Research Topics
| M H TrivediSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
A computerized clinical decision support system as a means of implementing depression guidelinesMadhukar H Trivedi
Department of Psychiatry of the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9119, USA
Psychiatr Serv 55:879-85. 2004..CompTMAP is part of a new era of comprehensive computerized decision support systems that take advantage of advances in automation and provide more complete clinical support to physicians in clinical practice...- Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based careMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Neuropsychopharmacology 32:2479-89. 2007..This approach signals a paradigm shift toward the use of measurement-based clinical decisions, both at the point of care and following each visit, to deliver optimal pharmacotherapy for depression... - Clinical and sociodemographic characteristics associated with suicidal ideation in depressed outpatientsMadhukar H Trivedi
Professor of Psychiatry, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
Can J Psychiatry 58:113-22. 2013..Clinical Trial Registration Number: Sequenced Treatment Alternatives to Relieve Depression, NCT00021528... - REVAMP - Research Evaluating the Value of Augmenting Medication with Psychotherapy: rationale and designMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Psychopharmacol Bull 41:5-33. 2008.... 
Clinical evidence for serotonin and norepinephrine reuptake inhibition of duloxetineMadhukar H Trivedi
Mood Disorders Program and Clinic, University of Texas Southwestern Medical School, Dallas, TX 75235 9119, USA
Int Clin Psychopharmacol 23:161-9. 2008..In summary, the data presented in this report provide clinical evidence of a mechanism for duloxetine involving both 5-HT and NE reuptake inhibition in humans and are consistent with preclinical evidence for 5-HT/NE reuptake inhibition...- Tools and strategies for ongoing assessment of depression: a measurement-based approach to remissionMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
J Clin Psychiatry 70:26-31. 2009.... - Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practiceMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
Am J Psychiatry 163:28-40. 2006.... - Symptom clusters as predictors of late response to antidepressant treatmentMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390 9119, USA
J Clin Psychiatry 66:1064-70. 2005..This article investigates the use of clusters of symptoms on the 17-item Hamilton Rating Scale for Depression (HAM-D-17) to define the pattern of late response versus nonresponse to antidepressant medication... - Effectiveness of low doses of paroxetine controlled release in the treatment of major depressive disorderMadhukar H Trivedi
Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Tex 75930, USA
J Clin Psychiatry 65:1356-64. 2004..If the 12.5-mg and 25-mg doses are found to be efficacious, these lower doses may well convey a superior tolerability profile for paroxetine CR in the treatment of MDD... - Cost and effectiveness of venlafaxine extended-release and selective serotonin reuptake inhibitors in the acute phase of outpatient treatment for major depressive disorderMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
J Clin Psychopharmacol 24:497-506. 2004..The purpose of this retrospective analysis was to estimate the cost and effectiveness of venlafaxine extended-release (VXR) compared with selective serotonin reuptake inhibitors in the outpatient treatment of major depressive disorder... - Clinical results for patients with major depressive disorder in the Texas Medication Algorithm ProjectMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75235, USA
Arch Gen Psychiatry 61:669-80. 2004..The Texas Medication Algorithm Project is an evaluation of an algorithm-based disease management program for the treatment of the self-declared persistently and seriously mentally ill in the public mental health sector... - Psychosocial outcomes in patients with recurrent major depressive disorder during 2 years of maintenance treatment with venlafaxine extended releaseMadhukar H Trivedi
University of Texas Southwestern Medical School, Dallas, Texas 75235, United States
J Affect Disord 126:420-9. 2010..Psychosocial outcomes from the Prevention of Recurrent Episodes of Depression with Venlafaxine ER for Two Years (PREVENT) study were evaluated... - Treatment-resistant depression: new therapies on the horizonMadhukar H Trivedi
Depression and Anxiety Disorders Program, The University of Texas, Southwestern Medical School, Dallas, Texas, USA
Ann Clin Psychiatry 15:59-70. 2003..This kind of therapeutic intervention may prove to be especially useful in treating patients with TRD... - Medication augmentation after the failure of SSRIs for depressionMadhukar H Trivedi
Mood Disorder Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
N Engl J Med 354:1243-52. 2006..Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach... - Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D reportMadhukar H Trivedi
Department of Psychiatry, University of Texas UT Southwestern Medical Center, Dallas 75390 9119, and the Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 67:185-95. 2006..The aim of this study was to examine sociodemographic and clinical correlates of HRQOL in a large cohort of outpatients with MDD... - Clinical evidence and potential neurobiological underpinnings of unresolved symptoms of depressionMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX 75235, USA
J Clin Psychiatry 69:246-58. 2008..This article reviews research on the current understanding and management of residual symptoms, i.e., subthreshold depressive symptoms present after recovery from a major depressive episode... 
