiles in the arterioles assumed an increasingly parabolic configuration with increasing levels of hemodilution...
  25. pmc Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells
    Beatriz Y Salazar Vázquez
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92037 0412, USA
    Am J Respir Cell Mol Biol 38:135-42. 2008
    ..Consequently, MetRBCs increased the viscosity related hypotension range compared with functional RBCs as NO shear stress vasodilation mediated responses are greater...
  26. ncbi request reprint Oxygen tension distribution in postcapillary venules in resting skeletal muscle
    Darin J Saltzman
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 285:H1980-5. 2003
    ..Results of this study may be attributable to three factors: 1) O2 diffusion between adjacent capillaries and venules, 2) structural remodeling in regions of lower PO2, and 3) O2-dependent local control mechanisms...
  27. ncbi request reprint Oxygen distribution and respiration by the microcirculation
    Amy G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Antioxid Redox Signal 6:1011-8. 2004
    ..Oxygen consumption by the endothelium and/or smooth muscle is also a factor in causing terminal lymphatic pO(2) to have the lowest oxygen level in the tissue, rendering this compartment most vulnerable in hypoxic conditions...
  28. ncbi request reprint Mechanotransduction and the homeostatic significance of maintaining blood viscosity in hypotension, hypertension and haemorrhage
    J Martini
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    J Intern Med 259:364-72. 2006
    ..Application of these findings to haemorrhagic shock resuscitation leads to the concept of hyperosmotic-hyperviscous resuscitation as a modality for maintaining the recovery of microvascular function...
  29. ncbi request reprint Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution
    Nanae Hangai-Hoger
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Crit Care Med 35:1123-32. 2007
    ..To determine how top loads with different doses of carbon monoxide (CO)-saturated saline solutions (CO-saline) affect microvascular and systemic hemodynamics and to delineate the corresponding biochemical mechanisms...
  30. pmc Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, Suite 405, La Jolla, CA 92037, USA
    J Appl Physiol 107:1548-58. 2009
    ..Although mechanistically attractive, neither of these hypotheses can be directly tested in vivo and will require further investigation...
  31. ncbi request reprint Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 9:375-84. 2007
    ..Assessment of tissue viability after exchange suggests that chelation treatment in cases of large exchange transfusions with acellular Hb could be potentially beneficial...
  32. ncbi request reprint Hemorrhagic shock resuscitation with carbon monoxide saturated blood
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, La Jolla, CA 92037, USA
    Resuscitation 72:306-18. 2007
    ..The precise cellular mechanisms involved require further elucidation. CO is a novel experimental strategy to improve tissue viability and requires the appropriated preclinical studies to confirm its efficacy...
  33. ncbi request reprint Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters
    Reto Wettstein
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Crit Care Med 31:1824-30. 2003
    ..5 cP, colloid osmotic pressure of 49 mm Hg, and p50 of 5.5 mm Hg, improves systemic and microvascular variables after hemorrhage compared with shed blood (SB) and 5% hydroxyethyl starch (HES)...
  34. ncbi request reprint Microvascular perspective of oxygen-carrying and -noncarrying blood substitutes
    Marcos Intaglietta
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Annu Rev Biomed Eng 8:289-321. 2006
    ..A feature of this material is that it is effective in small quantities, and therefore amplifies the equivalent supply of blood derived from blood donations...
  35. ncbi request reprint Microvascular and capillary perfusion following glycocalyx degradation
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, La Jolla, CA 92037, USA
    J Appl Physiol 102:2251-9. 2007
    ..These findings suggest that the decrease in the glycocalyx leads to capillary perfusion impairments...
  36. ncbi request reprint Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 27:380-9. 2007
    ..Conversely, the restoration of blood rheological properties improves resuscitation independently of the restitution of oxygen-carrying capacity...
  37. pmc Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 75:124-34. 2007
    ....
