JAMES TRUMAN

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint The morphostatic actions of juvenile hormone
    James W Truman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Insect Biochem Mol Biol 37:761-70. 2007
  2. ncbi request reprint Eclosion hormone provides a link between ecdysis-triggering hormone and crustacean cardioactive peptide in the neuroendocrine cascade that controls ecdysis behavior
    S C Gammie
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195, USA
    J Exp Biol 202:343-52. 1999
  3. pmc Steroid hormone secretion in insects comes of age
    James W Truman
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Proc Natl Acad Sci U S A 103:8909-10. 2006
  4. ncbi request reprint The origins of insect metamorphosis
    J W Truman
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    Nature 401:447-52. 1999
  5. ncbi request reprint Endocrine insights into the evolution of metamorphosis in insects
    James W Truman
    Department of Zoology, University of Washington, Seattle, Washington 98195 1800, USA
    Annu Rev Entomol 47:467-500. 2002
  6. ncbi request reprint Juvenile hormone is required to couple imaginal disc formation with nutrition in insects
    J W Truman
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Science 312:1385-8. 2006
  7. ncbi request reprint Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila
    James W Truman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Development 131:5167-84. 2004
  8. ncbi request reprint Patterns of embryonic neurogenesis in a primitive wingless insect, the silverfish, Ctenolepisma longicaudata: comparison with those seen in flying insects
    J W Truman
    Research School for Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
    Dev Genes Evol 208:357-68. 1998
  9. ncbi request reprint Postembryonic development of the midline glia in the CNS of Drosophila: proliferation, programmed cell death, and endocrine regulation
    T A Awad
    Department of Zoology, University of Washington, Seattle 98195, USA
    Dev Biol 187:283-97. 1997
  10. ncbi request reprint Genes that induce apoptosis: transcriptional regulation in identified, doomed neurons of the Drosophila CNS
    S Robinow
    Department of Zoology, University of Hawaii, 2538 The Mall, Honolulu, Hawaii 96822, USA
    Dev Biol 190:206-13. 1997

Research Grants

  1. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2009
  2. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2003
  3. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2007
  4. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2007
  5. HORMONE ACTION ON THE CENTRAL NERVOUS SYSTEM
    JAMES TRUMAN; Fiscal Year: 1980
  6. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 1999
  7. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 1999
  8. STEROID RECEPTORS AND CNS DEVELOPMENTS
    JAMES TRUMAN; Fiscal Year: 1993
  9. HORMONE ACTION ON THE CENTRAL NERVOUS SYSTEM
    JAMES TRUMAN; Fiscal Year: 1993

Detail Information

Publications60

  1. ncbi request reprint The morphostatic actions of juvenile hormone
    James W Truman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Insect Biochem Mol Biol 37:761-70. 2007
    ..This suppression of embryonic patterning then results in embryonic fields that remain dormant as long as JH is present. These are the primordia that can transform into imaginal discs once JH disappears in preparation for metamorphosis...
  2. ncbi request reprint Eclosion hormone provides a link between ecdysis-triggering hormone and crustacean cardioactive peptide in the neuroendocrine cascade that controls ecdysis behavior
    S C Gammie
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195, USA
    J Exp Biol 202:343-52. 1999
    ..EH release then facilitates the onset of ecdysis by enhancing the excitability of the CCAP neurons...
  3. pmc Steroid hormone secretion in insects comes of age
    James W Truman
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Proc Natl Acad Sci U S A 103:8909-10. 2006
  4. ncbi request reprint The origins of insect metamorphosis
    J W Truman
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    Nature 401:447-52. 1999
    ..This proposal has general implications for insect developmental biology...
  5. ncbi request reprint Endocrine insights into the evolution of metamorphosis in insects
    James W Truman
    Department of Zoology, University of Washington, Seattle, Washington 98195 1800, USA
    Annu Rev Entomol 47:467-500. 2002
    ..We discuss how complete metamorphosis may have influenced the molecular aspects of both ecdysone and JH signaling...
  6. ncbi request reprint Juvenile hormone is required to couple imaginal disc formation with nutrition in insects
    J W Truman
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Science 312:1385-8. 2006
    ....