Barriers to implementation of a computerized decision support system for depression: an observational report on lessons learned in "real world" clinical settingsMadhukar H Trivedi
Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
BMC Med Inform Decis Mak 9:6. 2009....- Remission, response without remission, and nonresponse in major depressive disorder: impact on functioningMadhukar H Trivedi
UT Southwestern Medical Center at Dallas, Texas 75390 9119, USA
Int Clin Psychopharmacol 24:133-8. 2009..Functioning may be a distinctly different outcome from symptom reduction. Treatments focused on producing high remission rates may improve patient functioning over and above that seen with patients who only achieve response... - Adjunctive aripiprazole in major depressive disorder: analysis of efficacy and safety in patients with anxious and atypical featuresMadhukar H Trivedi
UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
J Clin Psychiatry 69:1928-36. 2008..To evaluate the efficacy of adjunctive aripiprazole to standard antidepressant therapy (ADT) for patients with DSM-IV major depressive disorder with anxious/atypical features at baseline... - An integrated analysis of olanzapine/fluoxetine combination in clinical trials of treatment-resistant depressionMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
J Clin Psychiatry 70:387-96. 2009..To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant depression sponsored by Eli Lilly and Company... - Assessing physicians' use of treatment algorithms: Project IMPACTS study design and rationaleMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
Contemp Clin Trials 28:192-212. 2007..These new procedures and data points will also allow a more refined assessment of algorithm-driven treatment in the future... - TREAD: TReatment with Exercise Augmentation for Depression: study rationale and designMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Clin Trials 3:291-305. 2006..However, no randomized controlled trials have evaluated exercise as an augmentation strategy for patients with carefully diagnosed MDD who remain symptomatic following an adequate acute phase trial of antidepressant therapy... - Exercise as an augmentation strategy for treatment of major depressionMadhukar H Trivedi
University of Texas Southwestern Medical Center at Dallas, Mood Disorders Research Program and Clinic, 6363 Forest Park, Dallas, TX 75235, USA
J Psychiatr Pract 12:205-13. 2006..Practical tips on how practitioners can use exercise to enhance antidepressant treatment are discussed. Longer-term use of exercise is also likely to confer additional health benefits for this population... - Exercise as an augmentation treatment for nonremitted major depressive disorder: a randomized, parallel dose comparisonMadhukar H Trivedi
Division on Mood Disorders, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
J Clin Psychiatry 72:677-84. 2011..The Treatment with Exercise Augmentation for Depression (TREAD) study was designed to test the efficacy of aerobic exercise as an augmentation treatment for MDD patients who had not remitted with antidepressant treatment... - Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal riskMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
J Clin Psychiatry 72:757-64. 2011..This report evaluates the psychometric properties of a brief self- and clinician-rated measure of factors related to the risk of suicide attempt or completion... - Stimulant reduction intervention using dosed exercise (STRIDE) - CTN 0037: study protocol for a randomized controlled trialMadhukar H Trivedi
The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
Trials 12:206. 2011..CLINICAL TRIALS REGISTRY: ClinicalTrials.gov, NCT01141608 http://clinicaltrials.gov/ct2/show/NCT01141608?term=Stimulant+Reduction+Intervention+using+Dosed+Exercise&rank=1... - Using treatment algorithms for the effective management of treatment-resistant depressionM H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9101, USA
J Clin Psychiatry 62:25-9. 2001..Future directions for algorithm development and implementation are discussed... - Treatment strategies to improve and sustain remission in major depressive disorderMadhukar H Trivedi
Mood Disorders Program, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
Dialogues Clin Neurosci 10:377-84. 2008..Given the huge burden of major depressive illness, the low rate of full recovery remains suboptimal. The following article reports on some current treatment strategies available to improve rates of, and to sustain, remission in MDD... - Concise Associated Symptoms Tracking scale: a brief self-report and clinician rating of symptoms associated with suicidalityMadhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
J Clin Psychiatry 72:765-74. 2011.... - Determining the primary endpoint for a stimulant abuse trial: lessons learned from STRIDE (CTN 0037)Madhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 75390 9119, USA
Am J Drug Alcohol Abuse 37:339-49. 2011..Abstinence is the most desirable treatment outcome although a wide variety of other endpoints have been used... - Algorithm for the treatment of chronic depressionM H Trivedi
Depression and Anxiety Disorders Program, The University of Texas, Southwestern Medical Center at Dallas, 75390 9101, USA
J Clin Psychiatry 62:22-9. 2001..Utilization of a comprehensive treatment algorithm for chronic major depression should encourage efficient, efficacious treatment... - Algorithms in clinical psychiatry: a stepped approach toward the path to recoveryMadhukar Trivedi
Depression and Anxiety Disorders Program, University of Texas Southwestern Medical School, Dallas, Texas 75235 9101, USA
Psychopharmacol Bull 36:142-9. 2002.... - Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?M H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390, USA
J Clin Psychiatry 62:776-81. 2001..To examine the effects of bupropion sustained release (SR) and sertraline on anxiety in outpatients with recurrent DSM-IV-defined major depressive disorder... - Using treatment algorithms to bring patients to remissionMadhukar H Trivedi
St Paul Hospital, University of Texas Southwest Medical School, Dallas 75235 9101, USA
J Clin Psychiatry 64:8-13. 2003..It can be easily argued that the use of algorithms with the associated decision support tools increases the role of the clinician in assessment of the clinical status and subsequent treatment choices... - Development and implementation of computerized clinical guidelines: barriers and solutionsM H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
Methods Inf Med 41:435-42. 2002.... - Which depressed patients respond to nefazodone and when?M H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA madhukar trivedi utsouthwestern edu
J Clin Psychiatry 62:158-63. 2001.... - Anticipated Benefits of Care (ABC): psychometrics and predictive value in psychiatric disordersD Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
Psychol Med 40:955-65. 2010..No measure of patients' anticipated benefits of treatment on domains of everyday functioning has previously been available... - A comparison of alternative assessments of depressive symptom severity: a pilot studyM M Biggs
Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9086, USA
Psychiatry Res 95:55-65. 2000..While the clinician-rated itemized symptom severity rating scale remains the standard to assess the symptomatic outcome of the treatment of MDD, a self-report of identical symptomatology may be a reasonable alternative for many patients... - Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D reportMichael E Thase
Department of Psychiatry, University of Pittsburgh Medical Center, 3811 OHara St, Pittsburgh, PA 15213 2593, and Massachusetts General Hospital, USA
Am J Psychiatry 164:739-52. 2007..Cognitive therapy was compared with medication augmentation and switch strategies... - Major depression symptoms in primary care and psychiatric care settings: a cross-sectional analysisBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Ann Fam Med 5:126-34. 2007.... - Response in relation to baseline anxiety levels in major depressive disorder treated with bupropion sustained release or sertralineA J Rush
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9086, USA
Neuropsychopharmacology 25:131-8. 2001..Thus, the clinical decision to select between these two agents when treating depressed outpatients cannot rest on either levels of pretreatment anxiety or on anticipation of more rapid or more complete anxiolysis... - Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*DWilliam R Yates
Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
Gen Hosp Psychiatry 26:421-9. 2004..A significant percentage of patients with major depressive disorder (MDD) suffer from concurrent general medical conditions (GMCs)... - Acceptability of second-step treatments to depressed outpatients: a STAR*D reportStephen R Wisniewski
Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Am J Psychiatry 164:753-60. 2007..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches... - Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D reportA A Nierenberg
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 40:41-50. 2010..We describe the types and frequency of residual depressive symptoms and their relationship to subsequent depressive relapse after treatment with citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial... - A comparison of alternative assessments of depressive symptom severity: a pilot studyM M Biggs
Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
Psychiatry Res 96:269-79. 2000..While the clinician-rated itemized symptom severity rating scale remains the standard to assess the symptomatic outcome of the treatment of MDD, a self-report of identical symptomatology may be a reasonable alternative for many patients... - Dyadic discord at baseline is associated with lack of remission in the acute treatment of chronic depressionW H Denton
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, TX 75390 9121, USA
Psychol Med 40:415-24. 2010..This study investigated pretreatment dyadic discord as a predictor of non-remission and its relationship to depressive symptom change during acute treatment for chronic depression... - Indicators of pretreatment suicidal ideation in adults with major depressive disorderD W Morris
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
Acta Psychiatr Scand 121:480-4. 2010..The purpose of this report is to identify sociodemographic and clinical features that are associated with SI in major depressive disorder (MDD) patients prior to treatment with a selective serotonin reuptake inhibitor... - Implementation of the Texas Medication Algorithm Project patient and family education programMarcia G Toprac
TX, USA
J Clin Psychiatry 67:1362-72. 2006..The extent of participation, types of psychoeducation received, and predictors of receiving at least a minimum level of education are presented... - Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D reportMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 165:342-51. 2008..The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and 2 of the STAR*D study... - Efficacy and safety of mirtazapine in major depressive disorder patients after SSRI treatment failure: an open-label trialM Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 62:413-20. 2001..To evaluate the efficacy and safety of mirtazapine in depressed outpatients who have shown nonresponse or intolerance to selective serotonin reuptake inhibitor (SSRI) therapy... - Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trialEdward S Friedman
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 26:612-21. 2009..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention... - Family history of completed suicide and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) studyAndrew A Nierenberg
Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 01224, USA
J Affect Disord 108:129-34. 2008..It is unknown, however, whether patients with a family member who committed suicide differ from those without such a history... - Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression studyRoy H Perlis
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 66:159-66; quiz 147, 273-4. 2005..Irritability with or without depression has been associated with risk for suicide, violence, and cardiovascular disease... - Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*DMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 34:1299-308. 2004..Anxious depression, defined as Major Depressive Disorder (MDD) with high levels of anxiety symptoms, may represent a relatively common depressive subtype, with distinctive features... - Factors predicting reduced antidepressant response: experience with the SNRI duloxetine in patients with major depressionRobert H Howland
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Ann Clin Psychiatry 20:209-18. 2008..To identify putative demographic and clinical variables that correlate with antidepressant response to the SNRI duloxetine in major depression... - Insured and non-insured depressed outpatients: how do they compare?Ira M Lesser
Department of Psychiatry, Harbor UCLA Medical Center, The Los Angeles Biomedical Research Institute, Los Angeles, CA, USA
Ann Clin Psychiatry 19:73-82. 2007.... - A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D reportMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Bulfinch 351, 55 Fruit St, Boston, MA 02114, USA
Am J Psychiatry 163:1161-72. 2006.... - Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depressionAlan J Gelenberg
Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724-5002, USA
Biol Psychiatry 54:806-17. 2003..8%). Somnolence was significantly greater among the patients taking active medication (15.4%), compared with placebo (4.6%). CONCLUSIONS: Nefazodone is well-tolerated and is an effective maintenance therapy for chronic forms of MDD... - Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combinationPhilip T Ninan
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
J Clin Psychiatry 63:434-41. 2002..Among patients with a concurrent anxiety disorder, nefazodone. either alone or in combination with CBASP, improves anxiety symptoms faster than CBASP alone, independent of depressive symptom reduction... - Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: an examination of citalopram in the STAR*D studySidney Zisook
Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, California, USA
J Affect Disord 117:63-73. 2009..The purpose of this study was to determine whether, and in whom, treatment of MDD is associated with increased or emergent SI... - Clinical significance of monitoring early symptom change to predict outcomeM H Trivedi
Depression and Anxiety Disorders Program, The University of Texas, Southwestern Medical Center at Dallas, 75235-9101, USA
J Clin Psychiatry 62:27-33; discussion 37-40. 2001.... - Effect of age at onset on the course of major depressive disorderSidney Zisook
Department of Psychiatry, University of California, San Diego, CA 92093, USA
Am J Psychiatry 164:1539-46. 2007..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study... - Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatmentJames H Kocsis
Department of Psychiatry, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
J Affect Disord 110:55-61. 2008..These results and the consistency of similar results over time point to the dire need for patient and provider education regarding the signs and symptoms of depression and its treatment... - Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression studySheila M Marcus
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
Compr Psychiatry 49:238-46. 2008..This article examines sex differences in terms of illness attributes in a cohort of 2541 outpatients from across the United States who enrolled in the Sequenced Treatment Alternatives to Relieve Depression study... - Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D reportPatrick J McGrath
Department of Psychiatry, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
J Clin Psychiatry 69:1847-55. 2008.... - Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) studyMaurizio Fava
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Psychiatr Clin North Am 26:457-94, x. 2003..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study... - Use of treatment algorithms for depressionMadhukar H Trivedi
Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
