P L Triozzi

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer
    P L Triozzi
    The Arthur G James Cancer Hospital and Richard J Solove Research Institute The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
    Cancer 89:2646-54. 2000
  2. ncbi request reprint Effect of docetaxel chemotherapy on the activity of a gonadotropin releasing hormone vaccine in patients with advanced prostate cancer
    Pierre L Triozzi
    Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Prostate 65:316-21. 2005
  3. ncbi request reprint Infusion of unpulsed dendritic cells derived from granulocyte/macrophage colony-stimulating factor-mobilized peripheral blood CD34+ cells and monocytes in patients with advanced carcinoma
    Pierre L Triozzi
    The Arthur G James Cancer Hospital, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Hematother Stem Cell Res 12:279-87. 2003
  4. ncbi request reprint Phase I study of a plasmid DNA vaccine encoding MART-1 in patients with resected melanoma at risk for relapse
    Pierre L Triozzi
    University of Alabama at Birmingham Comprehensive Cancer Center, Alabama 35294 3300, USA
    J Immunother 28:382-8. 2005
  5. ncbi request reprint Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma
    Pierre L Triozzi
    The University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama 35294 3300, USA
    Clin Cancer Res 11:4168-75. 2005
  6. ncbi request reprint Intratumoral administration of a recombinant canarypox virus expressing interleukin 12 in patients with metastatic melanoma
    Pierre L Triozzi
    University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294, USA
    Hum Gene Ther 16:91-100. 2005
  7. ncbi request reprint Antitumor activity of the intratumoral injection of fowlpox vectors expressing a triad of costimulatory molecules and granulocyte/macrophage colony stimulating factor in mesothelioma
    Pierre L Triozzi
    University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294 3300, USA
    Int J Cancer 113:406-14. 2005
  8. ncbi request reprint Enhanced transduction of mouse bone marrow-derived dendritic cells by repetitive infection with self-complementary adeno-associated virus 6 combined with immunostimulatory ligands
    W A Aldrich
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
    Gene Ther 13:29-39. 2006
  9. ncbi request reprint A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF)
    Jose Lima
    Division of Hematology and Oncology, Department of Medicine, and the Comprehensive Cancer Center, University of Alabama at Birmingham, WTI 558, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Vaccine 23:1273-83. 2005
  10. ncbi request reprint Immunization of colorectal cancer patients with recombinant baculovirus-derived KSA (Ep-CAM) formulated with monophosphoryl lipid A in liposomal emulsion, with and without granulocyte-macrophage colony-stimulating factor
    Jeffrey Neidhart
    The University of Alabama at Birmingham, WTI 275 J2, 1530 Third Avenue South, Birmingham, AL 35294 3300, USA
    Vaccine 22:773-80. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer
    P L Triozzi
    The Arthur G James Cancer Hospital and Richard J Solove Research Institute The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
    Cancer 89:2646-54. 2000
    ..Dendritic cells (DCs) are potent initiators of immune responses, and the infiltration of DCs into tumors may confer an improved prognosis. Whether the injection of DCs directly into tumors can mediate biologic activity was examined...
  2. ncbi request reprint Effect of docetaxel chemotherapy on the activity of a gonadotropin releasing hormone vaccine in patients with advanced prostate cancer
    Pierre L Triozzi
    Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Prostate 65:316-21. 2005
    ..A pilot study was performed to determine how to best combine GnRH-DT vaccine with potentially immunosuppressive chemotherapy...
  3. ncbi request reprint Infusion of unpulsed dendritic cells derived from granulocyte/macrophage colony-stimulating factor-mobilized peripheral blood CD34+ cells and monocytes in patients with advanced carcinoma
    Pierre L Triozzi
    The Arthur G James Cancer Hospital, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Hematother Stem Cell Res 12:279-87. 2003
    ..The infusion of these dendritic cells has nonspecific immunomodulatory activity that may have clinical significance...
  4. ncbi request reprint Phase I study of a plasmid DNA vaccine encoding MART-1 in patients with resected melanoma at risk for relapse
    Pierre L Triozzi
    University of Alabama at Birmingham Comprehensive Cancer Center, Alabama 35294 3300, USA
    J Immunother 28:382-8. 2005
    ..This study underscores species differences in the ability to respond to plasmid immunogens...
  5. ncbi request reprint Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma
    Pierre L Triozzi
    The University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama 35294 3300, USA
    Clin Cancer Res 11:4168-75. 2005
    ..This response included the production of factors that may suppress the antitumor immunologic activity of these vectors...
  6. ncbi request reprint Intratumoral administration of a recombinant canarypox virus expressing interleukin 12 in patients with metastatic melanoma
    Pierre L Triozzi
    University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294, USA
    Hum Gene Ther 16:91-100. 2005
    ..The intratumoral injection of ALVAC-IL-12 at these dose levels and according to this schedule was well tolerated and resulted in measurable biologic response in patients with metastatic melanoma...