  38. pmc Exogenous nitric oxide induces protection during hemorrhagic shock
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 405, La Jolla, CA 92037, United States
    Resuscitation 80:707-12. 2009
    ..Hemodynamic responses to hemorrhagic shock were studied in the hamster window chamber...
  39. pmc Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction
    Pedro Cabrales
    La Jolla Bioengineering Institute, University of California, San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 295:H2212-8. 2008
    ..Further studies to establish PBH optimal dosage, efficacy, safety, and its effect on outcome are indicated before Hb-based O2-carrying blood substitutes are implemented in routine practice...
  40. doi request reprint Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters
    Pedro Cabrales
    La Jolla Bioengineering Institute, University of California, San Diego, La Jolla, California 92037, USA
    Shock 31:300-7. 2009
    ....
  41. pmc Balance between vasoconstriction and enhanced oxygen delivery
    Pedro Cabrales
    La Jolla Bioengineering Institute, Department of Bioengineering, University of California, San Diego, La Jolla, California 92037, USA
    Transfusion 48:2087-95. 2008
    ..Responses to facilitated O(2) transport, after exchange transfusion with PBH, were studied in the hamster window chamber model during acute extreme anemia to determine how PBH affects microvascular perfusion and tissue oxygenation...
  42. pmc Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 79:139-46. 2008
    ..Only recovery with PEG-Alb was sustained beyond 90 min. Hemodynamic functional benefits of PEG-Alb and the potential disadvantages associated with HSA, suggest PEG-Alb as better resuscitation solution...
  43. pmc Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA 92037, USA
    Resuscitation 77:379-86. 2008
    ..These results suggest the importance of restoration of blood rheological properties through enhancing plasma viscosity, influencing the re-establishment of microvascular perfusion during small volume resuscitation from hemorrhagic shock...
  44. ncbi request reprint Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2
    Nanae Hangai-Hoger
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Lymphat Res Biol 5:159-68. 2007
    ..Terminal lymphatic fluid is the compartment furthest removed from the oxygen supply, and therefore should present the lowest pO(2) in the tissue due to oxygen consumption by the tissue and the lymphatic vessel wall...
  45. pmc Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South, Suite 405, La Jolla, CA 92037, USA
    Am J Respir Cell Mol Biol 38:354-61. 2008
    ..Erythrocytes with increased Hb-O(2) affinity maintained hemodynamic conditions, Do(2) and decreased tissue Po(2). This study shows that in an anemic condition, maximal tissue Po(2) does not correspond to maximal Do(2) and Vo(2)...
  46. ncbi request reprint Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 28:461-7. 2007
    ..The HES MW does not seem to be a factor in compromising platelet adherence on stimulated endothelium. The longer initial intravascular persistence of H-HES might result in longer-lasting volume effects...
  47. ncbi request reprint The unusual properties of effective blood substitutes
    Amy G Tsai
    Department of Bioengineering, UCSD, 9500 Gilman Dr, La Jolla, CA 92092 0412, USA
    Keio J Med 51:17-20. 2002
    ....
  48. ncbi request reprint Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Blvd South, La Jolla, CA 92037, USA
    Am J Physiol Heart Circ Physiol 291:H2445-52. 2006
    ..Microhemodynamic data corresponded to microsphere-measured perfusion data in vital organs...
  49. ncbi request reprint Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure
    Pedro Cabrales
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H2146-53. 2005
    ..Microvascular resistance in arterioles with a diameter range of 70-80 microm showed an increase relative to control with alpha alpha Hb, whereas MP4 caused a decrease...
  50. ncbi request reprint Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92093 0412, USA
    Shock 23:549-55. 2005
    ..These findings suggest the possibility of using hyperviscous plasma expanders to prolong the period for initial treatment of blood losses and definitive institution therapy...
  51. ncbi request reprint Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle
    Paul C Johnson
    Dept of Bioengineering, Univ of California, San Diego, La Jolla, CA 92093 0412, USA
    J Appl Physiol 98:1177-84. 2005
    ..07, and tissue PO2 does not reach anaerobic levels...
