Research Topics
| John J TreanorSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Evaluation of a single dose of half strength inactivated influenza vaccine in healthy adultsJohn Treanor
Infectious Diseases Unit, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Vaccine 20:1099-105. 2002..These results suggest that when vaccine is in short supply, a strategy using a half dose in healthy adults could increase the number of people vaccinated with relatively little adverse impact on vaccine immunogenicity...- Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strainsJohn J Treanor
Department of Medicine, University of Rochester Medical Center, NY, USA
Clin Infect Dis 55:951-9. 2012..We conducted an assessment of the effectiveness of US influenza vaccines during the 2010-2011 season... 
Safety, efficacy, and immunogenicity of an inactivated influenza vaccine in healthy adults: a randomized, placebo-controlled trial over two influenza seasonsLisa A Jackson
Group Health Research Institute, Seattle, Washington, USA
BMC Infect Dis 10:71. 2010..The aim of this study was to assess the efficacy, safety, reactogenicity, and immunogenicity of a trivalent inactivated split virion influenza vaccine (TIV) in healthy adults over two influenza seasons in the US...- Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B virusesJ J Treanor
Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, USA
Vaccine 18:899-906. 1999..These results are consistent with those of previous studies using monovalent preparations of cold-adapted influenza vaccine in this model, and indicate that CAIV-T will be an effective means to prevent influenza illness in adults... - Dose-related safety and immunogenicity of a trivalent baculovirus-expressed influenza-virus hemagglutinin vaccine in elderly adultsJohn J Treanor
Infectious Disease Division, University of Rochester, Rochester, New York 14642, USA
J Infect Dis 193:1223-8. 2006..Influenza-virus hemagglutinin (HA) protein expressed in insect cells by recombinant baculovirus is a candidate influenza vaccine... - Rapid licensure of a new, inactivated influenza vaccine in the United StatesJohn J Treanor
University of Rochester, Rochester, New York 14642, USA
Hum Vaccin 1:239-44. 2005..We evaluated a split virus TIV (Fluarix, GSK), to generate data supportive of a license application in the US... - Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trialJohn J Treanor
University of Rochester, Rochester, NY, USA
JAMA 297:1577-82. 2007..A high priority in vaccine research is the development of influenza vaccines that do not use embryonated eggs as the substrate for vaccine production... - Immune correlates of protection against influenza in the human challenge modelJ Treanor
Infectious Diseases Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Biol (Basel) 115:97-104. 2003..Use of a consistent method for assessing mucosal IgA between studies may help to derive a target level for vaccination... - Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccineJohn J Treanor
Department of Medicine, University of Rochester, Rochester, NY, USA
N Engl J Med 354:1343-51. 2006..Influenza A (H5N1) viruses could cause a severe worldwide epidemic, with high attack rates, large numbers of deaths and hospitalizations, and wide disruption. Effective vaccines against these viruses in humans are urgently needed... 
Recombinant proteins produced in insect cellsJohn Treanor
Infectious Diseases Division, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Curr Top Microbiol Immunol 333:211-25. 2009..Recombinant approaches may be extremely valuable in combating future pandemics and further studies of recombinant pandemic vaccines in humans are needed...- Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humansJ J Treanor
Infectious Diseases Unit, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Vaccine 19:1732-7. 2001..These results suggest that baculovirus-expressed H5 HA can induce functional antibody in individuals who have not had prior exposure to H5 viruses, but that further studies to improve the immunogenicity of the vaccine are needed... - Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study GroupJ J Treanor
Infectious Diseases Unit, University of Rochester, NY 14642, USA
JAMA 283:1016-24. 2000..Previous studies have shown oseltamivir, a neuraminidase inhibitor, to be effective in preventing influenza and treating experimental influenza... - Respiratory viral infections in the elderlyJ Treanor
Infectious Disease Unit, University of Rochester School of Medicine, NY 14642, USA
Antiviral Res 44:79-102. 1999..Understanding of the immunology and pathogenesis of these infections in elderly adults is in its infancy, and considerable additional work will need to be performed towards development of effective control measures... - Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systemsFelix W Santiago
New York Influenza Center of Excellence, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 609, Rochester, NY 14642, USA felix
Vaccine 30:4606-16. 2012..Marked differences in the behavior of the individual proteins was evident suggesting that they are not equal when being used to detect an immune response. They were, nevertheless, similar at eliciting neutralizing antibody responses... - Experimental infection of humans with A2 respiratory syncytial virusF Eun-Hyung Lee
Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, USA
Antiviral Res 63:191-6. 2004..This model provides a safe and efficient mechanism for proof-of-concept studies of anti-viral agents and RSV vaccines, as well as for investigation of immune responses to infection... - Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variantNega Ali Goji
