Ralph Tripp

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. pmc Bioconjugated nanoparticle detection of respiratory syncytial virus infection
    Ralph A Tripp
    College of Veterinary Medicine, Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, GA 30602, USA
    Int J Nanomedicine 2:117-24. 2007
  2. ncbi request reprint Pathogenesis of respiratory syncytial virus infection
    Ralph A Tripp
    Division of Viral and Rickettsial Diseases, Viral and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
    Viral Immunol 17:165-81. 2004
  3. ncbi request reprint Serological cross-reactivity of members of the Metapneumovirus genus
    Rene Alvarez
    Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virus Res 105:67-73. 2004
  4. pmc Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection
    Lia M Haynes
    Respiratory and Enteric Virus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:6873-81. 2002
  5. pmc RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response
    Wenliang Zhang
    Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, 501 DW Brooks Dr, Rm 347, Athens, GA 30602, USA
    J Virol 82:12221-31. 2008
  6. pmc Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies
    Rene Alvarez
    Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 78:14003-11. 2004
  7. ncbi request reprint Pulmonary delivery of respiratory syncytial virus DNA vaccines using macroaggregated albumin particles
    Jennifer L Harcourt
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, 1600 Clifton Road NE, Mailstop G 09, Atlanta, GA 30333, USA
    Vaccine 22:2248-60. 2004
  8. ncbi request reprint Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate
    Saratchandra Shanmukh
    Department of Chemistry, Physics and Astronomy and Center for Disease Intervention, Department of Infectious Diseases, University of Georgia, Athens, Georgia 30602, USA
    Nano Lett 6:2630-6. 2006
  9. ncbi request reprint CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice
    Jennifer L Harcourt
    National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, 1600 Clifton Road NE, Mailstop G 09, Atlanta, GA 30333, USA
    Vaccine 21:2964-79. 2003
  10. ncbi request reprint Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infection
    Ralph A Tripp
    Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Neuroimmunol 129:141-53. 2002