  52. ncbi request reprint Microlymphatic and tissue oxygen tension in the rat mesentery
    Nanae Hangai-Hoger
    Dept of Bioengineering, 0412, Univ of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 286:H878-83. 2004
    ..The disparity between lymph and tissue Po(2) is attributed to the microlymphatic vessel wall and lymphocyte oxygen consumption...
  53. ncbi request reprint Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution
    Pedro Cabrales
    Dept of Bioengineering, 0412, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1708-16. 2005
    ....
  54. ncbi request reprint Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier
    Pedro Cabrales
    University of California, Department of Bioengineering, 0412, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 287:H363-73. 2004
    ..The use of PBH increased mean arterial pressure but reduced capillary pressure due to vasoconstriction and did not maintain FCD...
  55. ncbi request reprint Microvascular oxygen delivery and consumption following treatment with verapamil
    Nanae Hangai-Hoger
    Dept of Bioengineering, 0412, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1515-20. 2005
    ..These findings show that treatment with verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation...
  56. ncbi request reprint Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution
    Pedro Cabrales
    Dept of Bioengineering 0412, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 288:H1885-92. 2005
    ..the HbV(29) and rHSA groups (P < 0.05). Improved tissue Po(2) is obtained when red blood cells deliver oxygen in combination with a high- rather than low-affinity oxygen carrier...
  57. ncbi request reprint Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber
    Pedro Cabrales
    Dept of Bioengineering 0412, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 287:H1609-17. 2004
    ..42 ml O(2)/dl blood). The total hemoglobin in blood was similar in all cases; therefore, the improvement in tissue Po(2) and oxygen delivery appears to be due to the increased cooperativity of the new molecules...
  58. ncbi request reprint Hyperosmotic-hyperoncotic versus hyperosmotic-hyperviscous: small volume resuscitation in hemorrhagic shock
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Shock 22:431-7. 2004
    ....
  59. ncbi request reprint Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons
    Pedro Cabrales
    University of California San Diego, Department of Bioengineering, 0412, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 287:H320-30. 2004
    ..Oxygen ventilation (100%) led to a positive base excess for the PFC group (5.5 +/- 2.5 mmol/l) versus a negative balance (-0.8 +/- 1.4 mmol/l) for the HES 200 group, suggesting that microvascular findings corresponded to systemic events...
  60. ncbi request reprint Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin
    Pedro Cabrales
    Dept of Bioengineering, 0412, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 287:H2825-33. 2004
    ..These results suggest the impairment of tissue O2 metabolism after introduction of PBH into the circulation, which is mitigated as PBH concentration declines...
  61. ncbi request reprint Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 24:66-73. 2005
    ..Furthermore, PEG-Alb appears to provide early and long-term sustained systemic and microvascular recovery when used to restitute perfusion and metabolic conditions after resuscitation from hemorrhagic shock...
  62. ncbi request reprint Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Blvd S, Suite 405, La Jolla, CA 92037, USA
    Am J Physiol Heart Circ Physiol 289:H2392-400. 2005
    ..MP4 was significantly higher than MPA (P < 0.05) and was not statistically different from baseline, an effect due to the additional oxygen release to the tissue by the Hb MP4...
  63. ncbi request reprint Measurement of the cardiac output in small animals by thermodilution
    Pedro Cabrales
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Microvasc Res 66:77-82. 2003
    ..0 +/- 18.8 (ml/min)/kg. Repeated measurements were made. This technique allows correlating systemic flow changes to be correlated to those measured in the microcirculation of window chamber preparations...
  64. ncbi request reprint Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 291:H581-90. 2006
    ..Thus the fall in systemic and microvascular conditions during extreme hemodilution with low-viscosity plasma expanders seems to be, in part, from the decrease in blood viscosity independent of the reduction in oxygen content...