  7. ncbi request reprint Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila
    James W Truman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Development 131:5167-84. 2004
    ..This paper provides an overall view of the initial connections that eventually lead to the complex connectivity of the bulk of the thoracic neurons...
  8. ncbi request reprint Patterns of embryonic neurogenesis in a primitive wingless insect, the silverfish, Ctenolepisma longicaudata: comparison with those seen in flying insects
    J W Truman
    Research School for Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
    Dev Genes Evol 208:357-68. 1998
    ..The expansion of specific thoracic lineages was accompanied by the reduction of the terminal abdominal lineages as flying insects began to de-emphasize their cercal sensory system...
  9. ncbi request reprint Postembryonic development of the midline glia in the CNS of Drosophila: proliferation, programmed cell death, and endocrine regulation
    T A Awad
    Department of Zoology, University of Washington, Seattle 98195, USA
    Dev Biol 187:283-97. 1997
    ..The midline glial may play a role during CNS metamorphosis similar to that of their progenitors in the embryo, in stabilizing outgrowing neurites that cross or run along the midline...
  10. ncbi request reprint Genes that induce apoptosis: transcriptional regulation in identified, doomed neurons of the Drosophila CNS
    S Robinow
    Department of Zoology, University of Hawaii, 2538 The Mall, Honolulu, Hawaii 96822, USA
    Dev Biol 190:206-13. 1997
    ....
  11. ncbi request reprint Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis
    M Schubiger
    Department of Zoology, University of Washington, Seattle, WA 98195, USA
    Development 125:2053-62. 1998
    ..These observations support the hypothesis that different EcR isoforms control cell-type-specific responses during remodeling of the nervous system at metamorphosis...
  12. ncbi request reprint Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development
    J W Truman
    Department of Zoology, University of Washington, Seattle 98195
    Development 120:219-34. 1994
    ..The heterogeneity of EcR expression at the start of metamorphosis presumably reflects the diverse origins and requirements of the neurons that nevertheless are all exposed to a common hormonal signal...
  13. ncbi request reprint Developing grasshopper neurons show variable levels of guanylyl cyclase activity on arrival at their targets
    E E Ball
    Molecular Evolution and Systematics Group, Research School of Biological Sciences, Australian National University, Canberra, ACT
    J Comp Neurol 394:1-13. 1998
    ..We suggest that cGMP plays a role in, or reflects, the early stages of communication between a target and specific innervating neurons...
  14. ncbi request reprint Nitric oxide and cyclic GMP regulate retinal patterning in the optic lobe of Drosophila
    S M Gibbs
    Department of Zoology, Program in Neurobiology and Behavior, University of Washington, Seattle 98195, USA
    Neuron 20:83-93. 1998
    ..The disruptive effects of L-NAME were prevented with the addition of 8-bromo-cGMP. These results suggest NO and cGMP act to stabilize retinal growth cones at the start of synaptic assembly...
  15. ncbi request reprint Invariant association of ecdysis with increases in cyclic 3',5'-guanosine monophosphate immunoreactivity in a small network of peptidergic neurons in the hornworm, Manduca sexta
    J Ewer
    Zoology Department, University of Washington, Seattle 98195, USA
    J Comp Physiol A 181:319-30. 1997
    ..Finally, we found that the appearance of sensitivity to EH for triggering the cGMP response coincided with the time at which EH first triggers ecdysis...
  16. ncbi request reprint Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform
    S Robinow
    Department of Zoology, University of Washington, Seattle 98195
    Development 119:1251-9. 1993
    ..The correlation of a unique pattern of receptor isoform expression with a particular steroid-regulated fate suggests that variations in the pattern of receptor isoform expression may serve as important switches during development...
  17. ncbi request reprint Disruption of a behavioral sequence by targeted death of peptidergic neurons in Drosophila
    S L McNabb
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    Neuron 19:813-23. 1997
    ..The knockouts lacked the lights-on eclosion response despite having a normal circadian eclosion rhythm. This study represents a novel approach to the dissection of neuropeptide regulation of a complex behavioral program...
