M H Trivedi

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint A computerized clinical decision support system as a means of implementing depression guidelines
    Madhukar H Trivedi
    Department of Psychiatry of the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9119, USA
    Psychiatr Serv 55:879-85. 2004
  2. ncbi request reprint Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based care
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuropsychopharmacology 32:2479-89. 2007
  3. ncbi request reprint Cost and effectiveness of venlafaxine extended-release and selective serotonin reuptake inhibitors in the acute phase of outpatient treatment for major depressive disorder
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    J Clin Psychopharmacol 24:497-506. 2004
  4. ncbi request reprint Effectiveness of low doses of paroxetine controlled release in the treatment of major depressive disorder
    Madhukar H Trivedi
    Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex 75930, USA
    J Clin Psychiatry 65:1356-64. 2004
  5. ncbi request reprint REVAMP - Research Evaluating the Value of Augmenting Medication with Psychotherapy: rationale and design
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Psychopharmacol Bull 41:5-33. 2008
  6. ncbi request reprint Relationship between obesity and depression: characteristics and treatment outcomes with antidepressant medication
    Marisa S P Toups
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119
    Psychosom Med 75:863-72. 2013
  7. ncbi request reprint Cognitive dysfunction in unipolar depression: implications for treatment
    Madhukar H Trivedi
    Division of Mood Disorders, UT Southwestern Medical Center, Dallas, TX, United States Electronic address
    J Affect Disord 152:19-27. 2014
  8. doi request reprint Evaluation of the effects of extended release quetiapine fumarate monotherapy on sleep disturbance in patients with major depressive disorder: a pooled analysis of four randomized acute studies
    Madhukar H Trivedi
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Int J Neuropsychopharmacol 16:1733-44. 2013
  9. doi request reprint A randomized controlled trial of the efficacy and safety of lisdexamfetamine dimesylate as augmentation therapy in adults with residual symptoms of major depressive disorder after treatment with escitalopram
    Madhukar H Trivedi
    Department of Psychiatry, Comprehensive Center for Depression, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119
    J Clin Psychiatry 74:802-9. 2013
  10. doi request reprint Increase in work productivity of depressed individuals with improvement in depressive symptom severity
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Psychiatry 170:633-41. 2013

Research Grants

  1. Using Information Technology to Provide Measurement Based Care for Chronic Illnes
    Madhukar Trivedi; Fiscal Year: 2007
  2. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2003
  3. REVAMP Follow-Up
    Madhukar Trivedi; Fiscal Year: 2007
  4. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2007
  5. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2006
  6. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2006
  7. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2005
  8. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2005
  9. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2004
  10. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2004

Detail Information

Publications126 found, 100 shown here

  1. ncbi request reprint A computerized clinical decision support system as a means of implementing depression guidelines
    Madhukar H Trivedi
    Department of Psychiatry of the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9119, USA
    Psychiatr Serv 55:879-85. 2004
    ..CompTMAP is part of a new era of comprehensive computerized decision support systems that take advantage of advances in automation and provide more complete clinical support to physicians in clinical practice...
  2. ncbi request reprint Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based care
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuropsychopharmacology 32:2479-89. 2007
    ..This approach signals a paradigm shift toward the use of measurement-based clinical decisions, both at the point of care and following each visit, to deliver optimal pharmacotherapy for depression...
  3. ncbi request reprint Cost and effectiveness of venlafaxine extended-release and selective serotonin reuptake inhibitors in the acute phase of outpatient treatment for major depressive disorder
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    J Clin Psychopharmacol 24:497-506. 2004
    ..The purpose of this retrospective analysis was to estimate the cost and effectiveness of venlafaxine extended-release (VXR) compared with selective serotonin reuptake inhibitors in the outpatient treatment of major depressive disorder...
  4. ncbi request reprint Effectiveness of low doses of paroxetine controlled release in the treatment of major depressive disorder
    Madhukar H Trivedi
    Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex 75930, USA
    J Clin Psychiatry 65:1356-64. 2004
    ..If the 12.5-mg and 25-mg doses are found to be efficacious, these lower doses may well convey a superior tolerability profile for paroxetine CR in the treatment of MDD...
  5. ncbi request reprint REVAMP - Research Evaluating the Value of Augmenting Medication with Psychotherapy: rationale and design
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Psychopharmacol Bull 41:5-33. 2008
    ....
