Jay H Traverse
Affiliation: University of Minnesota
- Is the measurement of left ventricular ejection fraction the proper end point for cell therapy trials? An analysis of the effect of bone marrow mononuclear stem cell administration on left ventricular ejection fraction after ST-segment elevation myocardiaJay H Traverse
The Minneapolis Heart Institute at Abbott Northwestern Hospital, MN 55407, USA
Am Heart J 162:671-7. 2011....
- Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarctionJay H Traverse
Minneapolis Heart Institute, Abbott Northwestern Hospital, MN 55407, USA
Am Heart J 160:428-34. 2010..However, results from trials performed in the United States have not yet been presented...
- Cell therapy for acute myocardial infarction--where do we go from here?Jay H Traverse
Cardiovascular Division, Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, University of Minnesota Medical School, Minneapolis, MN, USA
J Cardiovasc Transl Res 1:64-70. 2008..We believe that future cell therapy trials should attempt to incorporate these important issues in designing upcoming clinical trials in order for the field to move forward...
- Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarctionJay H Traverse
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN University of Minnesota School of Medicine, Minneapolis, MN 55407, USA
Am Heart J 158:356-63. 2009..This study will provide further insight into the clinical feasibility and appropriate timing of autologous BMMNC therapy in high-risk patients after AMI and percutaneous coronary intervention...
- Using biomaterials to improve the efficacy of cell therapy following acute myocardial infarctionJay H Traverse
Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, MN 55407, USA
J Cardiovasc Transl Res 5:67-72. 2012..This review discusses the potential use of biologically based ECM surrogates in the clinical setting following STEMI...
- Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failureJay H Traverse
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Circ Res 100:1643-9. 2007..These findings demonstrate that coronary K(+)(ATP) channel activity contribute to the regulation of resting MBF in CHF, and that endogenous adenosine may act to inhibit MVO(2) in the failing heart...
- Measurement of myocardial free radical production during exercise using EPR spectroscopyJay H Traverse
Cardiovascular Division, University of Minnesota Medical School, Mayo Mail Code 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Am J Physiol Heart Circ Physiol 290:H2453-8. 2006..Thus, in contrast to skeletal muscle, submaximal treadmill exercise did not result in detectable free radical production by the heart...
- Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing heartsYingjie Chen
Department of Medicine, Univ of Minnesota Medical School, Minneapolis, MN 55455, USA
Am J Physiol Heart Circ Physiol 289:H2212-9. 2005..Decreased DDAH activity and DDAH-2 protein expression may cause accumulation of endogenous inhibitors of endothelial NOS, thereby contributing to endothelial dysfunction in the failing heart...
- Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heartYingjie Chen
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
Am J Physiol Heart Circ Physiol 288:H133-41. 2005..Cytosolic Cu/Zn-containing SOD was unchanged. Both increased O(2)(-). production and decreased vascular O(2)(-). scavenging ability by EC-SOD could have contributed to endothelial dysfunction in the failing hearts...
- Nitric oxide modulates myocardial oxygen consumption in the failing heartYingjie Chen
Department of Medicine, Division of Cardiology, University of Minnesota Medical School, Minneapolis 55455, USA
Circulation 106:273-9. 2002..CONCLUSIONS: The results indicate that endogenous NO can modulate MVO2 in failing hearts, but unlike the normal heart, this NO appears to be produced, at least in part, by iNOS...
- Effect of PDE5 inhibition on coronary hemodynamics in pacing-induced heart failureYingjie Chen
Department of Medicine, Division of Cardiology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Am J Physiol Heart Circ Physiol 284:H1513-20. 2003..Furthermore, Western blotting showed decreased PDE5 protein expression in myocardium from failing hearts. These findings demonstrate that PDE5 contributes little to regulation of coronary hemodynamics in CHF...
- Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trialJay H Traverse
Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, Minnesota, USA
JAMA 308:2380-9. 2012....
- Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failureJay H Traverse
Division of Cardiology, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
Am J Physiol Heart Circ Physiol 282:H2278-83. 2002..05). Although L-NNA significantly increased LV systolic pressure, similar increases in pressure produced by phenylephrine did not increase MVO(2). The findings suggest that NO exerts tonic inhibition on respiration in the failing heart...
- Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trialJay H Traverse
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota, USA
JAMA 306:2110-9. 2011..However, because a substantial number of patients may not present for early cell delivery, the efficacy of autologous BMC delivery 2 to 3 weeks post-MI warrants investigation...