  18. ncbi request reprint Isolation, characterization and expression of the eclosion hormone gene of Drosophila melanogaster
    F M Horodyski
    Department of Zoology, University of Washington, Seattle
    Eur J Biochem 215:221-8. 1993
    ..These cells show massive depletion of immunoreactive EH at ecdysis...
  19. ncbi request reprint Tiling of the body wall by multidendritic sensory neurons in Manduca sexta
    W B Grueber
    Department of Zoology, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 440:271-83. 2001
    ..These properties of the da system likely allow insects to discriminate the quality and location of several types of stimuli acting on the cuticle...
  20. ncbi request reprint The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster
    J D Baker
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195, USA
    J Exp Biol 202:3037-48. 1999
    ..A waning in the inhibition eventually allows ecdysis to begin 30-40 min later...
  21. ncbi request reprint Steroid control of muscle remodeling during metamorphosis in Manduca sexta
    C D Hegstrom
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    J Neurobiol 29:535-50. 1996
    ..Unilateral axotomy blocks proliferation within the rudiment, but it does not block its subsequent differentiation into a very thin muscle in the adult...
  22. ncbi request reprint Neural network partitioning by NO and cGMP
    N L Scholz
    University of Washington, Department of Zoology, Seattle, Washington 98195 1800, USA
    J Neurosci 21:1610-8. 2001
    ..This suggests that the NO-cGMP pathway may interact with other biochemical cascades to partition rhythmic motor output from the ganglion...
  23. ncbi request reprint Remodeling dendrites during insect metamorphosis
    D W Williams
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    J Neurobiol 64:24-33. 2005
    ..The potential relationship between hormone-induced transcriptional change and the calcium dynamics in dendritic morphogenesis is discussed...
  24. ncbi request reprint Hormonal control of ventral diaphragm myogenesis during metamorphosis of the moth, Manduca sexta
    D T Champlin
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Dev Genes Evol 209:265-74. 1999
    ..Thus, ecdysteroid and juvenile hormone collaborate to determine the size and shape of the adult musculature...
  25. ncbi request reprint Soluble guanylate cyclase is required during development for visual system function in Drosophila
    S M Gibbs
    Graduate Program in Neurobiology and Behavior, Department of Zoology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 21:7705-14. 2001
    ..We propose that diminished sGC activity in the visual system during development causes inappropriate or inadequate formation of first-order retinal synapses, leading to defects in visual system function and visually mediated behavior...
  26. ncbi request reprint Ecdysteroid coordinates optic lobe neurogenesis via a nitric oxide signaling pathway
    D T Champlin
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Development 127:3543-51. 2000
    ..The consequence of these opposing pathways is a sharpening of the responsiveness to the steroid, thereby facilitating a tight coordination between development of the different elements of the adult visual system...
  27. ncbi request reprint The RXR ortholog USP suppresses early metamorphic processes in Drosophila in the absence of ecdysteroids
    M Schubiger
    Department of Zoology, University of Washington, Seattle WA 98195, USA
    Development 127:1151-9. 2000
    ..Our observations suggest that silencing by the unliganded EcR/USP receptor and the subsequent release of silencing by moderate steroid levels may play an important role in coordinating early phases of steroid driven development...
  28. ncbi request reprint Development and organization of a nitric-oxide-sensitive peripheral neural plexus in larvae of the moth, Manduca sexta
    W B Grueber
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    J Comp Neurol 404:127-41. 1999
    ..Cyclic GMP is detected primarily in the cytoplasm of plexus neurons and extends into the finest peripheral dendrites. Our results suggest that cGMP participates in the development and/or physiology of this peripheral neural plexus...
  29. ncbi request reprint Ecdysteroids govern two phases of eye development during metamorphosis of the moth, Manduca sexta
    D T Champlin
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Development 125:2009-18. 1998
    ..This capacity to regulate distinct phases of development by different concentrations of a single hormone is probably achieved by differential sensitivity of target gene promoters to induction by the hormone-bound receptor(s)...