  6. ncbi request reprint Relationship between obesity and depression: characteristics and treatment outcomes with antidepressant medication
    Marisa S P Toups
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119
    Psychosom Med 75:863-72. 2013
    ..Obesity and major depressive disorder often co-occur. However, differences between obese and normal-weight depressed patients and the moderating effect of obesity on antidepressant treatment outcome are not well studied...
  7. ncbi request reprint Cognitive dysfunction in unipolar depression: implications for treatment
    Madhukar H Trivedi
    Division of Mood Disorders, UT Southwestern Medical Center, Dallas, TX, United States Electronic address
    J Affect Disord 152:19-27. 2014
    ....
  8. doi request reprint Evaluation of the effects of extended release quetiapine fumarate monotherapy on sleep disturbance in patients with major depressive disorder: a pooled analysis of four randomized acute studies
    Madhukar H Trivedi
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Int J Neuropsychopharmacol 16:1733-44. 2013
    ..05). In conclusion, quetiapine XR (50-300 mg/d) monotherapy improved symptoms of sleep disturbance vs. placebo in patients with MDD, including those with either high or low baseline sleep disturbance levels. ..
  9. doi request reprint A randomized controlled trial of the efficacy and safety of lisdexamfetamine dimesylate as augmentation therapy in adults with residual symptoms of major depressive disorder after treatment with escitalopram
    Madhukar H Trivedi
    Department of Psychiatry, Comprehensive Center for Depression, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119
    J Clin Psychiatry 74:802-9. 2013
    ..Evaluate the efficacy and safety of lisdexamfetamine dimesylate augmentation for major depressive disorder (MDD) in escitalopram nonremitters...
  10. doi request reprint Increase in work productivity of depressed individuals with improvement in depressive symptom severity
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Psychiatry 170:633-41. 2013
    ..The authors sought to identify baseline clinical and sociodemographic characteristics associated with work productivity in depressed outpatients and to assess the effect of treatment on work productivity...
  11. ncbi request reprint Clinical and sociodemographic characteristics associated with suicidal ideation in depressed outpatients
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Can J Psychiatry 58:113-22. 2013
    ..To identify clinical and sociodemographic characteristics associated with suicidal ideation (SI) among patients seeking care for depression in routine primary and psychiatric care settings...
  12. pmc Treatment strategies to improve and sustain remission in major depressive disorder
    Madhukar H Trivedi
    Mood Disorders Program, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    Dialogues Clin Neurosci 10:377-84. 2008
    ..Given the huge burden of major depressive illness, the low rate of full recovery remains suboptimal. The following article reports on some current treatment strategies available to improve rates of, and to sustain, remission in MDD...
  13. doi request reprint Remission, response without remission, and nonresponse in major depressive disorder: impact on functioning
    Madhukar H Trivedi
    UT Southwestern Medical Center at Dallas, Texas 75390 9119, USA
    Int Clin Psychopharmacol 24:133-8. 2009
    ..Functioning may be a distinctly different outcome from symptom reduction. Treatments focused on producing high remission rates may improve patient functioning over and above that seen with patients who only achieve response...
  14. ncbi request reprint Adjunctive aripiprazole in major depressive disorder: analysis of efficacy and safety in patients with anxious and atypical features
    Madhukar H Trivedi
    UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 69:1928-36. 2008
    ..To evaluate the efficacy of adjunctive aripiprazole to standard antidepressant therapy (ADT) for patients with DSM-IV major depressive disorder with anxious/atypical features at baseline...
  15. ncbi request reprint Symptom clusters as predictors of late response to antidepressant treatment
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390 9119, USA
    J Clin Psychiatry 66:1064-70. 2005
    ..This article investigates the use of clusters of symptoms on the 17-item Hamilton Rating Scale for Depression (HAM-D-17) to define the pattern of late response versus nonresponse to antidepressant medication...
  16. ncbi request reprint Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ....
  17. pmc Barriers to implementation of a computerized decision support system for depression: an observational report on lessons learned in "real world" clinical settings
    Madhukar H Trivedi
    Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
    BMC Med Inform Decis Mak 9:6. 2009
    ....
  18. ncbi request reprint Medication augmentation after the failure of SSRIs for depression
    Madhukar H Trivedi
    Mood Disorder Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    N Engl J Med 354:1243-52. 2006
    ..Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach...