  65. ncbi request reprint Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model
    Judith Martini
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 291:H310-7. 2006
    ..We conclude that a minimum viscosity level is necessary for generating the shear stress required for maintaining normal cardiovascular function...
  66. ncbi request reprint Oxygen release from arterioles with normal flow and no-flow conditions
    Pedro Cabrales
    La Jolla Bioengineering Institute, University of California San Diego, La Jolla, CA 92037, USA
    J Appl Physiol 100:1569-76. 2006
    ..6 vs. 1.8 x 10(-5) ml O2.cm(-2).s(-1), P < 0.05). The oxygen cost induced by wall shear stress, suggested by our findings, may be >15% of the total oxygen delivery to tissues by arterioles during flow in this preparation...
  67. ncbi request reprint Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Blvd South, Suite 405, CA 92037, USA
    J Appl Physiol 100:1181-7. 2006
    ..The vessel wall consumes oxygen in proportion to the local Po2, and an impairment of NO availability renders the circulation more sensitive to changes in the oxygen supply...
  68. ncbi request reprint Blood and plasma viscosity and microvascular function in hemodilution. A perspective from La Jolla, California
    Michelle C Mazzoni
    Alliance Pharmaceutical Corporation, San Diego, CA, USA
    Eur Surg Res 34:101-5. 2002
  69. pmc Impact of enzymatic degradation of the endothelial glycocalyx on vascular permeability in an awake hamster model
    S A Landsverk
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Crit Care Res Pract 2012:842545. 2012
    ..Conclusion. Vascular leakage was not confirmed in an in vivo, whole body model after degradation of the endothelial glycocalyx. The microcirculation was affected, but no relationship between plasma levels of HA and FCD was seen...
  70. ncbi request reprint pO(2) measurements by phosphorescence quenching: characteristics and applications of an automated system
    Heinz Kerger
    Department of Anesthesiology, University Hospital of Mannheim, D 68135 Mannheim, Germany
    Microvasc Res 65:32-8. 2003
    ..The automated system fits the phosphorescence decay data to a single exponential and allows repeated pO(2) measurements in rapid sequence...
  71. ncbi request reprint Systemic and microvascular responses to hemorrhagic shock and resuscitation with Hb vesicles
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169 8555, Japan
    Am J Physiol Heart Circ Physiol 283:H1191-9. 2002
    ..The recovery of base excess and improved tissue oxygenation appears to be primarily due to the increased oxygen-carrying capacity of HbV fluid resuscitation...
  72. ncbi request reprint Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery
    Amy G Tsai
    Am J Physiol Heart Circ Physiol 289:H1777; author reply H1778-9. 2005
    ..72) was higher than that for the other half (mean Po(2) = 39 mmHg; R = -0.38). These results support the theoretical predictions of EATs and plasma Po(2) gradients in capillaries...
  73. ncbi request reprint Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive
    Seetharama A Acharya
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Artif Cells Blood Substit Immobil Biotechnol 33:239-55. 2005
    ..The results demonstrate that a non-hypertensive PEG-Hb can be generated by conjugation of a lower number of PEG chains than previously reported...
  74. ncbi request reprint Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda Univ, Tokyo 169 8555, Japan
    Am J Physiol Heart Circ Physiol 288:H2897-903. 2005
    ..55) overwhelming red blood cells when the Po(2) was reduced (e.g., <10 mmHg) despite a small dosage of HbV. This result supports the possible utilization of Hb-based O(2) carriers with lower P(50) for oxygenation of ischemic tissues...
  75. ncbi request reprint Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function
    Belur N Manjula
    Departments of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Protein J 24:133-46. 2005
    ....
  76. pmc Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation
    Seetharama A Acharya
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Biochem J 405:503-11. 2007
    ....
  77. ncbi request reprint New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions
    Amy G Tsai
    J Appl Physiol 102:2081-2; author reply 2083. 2007