GABRIEL TRAVIS

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies
    Tam V Bui
    Sytera, Inc, 505 Coast Boulevard South, La Jolla, CA 92037, USA
    J Biol Chem 281:18112-9. 2006
  2. pmc Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina
    Joanna J Kaylor
    Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California, USA
    Nat Chem Biol 9:30-6. 2013
  3. pmc Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents
    Gabriel H Travis
    Department of Ophthalmology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Annu Rev Pharmacol Toxicol 47:469-512. 2007
  4. ncbi request reprint Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases
    Roxana A Radu
    Jules Stein Eye Institute, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 46:4393-401. 2005
  5. pmc Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation
    Roxana A Radu
    Department of Ophthalmology, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 49:3821-9. 2008
  6. pmc Analysis of the retinoid isomerase activities in the retinal pigment epithelium and retina
    Gabriel H Travis
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Methods Mol Biol 652:329-39. 2010
  7. pmc The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors
    Minghao Jin
    Department of Ophthalmology, Neuroscience Center, Louisiana State University School of Medicine, New Orleans, Louisiana 70112, USA
    J Neurosci 29:1486-95. 2009
  8. pmc Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight
    Nathan L Mata
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuron 36:69-80. 2002
  9. ncbi request reprint Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells
    Nathan L Mata
    Jules Stein Eye Institute, University of California School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 279:635-43. 2004
  10. pmc Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
    Roxana A Radu
    Jules Stein Eye Institute and Department of Biological Chemistry, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:4742-7. 2003

Collaborators

  • Dean Bok
  • Steven Nusinowitz
  • Krzysztof Palczewski
  • Roxana A Radu
  • Nathan L Mata
  • Tam V Bui
  • Joanna J Kaylor
  • Quan Yuan
  • Minghao Jin
  • Marcia Lloyd
  • Jane Hu
  • Yun Han
  • Paul Kim
  • Jacob Makshanoff
  • Shanta Sarfare
  • Anita Kim
  • Jeremy Cook
  • Tongzhou Xu
  • Anh Miu
  • C Nathaniel Roybal
  • Samer Habib
  • Songhua Li
  • Jennifer H Peng
  • Alberto Ruiz
  • Ken Widder
  • Jay Lichter
  • Walid N Moghrabi
  • Jung S Lee
  • Joseph Horwitz
  • Paul A Sieving
  • Xinran Liu
  • Richard C Clemmons

Detail Information

Publications11

  1. ncbi request reprint Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies
    Tam V Bui
    Sytera, Inc, 505 Coast Boulevard South, La Jolla, CA 92037, USA
    J Biol Chem 281:18112-9. 2006
    ..Fluorescence properties of A2PE-H(2) and other related fluorophores characterized in this report have significance for evaluation of human retinal diseases characterized by aberrant fundus autofluorescence...
  2. pmc Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina
    Joanna J Kaylor
    Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California, USA
    Nat Chem Biol 9:30-6. 2013
    ..Purified DES1 had very high isomerase-2 activity in the presence of appropriate cofactors, suggesting that DES1 by itself is sufficient for isomerase activity...
  3. pmc Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents
    Gabriel H Travis
    Department of Ophthalmology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Annu Rev Pharmacol Toxicol 47:469-512. 2007
    ..Recent progress in both areas provides hope that multiple inherited retinal diseases will soon be treated by pharmaceutical intervention...
  4. ncbi request reprint Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases
    Roxana A Radu
    Jules Stein Eye Institute, University of California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 46:4393-401. 2005
    ..Here, we used an animal model that manifests accelerated lipofuscin accumulation (ABCA4-/- mutant) to evaluate the efficacy of a therapeutic approach based on reduction of serum retinol...
  5. pmc Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation
    Roxana A Radu
    Department of Ophthalmology, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 49:3821-9. 2008
    ..Here the authors tested the hypothesis that dietary supplementation with vitamin A may accelerate lipofuscin pigment formation in abca4(-/-) mice...
  6. pmc Analysis of the retinoid isomerase activities in the retinal pigment epithelium and retina
    Gabriel H Travis
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Methods Mol Biol 652:329-39. 2010
    ..Isomerase-2 appears to be present in Müller cells but has not yet been identified. Methods are provided in this chapter for assaying isomerase-2 in chicken retina homogenates...
  7. pmc The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors
    Minghao Jin
    Department of Ophthalmology, Neuroscience Center, Louisiana State University School of Medicine, New Orleans, Louisiana 70112, USA
    J Neurosci 29:1486-95. 2009
    ....
  8. pmc Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight
    Nathan L Mata
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuron 36:69-80. 2002
    ..Together these activities comprise a novel pathway that regenerates opsin photopigments at a rate 20-fold faster than the known visual cycle. We suggest that this pathway is responsible for sustained daylight vision in vertebrates...
  9. ncbi request reprint Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells
    Nathan L Mata
    Jules Stein Eye Institute, University of California School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 279:635-43. 2004
    ..These observations suggest that Rpe65 presents retinyl esters as substrate to the isomerase for synthesis of visual chromophore. This proposed function explains the phenotype in mice and humans lacking Rpe65...
  10. pmc Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
    Roxana A Radu
    Jules Stein Eye Institute and Department of Biological Chemistry, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:4742-7. 2003
    ..Finally, the results suggest that isotretinoin may be an effective treatment for other forms of retinal or macular degeneration associated with lipofuscin accumulation...
  11. pmc Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol
    Nathan L Mata
    Sytera, Inc, La Jolla, California 92037, USA
    Biochemistry 44:11715-21. 2005
    ..Kinetic analysis of these two activities suggests that they act in concert to drive the formation of 11-cis-retinoids in chicken retinas. These activities may be part of a new visual cycle for the regeneration of chromophores in cones...

Research Grants22

  1. The Role of Muller Cells in Visual Pigment Regeneration
    Gabriel H Travis; Fiscal Year: 2010
    ..This project is to study the biochemical mechanisms of visual-pigment regeneration. Defects in pigment regeneration cause inherited blinding diseases. The project will help us understand how these genetic diseases arise. ..
  2. The Role of Muller Cells in Visual Pigment Regeneration
    GABRIEL TRAVIS; Fiscal Year: 2009
    ..This project is to study the biochemical mechanisms of visual-pigment regeneration. Defects in pigment regeneration cause inherited blinding diseases. The project will help us understand how these genetic diseases arise. ..
  3. Biochemical and Genetic Analysis of the Visual Cycle
    GABRIEL TRAVIS; Fiscal Year: 2006
    ....
  4. REGENERATION OF CONE PIGMENTS & TREATMENT OF STARGARDT'S
    GABRIEL TRAVIS; Fiscal Year: 2006
    ..If successful, this strategy should lead to the initiation of clinical trials on patients with active Stargardt's disease. ..
  5. REGENERATION OF CONE PIGMENTS & TREATMENT OF STARGARDT'S
    GABRIEL TRAVIS; Fiscal Year: 2004
    ..If successful, this strategy should lead to the initiation of clinical trials on patients with active Stargardt's disease. ..
  6. REGENERATION OF CONE PIGMENTS & TREATMENT OF STARGARDT'S
    GABRIEL TRAVIS; Fiscal Year: 2003
    ..If successful, this strategy should lead to the initiation of clinical trials on patients with active Stargardt's disease. ..
  7. FUNCTIONAL ANALYSIS OF THE PHOTORECEPTOR RIM PROTEIN
    GABRIEL TRAVIS; Fiscal Year: 2000
    ..phosphorylation? (h) what is the phenotype that results from absence of the rim protein in developing and mature outer segments? and (i) are any of the human inherited retinal dystrophies caused by mutations in the rim protein gene? ..
  8. FUNCTIONAL ANALYSIS OF THE PHOTORECEPTOR RIM PROTEIN
    GABRIEL TRAVIS; Fiscal Year: 2001
    ..phosphorylation? (h) what is the phenotype that results from absence of the rim protein in developing and mature outer segments? and (i) are any of the human inherited retinal dystrophies caused by mutations in the rim protein gene? ..
  9. Biochemical and Genetic Analysis of the Visual Cycle
    GABRIEL TRAVIS; Fiscal Year: 2009
    ....
  10. FUNCTIONAL ANALYSIS OF THE PHOTORECEPTOR RIM PROTEIN
    GABRIEL TRAVIS; Fiscal Year: 1999
    ..phosphorylation? (h) what is the phenotype that results from absence of the rim protein in developing and mature outer segments? and (i) are any of the human inherited retinal dystrophies caused by mutations in the rim protein gene? ..
  11. Biochemical and Genetic Analysis of the Visual Cycle
    GABRIEL TRAVIS; Fiscal Year: 2007
    ....
  12. FUNCTIONAL ANALYSIS OF THE PHOTORECEPTOR RIM PROTEIN
    GABRIEL TRAVIS; Fiscal Year: 2001
    ..phosphorylation? (h) what is the phenotype that results from absence of the rim protein in developing and mature outer segments? and (i) are any of the human inherited retinal dystrophies caused by mutations in the rim protein gene? ..
  13. Biochemical and Genetic Analysis of the Visual Cycle
    GABRIEL TRAVIS; Fiscal Year: 2005
    ....
  14. REGENERATION OF CONE PIGMENTS & TREATMENT OF STARGARDT'S
    GABRIEL TRAVIS; Fiscal Year: 2005
    ..If successful, this strategy should lead to the initiation of clinical trials on patients with active Stargardt's disease. ..
  15. FUNCTION /INTERACTION OF RDS/PERIPHERIN IN PHOTORECEPTOR
    GABRIEL TRAVIS; Fiscal Year: 2001
    ..Further, valuable tools will have been created to study the biochemical etiologies of human retinal dystrophies caused by mutations in the RDS gene. ..
  16. REGENERATION OF CONE PIGMENTS & TREATMENT OF STARGARDT'S
    GABRIEL TRAVIS; Fiscal Year: 2002
    ..If successful, this strategy should lead to the initiation of clinical trials on patients with active Stargardt's disease. ..
  17. FUNCTION /INTERACTION OF RDS/PERIPHERIN IN PHOTORECEPTOR
    GABRIEL TRAVIS; Fiscal Year: 2003
    ..Further, valuable tools will have been created to study the biochemical etiologies of human retinal dystrophies caused by mutations in the RDS gene. ..
  18. FUNCTION /INTERACTION OF RDS/PERIPHERIN IN PHOTORECEPTOR
    GABRIEL TRAVIS; Fiscal Year: 2002
    ..Further, valuable tools will have been created to study the biochemical etiologies of human retinal dystrophies caused by mutations in the RDS gene. ..