  19. ncbi request reprint Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D report
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas UT Southwestern Medical Center, Dallas 75390 9119, and the Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:185-95. 2006
    ..The aim of this study was to examine sociodemographic and clinical correlates of HRQOL in a large cohort of outpatients with MDD...
  20. doi request reprint Clinical evidence for serotonin and norepinephrine reuptake inhibition of duloxetine
    Madhukar H Trivedi
    Mood Disorders Program and Clinic, University of Texas Southwestern Medical School, Dallas, TX 75235 9119, USA
    Int Clin Psychopharmacol 23:161-9. 2008
    ..In summary, the data presented in this report provide clinical evidence of a mechanism for duloxetine involving both 5-HT and NE reuptake inhibition in humans and are consistent with preclinical evidence for 5-HT/NE reuptake inhibition...
  21. ncbi request reprint Exercise as an augmentation strategy for treatment of major depression
    Madhukar H Trivedi
    University of Texas Southwestern Medical Center at Dallas, Mood Disorders Research Program and Clinic, 6363 Forest Park, Dallas, TX 75235, USA
    J Psychiatr Pract 12:205-13. 2006
    ..Practical tips on how practitioners can use exercise to enhance antidepressant treatment are discussed. Longer-term use of exercise is also likely to confer additional health benefits for this population...
  22. ncbi request reprint TREAD: TReatment with Exercise Augmentation for Depression: study rationale and design
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Clin Trials 3:291-305. 2006
    ..However, no randomized controlled trials have evaluated exercise as an augmentation strategy for patients with carefully diagnosed MDD who remain symptomatic following an adequate acute phase trial of antidepressant therapy...
  23. ncbi request reprint Clinical evidence and potential neurobiological underpinnings of unresolved symptoms of depression
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
    J Clin Psychiatry 69:246-58. 2008
    ..This article reviews research on the current understanding and management of residual symptoms, i.e., subthreshold depressive symptoms present after recovery from a major depressive episode...
  24. pmc Assessing physicians' use of treatment algorithms: Project IMPACTS study design and rationale
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Contemp Clin Trials 28:192-212. 2007
    ..These new procedures and data points will also allow a more refined assessment of algorithm-driven treatment in the future...
  25. ncbi request reprint Treatment-resistant depression: new therapies on the horizon
    Madhukar H Trivedi
    Depression and Anxiety Disorders Program, The University of Texas, Southwestern Medical School, Dallas, Texas, USA
    Ann Clin Psychiatry 15:59-70. 2003
    ..This kind of therapeutic intervention may prove to be especially useful in treating patients with TRD...
  26. doi request reprint Tools and strategies for ongoing assessment of depression: a measurement-based approach to remission
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 70:26-31. 2009
    ....
  27. doi request reprint Concise Associated Symptoms Tracking scale: a brief self-report and clinician rating of symptoms associated with suicidality
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 72:765-74. 2011
    ....
  28. pmc Determining the primary endpoint for a stimulant abuse trial: lessons learned from STRIDE (CTN 0037)
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 75390 9119, USA
    Am J Drug Alcohol Abuse 37:339-49. 2011
    ..Abstinence is the most desirable treatment outcome although a wide variety of other endpoints have been used...
  29. ncbi request reprint An integrated analysis of olanzapine/fluoxetine combination in clinical trials of treatment-resistant depression
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 70:387-96. 2009
    ..To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant depression sponsored by Eli Lilly and Company...
  30. ncbi request reprint Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?
    M H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Clin Psychiatry 62:776-81. 2001
    ..To examine the effects of bupropion sustained release (SR) and sertraline on anxiety in outpatients with recurrent DSM-IV-defined major depressive disorder...
  31. ncbi request reprint Using treatment algorithms for the effective management of treatment-resistant depression
    M H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9101, USA
    J Clin Psychiatry 62:25-9. 2001
    ..Future directions for algorithm development and implementation are discussed...
  32. pmc Stimulant reduction intervention using dosed exercise (STRIDE) - CTN 0037: study protocol for a randomized controlled trial
    Madhukar H Trivedi
    The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    Trials 12:206. 2011
    ....
  33. ncbi request reprint Algorithm for the treatment of chronic depression
    M H Trivedi
    Depression and Anxiety Disorders Program, The University of Texas, Southwestern Medical Center at Dallas, 75390 9101, USA
    J Clin Psychiatry 62:22-9. 2001
    ..Utilization of a comprehensive treatment algorithm for chronic major depression should encourage efficient, efficacious treatment...
