Matthew C Trudeau

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc hERG potassium channel gating is mediated by N- and C-terminal region interactions
    Ahleah S Gustina
    Program in Neuroscience and 2 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 137:315-25. 2011
  2. pmc The eag domain regulates hERG channel inactivation gating via a direct interaction
    Ahleah S Gustina
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 141:229-41. 2013
  3. pmc hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome
    Matthew C Trudeau
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 138:581-92. 2011
  4. pmc Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels
    Elena C Gianulis
    Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:22160-9. 2011
  5. pmc A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels
    Ahleah S Gustina
    Program in Neuroscience and Department of Physiology, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:13082-7. 2009
  6. doi request reprint HERG potassium channel regulation by the N-terminal eag domain
    Ahleah S Gustina
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Cell Signal 24:1592-8. 2012
  7. pmc Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels
    Elena C Gianulis
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201
    J Gen Physiol 142:351-66. 2013

Collaborators

  • Ahleah S Gustina
  • Elena C Gianulis
  • Qiangni Liu

Detail Information

Publications7

  1. pmc hERG potassium channel gating is mediated by N- and C-terminal region interactions
    Ahleah S Gustina
    Program in Neuroscience and 2 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 137:315-25. 2011
    ..Together, these data suggest that the mechanism for regulation of slow deactivation in hERG channels is an interaction between the N-terminal PAS domain and the C-terminal CNBD...
  2. pmc The eag domain regulates hERG channel inactivation gating via a direct interaction
    Ahleah S Gustina
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 141:229-41. 2013
    ..The results show that N-terminal region-dependent regulation of channel inactivation and resurgent current properties are caused by a direct interaction of the eag domain with the rest of the hERG channel...
  3. pmc hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome
    Matthew C Trudeau
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gen Physiol 138:581-92. 2011
    ..A decrease in outward current density of hERG1a/hERG1b channels by hERG1a NTRs may be a mechanism for LQTS...
  4. pmc Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels
    Elena C Gianulis
    Program in Molecular Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:22160-9. 2011
    ....
  5. pmc A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels
    Ahleah S Gustina
    Program in Neuroscience and Department of Physiology, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:13082-7. 2009
    ....
  6. doi request reprint HERG potassium channel regulation by the N-terminal eag domain
    Ahleah S Gustina
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Cell Signal 24:1592-8. 2012
    ....
  7. pmc Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels
    Elena C Gianulis
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201
    J Gen Physiol 142:351-66. 2013
    ....