University of Rochester Medical Center, Rochester, New York 14642, USA
J Infect Dis 198:635-41. 2008..We administered a single dose of influenza A/Vietnam/1203/2004 (H5N1, clade 1) vaccine to subjects who had received 2 doses of influenza A/Hong Kong/156/1997 (H5N1, clade 0) vaccine in 1998... - Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virusFelix W Santiago
New York Influenza Center of Excellence, University of Rochester Medical Center, Rochester, NY, USA
Vaccine 29:8888-97. 2011..These findings suggest that pre-vaccination against H5 influenza has the potential to prime immunity against emerging drifted H5 strains, and could also lower the dose requirements of vaccination in the event of a pandemic... - Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: a randomized, placebo-controlled trialJohn J Treanor
University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA john
Vaccine 29:7733-9. 2011..We conducted this study to determine the protective efficacy a recombinant, baculovirus-expressed seasonal trivalent influenza virus hemagglutinin (rHA0) vaccine (FluBlok(®))... - Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adultsJohn J Treanor
University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, Box 689, Rochester, NY 14642, USA
Vaccine 28:8268-74. 2010..We evaluated a novel influenza vaccine consisting of the globular head of the HA1 domain of the A/Solomon Islands/3/2006 (H1N1) influenza virus (VAX125) genetically fused to the TLR5 ligand, flagellin, and produced in E. coli... - Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and olderAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY, USA
J Infect Dis 200:172-80. 2009..To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed... - Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
University of Rochester, Rochester, NY, USA
J Pediatr 155:495-9. 2009..We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born at > or =32 and <37 weeks of gestation and with birth weight > or =2000 but <3000 g... - Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccineXiao Song He
Department of Medicine, Stanford University School of Medicine, Stanford, USA
J Infect Dis 207:288-96. 2013.... - Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive studyMichael E Pichichero
Department of Microbiology Immunology, University of Rochester, Rochester, New York, NY, USA
Lancet 360:1737-41. 2002..We aimed to measure concentrations of mercury in blood, urine, and stools of infants who received such vaccines... - Mercury levels in newborns and infants after receipt of thimerosal-containing vaccinesMichael E Pichichero
Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
Pediatrics 121:e208-14. 2008..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines... - Psychosocial factors and the response to influenza vaccination in older adultsJan A Moynihan
Department of Psychiatry, University of Rochester Medical Center, Box PSYCH, 300 Crittenden Blvd, Rochester, NY 14642, USA
Psychosom Med 66:950-3. 2004..We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine... - Intranasal administration of a proteosome-influenza vaccine is well-tolerated and induces serum and nasal secretion influenza antibodies in healthy human subjectsJohn Treanor
Infectious Diseases Unit, University of Rochester School of Medicine, 601 Elmwood Avenue, Room 3 6308, Rochester, NY 14642 0001, USA
Vaccine 24:254-62. 2006..Further evaluation of mucosal influenza immunization using the proteosome adjuvant/delivery system is clearly warranted... - Pandemic (avian) influenzaSumanth Rajagopal
Department of Medicine, Infectious Diseases Division, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Semin Respir Crit Care Med 28:159-70. 2007..g., adamantanes and neuraminidase inhibitors)... - CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza virusesKristin Scheible
New York Influenza Center of Excellence, David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 29:2159-68. 2011.... - Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunizationJessica L Halliley
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 28:3582-7. 2010..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored... - Fever and progressive respiratory failure in three elderly family membersF Eun-Hyung Lee
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
Chest 128:1863-4, 1865-7. 2005 - Label-free, arrayed sensing of immune response to influenza antigensCharles R Mace
Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
Talanta 83:1000-5. 2011.... - Influenza vaccine--outmaneuvering antigenic shift and driftJohn Treanor
Infectious Diseases Unit, University of Rochester Medical Center, Rochester, NY, USA
N Engl J Med 350:218-20. 2004 - Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adultsJohn Treanor
Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 24:6913-23. 2006..This suggests that local immune events in the tissue are distinct from the parameters measured in the peripheral blood... - B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variantJane Baer
David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology and Immunology, Rochester, NY, USA
Vaccine 28:907-15. 2010..These observations suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains... - CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccineJennifer L Nayak
Department of Pediatrics, Department of Pediatrics, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY 14642, USA