  30. ncbi request reprint Ecdysteroid control of cell proliferation during optic lobe neurogenesis in the moth Manduca sexta
    D T Champlin
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    Development 125:269-77. 1998
    ..Initially, moderate levels of ecdysteroid stimulate proliferation. Later, high levels of 20-hydroxyecdysone trigger a wave of apoptosis within the anlage that marks completion of its proliferative phase...
  31. ncbi request reprint Commitment of abdominal neuroblasts in Drosophila to a male or female fate is dependent on genes of the sex-determining hierarchy
    B J Taylor
    Department of Zoology, University of Washington, Seattle 98195
    Development 114:625-42. 1992
    ..Neuroblasts become determined to adopt a male or female state at the end of the first larval instar, a time when abdominal neuroblasts enter their first postembryonic S-phase...
  32. ncbi request reprint An endogenous elevation of cGMP increases the excitability of identified insect neurosecretory cells
    S C Gammie
    Zoology Department, University of Washington, Seattle 98195 1800, USA
    J Comp Physiol A 180:329-37. 1997
    ..The results of these manipulations are consistent with the hypothesis that cGMP may partially increase excitability in Cell 27 by enhancing an inward Ca2+ current...
  33. ncbi request reprint Nitric oxide-sensitive guanylate cyclase activity is associated with the maturational phase of neuronal development in insects
    J W Truman
    Research School of Biological Sciences, Australian National University, Canberra
    Development 122:3949-58. 1996
    ..Comparative studies on other insects indicate that the association between an NO-sensitive guanylate cyclase and synaptogenesis is an ancient one, as evidenced by its presence in both ancient and more recently evolved insect groups...
  34. ncbi request reprint Synapse loss and axon retraction in response to local muscle degeneration
    C D Hegstrom
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    J Neurobiol 31:175-88. 1996
    ..The results suggest that local steroid treatments that result in local muscle degeneration bring about a loss of synaptic contacts from regions of muscle degeneration...
  35. ncbi request reprint The roles of central and peripheral eclosion hormone release in the control of ecdysis behavior in Manduca sexta
    R S Hewes
    Department of Zoology, University of Washington, Seattle 98195
    J Comp Physiol A 168:697-707. 1991
    ..5. Antidromic stimulation of the proctodeal nerve stumps following proctodeal nerve removal triggered precocious ecdysis. This result further supports the conclusion that centrally released EH is sufficient to trigger the motor program...
  36. ncbi request reprint Drosophila glutamate receptor RNA expression in embryonic and larval muscle fibers
    D A Currie
    Department of Zoology, University of Washington, Seattle 98195, USA
    Dev Dyn 203:311-6. 1995
    ..These results indicate that although the DGluR-II gene is expressed in somatic muscle cells it is not selectively expressed in nuclei near the synaptic site...
  37. ncbi request reprint Metamorphosis of the ecdysis motor pattern in the hawkmoth, Manduca sexta
    K A Mesce
    Department of Zoology, University of Washington, Seattle 98195
    J Comp Physiol A 163:287-99. 1988
    ..We speculate that its underlying neural circuitry is conserved through development and later modulated to produce the novel ecdysis pattern expressed in the adult stage...
  38. ncbi request reprint Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing
    Margrit Schubiger
    Department of Biology, Box 35 1800, University of Washington, Seattle, WA 98195, USA
    Development 132:5239-48. 2005
    ..In this way, the ecdysone signal can function as a developmental timer coordinating development within the imaginal disc...
  39. ncbi request reprint Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila
    Heather L D Brown
    Department of Biology, University of Washington, Seattle WA 98195, USA
    Development 133:275-85. 2006
    ..These results are consistent with the role of activation versus derepression via EcR for successive phases of neuronal remodeling and suggest that functional ecdysone receptor is necessary for some, but not all, remodeling events...
  40. ncbi request reprint Hormonal control of insect ecdysis: endocrine cascades for coordinating behavior with physiology
    James W Truman
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    Vitam Horm 73:1-30. 2005
  41. pmc The pupal specifier broad directs progressive morphogenesis in a direct-developing insect
    Deniz F Erezyilmaz
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Proc Natl Acad Sci U S A 103:6925-30. 2006
    ..After this shift in br expression, the progressive changes that occur within the nymphal series in basal insects became compressed to the one short period of morphogenesis seen in the larva-to-pupa transition of holometabolous insects...
