JAMES TRIMMER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Antibody-based validation of CNS ion channel drug targets
    Kenneth J Rhodes
    Discovery Neurobiology, Biogen Idec, Cambridge, MA 02142, USA
    J Gen Physiol 131:407-13. 2008
  2. pmc Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance
    Colleen F Manning
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e38313. 2012
  3. pmc Mining recent brain proteomic databases for ion channel phosphosite nuggets
    Oscar Cerda
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA
    J Gen Physiol 137:3-16. 2011
  4. ncbi request reprint Localization of voltage-gated ion channels in mammalian brain
    James S Trimmer
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616 8635, USA
    Annu Rev Physiol 66:477-519. 2004
  5. ncbi request reprint The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels
    Durga P Mohapatra
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Neurosci 26:685-95. 2006
  6. pmc Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel
    Durga P Mohapatra
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616 8519, USA
    Channels (Austin) 3:46-56. 2009
  7. ncbi request reprint Graded regulation of the Kv2.1 potassium channel by variable phosphorylation
    Kang Sik Park
    Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
    Science 313:976-9. 2006
  8. pmc Localization and targeting of voltage-dependent ion channels in mammalian central neurons
    Helene Vacher
    Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, California 95616 8519, USA
    Physiol Rev 88:1407-47. 2008
  9. ncbi request reprint Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Neurosci 26:13505-14. 2006
  10. ncbi request reprint A primary culture system for biochemical analyses of neuronal proteins
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, Genome and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA
    J Neurosci Methods 144:165-73. 2005

Collaborators

Detail Information

Publications48

  1. pmc Antibody-based validation of CNS ion channel drug targets
    Kenneth J Rhodes
    Discovery Neurobiology, Biogen Idec, Cambridge, MA 02142, USA
    J Gen Physiol 131:407-13. 2008
  2. pmc Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance
    Colleen F Manning
    Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e38313. 2012
    ....
  3. pmc Mining recent brain proteomic databases for ion channel phosphosite nuggets
    Oscar Cerda
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA
    J Gen Physiol 137:3-16. 2011
    ....
  4. ncbi request reprint Localization of voltage-gated ion channels in mammalian brain
    James S Trimmer
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616 8635, USA
    Annu Rev Physiol 66:477-519. 2004
    ..We then discuss the implications of these results in terms of neuronal physiology and neuronal mechanisms underlying the observed patterns of expression...
  5. ncbi request reprint The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels
    Durga P Mohapatra
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Neurosci 26:685-95. 2006
    ..1 channel by cholinergic and other neuromodulatory stimuli...
  6. pmc Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel
    Durga P Mohapatra
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616 8519, USA
    Channels (Austin) 3:46-56. 2009
    ..1-containing channels. These studies together demonstrate a specific contribution of modulation of KV2.1 channels in the activity-dependent regulation of intrinsic neuronal excitability...
  7. ncbi request reprint Graded regulation of the Kv2.1 potassium channel by variable phosphorylation
    Kang Sik Park
    Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
    Science 313:976-9. 2006
    ..Mutations at multiple sites were additive, showing that variable phosphorylation of Kv2.1 at a large number of sites allows graded activity-dependent regulation of channel gating and neuronal firing properties...
  8. pmc Localization and targeting of voltage-dependent ion channels in mammalian central neurons
    Helene Vacher
    Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, California 95616 8519, USA
    Physiol Rev 88:1407-47. 2008
    ..Finally, we discuss the emerging mechanisms for determining the discrete subcellular distributions observed for many neuronal ion channels...
  9. ncbi request reprint Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Neurosci 26:13505-14. 2006
    ..Distinct regulation of individual phosphorylation sites allows for graded and bidirectional homeostatic regulation of Kv2.1 function. S603 phosphorylation represents a sensitive bidirectional biosensor of neuronal activity...
  10. ncbi request reprint A primary culture system for biochemical analyses of neuronal proteins
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, Genome and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA
    J Neurosci Methods 144:165-73. 2005
    ..The procedures described here are also suitable for comprehensive studies of expression, localization, post-translational modification, and function of neuronal proteins in the same neuronal culture system...
  11. ncbi request reprint Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Neurosci 25:11184-93. 2005
    ..1 in response to hypoxia/ischemia suppresses neuronal excitability and could confer neuroprotection in response to brief ischemic insults...
  12. pmc SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development
    Evgenia Kalashnikova
    Department of Pharmacology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    Neuron 65:80-93. 2010
    ..Intriguingly, SynDIG1 content in dendritic spines is regulated by neuronal activity. Altogether, we define SynDIG1 as an activity-regulated transmembrane protein that regulates excitatory synapse development...