J Infect Dis 207:297-305. 2013.... - Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factorJames J Kobie
Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA
Arthritis Res Ther 13:R209. 2011..Therefore, we asked if short-term effector (d5-d10) and memory (1 month or later) B cell responses to antigen were compromised in RA patients treated with anti-TNF therapy... - Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infectionMatthew P Bernard
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Vaccine 28:1363-72. 2010..These new findings support an essential role for Cox-2 in regulating humoral immunity... - Clinical responses to undiluted and diluted smallpox vaccineSharon E Frey
Department of Medicine, National Institute of Allergy and Infectious Diseases Vaccine and Treatment Evaluation Unit, Saint Louis University School of Medicine, St. Louis, USA
N Engl J Med 346:1265-74. 2002..0) pfu per milliliter (approximately 10,000 pfu per dose) and induce local viral replication and vesicle formation in more than 97 percent of persons... - Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus sheddingAnn R Falsey
Department of Medicine Infectious Disease Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Clin Microbiol 41:4160-5. 2003..Quantitative RT-PCR has an excellent correlation with viral titers, as measured by culture, and should be a useful tool for future studies addressing viral load and disease pathogenesis... - Weathering the influenza vaccine crisisJohn Treanor
Infectious Diseases Unit, University of Rochester Medical Center, Rochester, NY, USA
N Engl J Med 351:2037-40. 2004 - Simulation and prediction of the adaptive immune response to influenza A virus infectionHa Youn Lee
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York 14642, USA
J Virol 83:7151-65. 2009..We further compared alternative model structures, for example, B-cell activation directly by the virus versus that through professional antigen-presenting cells or dendritic cell licensing of CD8 T cells... - Recovery of drug-resistant influenza virus from immunocompromised patients: a case seriesMichael G Ison
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
J Infect Dis 193:760-4. 2006..We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir... 
Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humansMatthew R Sandbulte
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
PLoS Med 4:e59. 2007..We hypothesized that an immune response to huN1 could mediate cross-protection against H5N1 influenza virus infection...- Dose-dependent neutralizing-antibody responses to vacciniaRobert B Belshe
Center for Vaccine Development, Saint Louis University School of Medicine, St Louis, Missouri 63110, USA
J Infect Dis 189:493-7. 2004..Larger lesion size and fever after vaccination were associated with significantly higher neutralizing-antibody titers after vaccination... - Evaluation of the safety and immunogenicity of a booster (third) dose of inactivated subvirion H5N1 influenza vaccine in humansKenneth M Zangwill
University of California, Los Angeles, CA, USA
J Infect Dis 197:580-3. 2008..5-mug-dose groups had a MN GMT > or =1:40, respectively. Five months later, MN GMTs were significantly greater than those after the second dose. (Trial registration: Clinical Trials.gov identifier NCT00240968 .)... - Infection-induced proinflammatory cytokines are associated with decreases in positive affect, but not increases in negative affectDenise Janicki-Deverts
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA
Brain Behav Immun 21:301-7. 2007..There were no associations between cytokines and negative affect. Findings support a causal association between pathogen-induced local cytokine production and changes in positive affect over a 24-h timeline... - Positive emotional style predicts resistance to illness after experimental exposure to rhinovirus or influenza a virusSheldon Cohen
Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213 3890
Psychosom Med 68:809-15. 2006..This work did not control for social and cognitive factors closely associated with PES. We replicate the original study using a different virus and controls for these alternative explanations... - Vaccines for seasonal and pandemic influenzaKristin L Nichol
University of Minnesota and Minneapolis VA Medical Center, Minneapolis, MN, USA
J Infect Dis 194:S111-8. 2006..Additional experimental approaches are required to achieve the ultimate goal for seasonal and pandemic influenza prevention--namely, the ability to generate broadly cross-reactive and durable protection in humans... - Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body?Gregory E Miller
Department of Psychology, University of British Columbia, Vancouver, Canada
Psychosom Med 66:215-23. 2004.... - Objective and subjective socioeconomic status and susceptibility to the common coldSheldon Cohen
Department of Psychology, Carnegie Mellon University, Department of Otolaryngology, Pittsburgh s Children s Hospital, Pittsburgh, PA 15213, USA
Health Psychol 27:268-74. 2008..We ask whether subjective socioeconomic status (SES) predicts who develops a common cold when exposed to a cold virus... - Loneliness, social network size, and immune response to influenza vaccination in college freshmenSarah D Pressman
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Health Psychol 24:297-306. 2005..None of these variables were associated with social network size, and hence none were potential mediators of the relation between network size and immunization response...