  42. ncbi request reprint Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons
    Darren W Williams
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Development 132:3631-42. 2005
    ..Finally, we find that phagocytic blood cells not only engulf neuronal debris but also attack and sever intact branches that show signs of destabilization...
  43. ncbi request reprint Local caspase activity directs engulfment of dendrites during pruning
    Darren W Williams
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Nat Neurosci 9:1234-6. 2006
    ..A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons...
  44. ncbi request reprint Molecular patterning mechanism underlying metamorphosis of the thoracic leg in Manduca sexta
    Kohtaro Tanaka
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Dev Biol 305:539-50. 2007
    ..In addition, we find that, during the adult leg development, some cells in the leg express the patterning genes de novo suggesting that the remodeling of the leg involves changes in the patterning gene regulation...
  45. ncbi request reprint Delta expression in post-mitotic neurons identifies distinct subsets of adult-specific lineages in Drosophila
    Carson Cornbrooks
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Dev Neurobiol 67:23-38. 2007
    ..Altogether, these data reveal a fundamental pattern of Delta expression that is indicative of an underlying developmental program that confers identity to adult lineage neurons...
  46. doi request reprint The role of Broad in the development of Tribolium castaneum: implications for the evolution of the holometabolous insect pupa
    Yuichiro Suzuki
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Development 135:569-77. 2008
    ..Our findings show that the br isoform functions are broadly conserved within the Holometabola and suggest that evolution of br isoform expression may have played an important role in the evolution of the pupa in holometabolous insects...
  47. ncbi request reprint The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster
    Christen Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 15:1796-807. 2005
    ..We present evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved...
  48. ncbi request reprint The role of nutrition in creation of the eye imaginal disc and initiation of metamorphosis in Manduca sexta
    Steven G B MacWhinnie
    Department of Biology, University of Southern Maine, 96 Falmouth Street, Portland, ME 04103 9300, USA
    Dev Biol 285:285-97. 2005
    ..Instead, creation of the late-forming imaginal discs in Manduca appears to be controlled by unidentified endocrine factors whose activation is regulated by the nutritional state of the animal...
  49. ncbi request reprint Modulation of ecdysis in the moth Manduca sexta: the roles of the suboesophageal and thoracic ganglia
    Megumi Fuse
    Department of Zoology, University of Washington, Seattle, WA 98195 38100, USA
    J Exp Biol 205:1047-58. 2002
    ..CO(2) therefore appears to be a novel and non-invasive tool for studies of ecdysis behavior in insects...
  50. ncbi request reprint Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster
    Orie T Shafer
    Department of Zoology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:5946-54. 2002
    ..The differing profiles of TIM and PER nuclear accumulation suggest that PER and TIM have distinct functions in the nuclei of vLNs...
  51. ncbi request reprint Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program
    James D Baker
    Department of Zoology, University of Washington, Box 351800 Seattle, WA 91895, USA
    J Exp Biol 205:2555-65. 2002
    ..A set of decapitation experiments utilizing rickets mutants and flies that lack cells containing the neuropeptide eclosion hormone, reveals a multicomponent control to the activation of this behavioral program...
  52. ncbi request reprint E74 exhibits stage-specific hormonal regulation in the epidermis of the tobacco hornworm, manduca sexta
    Geoffrey E Stilwell
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Dev Biol 258:76-90. 2003
    ..Thus, MsE74B appears to have a similar role at the onset of metamorphosis in Manduca as it does in Drosophila, whereas MsE74A is regulated differently at pupation in Manduca than at pupariation in Drosophila...
  53. ncbi request reprint Isoform specific control of gene activity in vivo by the Drosophila ecdysone receptor
    Margrit Schubiger
    Department of Biology, University of Washington, Seattle WA 98195, USA
    Mech Dev 120:909-18. 2003
    ..EcR-B1 or EcR-B2 over-expression had little or no effect...