J Clin Psychiatry 67:1458-65. 2006 - What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depressionBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Psychiatr Serv 60:1439-45. 2009..STAR*D demonstrated that inclusion of more real-world patients in clinical trials is both feasible and informative. Policy implications of the findings, as well as the study's limitations, are discussed... - Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depressionMichael E Thase
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
J Clin Psychiatry 63:493-500. 2002..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances... - Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorderR H Perlis
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Acta Psychiatr Scand 119:282-9. 2009..We examined clinical correlates of irritability in a confirmatory cohort of Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study participants with major depressive disorder (MDD)... - The Texas Children's Medication Algorithm Project: report of the Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive DisorderC W Hughes
University of Texas Southwestern Medical Center, Dallas, USA
J Am Acad Child Adolesc Psychiatry 38:1442-54. 1999..A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD... - Concurrent anxiety and substance use disorders among outpatients with major depression: clinical features and effect on treatment outcomeRobert H Howland
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, United States
Drug Alcohol Depend 99:248-60. 2009.... - Remission of maternal depression: relations to family functioning and youth internalizing and externalizing symptomsCynthia Ewell Foster
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
J Clin Child Adolesc Psychol 37:714-24. 2008..9% of the variance... - Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combinationJohn Zajecka
Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, 1725 W. Harrison Street, Suite 955, Chicago, IL 60612, USA
J Clin Psychiatry 63:709-16. 2002..Treatment with nefazodone, CBASP, and combined treatment improved sexual interest/satisfaction, with greatest improvement observed with combined treatment... - Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) studyAndrew A Nierenberg
Depression Clinical and Research Program, ACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 01224, USA
J Psychiatr Res 41:214-21. 2007.... - Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*DBradley N Gaynes
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
J Gen Intern Med 23:551-60. 2008..Whether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown... - Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT StudyJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
J Clin Psychiatry 68:1014-23. 2007..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression... - Factors associated with concomitant psychotropic drug use in the treatment of major depression: a STAR*D ReportRchard C Shelton
Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
CNS Spectr 14:487-98. 2009..Concomitant psychotropic medication (CPM) treatment is common in persons with major depression (MDD). However, relationships with patient characteristics and response to treatment are unclear... - A SPECT HMPAO study of regional cerebral blood flow in depressed adolescents and normal controlsR A Kowatch
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
Prog Neuropsychopharmacol Biol Psychiatry 23:643-56. 1999..Further controlled studies with larger numbers of MDD subjects and normal age- and gender-matched controls are necessary before any definitive conclusions can be made from these findings... - Diagnostic utility of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) in the elderlyP Murali Doraiswamy
Department of Psychiatry, and the Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA
Acta Psychiatr Scand 122:226-34. 2010..the Quick Inventory of Depressive Symptomatology-Clinician-rated (QIDS-C(16)) and Self-report (QIDS-SR(16)) scales to detect a current major depressive episode in the elderly... - Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of anxiety symptoms in major depressive disorder: a meta-analysis of individual patient data from 10 double-blind, randomized clinical trialsGeorge I Papakostas
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Psychiatr Res 42:134-40. 2008..09, p=0.569), or HAM-A scores at endpoint (3.30+/-2.89 vs. 3.31+/-2.89, p=0.552). Contrary to clinician impression, there does not appear to be any difference in the anxiolytic efficacy of bupropion and the SSRIs when used to treat MDD... - Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D studyRoy H Perlis
Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 64:689-97. 2007.... - Consensus recommendations for improving adherence, self-management, and outcomes in patients with depressionMadhukar H Trivedi
Mood Disorders Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
CNS Spectr 12:1-27. 2007.... - Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP TrialJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
Arch Gen Psychiatry 66:1178-88. 2009..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone... - Health-related quality of life in depression: a STAR*D reportElla J Daly
Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
Ann Clin Psychiatry 22:43-55. 2010..This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial... - Remission of depression and the Texas Medication Algorithm ProjectMadhukar H Trivedi
Depression and Anxiety Disorders Program, University of Texas, Southwestern Medical Center, Dallas, USA
Manag Care Interface . 2003 - A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D reportAndrew A Nierenberg
Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
Am J Psychiatry 163:1519-30; quiz 1665. 2006..This study compared the effectiveness of lithium versus triiodothyronine (T(3)) augmentation as a third-step treatment for patients with major depressive disorder... - Effects of fluoxetine on the polysomnogram in outpatients with major depressionM H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235, USA
Neuropsychopharmacology 20:447-59. 1999..Conversely, subjective measures of sleep indicated a steady improvement during acute phase treatment. After fluoxetine was discontinued, total REM sleep and sleep efficiency were found to be increased as compared to baseline... - Physical activity dose-response effects on outcomes of depression and anxietyA L Dunn
The Cooper Institute, Dallas, TX 75230, USA
Med Sci Sports Exerc 33:S587-97; discussion 609-10. 2001..The purpose of this study was to examine the scientific evidence for a dose-response relation of physical activity with depressive and anxiety disorders... - A psychometric evaluation of the clinician-rated Quick Inventory of Depressive Symptomatology (QIDS-C16) in patients with bipolar disorderIra H Bernstein
The University of Texas, Arlington, TX, USA
Int J Methods Psychiatr Res 18:138-46. 2009..The QIDS-C16 is suitable for use with patients with BD and can be used as an outcome measure in trials enrolling both BD and MDD patients... - A psychometric evaluation of the CDRS and MADRS in assessing depressive symptoms in childrenShailesh Jain
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Am Acad Child Adolesc Psychiatry 46:1204-12. 2007..This study compared the psychometric properties of the Children's Depression Rating Scale-Revised (CDRS-R) and the Montgomery-Asberg Depression Rating Scale (MADRS) in children with major depressive disorder... - The DOSE study: a clinical trial to examine efficacy and dose response of exercise as treatment for depressionAndrea L Dunn
Division of Research, The Cooper Institute, Dallas, TX 75230, USA
Control Clin Trials 23:584-603. 2002..This study is the first to examine dose-response effects of exercise in participants diagnosed with MDD... - Strategies to enhance the therapeutic efficacy of antidepressants: targeting residual symptomsBenji T Kurian
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9119, USA
Expert Rev Neurother 9:975-84. 2009..This article reviews the prevalence and clinical impact of common residual symptoms and discusses the utility of aggressively addressing residual symptoms to enhance the efficacy of antidepressant medications... - Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study dataDavid W Morris
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
J Clin Psychiatry 68:1339-47. 2007.... - Continuation treatment of chronic depression: a comparison of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combinationJames H Kocsis
Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
Psychopharmacol Bull 37:73-87. 2003..COMB was associated with less symptom re-emergence during the continuation phase than either monotherapy, particularly for partial remitters... - Defining and measuring functional recovery from depressionTracy L Greer
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9119, USA
CNS Drugs 24:267-84. 2010..The development of treatments that specifically target improvements in functional impairments is needed, and may require the use of novel treatment strategies... - Treating depression complicated by comorbid medical illness or anxietyMadhukar H Trivedi
Department of Psychiatry and Mood Disorders Research Program and Clinic, University of Texas Southwestern Medical Center, Dallas, USA
J Clin Psychiatry 68:e01. 2007.... - Outcomes on the pharmacopsychometric triangle in bupropion-SR vs. buspirone augmentation of citalopram in the STAR*D trialP Bech
Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
Acta Psychiatr Scand 125:342-8. 2012..buspirone in the acute therapy of major depression in the STAR*D study. The triangle provides a composite view in three domains of antidepressive activity, side effects, and quality of life... - Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteersM D Devous
Nuclear Medicine Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9061, USA
J Nucl Med 42:535-42. 2001..Frontopolar and temporal increases observed in our study appear to be unique to humans... - Does exercise improve self-reported sleep quality in non-remitted major depressive disorder?C D Rethorst
University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
Psychol Med 43:699-709. 2013..The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality... - Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depressionS G Kornstein
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Psychol Med 35:683-92. 2005..The NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provides a unique opportunity to evaluate PME in depressed women seeking treatment in primary care or psychiatric settings...
Research Grants
- Using Information Technology to Provide Measurement Based Care for Chronic IllnesMadhukar Trivedi; Fiscal Year: 2007....
- REVAMP Follow-UpMadhukar Trivedi; Fiscal Year: 2007....
- Computerized Decision Support System for DepressionMadhukar Trivedi; Fiscal Year: 2007..Comparisons will be made between CDSS-D, PPA-D, and UC-D. ..
- Treatment with Exercise Augmentation for DepressionMadhukar Trivedi; Fiscal Year: 2006....