  34. ncbi request reprint Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75235, USA
    Arch Gen Psychiatry 61:669-80. 2004
    ..The Texas Medication Algorithm Project is an evaluation of an algorithm-based disease management program for the treatment of the self-declared persistently and seriously mentally ill in the public mental health sector...
  35. doi request reprint Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    J Clin Psychiatry 72:757-64. 2011
    ..This report evaluates the psychometric properties of a brief self- and clinician-rated measure of factors related to the risk of suicide attempt or completion...
  36. doi request reprint Exercise as an augmentation treatment for nonremitted major depressive disorder: a randomized, parallel dose comparison
    Madhukar H Trivedi
    Division on Mood Disorders, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 72:677-84. 2011
    ..The Treatment with Exercise Augmentation for Depression (TREAD) study was designed to test the efficacy of aerobic exercise as an augmentation treatment for MDD patients who had not remitted with antidepressant treatment...
  37. ncbi request reprint Algorithms in clinical psychiatry: a stepped approach toward the path to recovery
    Madhukar Trivedi
    Depression and Anxiety Disorders Program, University of Texas Southwestern Medical School, Dallas, Texas 75235 9101, USA
    Psychopharmacol Bull 36:142-9. 2002
    ....
  38. ncbi request reprint Development and implementation of computerized clinical guidelines: barriers and solutions
    M H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
    Methods Inf Med 41:435-42. 2002
    ....
  39. ncbi request reprint Using treatment algorithms to bring patients to remission
    Madhukar H Trivedi
    St Paul Hospital, University of Texas Southwest Medical School, Dallas 75235 9101, USA
    J Clin Psychiatry 64:8-13. 2003
    ..It can be easily argued that the use of algorithms with the associated decision support tools increases the role of the clinician in assessment of the clinical status and subsequent treatment choices...
  40. pmc Psychosocial outcomes in patients with recurrent major depressive disorder during 2 years of maintenance treatment with venlafaxine extended release
    Madhukar H Trivedi
    University of Texas Southwestern Medical School, Dallas, Texas 75235, United States
    J Affect Disord 126:420-9. 2010
    ..Psychosocial outcomes from the Prevention of Recurrent Episodes of Depression with Venlafaxine ER for Two Years (PREVENT) study were evaluated...
  41. ncbi request reprint Which depressed patients respond to nefazodone and when?
    M H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA madhukar trivedi utsouthwestern edu
    J Clin Psychiatry 62:158-63. 2001
    ....
  42. ncbi request reprint A comparison of alternative assessments of depressive symptom severity: a pilot study
    M M Biggs
    Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Psychiatry Res 95:55-65. 2000
    ..While the clinician-rated itemized symptom severity rating scale remains the standard to assess the symptomatic outcome of the treatment of MDD, a self-report of identical symptomatology may be a reasonable alternative for many patients...
  43. doi request reprint Anticipated Benefits of Care (ABC): psychometrics and predictive value in psychiatric disorders
    D Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    Psychol Med 40:955-65. 2010
    ..No measure of patients' anticipated benefits of treatment on domains of everyday functioning has previously been available...
  44. pmc Major depression symptoms in primary care and psychiatric care settings: a cross-sectional analysis
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Ann Fam Med 5:126-34. 2007
    ....
  45. ncbi request reprint Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 OHara St, Pittsburgh, PA 15213 2593, and Massachusetts General Hospital, USA
    Am J Psychiatry 164:739-52. 2007
    ..Cognitive therapy was compared with medication augmentation and switch strategies...
  46. ncbi request reprint Indicators of pretreatment suicidal ideation in adults with major depressive disorder
    D W Morris
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    Acta Psychiatr Scand 121:480-4. 2010
    ..The purpose of this report is to identify sociodemographic and clinical features that are associated with SI in major depressive disorder (MDD) patients prior to treatment with a selective serotonin reuptake inhibitor...
  47. ncbi request reprint Response in relation to baseline anxiety levels in major depressive disorder treated with bupropion sustained release or sertraline
    A J Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9086, USA
    Neuropsychopharmacology 25:131-8. 2001
    ..Thus, the clinical decision to select between these two agents when treating depressed outpatients cannot rest on either levels of pretreatment anxiety or on anticipation of more rapid or more complete anxiolysis...