  54. ncbi request reprint Mechanisms of dendritic elaboration of sensory neurons in Drosophila: insights from in vivo time lapse
    Darren W Williams
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    J Neurosci 24:1541-50. 2004
    ..With later JHm treatments, extension programs appear normal, but retraction programs are maintained beyond their normal time. The JH treatments show the importance of retraction programs in establishing the overall arbor shape...
  55. ncbi request reprint Overexpression of broad: a new insight into its role in the Drosophila prothoracic gland cells
    Xiaofeng Zhou
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    J Exp Biol 207:1151-61. 2004
    ..Overexpression of each of the BR isoforms caused degeneration of the PG cells but on different time courses, indicating that BR is a signal for the degeneration of the PG cells that normally occurs during the pupal-adult transition...
  56. ncbi request reprint Flies by night: Effects of changing day length on Drosophila's circadian clock
    Orie T Shafer
    Department of Zoology, University of Washington, Seattle, WA 98195, USA
    Curr Biol 14:424-32. 2004
    ..We manipulated LD cycles to assess the effects of altered day length on PER and TIM dynamics in clock cells within the central brain as well as light-induced resetting of locomotor rhythms...
  57. ncbi request reprint Development of the adult leg epidermis in Manduca sexta: contribution of different larval cell populations
    Kohtaro Tanaka
    Department of Biology, University of Washington, 351800 Seattle, WA 98195 1800, USA
    Dev Genes Evol 215:78-89. 2005
    ..The second population consists of polymorphic cells that contribute to the larval, pupal and adult leg epidermis...
  58. pmc Light and peptidergic eclosion hormone neurons stimulate a rapid eclosion response that masks circadian emergence in Drosophila
    Susan L McNabb
    Department of Zoology, Box 351800, University of Washington, Seattle, WA 98195 1800, USA
    J Exp Biol 211:2263-74. 2008
    ..The LOn signal does not influence the latency of wing spreading, an EH-regulated post-ecdysis behavior...
  59. ncbi request reprint Juvenile hormone acts at embryonic molts and induces the nymphal cuticle in the direct-developing cricket
    Deniz F Erezyilmaz
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Dev Genes Evol 214:313-23. 2004
    ....
  60. ncbi request reprint Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading
    Elizabeth M Dewey
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 14:1208-13. 2004
    ..It is the first member of the cystine knot family to have a defined function in invertebrates. Mutants show that the spectrum of bursicon actions is broader than formerly demonstrated...

Research Grants44

  1. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2009
    ..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
  2. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2003
    ..5) Utilize a neuron-myoblast coculture system to examine how neurons are able to direct the type of EcR isoform expressed in embryonic muscle and how receptor isoform choice relates to muscle growth and maturation responses. ..
  3. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2007
    ..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
  4. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2007
    ..5) Use EcR dominant-negative mutations to selectively suppress cytodynamic modules to establish the role of each on growth dynamics and on the final form of the arbor. ..
  5. HORMONE ACTION ON THE CENTRAL NERVOUS SYSTEM
    JAMES TRUMAN; Fiscal Year: 1980
    ..The neural circuitry involved in behaviors that are influenced by the hormone will be studied. Attempts will be made to relate the hormone induced changes in the target cells to this circuitry...
  6. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 1999
    ..The impact of altering proliferation patterns on the differentiation of the optic lobes will be determined. ..
  7. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 1999
    ..4) Use juvenile hormone treatments to try to redirect EcR expression and to modify the pattern of ecdysone responsive gene expression. The latter will then be related to the effects of such treatments on neuronal responses. ..
  8. STEROID RECEPTORS AND CNS DEVELOPMENTS
    JAMES TRUMAN; Fiscal Year: 1993
    ..5.) To begin an examination of the relationship of EcR expression to the activation of "early" genes that mediate ecdysteroid action...
  9. HORMONE ACTION ON THE CENTRAL NERVOUS SYSTEM
    JAMES TRUMAN; Fiscal Year: 1993
    ..Specific lineage groups will be cultured and their differentiation in vitro in response to steroids will be compared to their normal fate in vivo...