Natalia Tretyakova

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach
    Natalia Tretyakova
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Biochemistry 41:9535-44. 2002
  2. ncbi request reprint Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane
    Natalia Tretyakova
    University of Minnesota Cancer Center and Department of Medicinal Chemistry, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:284-9. 2007
  3. pmc Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase
    Delshanee Kotandeniya
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Biochemistry 52:4075-88. 2013
  4. pmc Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice
    Melissa Goggin
    Cancer Center and the Department of Medicinal Chemistry, University of Minnesota, 760E CCRB, 806 Mayo, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:1163-70. 2008
  5. pmc Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA
    Delshanee Kotandeniya
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 24:1966-75. 2011
  6. ncbi request reprint Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Rebecca Ziegel
    Department of Medicinal Chemistry, University of Minnesota School of Pharmacy, Minneapolis, Minnesota 55455, USA
    Biochemistry 43:540-9. 2004
  7. pmc Column switching HPLC-ESI(+)-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene
    Melissa Goggin
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:808-12. 2010
  8. pmc DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure
    Uthpala Seneviratne
    Department of Chemistry, Department of Medicinal Chemistry, and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:1556-67. 2010
  9. pmc Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases
    Srikanth Kotapati
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 287:38800-11. 2012
  10. pmc Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane
    Rachel Loeber
    University of Minnesota Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:645-54. 2006

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach
    Natalia Tretyakova
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Biochemistry 41:9535-44. 2002
    ..The stable isotope labeling HPLC-ESI-MS/MS approach described in this work is universally applicable to studies of modifications to isolated DNA by other carcinogens and alkylating drugs...
  2. ncbi request reprint Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane
    Natalia Tretyakova
    University of Minnesota Cancer Center and Department of Medicinal Chemistry, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:284-9. 2007
    ..Although N1HX-N7G-BD adducts are less abundant in DEB-treated DNA than the corresponding guanine-guanine cross-links, they may play a role in the induction of both AT and GC base pair mutations...
  3. pmc Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase
    Delshanee Kotandeniya
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Biochemistry 52:4075-88. 2013
    ....
  4. pmc Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice
    Melissa Goggin
    Cancer Center and the Department of Medicinal Chemistry, University of Minnesota, 760E CCRB, 806 Mayo, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:1163-70. 2008
    ..Quantitative methods presented here may be used not only for studies of biological significance in animal models but potentially to predict risk associated with human exposure to BD...
  5. pmc Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA
    Delshanee Kotandeniya
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 24:1966-75. 2011
    ..Faster rates of alkyl transfer were observed when O(6)-POB-dG was paired with T rather than with C (k = 1.74 × 10(6) M(-1) s(-1) vs 1.17 × 10(6) M(-1) s(-1))...
  6. ncbi request reprint Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Rebecca Ziegel
    Department of Medicinal Chemistry, University of Minnesota School of Pharmacy, Minneapolis, Minnesota 55455, USA
    Biochemistry 43:540-9. 2004
    ..These results indicate that, unlike N2-guanine adducts of PAH diol epoxides, NNK-induced N7- and O6-alkylguanine adducts are not preferentially formed at the endogenously methylated CG sites within the p53 tumor suppressor gene...
  7. pmc Column switching HPLC-ESI(+)-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene
    Melissa Goggin
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:808-12. 2010
    ..On the basis of their exocyclic structure, which prevents normal Watson-Crick base pairing, these adducts could be responsible for mutations at the A:T base pairs observed following exposure to DEB...
  8. pmc DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure
    Uthpala Seneviratne
    Department of Chemistry, Department of Medicinal Chemistry, and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:1556-67. 2010
    ..Interestingly, structurally modified DNA duplexes were more thermodynamically stable when an adenine residue was placed opposite 1,N⁶-γ-HMHP-dA instead of thymine, suggesting that these adducts may preferentially pair with dA...
  9. pmc Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases
    Srikanth Kotapati
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 287:38800-11. 2012
    ....
  10. pmc Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane
    Rachel Loeber
    University of Minnesota Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:645-54. 2006
    ..AGT-DNA cross-linking is a likely mechanism of DEB-mediated cytotoxicity in cells expressing this important repair protein...
  11. pmc Capillary HPLC-accurate mass MS/MS quantitation of N7-(2,3,4-trihydroxybut-1-yl)-guanine adducts of 1,3-butadiene in human leukocyte DNA
    Dewakar Sangaraju
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Chem Res Toxicol 26:1486-97. 2013
    ..The availability of sensitive HPLC-ESI⁺-HRMS/MS methodology for BD-induced DNA adducts in humans will enable future population studies of interindividual and ethnic differences in BD bioactivation to DNA-reactive epoxides...
  12. pmc NanoHPLC-nanoESI(+)-MS/MS quantitation of bis-N7-guanine DNA-DNA cross-links in tissues of B6C3F1 mice exposed to subppm levels of 1,3-butadiene
    Dewakar Sangaraju
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anal Chem 84:1732-9. 2012
    ..To our knowledge, this is the first quantitative analysis of DEB specific DNA adducts following low ppm and subppm exposure to BD...