  48. ncbi request reprint Acceptability of second-step treatments to depressed outpatients: a STAR*D report
    Stephen R Wisniewski
    Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 164:753-60. 2007
    ..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches...
  49. ncbi request reprint Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D
    William R Yates
    Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
    Gen Hosp Psychiatry 26:421-9. 2004
    ..A significant percentage of patients with major depressive disorder (MDD) suffer from concurrent general medical conditions (GMCs)...
  50. ncbi request reprint A comparison of alternative assessments of depressive symptom severity: a pilot study
    M M Biggs
    Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Psychiatry Res 96:269-79. 2000
    ..While the clinician-rated itemized symptom severity rating scale remains the standard to assess the symptomatic outcome of the treatment of MDD, a self-report of identical symptomatology may be a reasonable alternative for many patients...
  51. pmc Dyadic discord at baseline is associated with lack of remission in the acute treatment of chronic depression
    W H Denton
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, TX 75390 9121, USA
    Psychol Med 40:415-24. 2010
    ..This study investigated pretreatment dyadic discord as a predictor of non-remission and its relationship to depressive symptom change during acute treatment for chronic depression...
  52. doi request reprint Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report
    A A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 40:41-50. 2010
    ..We describe the types and frequency of residual depressive symptoms and their relationship to subsequent depressive relapse after treatment with citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  53. doi request reprint Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 165:342-51. 2008
    ..The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and 2 of the STAR*D study...
  54. ncbi request reprint Implementation of the Texas Medication Algorithm Project patient and family education program
    Marcia G Toprac
    TX, USA
    J Clin Psychiatry 67:1362-72. 2006
    ..The extent of participation, types of psychoeducation received, and predictors of receiving at least a minimum level of education are presented...
  55. ncbi request reprint Efficacy and safety of mirtazapine in major depressive disorder patients after SSRI treatment failure: an open-label trial
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 62:413-20. 2001
    ..To evaluate the efficacy and safety of mirtazapine in depressed outpatients who have shown nonresponse or intolerance to selective serotonin reuptake inhibitor (SSRI) therapy...
  56. ncbi request reprint Family history of completed suicide and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 01224, USA
    J Affect Disord 108:129-34. 2008
    ..It is unknown, however, whether patients with a family member who committed suicide differ from those without such a history...
  57. ncbi request reprint Insured and non-insured depressed outpatients: how do they compare?
    Ira M Lesser
    Department of Psychiatry, Harbor UCLA Medical Center, The Los Angeles Biomedical Research Institute, Los Angeles, CA, USA
    Ann Clin Psychiatry 19:73-82. 2007
    ....
  58. doi request reprint Factors predicting reduced antidepressant response: experience with the SNRI duloxetine in patients with major depression
    Robert H Howland
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Ann Clin Psychiatry 20:209-18. 2008
    ..To identify putative demographic and clinical variables that correlate with antidepressant response to the SNRI duloxetine in major depression...
  59. doi request reprint Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trial
    Edward S Friedman
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:612-21. 2009
    ..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention...
  60. ncbi request reprint A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Bulfinch 351, 55 Fruit St, Boston, MA 02114, USA
    Am J Psychiatry 163:1161-72. 2006
    ....
  61. ncbi request reprint Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 34:1299-308. 2004
    ..Anxious depression, defined as Major Depressive Disorder (MDD) with high levels of anxiety symptoms, may represent a relatively common depressive subtype, with distinctive features...
  62. ncbi request reprint Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study
    Roy H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 66:159-66; quiz 147, 273-4. 2005
    ..Irritability with or without depression has been associated with risk for suicide, violence, and cardiovascular disease...
  63. pmc Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder
    C D Rethorst
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Psychiatry 18:1119-24. 2013
    ..Our results also confirm findings from studies of antidepressant medications that tie decreasing IL-1β to positive depression treatment outcomes. ..
  64. doi request reprint Does exercise improve self-reported sleep quality in non-remitted major depressive disorder?
    C D Rethorst
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    Psychol Med 43:699-709. 2013
    ..The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality...
  65. doi request reprint Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: an examination of citalopram in the STAR*D study
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, California, USA
    J Affect Disord 117:63-73. 2009
    ..The purpose of this study was to determine whether, and in whom, treatment of MDD is associated with increased or emergent SI...
  66. ncbi request reprint Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression
    Alan J Gelenberg
    Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724 5002, USA
    Biol Psychiatry 54:806-17. 2003
    ..This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence was conducted for patients with chronic MDD...
  67. ncbi request reprint Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    Philip T Ninan
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Clin Psychiatry 63:434-41. 2002
    ....
  68. pmc Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder
    R H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Acta Psychiatr Scand 119:282-9. 2009
    ..We examined clinical correlates of irritability in a confirmatory cohort of Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study participants with major depressive disorder (MDD)...
  69. ncbi request reprint Clinical significance of monitoring early symptom change to predict outcome
    M H Trivedi
    Depression and Anxiety Disorders Program, The University of Texas, Southwestern Medical Center at Dallas, 75235-9101, USA
    J Clin Psychiatry 62:27-33; discussion 37-40. 2001
    ....
  70. ncbi request reprint Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report
    Patrick J McGrath
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 69:1847-55. 2008
    ....
  71. pmc Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Affect Disord 110:55-61. 2008
    ..These results and the consistency of similar results over time point to the dire need for patient and provider education regarding the signs and symptoms of depression and its treatment...
  72. ncbi request reprint Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  73. ncbi request reprint Use of treatment algorithms for depression
    Madhukar H Trivedi
    Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Psychiatry 67:1458-65. 2006
  74. ncbi request reprint Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychiatr Clin North Am 26:457-94, x. 2003
    ..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study...
  75. ncbi request reprint Effect of age at onset on the course of major depressive disorder
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Am J Psychiatry 164:1539-46. 2007
    ..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study...
  76. doi request reprint What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Psychiatr Serv 60:1439-45. 2009
    ..STAR*D demonstrated that inclusion of more real-world patients in clinical trials is both feasible and informative. Policy implications of the findings, as well as the study's limitations, are discussed...
  77. pmc Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression study
    Sheila M Marcus
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Compr Psychiatry 49:238-46. 2008
    ..This article examines sex differences in terms of illness attributes in a cohort of 2541 outpatients from across the United States who enrolled in the Sequenced Treatment Alternatives to Relieve Depression study...
  78. ncbi request reprint The Texas Children's Medication Algorithm Project: report of the Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive Disorder
    C W Hughes
    University of Texas Southwestern Medical Center, Dallas, USA
    J Am Acad Child Adolesc Psychiatry 38:1442-54. 1999
    ..A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD...
  79. ncbi request reprint Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study
    Andrew A Nierenberg
    Depression Clinical and Research Program, ACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 01224, USA
    J Psychiatr Res 41:214-21. 2007
    ....
  80. ncbi request reprint Factors associated with concomitant psychotropic drug use in the treatment of major depression: a STAR*D Report
    Rchard C Shelton
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    CNS Spectr 14:487-98. 2009
    ..Concomitant psychotropic medication (CPM) treatment is common in persons with major depression (MDD). However, relationships with patient characteristics and response to treatment are unclear...
  81. pmc Remission of maternal depression: relations to family functioning and youth internalizing and externalizing symptoms
    Cynthia Ewell Foster
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
    J Clin Child Adolesc Psychol 37:714-24. 2008
    ..9% of the variance...
  82. doi request reprint Concurrent anxiety and substance use disorders among outpatients with major depression: clinical features and effect on treatment outcome
    Robert H Howland
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, United States
    Drug Alcohol Depend 99:248-60. 2009
    ....
  83. ncbi request reprint Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  84. pmc Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*D
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    J Gen Intern Med 23:551-60. 2008
    ..Whether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown...
  85. ncbi request reprint Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination
    John Zajecka
    Department of Psychiatry, Rush Presbyterian St Luke s Medical Center, 1725 W Harrison Street, Suite 955, Chicago, IL 60612, USA
    J Clin Psychiatry 63:709-16. 2002
    ..This study compares the effects of antidepressant medication, psychotherapy, and combined treatment on sexual interest/satisfaction and function in patients with chronic major depression...
  86. ncbi request reprint Effects of fluoxetine on the polysomnogram in outpatients with major depression
    M H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Neuropsychopharmacology 20:447-59. 1999
    ..Conversely, subjective measures of sleep indicated a steady improvement during acute phase treatment. After fluoxetine was discontinued, total REM sleep and sleep efficiency were found to be increased as compared to baseline...
  87. ncbi request reprint Diagnostic utility of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) in the elderly
    P Murali Doraiswamy
    Department of Psychiatry, and the Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA
    Acta Psychiatr Scand 122:226-34. 2010
    ..the Quick Inventory of Depressive Symptomatology-Clinician-rated (QIDS-C(16)) and Self-report (QIDS-SR(16)) scales to detect a current major depressive episode in the elderly...