  13. ncbi request reprint Regulation of ion channel localization and phosphorylation by neuronal activity
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    Nat Neurosci 7:711-8. 2004
    ..Our finding that neuronal activity modifies the phosphorylation state, localization and function of Kv2.1 suggests an important link between excitatory neurotransmission and the intrinsic excitability of pyramidal neurons...
  14. pmc Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel
    Durga P Mohapatra
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, Davis, California 95616, USA
    J Neurosci 28:4982-94. 2008
    ..1 trafficking, gating, and phosphorylation-dependent modulation through cytoplasmic N/C-terminal interaction, which resembles alpha/beta subunit interaction in other Kv channels...
  15. doi request reprint Potassium channel phosphorylation in excitable cells: providing dynamic functional variability to a diverse family of ion channels
    Kang Sik Park
    Section of Neurobiology, Physiology and Behavior, College of Biological Sciences, Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, USA
    Physiology (Bethesda) 23:49-57. 2008
    ....
  16. pmc Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, 95616, USA
    J Comp Neurol 496:289-302. 2006
    ..These studies provide new insights into the polarized localization of Slo1 channels in mammalian central neurons and provide further evidence for a key role in regulating neurotransmitter release in glutamatergic and GABAergic terminals...
  17. ncbi request reprint Proteomic analyses of K(v)2.1 channel phosphorylation sites determining cell background specific differences in function
    Kang Sik Park
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    Channels (Austin) 1:59-61. 2007
    ..1 in different cell types under basal conditions, and in the same cell type under basal versus stimulated conditions...
  18. ncbi request reprint Kv1.1 takes a deTOR from the axon to the dendrite
    Eliana Clark
    Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Neuron 52:399-401. 2006
    ..1 occurs in CA1 dendrites of rat hippocampal slices and in cultured neurons. This local translation is inhibited by NMDA receptor-mediated synaptic signaling acting through the mTOR kinase...
  19. pmc Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain
    Frank J Berendt
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, School of Medicine, University of California, Davis, California 95616 8519, USA
    J Proteome Res 9:1976-84. 2010
    ....
  20. ncbi request reprint Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability
    Hiroaki Misonou
    Department of Pharmacology, 3503 GBSF, School of Medicine, University of California, Davis, CA 95616 8635, USA
    Neurotoxicology 26:743-52. 2005
    ..1 localization and function in neurons, and summarize recent work regarding dynamic regulation of these characteristics. We also discuss possible roles of the Kv2.1 channel in neuronal and network excitability...
  21. pmc Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits
    Edward Seikel
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, California 95616, USA
    Biochemistry 48:5721-30. 2009
    ..2 alone. In conclusion, transmembrane DPPX-S and cytoplasmic KChIPs, despite having distinct structures and binding sites on Kv4.2, exert similar effects on Kv4.2 trafficking, but distinct effects on Kv4.2 gating...
  22. pmc Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity
    Jiusheng Yan
    Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, California 95616, USA
    Mol Cell Proteomics 7:2188-98. 2008
    ....
  23. pmc Complete 3D visualization of primate striosomes by KChIP1 immunostaining
    Shawn Mikula
    Center for Neuroscience, University of California Davis, Davis, California 95618, USA
    J Comp Neurol 514:507-17. 2009
    ..The perceived variable spatial organization of the striosomes in primates belies many invariant features that may reflect striatal function, development, and pathophysiology...
  24. pmc Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression
    Jae Won Yang
    Section of Neurobiology, Physiology, and Behavior, College of Biological Sciences, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 104:20055-60. 2007
    ..These data support Kv1.2 phosphorylation at these clustered C-terminal sites as playing an important role in regulating trafficking of Kv1.2-containing Kv channels...
  25. pmc Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus
    H Jurgen Wenzel
    Department of Neurological Surgery, School of Medicine, University of California Davis, 1515 Newton Court, Davis, CA 95618, USA
    Epilepsia 48:2023-46. 2007
    ..We examined the neuropathological consequences of seizure activity in the Kv1.1(-/-) (knock-out) mouse, and explored the effects of injecting a viral vector carrying the deleted Kcna1 gene into hippocampal neurons...
  26. ncbi request reprint The surprising catch of a voltage-gated potassium channel in a neuronal SNARE
    Durga P Mohapatra
    Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
    Sci STKE 2007:pe37. 2007
    ..That Kv2.1 is phosphorylated at numerous sites within the syntaxin 1A binding segment raises the possibility that its role in secretion may be dynamically regulated by diverse signaling events...
  27. ncbi request reprint Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA
    Crit Rev Biochem Mol Biol 39:125-45. 2004
    ..Here we review the mechanisms regulating the abundance and distribution of Kv channels in mammalian neurons and discuss how dynamic regulation of these events impacts neuronal signaling...
