Affiliation: University of Rochester
- Intranasal administration of a proteosome-influenza vaccine is well-tolerated and induces serum and nasal secretion influenza antibodies in healthy human subjectsJohn Treanor
Infectious Diseases Unit, University of Rochester School of Medicine, 601 Elmwood Avenue, Room 3 6308, Rochester, NY 14642 0001, USA
Vaccine 24:254-62. 2006..Further evaluation of mucosal influenza immunization using the proteosome adjuvant/delivery system is clearly warranted...
- B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variantJane Baer
David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology and Immunology, Rochester, NY, USA
Vaccine 28:907-15. 2010..These observations suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains...
- Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
University of Rochester, Rochester, NY, USA
J Pediatr 155:495-9. 2009..We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born at > or =32 and <37 weeks of gestation and with birth weight > or =2000 but <3000 g...
- Psychosocial factors and the response to influenza vaccination in older adultsJan A Moynihan
Department of Psychiatry, University of Rochester Medical Center, Box PSYCH, 300 Crittenden Blvd, Rochester, NY 14642, USA
Psychosom Med 66:950-3. 2004..We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine...
- Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunizationJessica L Halliley
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 28:3582-7. 2010..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored...
- Recombinant proteins produced in insect cellsJohn Treanor
Infectious Diseases Division, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Curr Top Microbiol Immunol 333:211-25. 2009..Recombinant approaches may be extremely valuable in combating future pandemics and further studies of recombinant pandemic vaccines in humans are needed...
- Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive studyMichael E Pichichero
Department of Microbiology Immunology, University of Rochester, Rochester, New York, NY, USA
Lancet 360:1737-41. 2002..We aimed to measure concentrations of mercury in blood, urine, and stools of infants who received such vaccines...
- Mercury levels in newborns and infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
Pediatrics 121:e208-14. 2008..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines...
- Simulation and prediction of the adaptive immune response to influenza A virus infectionHa Youn Lee
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA
J Virol 83:7151-65. 2009..We further compared alternative model structures, for example, B-cell activation directly by the virus versus that through professional antigen-presenting cells or dendritic cell licensing of CD8 T cells...
- Pandemic (avian) influenzaSumanth Rajagopal
Department of Medicine, Infectious Diseases Division, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Semin Respir Crit Care Med 28:159-70. 2007..g., adamantanes and neuraminidase inhibitors)...
- Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adultsJohn Treanor
Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 24:6913-23. 2006..This suggests that local immune events in the tissue are distinct from the parameters measured in the peripheral blood...
- Evaluation of a single dose of half strength inactivated influenza vaccine in healthy adultsJohn Treanor
Infectious Diseases Unit, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Vaccine 20:1099-105. 2002..These results suggest that when vaccine is in short supply, a strategy using a half dose in healthy adults could increase the number of people vaccinated with relatively little adverse impact on vaccine immunogenicity...
- Weathering the influenza vaccine crisisJohn Treanor
Infectious Diseases Unit, University of Rochester Medical Center, Rochester, NY, USA
N Engl J Med 351:2037-40. 2004
- Influenza vaccine--outmaneuvering antigenic shift and driftJohn Treanor
Infectious Diseases Unit, University of Rochester Medical Center, Rochester, NY, USA
N Engl J Med 350:218-20. 2004
- Phase I, randomized, controlled trial to study the reactogenicity and immunogenicity of a nasal, inactivated trivalent influenza virus vaccine in healthy adultsScott A Halperin
Dalhousie University, Halifax, Nova Scotia, Canada
Hum Vaccin 1:37-42. 2005..We conclude that this trivalent, split virion, inactivated nasal influenza vaccine formulated with lipid/polysaccharide molecule carriers is well tolerated and modestly immunogenic in healthy adults...
- Immune responses and antibody decay after immunization of adolescents and adults with an acellular pertussis vaccine: the APERT StudyThuan Le
UCLA Center for Vaccine Research, Research and Education Institute, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance 90502, USA
J Infect Dis 190:535-44. 2004..These findings support the use of ACP booster immunizations for adolescents and adults, to provide sustained levels of antibody...
- Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in childrenDavid I Bernstein
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
Pediatr Infect Dis J 22:28-34. 2003..The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T...
- Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged childrenPedro A Piedra
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Pediatrics 110:662-72. 2002..To provide additional information on the safety of trivalent, cold-adapted influenza vaccine (CAIV-T) in children...
- Serum antibody responses after intradermal vaccination against influenzaRobert B Belshe
Department of Internal Medicine, Division of Infectious Diseases and Immunology, Saint Louis University, St Louis, MO 63110, USA
N Engl J Med 351:2286-94. 2004..If found to be safe and immunogenic, reduced doses of influenza vaccine given by the intradermal route could increase the number of available doses of vaccine...
- Safety and immunogenicity of a trivalent, inactivated, mammalian cell culture-derived influenza vaccine in healthy adults, seniors, and childrenScott A Halperin
Department of Pediatrics, Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 University Avenue, NS, B3J 3G9, Halifax, Canada
Vaccine 20:1240-7. 2002..We conclude that the cell culture-derived vaccine was safe and immunogenic in children, healthy adults and seniors...
- Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infantsH Fred Clark
University of Pennsylvania School of Medicine, Philadelphia, and Merck and Co, Inc, West Point, Pennsylvania 19486, USA
J Pediatr 144:184-90. 2004..To investigate safety, efficacy, and immunogenicity of live quadrivalent rotavirus vaccine (QRV) containing human-bovine (WC3) reassortant rotavirus serotypes G1, G2, G3, and P1a...
- Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)Rafael Harpaz
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, USA
MMWR Recomm Rep 57:1-30; quiz CE2-4. 2008..Before administration of zoster vaccine, patients do not need to be asked about their history of varicella (chickenpox) or to have serologic testing conducted to determine varicella immunity...
- Cellular and humoral immunity following Snow Mountain virus challengeLisa Lindesmith
School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
J Virol 79:2900-9. 2005..To our knowledge, this is the first report characterizing T-cell and cytokine responses following live norovirus challenge...
- Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT)Joel I Ward
University of California Los Angeles UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, David Geffen School of Medicine UCLA, Torrance, California 90502 2502, USA
Clin Infect Dis 43:151-7. 2006..Acellular pertussis (aP) booster immunizations have been recommended for adolescents and older persons to enhance long-term protection and to possibly reduce community transmission of infections...
- Recovery of drug-resistant influenza virus from immunocompromised patients: a case seriesMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:760-4. 2006..We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir...
- Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatmentLuis Barroso
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
Antivir Ther 10:901-10. 2005..Oseltamivir is the only oral neuraminidase inhibitor currently available; we determined the tolerability and antiviral efficacy of oral peramivir for treatment and prophylaxis of experimental human influenza A and B...
- Prevalence of antibody to Bordetella pertussis antigens in serum specimens obtained from 1793 adolescents and adultsJames D Cherry
University of CaliforniaLos Angeles Center for Vaccine Research, Research and Education Institute, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, USA
Clin Infect Dis 39:1715-8. 2004..There was minimal variation in antibody prevalence with respect to geographic area, age, sex, or race...
- Efficacy of an acellular pertussis vaccine among adolescents and adultsJoel I Ward
UCLA Center for Vaccine Research, Research and Education Institute, Harbor UCLA Medical Center, David Geffen School of Medicine, UCLA, Torrance, Calif 90502, USA
N Engl J Med 353:1555-63. 2005..This trial of an acellular pertussis vaccine among adolescents and adults evaluated the incidence of pertussis, vaccine safety, immunogenicity, and protective efficacy...