  13. ncbi request reprint Sequence distribution of acetaldehyde-derived N2-ethyl-dG adducts along duplex DNA
    Brock Matter
    University of Minnesota Cancer Center and Department of Medicinal Chemistry, Minneapolis 55455, USA
    Chem Res Toxicol 20:1379-87. 2007
    ....
  14. pmc Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation
    Melissa Goggin
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Chem Res Toxicol 24:809-17. 2011
    ..Our results indicate that DEB-induced N7G-N1A-BD and 1,N(6)-HMHP-dA adducts persist in vivo, potentially contributing to mutations and cancer observed as a result of BD exposure...
  15. ncbi request reprint Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry
    Soobong Park
    Cancer Center and the Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Am Chem Soc 127:14355-65. 2005
    ..Different cross-linking specificities of DEB stereoisomers provide a likely structural basis for their distinct biological activities...
  16. ncbi request reprint Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences
    Mathur Rajesh
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Biochemistry 44:2197-207. 2005
    ....
  17. pmc Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural elucidation, and mechanistic studies
    Uthpala Seneviratne
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:118-33. 2010
    ..Formation of exocyclic DEB-adenine lesions following exposure to 1,3-butadiene provides a possible mechanism of mutagenesis at the A:T base pairs...
  18. ncbi request reprint Synthesis of DNA oligodeoxynucleotides containing structurally defined N6-(2-hydroxy-3-buten-1-yl)-adenine adducts of 3,4-epoxy-1-butene
    Danae Quirk Dorr
    Department of Medicinal Chemistry and The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Chem Biol Interact 166:104-11. 2007
    ..N6-HB-dA-containing oligomers generated in this study will be used for structural and biological studies...
  19. pmc Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides
    Rebecca Guza
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:22601-10. 2009
    ..g. the rate of alkyl transfer from DNA to AGT...
  20. ncbi request reprint Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences
    Brock Matter
    Department of Medicinal Chemistry, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:731-41. 2004
    ..The targeted formation of N(2)-BPDE-dG at (Me)CG dinucleotides within the p53 gene is consistent with the high prevalence of G --> T transversions at these sites in smoking-induced lung cancer...
  21. ncbi request reprint K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts
    Rebecca Ziegel
    Department of Medicinal Chemistry, University of Minnesota School of Pharmacy, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:541-50. 2003
    ..Therefore, our data support the involvement of NNK and other tobacco specific nitrosamines in mutagenesis and carcinogenesis...
  22. ncbi request reprint HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene
    Melissa Goggin
    Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:839-47. 2007
    ..Control animals did not contain either bis-N7G-BD lesion. Sensitive and specific quantitative methods for bis-N7G-BD analysis developed in this work provide a unique biomarker of DEB-induced DNA alkylation following exposure to BD...
  23. doi request reprint Quantitative high-performance liquid chromatography-electrospray ionization tandem mass spectrometry analysis of bis-N7-guanine DNA-DNA cross-links in white blood cells of cancer patients receiving cyclophosphamide therapy
    Bhaskar Malayappan
    Departments of Medicinal Chemistry, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anal Chem 82:3650-8. 2010
    ..This methodology will be useful for future investigations of the interindividual differences for CPA-induced DNA-DNA cross-linking...
  24. ncbi request reprint Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity
    Soobong Park
    Department of Medicinal Chemistry, University of Minnesota Cancer Center, Mayo Mail Code 806, Room 760 E CCRB, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:1638-51. 2004
    ..The formation of bifunctional guanine-adenine adducts is likely to contribute to AT base pair substitutions and deletion mutations following DEB exposure...
  25. ncbi request reprint Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane
    Soobong Park
    University of Minnesota Cancer Center and Department of Medicinal Chemistry, 806 Mayo, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:129-36. 2004
    ..These studies provide the first rigorous characterization of the covalent structure and hydrolytic stability of the major DEB-induced DNA-DNA cross-link...
  26. pmc Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation
    Melissa Goggin
    Masonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 69:2479-86. 2009
    ..Furthermore, a rat model of sensitivity to BD may be more appropriate than a mouse model for assessing human risk associated with BD exposure, because rats and humans seem to be similar with respect to DEB formation...
  27. ncbi request reprint Obesity effects on cyclophosphamide-induced DNA damage in hematopoietic cell transplant recipients
    L aurelle A Johnson
    University of Minnesota, College of Pharmacy, Department of Experimental and Clinical Pharmacology, 308 Harvard Street SE, 7 115C WDH, Minneapolis, MN 55443, USA
    In Vivo 26:853-7. 2012
    ..The effect of obesity on exposure to cyclophosphamide-induced G-NOR-G crosslinks is not known. Therefore we sought to determine whether obesity affects the formation of cyclophosphamide-specific G-NOR-G crosslinks...