  28. pmc Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K
    Helene Vacher
    Department of Pharmacology, School of Medicine, University of California, One Shields Ave, Davis, CA 95616 8635, USA
    FASEB J 21:906-14. 2007
    ..Together, these data showed that luminal DTX expression increases surface expression of functional Kv1.1 homotetrameric channels and support a model whereby a DTX-like ER protein regulates abundance of cell surface Kv1 channels...
  29. ncbi request reprint Peering into the birth canal during ion channel parturition
    James S Trimmer
    Department of Pharmacology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    Neuron 44:214-6. 2004
    ..probe T1 domain structure within the ribosomal tunnel. They find that the T1 domain forms secondary structure within the tunnel, in preparation for its immediate role in governing channel assembly upon exit...
  30. ncbi request reprint Mossy fibre contact triggers the targeting of Kv4.2 potassium channels to dendrites and synapses in developing cerebellar granule neurons
    Koji Shibasaki
    Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Japan
    J Neurochem 89:897-907. 2004
    ..2 channels is dynamically regulated by synaptic activity. This activity-dependent regulation of Kv4.2 localization provides a crucial yet dynamic link between synaptic activity and dendritic excitability...
  31. ncbi request reprint A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
    Riichi Shibata
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 278:36445-54. 2003
    ..2 hydrophobic domain. These studies point to an essential role for KChIPs in determining both the biophysical and molecular characteristics of Kv4 channels and provide a molecular basis for the dramatic phenotype of KChIP knockout mice...
  32. ncbi request reprint Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
    J Neurosci Res 73:465-70. 2003
    ..The altered Nav channel isoform localization and complement induced by demyelination may contribute to the pathophysiology of demyelinating disorders and nerve injury...
  33. ncbi request reprint Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells
    Sonja J Pyott
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    J Neurosci 24:9469-74. 2004
    ..These results indicate a novel function of BK channels in mammalian inner hair cells and provide a framework for future research...
  34. pmc Clustering of neuronal potassium channels is independent of their interaction with PSD-95
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 159:663-72. 2002
    ..These data suggest that the primary function of PSD-95 at juxtaparanodes lies outside of its accepted role in mediating the high density clustering of Kv1 potassium channels at these sites...
  35. ncbi request reprint Role of heteromultimers in the generation of myocardial transient outward K+ currents
    Weinong Guo
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 90:586-93. 2002
    ..2/Kv4.3 alpha subunits and KChIP2. The results here also suggest that Kv4.2 is the primary determinant of the regional heterogeneity in I(to,f) expression in adult mouse ventricle...
  36. ncbi request reprint KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain
    Kenneth J Rhodes
    Neuroscience, Wyeth Discovery Research, Princeton, New Jersey 08543, USA
    J Neurosci 24:7903-15. 2004
    ....
  37. pmc Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:5731-9. 2008
    ..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2...
  38. ncbi request reprint Calnexin regulates mammalian Kv1 channel trafficking
    Louis N Manganas
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794, USA
    Biochem Biophys Res Commun 322:577-84. 2004
    ..2 channel surface expression. These results provide yet another component in the elaborate repertoire of determinants regulating the density of Kv1 channels in the plasma membrane...
  39. ncbi request reprint Characterization of zebrafish PSD-95 gene family members
    Martin P Meyer
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305, USA
    J Neurobiol 63:91-105. 2005
    ..These data are consistent with the idea that PSD-95 family members are involved in synapse assembly and function, and provide a platform for future functional studies in vivo in a highly tractable model organism...
  40. ncbi request reprint Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment
    Hanne B Rasmussen
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    J Cell Sci 120:953-63. 2007
    ..By contrast, deletion of the ankyrin-G-binding motif in KCNQ3 significantly reduces AIS enrichment of the complex, implicating KCNQ3 as a major determinant of M channel localization to the AIS...
  41. ncbi request reprint Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking
    Claire R Campomanes
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 277:8298-305. 2002
    ....
  42. ncbi request reprint Polarized distribution of ion channels within microdomains of the axon initial segment
    Audra Van Wart
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794 5230, USA
    J Comp Neurol 500:339-52. 2007
    ..This precise arrangement of ion channels within the axon initial segment is likely an important determinant of the firing properties of ganglion cells and other mammalian neurons...
  43. ncbi request reprint Unexpected cross talk: small GTPase regulation of calcium channel trafficking
    James S Trimmer
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794 USA
    Sci STKE 2002:pe2. 2002
    ....