Collaborators

Detail Information

Publications42

  1. pmc Bioconjugated nanoparticle detection of respiratory syncytial virus infection
    Ralph A Tripp
    College of Veterinary Medicine, Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, GA 30602, USA
    Int J Nanomedicine 2:117-24. 2007
    ....
  2. ncbi request reprint Pathogenesis of respiratory syncytial virus infection
    Ralph A Tripp
    Division of Viral and Rickettsial Diseases, Viral and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
    Viral Immunol 17:165-81. 2004
    ..This review summarizes important aspects of these findings, and provides current perspective on processes that may contribute to RSV disease pathogenesis...
  3. ncbi request reprint Serological cross-reactivity of members of the Metapneumovirus genus
    Rene Alvarez
    Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virus Res 105:67-73. 2004
    ..These reagents provide new tools and methods for investigating HMPV infection, for differentiating HMPV from RSV infection, and may be useful for characterizing potential links between HMPV with other respiratory complications...
  4. pmc Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection
    Lia M Haynes
    Respiratory and Enteric Virus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:6873-81. 2002
    ..The results suggest that combined anti-viral and anti-SP antibody treatment may be effective in treating RSV disease...
  5. pmc RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response
    Wenliang Zhang
    Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, 501 DW Brooks Dr, Rm 347, Athens, GA 30602, USA
    J Virol 82:12221-31. 2008
    ..The results support the hypothesis that siRNAs can be developed as effective antiviral drugs that can be used to reduce the viral load and parameters of pathogenesis without limiting the induction of the memory immune response...
  6. pmc Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies
    Rene Alvarez
    Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 78:14003-11. 2004
    ..This study shows that BALB/c mice are amenable for HMPV studies and indicates that HMPV persists as infectious virus in the lungs of normal mice for several weeks postinfection...
  7. ncbi request reprint Pulmonary delivery of respiratory syncytial virus DNA vaccines using macroaggregated albumin particles
    Jennifer L Harcourt
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, 1600 Clifton Road NE, Mailstop G 09, Atlanta, GA 30333, USA
    Vaccine 22:2248-60. 2004
    ..This study shows that MAA may be a useful carrier for RSV DNA vaccines...
  8. ncbi request reprint Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate
    Saratchandra Shanmukh
    Department of Chemistry, Physics and Astronomy and Center for Disease Intervention, Department of Infectious Diseases, University of Georgia, Athens, Georgia 30602, USA
    Nano Lett 6:2630-6. 2006
    ..The method provides rapid diagnostics for detection and characterization of viruses generating reproducible spectra without viral manipulation...
  9. ncbi request reprint CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice
    Jennifer L Harcourt
    National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, 1600 Clifton Road NE, Mailstop G 09, Atlanta, GA 30333, USA
    Vaccine 21:2964-79. 2003
    ..The addition of CD40L to DNA vaccines encoding the F glycoprotein enhanced virus clearance and some aspects of the immune response to RSV challenge, suggesting that CD40L may enhance the durability of RSV DNA vaccines...
  10. ncbi request reprint Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infection
    Ralph A Tripp
    Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Neuroimmunol 129:141-53. 2002
    ..These results suggest that SP receptor expression may be important in the development of primary and secondary immune responses to respiratory virus infections...
  11. pmc Human metapneumovirus establishes persistent infection in the lungs of mice and is reactivated by glucocorticoid treatment
    Yuru Liu
    Animal Health Research Center, University of Georgia, 111 Carlton Street, Athens, GA 30602, USA
    J Virol 83:6837-48. 2009
    ..The findings show that HMPV persists in neural fibers and suggest a mechanism for disease chronicity that has important implications for HMPV disease intervention strategies...
  12. pmc Vaccination to induce antibodies blocking the CX3C-CX3CR1 interaction of respiratory syncytial virus G protein reduces pulmonary inflammation and virus replication in mice
    Wenliang Zhang
    College of Veterinary Medicine, Department of Infectious Disease, 111 Carlton Street, University of Georgia, Athens, Georgia 30602, USA
    J Virol 84:1148-57. 2010
    ..The results suggest that RSV vaccines that induce antibodies that block G protein CX3C-CX3CR1 interaction may offer a new, safe, and efficacious RSV vaccine strategy...
  13. pmc Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15)
    Elizabeth C Moore
    Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, GA 30602, USA
    Virol J 5:116. 2008
    ..These results show an important role for SOCS1 regulation of the antiviral host response to RSV infection, and demonstrate a novel role for RSV G protein manipulation of SOCS3 and modulation of ISG15 and IFNbeta mRNA expression...
  14. pmc Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in mice
    Congrong Miao
    National Centers for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Gen Virol 90:1119-23. 2009
    ..Thus, this mAb has two independent actions that could facilitate treatment and/or prevention of RSV infection by reducing both virus replication and virus-induced pulmonary inflammation...
  15. pmc Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination
    Yongjun Wen
    Department of Pathology, University of Georgia, Athens, Georgia 30602, USA
    J Virol 85:1634-44. 2011