  88. ncbi request reprint A SPECT HMPAO study of regional cerebral blood flow in depressed adolescents and normal controls
    R A Kowatch
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:643-56. 1999
    ..Further controlled studies with larger numbers of MDD subjects and normal age- and gender-matched controls are necessary before any definitive conclusions can be made from these findings...
  89. ncbi request reprint A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report
    Andrew A Nierenberg
    Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
    Am J Psychiatry 163:1519-30; quiz 1665. 2006
    ..This study compared the effectiveness of lithium versus triiodothyronine (T(3)) augmentation as a third-step treatment for patients with major depressive disorder...
  90. ncbi request reprint Consensus recommendations for improving adherence, self-management, and outcomes in patients with depression
    Madhukar H Trivedi
    Mood Disorders Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    CNS Spectr 12:1-27. 2007
    ....
  91. ncbi request reprint Health-related quality of life in depression: a STAR*D report
    Ella J Daly
    Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Ann Clin Psychiatry 22:43-55. 2010
    ..This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  92. pmc Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  93. ncbi request reprint Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study
    Roy H Perlis
    Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 64:689-97. 2007
    ....
  94. ncbi request reprint Remission of depression and the Texas Medication Algorithm Project
    Madhukar H Trivedi
    Depression and Anxiety Disorders Program, University of Texas, Southwestern Medical Center, Dallas, USA
    Manag Care Interface . 2003
  95. ncbi request reprint Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of anxiety symptoms in major depressive disorder: a meta-analysis of individual patient data from 10 double-blind, randomized clinical trials
    George I Papakostas
    Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 42:134-40. 2008
    ..09, p=0.569), or HAM-A scores at endpoint (3.30+/-2.89 vs. 3.31+/-2.89, p=0.552). Contrary to clinician impression, there does not appear to be any difference in the anxiolytic efficacy of bupropion and the SSRIs when used to treat MDD...
  96. ncbi request reprint Physical activity dose-response effects on outcomes of depression and anxiety
    A L Dunn
    The Cooper Institute, Dallas, TX 75230, USA
    Med Sci Sports Exerc 33:S587-97; discussion 609-10. 2001
    ..The purpose of this study was to examine the scientific evidence for a dose-response relation of physical activity with depressive and anxiety disorders...
  97. ncbi request reprint The DOSE study: a clinical trial to examine efficacy and dose response of exercise as treatment for depression
    Andrea L Dunn
    Division of Research, The Cooper Institute, Dallas, TX 75230, USA
    Control Clin Trials 23:584-603. 2002
    ..This study is the first to examine dose-response effects of exercise in participants diagnosed with MDD...
  98. ncbi request reprint Continuation treatment of chronic depression: a comparison of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    Psychopharmacol Bull 37:73-87. 2003
    ..COMB was associated with less symptom re-emergence during the continuation phase than either monotherapy, particularly for partial remitters...
  99. pmc Strategies to enhance the therapeutic efficacy of antidepressants: targeting residual symptoms
    Benji T Kurian
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9119, USA
    Expert Rev Neurother 9:975-84. 2009
    ..This article reviews the prevalence and clinical impact of common residual symptoms and discusses the utility of aggressively addressing residual symptoms to enhance the efficacy of antidepressant medications...
  100. doi request reprint A psychometric evaluation of the clinician-rated Quick Inventory of Depressive Symptomatology (QIDS-C16) in patients with bipolar disorder
    Ira H Bernstein
    The University of Texas, Arlington, TX, USA
    Int J Methods Psychiatr Res 18:138-46. 2009
    ..The QIDS-C16 is suitable for use with patients with BD and can be used as an outcome measure in trials enrolling both BD and MDD patients...

Research Grants12

  1. Using Information Technology to Provide Measurement Based Care for Chronic Illnes
    Madhukar Trivedi; Fiscal Year: 2007
    ....
  2. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2003
    ....
  3. REVAMP Follow-Up
    Madhukar Trivedi; Fiscal Year: 2007
    ....
  4. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2007
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. ..
  5. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2006
    ....
  6. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2006
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. ..
  7. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2005
    ....
  8. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2005
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. ..
  9. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2004
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. ..
  10. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2004
    ....
  11. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2003
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. ..