  44. pmc The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4
    Shun Fujinami
    Graduate School of Life Sciences, Toyo University, Oura gun, Gunma 374 0193, Japan
    Microbiology 153:4027-38. 2007
    ..The results suggest interactions between McpX and Na(V)BP that affect their co-localization. The inverse chemotaxis phenotype of ncbA mutants may result in part from MCP delocalization...
  45. ncbi request reprint Novel clustering of sodium channel Na(v)1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina
    Audra Van Wart
    Department of Neurobiology and Behavior, Centers for Molecular Medicine, State University of New York, Stony Brook, NY 11794 5230, USA
    Mol Cell Neurosci 28:661-73. 2005
    ..2 to Na(v)1.6 at nodes of Ranvier and initial segments. This represents the first instance of high-density clustering of Na(v)1.1 channels, which may contribute to synaptic interactions among retinal neurons in the inner plexiform layer...
  46. ncbi request reprint Functional specialization of the axon initial segment by isoform-specific sodium channel targeting
    Tatiana Boiko
    Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794, USA
    J Neurosci 23:2306-13. 2003
    ..Expression at nodes but not initial segments exhibits an additional requirement for intact myelination. Because of their high density at the initial segment, Na(v)1.6 channels may be crucial in determining neuronal firing properties...
  47. ncbi request reprint Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells
    Brian W Strassle
    Neuroscience Division, Wyeth Research, Princeton, New Jersey 08543, USA
    J Comp Neurol 484:144-55. 2005
    ..2 and KChIP1, and perhaps also KChIP3 and 4, play a critical role in regulating postsynaptic excitability at the cerebellar mossy-fiber/granule cell synapse...

Research Grants22

  1. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2007
    ..These studies will yield important insights into the reciprocal physiological regulation of Kv2.1, a regulator of homeostatic plasticity, and Kv4.2, a determinant of activity-dependent potentiation. ..
  2. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2001
    ..abstract_text> ..
  3. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2009
    ..These studies will yield important insights into the reciprocal physiological regulation of Kv2.1, a regulator of homeostatic plasticity, and Kv4.2, a determinant of activity-dependent potentiation. ..
  4. K+ Channel Alpha & Beta Subunit Interaction
    JAMES TRIMMER; Fiscal Year: 2009
    ..It focuses on neuronal ion channels and their regulatory enzymes that are important targets for developing new therapeutics for epilepsy. ..
  5. K+ Channel Alpha & Beta Subunit Interaction
    James S Trimmer; Fiscal Year: 2010
    ..It focuses on neuronal ion channels and their regulatory enzymes that are important targets for developing new therapeutics for epilepsy. ..
  6. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2009
    ..These studies will yield important insights into the reciprocal physiological regulation of Kv2.1, a regulator of homeostatic plasticity, and Kv4.2, a determinant of activity-dependent potentiation. ..
  7. Determinants of Dendritic Potassium Channel Localization
    James S Trimmer; Fiscal Year: 2010
    ..It focuses on neuronal ion channels and their regulatory enzymes that are important targets for developing new therapeutics for epilepsy and stroke. ..
  8. NINDS/UC Davis NeuroMab Hybridoma Facility
    JAMES TRIMMER; Fiscal Year: 2007
    ..Moreover, NeuroMabs may find additional i applications in direct functional analyses of proteins, in diagnostic procedures, and as therapeutics. ..
  9. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2002
    ..abstract_text> ..
  10. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2003
    ..abstract_text> ..
  11. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2004
    ..abstract_text> ..
  12. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2004
    ..abstract_text> ..
  13. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2005
    ..These studies will yield important insights into the reciprocal physiological regulation of Kv2.1, a regulator of homeostatic plasticity, and Kv4.2, a determinant of activity-dependent potentiation. ..
  14. NINDS/UC Davis NeuroMab Hybridoma Facility
    JAMES TRIMMER; Fiscal Year: 2005
    ..Moreover, NeuroMabs may find additional i applications in direct functional analyses of proteins, in diagnostic procedures, and as therapeutics. ..
  15. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2006
    ..These studies will yield important insights into the reciprocal physiological regulation of Kv2.1, a regulator of homeostatic plasticity, and Kv4.2, a determinant of activity-dependent potentiation. ..
  16. Determinants of Dendritic Potassium Channel Localization
    JAMES TRIMMER; Fiscal Year: 2007
    ..These studies will yield important insights into the reciprocal physiological regulation of Kv2.1, a regulator of homeostatic plasticity, and Kv4.2, a determinant of activity-dependent potentiation. ..
  17. K+ Channel Alpha & Beta Subunit Interaction
    James S Trimmer; Fiscal Year: 2010
    ..It focuses on neuronal ion channels and their regulatory enzymes that are important targets for developing new therapeutics for epilepsy. ..