    ..Together, these data indicate that recombinant RABVs expressing these molecules activate/recruit DCs and enhance protective immune responses...
  16. pmc The host response and molecular pathogenesis associated with respiratory syncytial virus infection
    Christine M Oshansky
    Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    Future Microbiol 4:279-97. 2009
    ..This review discusses RSV manipulation of the host response to infection and related disease pathogenesis...
  17. doi request reprint Quantitative surface-enhanced Raman spectroscopy based analysis of microRNA mixtures
    Jeremy D Driskell
    Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, Georgia 30602, USA
    Appl Spectrosc 63:1107-14. 2009
    ..These results demonstrate the applicability of SERS for quantitative detection and profiling of miRNAs and suggest that SERS may prove to be a novel, label-free method for identification of disease biomarkers...
  18. doi request reprint Respiratory syncytial virus proteins modulate suppressors of cytokine signaling 1 and 3 and the type I interferon response to infection by a toll-like receptor pathway
    Christine M Oshansky
    Department of Infectious Diseases, College of Veterinary Medicine, Center for Disease Intervention, University of Georgia, Athens, Georgia
    Viral Immunol 22:147-61. 2009
    ..These findings indicate that RSV surface proteins signal through the TLR pathway, suggesting that this may be an important mechanism to reduce type I IFN expression to aid virus replication...
  19. doi request reprint Label-free SERS detection of microRNA based on affinity for an unmodified silver nanorod array substrate
    Jeremy D Driskell
    University of Georgia, Nanoscale Science and Engineering Center and Department of Infectious Diseases, 111 Carlton St AHRC Athens, GA 30602, USA
    Chem Commun (Camb) 46:3298-300. 2010
    ..A silver nanorod array has been used for the intrinsic SERS detection of microRNAs based on different binding affinities of ssRNA, thiolated ssDNA, and the RNA:DNA duplex, eliminating the need for a labelling step...
  20. doi request reprint Replication and pathogenesis associated with H5N1, H5N2, and H5N3 low-pathogenic avian influenza virus infection in chickens and ducks
    Egbert Mundt
    Department of Population Health, Poultry Diagnostic and Research Center, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Arch Virol 154:1241-8. 2009
    ....
  21. doi request reprint Animal models for evaluation of influenza vaccines
    Ralph A Tripp
    Center for Disease Intervention, Animal Health Research Center, University of Georgia, 111 Carlton St, Athens, GA 30602, USA
    Curr Top Microbiol Immunol 333:397-412. 2009
    ..This chapter discusses animal models for evaluating vaccines and discusses the challenges and strengths of these models...
  22. ncbi request reprint Cytokines and respiratory syncytial virus infection
    Ralph A Tripp
    College of Veterinary Medicine, Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
    Proc Am Thorac Soc 2:147-9. 2005
    ..In this report, we discuss the role of cytokines and chemokines in the response to RSV infection, and the potential role for suppressor of cytokine signaling (SOCS) proteins in regulating these responses...
  23. ncbi request reprint Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxis
    Jennifer L Harcourt
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Atlanta, GA, USA
    J Infect Dis 190:1936-40. 2004
    ..In the present study, we show that anti-RSV G protein antibody responses after recent RSV infection or vaccination are associated with inhibition of RSV G protein CX3C-CX3CR1 interaction and RSV G protein-mediated leukocyte chemotaxis...
  24. pmc The immune response to human metapneumovirus is associated with aberrant immunity and impaired virus clearance in BALB/c mice
    Rene Alvarez
    College of Veterinary Medicine, Department of Infectious University of Georgia, Athens, GA 30602, USA
    J Virol 79:5971-8. 2005
    ..These features are consistent with virus persistence and indicate that the immune response to HMPV is unique compared to the immune response to RSV...
  25. ncbi request reprint Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins
    Ralph A Tripp
    National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G 09, Atlanta, GA 30333, USA
    J Virol Methods 128:21-8. 2005
    ..The mAbs characterized should prove useful for developing SARS-CoV diagnostic assays and for studying the biology of infection and pathogenesis of disease...
  26. doi request reprint Therapeutic monoclonal antibody treatment targeting respiratory syncytial virus (RSV) G protein mediates viral clearance and reduces the pathogenesis of RSV infection in BALB/c mice
    Lia M Haynes
    National Centers for Immunization and Respiratory Diseases, Div of Viral Diseases, Respiratory and Gastroenteritis Viruses Branch, 1600 Clifton Rd NE, Mailstop G 18, Atlanta, GA 30333, USA
    J Infect Dis 200:439-47. 2009
    ....
  27. ncbi request reprint Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA
    Ralph A Tripp
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 185:1388-94. 2002
    ..The results suggest that RSV infection induces both Th1 and Th2 cytokine expression and CC chemokine expression...
  28. pmc Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance P
    Lia M Haynes
    Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 77:9831-44. 2003
    ..These data suggest that the G glycoprotein, and in particular the G glycoprotein CX3C motif, is key in the enhanced inflammatory response to FI-RSV vaccination, possibly through the induction of substance P...
  29. pmc Prophylactic treatment with a G glycoprotein monoclonal antibody reduces pulmonary inflammation in respiratory syncytial virus (RSV)-challenged naive and formalin-inactivated RSV-immunized BALB/c mice
    Gertrud U Radu
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G 18, Atlanta, GA 30333, USA
    J Virol 84:9632-6. 2010
    ..It is possible that antibodies with similar reactivities might prevent enhanced disease and improve the safety of nonlive virus vaccines...
  30. pmc Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G protein
    Xia Qing Li
    Department of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA
    J Virol 80:537-40. 2006
    ..These findings suggest a mechanism for disease chronicity and have important implications for RSV disease intervention strategies...
  31. pmc Respiratory syncytial virus F and G proteins induce interleukin 1alpha, CC, and CXC chemokine responses by normal human bronchoepithelial cells
    Christine M Oshansky
    Department of Infectious Diseases, College of Veterinary Medicine, Center for Disease Intervention, University of Georgia, Athens, Georgia 30602, USA
    J Infect Dis 201:1201-7. 2010
    ....
  32. pmc The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P
    Ralph A Tripp
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 77:6580-4. 2003
    ..These data suggest new approaches for treating some aspects of RSV disease...
  33. ncbi request reprint Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses
    Jennifer Harcourt
    Division of Viral and Rickettsial Diseases, Viral and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 176:1600-8. 2006
    ..In addition, we show that CX3CR1+ cells constitute a major component of the cytotoxic response to RSV infection. These results suggest that G protein and the G protein CX3C motif reduce the antiviral T cell response to RSV infection...
  34. doi request reprint Therapeutic applications of RNAi for silencing virus replication
    Ralph A Tripp
    Department of Infectious Diseases, College of Veterinary Medicine, Center for Disease Intervention, University of Georgia, Athens, GA, USA
    Methods Mol Biol 555:43-61. 2009
    ..The methods and caveats to achieve these goals are discussed...
  35. pmc Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge
    S Mark Tompkins
    Department of Infectious Diseases, University of Georgia, Athens, GA, USA
    Virology 362:139-50. 2007
    ..The efficacy of rPIV5-H3 as a live vaccine was examined in 6-week-old BALB/c mice. The results show that a single dose inoculation provides broad and considerable immunity against influenza A virus infection...
  36. pmc Real-time detection of virus particles and viral protein expression with two-color nanoparticle probes
    Amit Agrawal
    Department of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    J Virol 79:8625-8. 2005
    ..A major development is use of dual-color quantum dots or fluorescence energy transfer nanobeads that can be simultaneously excited with a single light source...
  37. ncbi request reprint An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infection
    Kristin A Birkness
    Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Immunol Cell Biol 85:160-8. 2007
    ..001). This model may provide insight into the earliest stages of granuloma formation in those newly infected...
  38. ncbi request reprint Recombinant vaccines for influenza virus
    Ralph A Tripp
    University of Georgia, Department of Infectious Diseases, 111 Carlton St, Athens, GA 30602, USA
    Curr Opin Investig Drugs 9:836-45. 2008
    ....
  39. ncbi request reprint Role of cytokines in the development and maintenance of memory T cells during respiratory viral infection
    Ralph A Tripp
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Respiratory and Enteric Viruses Branch, 1600 Clifton Rd, Mailstop G 09, Atlanta, GA 30333, USA
    Curr Pharm Des 9:51-9. 2003
    ..This review addresses aspects of T cell biology that constitute the response to respiratory viral infections...
  40. ncbi request reprint Perspective on the host response to human metapneumovirus infection: what can we learn from respiratory syncytial virus infections?
    Surendran Mahalingam
    Viral Arthritis Asthma Research Group, School of Health Sciences, University of Canberra, Canberra, ACT 2601, Australia
    Microbes Infect 8:285-93. 2006
    ..This review provides a current perspective on the processes associated with HMPV infection, immunity, and disease pathogenesis...
  41. ncbi request reprint The brume surrounding respiratory syncytial virus persistence
    Ralph A Tripp
    Am J Respir Crit Care Med 169:778-9. 2004
  42. ncbi request reprint Serum mannose-binding lectin levels are linked with respiratory syncytial virus (RSV) disease
    Lucas Zimon Giacomini Ribeiro
    Laboratorio de Virologia, Instituto de Ciencias Biomedicas, Universidade Federal de Uberlândia UFU, Av Pará, 1720, Bloco 4C, andar superior, Campus Umuarama, 38400 902, Uberlandia, Minas Gerais, Brazil
    J Clin Immunol 28:166-73. 2008
    ..These results suggest that low serum MBL levels may be a marker of RSV disease severity in children and that MBL may be important in limiting RSV disease pathogenesis...

Research Grants6

  1. Antibody inhibition of respiratory syncytial virus G protein activity
    Ralph Tripp; Fiscal Year: 2007
    ....
  2. Immunobiology of Influenza Virus Infection: Approaches for an Emerging Zoonotic D
    Ralph Tripp; Fiscal Year: 2007
    ..The goal of the meeting is to accelerate anti-viral vaccine and therapeutic development, to facilitate a rapid response to the threat of emerging viruses, with the focus of the meeting centered on influenza viruses. ..
  3. Antibody inhibition of respiratory syncytial virus G protein activity
    Ralph Tripp; Fiscal Year: 2009
    ..abstract_text> ..
  4. Antibody inhibition of respiratory syncytial virus G protein activity
    Ralph A Tripp; Fiscal Year: 2010
    ..abstract_text> ..
  5. RSV Nanocapsule Vaccine Engineered with a G Protein Peptide Payload
    Ralph A Tripp; Fiscal Year: 2010
    ..The long-term goal of our research is to develop a novel nanocapsule vaccine engineered to carry a RSV G protein polypeptide that we have previously shown to induce neutralizing and disease protective antibody. ..