  7. ncbi request reprint Antitumor activity of the intratumoral injection of fowlpox vectors expressing a triad of costimulatory molecules and granulocyte/macrophage colony stimulating factor in mesothelioma
    Pierre L Triozzi
    University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294 3300, USA
    Int J Cancer 113:406-14. 2005
    ..The results also suggest potential limitations to the intratumoral administration of cytokines, such as GM-CSF, in mesothelioma...
  8. ncbi request reprint Enhanced transduction of mouse bone marrow-derived dendritic cells by repetitive infection with self-complementary adeno-associated virus 6 combined with immunostimulatory ligands
    W A Aldrich
    Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
    Gene Ther 13:29-39. 2006
    ..These studies demonstrate the potential utility of sc rAAV serotype 6-based vectors in transduction of DC for genetic vaccination approaches...
  9. ncbi request reprint A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF)
    Jose Lima
    Division of Hematology and Oncology, Department of Medicine, and the Comprehensive Cancer Center, University of Alabama at Birmingham, WTI 558, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Vaccine 23:1273-83. 2005
    ..In contrast, a single low-dose immunization with CEA-GMCSF fusion plasmids provided better tumor protection than low-dose CEA plasmid alone and resulted in lower titers of GM-CSF antibodies...
  10. ncbi request reprint Immunization of colorectal cancer patients with recombinant baculovirus-derived KSA (Ep-CAM) formulated with monophosphoryl lipid A in liposomal emulsion, with and without granulocyte-macrophage colony-stimulating factor
    Jeffrey Neidhart
    The University of Alabama at Birmingham, WTI 275 J2, 1530 Third Avenue South, Birmingham, AL 35294 3300, USA
    Vaccine 22:773-80. 2004
    ..Co-administration of GM-CSF with this formulation is an effective method of generating KSA-specific T-helper (Th) 1-associated cellular immune responses...
  11. ncbi request reprint Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells
    A V Pereboev
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Gene Ther 9:1189-93. 2002
    ..Finally, we show that the CAR/G28 fusion protein promotes highly efficient transduction of DCs of both rhesus monkey and human origin...
  12. ncbi request reprint High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN
    Nikolay Korokhov
    Vector Logics, Inc, Birmingham, Alabama 35233, USA
    Cancer Biol Ther 4:289-94. 2005
    ..These data demonstrate the usefulness of DC-SIGN as a DC-restricted targeting motif for Ad-mediated vaccination strategies...
  13. ncbi request reprint Augmentation of antitumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvant
    Selvarangan Ponnazhagan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Gene Ther 15:856-64. 2004
    ..These data indicate that robust rAAV transgene expression of a tumor antigen followed by transient plasmid delivery to recruit and activate dendritic cells is an effective method of eliciting antitumor cellular immune responses...
  14. ncbi request reprint Enhanced gene transfer to mouse dendritic cells using adenoviral vectors coated with a novel adapter molecule
    Alexander V Pereboev
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Ther 9:712-20. 2004
    ....
  15. ncbi request reprint A phase I study of an anti-GD3 monoclonal antibody, KW-2871, in patients with metastatic melanoma
    Andres Forero
    Department of Medicine, Division of Hematology Oncology, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294 3300, USA
    Cancer Biother Radiopharm 21:561-8. 2006
    ..KW-2871 (IgG1 kappa chimeric antibody) targets GD3, which is upregulated in melanomas. We conducted a phase I trial of KW-2871 in patients with metastatic melanoma...
  16. ncbi request reprint Anti-GD3 monoclonal antibody effects on lymphocytes and antibody-dependent cellular cytotoxicity
    Pierre L Triozzi
    Department of Medicine, Division of Hematology Oncology, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294 3300, USA
    Cancer Biother Radiopharm 21:553-60. 2006
    ..Because GD3 is expressed also on a subpopulation of human lymphocytes, we characterized the in vitro immune effects of murine R24 and a chimeric anti-GD3 antibody (KW-2871)...
  17. ncbi request reprint Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival
    Hong M Moulton
    AVI BioPharma, Inc, Portland, Oregon 97258, USA
    Clin Cancer Res 8:2044-51. 2002
    ....
  18. pmc Genetically targeted adenovirus vector directed to CD40-expressing cells
    Natalya Belousova
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, USA
    J Virol 77:11367-77. 2003
    ....
  19. pmc Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge
    Nikolay Korokhov
    VectorLogics, Inc, Alabama 35294, USA
    J Virol 77:12931-40. 2003
    ..Since this gene transfer is independent of the expression of the native Ad5 receptor by the target cells, this strategy results in the derivation of truly targeted Ad vectors suitable for tissue-specific gene therapy...
  20. doi request reprint Targeted therapy for uveal melanoma
    Pierre L Triozzi
    Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, United States
    Cancer Treat Rev 34:247-58. 2008
    ..Clinical trials of some of these approaches have been initiated in patients with metastatic uveal melanoma as well as in the adjuvant setting after primary therapy...