- Long-term follow-up of patients undergoing postconditioning during ST-elevation myocardial infarctionSantiago Garcia
Minneapolis VA Medical Center, Minneapolis, MN, USA
J Cardiovasc Transl Res 4:92-8. 2011..The beneficial effects of postconditioning on cardiac function persist beyond 3 years...
- A regional system to provide timely access to percutaneous coronary intervention for ST-elevation myocardial infarctionTimothy D Henry
Minneapolis Heart Institute Foundation, 920 E 28th St, Ste 40, Minneapolis, MN 55407, USA
Circulation 116:721-8. 2007..In the United States, transfer times are consistently long; therefore, many believe a transfer for PCI strategy for STEMI is not practical...
- ET-A receptor activity restrains coronary blood flow in the failing heartMingxiao Hou
Department of Medicine, University of Minnesota Health Sciences Center, Minneapolis, USA
J Cardiovasc Pharmacol 43:764-9. 2004..Thus, although ET-A receptor blockade caused a modest increase in coronary flow, this did not result in an increase of MVO2, implying that ET-A-mediated coronary vasoconstriction did not limit oxygen uptake by the failing heart...
- Oxidative stress regulates left ventricular PDE5 expression in the failing heartZhongbing Lu
Cardiovascular Division, University of Minnesota, Minneapolis, MN 55455, USA
Circulation 121:1474-83. 2010..The purpose of this study is to test the hypothesis that oxidative stress causes increased PDE5 expression in cardiac myocytes and that increased PDE5 contributes to the development of CHF...
- Circadian dependence of infarct size and left ventricular function after ST elevation myocardial infarctionRonald Reiter
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN 55407, USA
Circ Res 110:105-10. 2012..In rodents, infarct size after ischemia/reperfusion exhibits a circadian dependence on the time of coronary occlusion. It is not known if a similar circadian dependence of infarct size occurs in humans...
- Comparison of safety and efficacy of sirolimus-eluting stents versus bare metal stents in patients with ST-segment elevation myocardial infarctionMarc C Newell
Department of Internal Medicine, Abbott Northwestern Hospital, Minneapolis, USA
Am J Cardiol 97:1299-302. 2006..01) and the need for target vessel revascularization (p = 0.02). In conclusion, SESs are safe and effective in STEMI at 6 months...
- Patients with coronary artery disease not amenable to traditional revascularization: prevalence and 3-year mortalityBenjamin Williams
Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota 55407, USA
Catheter Cardiovasc Interv 75:886-91. 2010..To determine the contemporary prevalence of and mortality in patients with coronary artery disease (CAD) not amenable to revascularization...
- A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarctionJoshua M Hare
Department of Medicine, Cardiovascular Division and the Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
J Am Coll Cardiol 54:2277-86. 2009..Our aim was to investigate the safety and efficacy of intravenous allogeneic human mesenchymal stem cells (hMSCs) in patients with myocardial infarction (MI)...
- Clinical, angiographic, and interventional follow-up of patients with aortic-saphenous vein graft connectorsJay H Traverse
Minneapolis Cardiology Associates, Minneapolis Heart Institute at Abbott Northwestern Hospital, 920 East 28th Street, Suite 300, Minneapolis, Minn 55407, USA
Circulation 108:452-6. 2003....
- Preinfarction angina reduces infarct size in ST-elevation myocardial infarction treated with percutaneous coronary interventionRonald Reiter
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN 55407, USA
Circ Cardiovasc Interv 6:52-8. 2013..However, the benefits of preinfarction angina in the setting of primary percutaneous coronary intervention with stenting is inconclusive because of the greater achievement of infarct artery patency and speed of reperfusion...
- Emerging therapies for refractory anginaDaniel Satran
Division of Cardiovascular Disease, Minneapolis Heart Institute Foundation Abbott Northwestern Hospital, University of Minnesota, USA
Minn Med 91:36-9. 2008....
- Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trialDouglas W Losordo
Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital, Chicago, IL 60611, USA
Circulation 115:3165-72. 2007..Preclinical studies have indicated that human CD34+ stem cells induce neovascularization in ischemic myocardium, which enhances perfusion and function...
- CPCs as treatment for chronic total coronary artery occlusionsJay H Traverse
Circ Res 98:e1. 2006
- The anticoagulant therapy with bivalirudin to assist in the performance of percutaneous coronary intervention in patients with heparin-induced thrombocytopenia (ATBAT) study: main resultsKenneth W Mahaffey
Duke Clinical Research Institute, Durham, NC 27715, USA
J Invasive Cardiol 15:611-6. 2003..Bivalirudin appeared safe and provided effective anticoagulation during PCI. These data, and extensive experience with bivalirudin in PCI, support its use in high-risk patients with HIT requiring PCI...