  28. ncbi request reprint Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards
    Shawn Balcome
    Department of Medicinal Chemistry, University of Minnesota Cancer Center, Room 760E, Box 806 Mayo, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:950-62. 2004
    ..The presence of cross-linked adenine-adenine lesions may explain the enhanced cytotoxicity and mutagenicity of NMs in cells deficient in N3-alkyladenine glycosylase...
  29. pmc Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards
    Rachel Loeber
    Department of Medicinal Chemistry and Cancer Center and Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:787-95. 2008
    ..Because AGT is overexpressed in many tumor types, further investigations of the potential role of AGT-DNA cross-linking in the antitumor and mutagenic activity of antitumor nitrogen mustards are warranted...
  30. pmc Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-beta-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS
    Brock Matter
    Department of Medicinal Chemistry, University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:5449-60. 2006
    ..The formation of oxazolone lesions in rat liver DNA, their relative stability in the presence of oxidants and their potent mispairing characteristics suggest that oxazolone may play a role in oxidative stress-mediated mutagenesis...
  31. ncbi request reprint Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4-diepoxybutane: synthesis and stability at physiological pH
    Sergey Antsypovich
    Department of Medicinal Chemistry and The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:641-9. 2007
    ..These results indicate that DEB-induced alkylation of N6-adenine in DNA is unlikely to lead to DNA-DNA cross-linking but instead can result in the formation of exocyclic dA adducts...
  32. pmc Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences
    Rebecca Guza
    Department of Medicinal Chemistry and The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:531-8. 2006
    ....
  33. ncbi request reprint NanoLC/ESI(+) HRMS (3) Quantitation of DNA Adducts Induced by 1,3-Butadiene
    Dewakar Sangaraju
    Department of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA
    J Am Soc Mass Spectrom 25:1124-35. 2014
    ..20 ± 0.12 d) and to detect EB-GII in human blood DNA. To our knowledge, this is the first application of nanoLC/ESI(+)-HRMS(3) Orbitrap methodology to quantitative analysis of DNA adducts in vivo. ..
  34. pmc Formation of cyclophosphamide specific DNA adducts in hematological diseases
    L aurelle A Johnson
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 58:708-14. 2012
    ..Therefore we sought to determine whether FA patients have higher in vivo exposure to the cyclophosphamide specific interstrand DNA crosslink, G-NOR-G, relative to patients without FA...
  35. pmc The 5'-GNC site for DNA interstrand cross-linking is conserved for diepoxybutane stereoisomers
    Julie T Millard
    Department of Chemistry, Colby College, 5757 Mayflower Hill Drive, Waterville, Maine 04901, USA
    Chem Res Toxicol 19:16-9. 2006
    ..These results help explain the observed differences between the biological activities of DEB stereoisomers...
  36. pmc Quantitation of DNA adducts by stable isotope dilution mass spectrometry
    Natalia Tretyakova
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 25:2007-35. 2012
    ....
  37. pmc Mapping structurally defined guanine oxidation products along DNA duplexes: influence of local sequence context and endogenous cytosine methylation
    Xun Ming
    Department of Medicinal Chemistry and the Masonic Cancer Center and Biostatistics and Bioinformatics Core at the Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States
    J Am Chem Soc 136:4223-35. 2014
    ....
  38. pmc APOBEC3B is an enzymatic source of mutation in breast cancer
    Michael B Burns
    Biochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 494:366-70. 2013
    ..Our data suggest a model in which APOBEC3B-catalysed deamination provides a chronic source of DNA damage in breast cancers that could select TP53 inactivation and explain how some tumours evolve rapidly and manifest heterogeneity...
  39. ncbi request reprint Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
    Pramod Upadhyaya
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:180-90. 2003
    ..Thus, DNA that had been allowed to react with NNALCH(2)OAc contained adducts 17, 19, and 21. The results of this study provide markers for investigating the role of specific NNAL-DNA adducts in carcinogenesis by NNAL and NNK...
  40. pmc 3'-Exonuclease resistance of DNA oligodeoxynucleotides containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine
    Soobong Park
    University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Nucleic Acids Res 31:1984-94. 2003
    ..In contrast, O(6)-methylguanine lesion used as a control does not induce similar structural changes in DNA and does not prevent its digestion by SVPDE...
  41. ncbi request reprint Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane
    Min Young Kim
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 20:790-7. 2007
    ..Our results are consistent with the stereospecific induction of promutagenic nucleobase adducts other than G-G cross-links by DEB stereoisomers...
  42. ncbi request reprint Spectral differentiation and immunoaffinity capillary electrophoresis separation of enantiomeric benzo(a)pyrene diol epoxide-derived DNA adducts
    Beata Miksa
    Department of Chemistry, Kansas State University, Manhattan, KS 66502, USA
    Chem Res Toxicol 20:1192-9. 2007
    ..The methodologies described in this manuscript could also be used for analysis of DNA adducts following enzymatic hydrolysis of BPDE-adducted DNA to free nucleosides...
  43. ncbi request reprint Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
    Gerd P Pfeifer
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California, CA 91010, USA
    Oncogene 21:7435-51. 2002
    ..The available data suggest that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations...