Dirk Trauner

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Total synthesis of (-)-heptemerone B and (-)-guanacastepene E
    Aubry K Miller
    Department of Chemistry, University of California Berkeley, Berkeley, CA 94720 1460, USA
    J Am Chem Soc 128:17057-62. 2006
  2. ncbi request reprint Potassium channels: symmetric, selective, and sensitive
    Dirk Trauner
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
    Angew Chem Int Ed Engl 42:5671-5. 2003
  3. ncbi request reprint Metabolic modulation of potassium channels
    Dirk Trauner
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
    Sci STKE 2004:pe22. 2004
  4. pmc Protein surface recognition by rational design: nanomolar ligands for potassium channels
    Stefan N Gradl
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 1460, USA
    J Am Chem Soc 125:12668-9. 2003
  5. pmc Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR
    Rika Numano
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:6814-9. 2009
  6. pmc A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
    Harald Janovjak
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA
    Nat Neurosci 13:1027-32. 2010
  7. pmc Photochemical control of endogenous ion channels and cellular excitability
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California Berkeley, 121 Life Sciences Addition, Berkeley, California 94720, USA
    Nat Methods 5:331-8. 2008
  8. pmc Tuning photochromic ion channel blockers
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    ACS Chem Neurosci 2:536-43. 2011
  9. pmc Optogenetic photochemical control of designer K+ channels in mammalian neurons
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurophysiol 106:488-96. 2011
  10. ncbi request reprint Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 129:260-1. 2007

Research Grants

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Total synthesis of (-)-heptemerone B and (-)-guanacastepene E
    Aubry K Miller
    Department of Chemistry, University of California Berkeley, Berkeley, CA 94720 1460, USA
    J Am Chem Soc 128:17057-62. 2006
    ..The absolute configuration of the two key building blocks was established through an asymmetric reduction and an asymmetric ene reaction...
  2. ncbi request reprint Potassium channels: symmetric, selective, and sensitive
    Dirk Trauner
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
    Angew Chem Int Ed Engl 42:5671-5. 2003
  3. ncbi request reprint Metabolic modulation of potassium channels
    Dirk Trauner
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
    Sci STKE 2004:pe22. 2004
    ..Although the exact function of the beta subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism...
  4. pmc Protein surface recognition by rational design: nanomolar ligands for potassium channels
    Stefan N Gradl
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 1460, USA
    J Am Chem Soc 125:12668-9. 2003
    ..The rational design and development of four-fold symmetrical ligands for potassium channels is described...
  5. pmc Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR
    Rika Numano
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:6814-9. 2009
    ..The ability to generate opposite responses with a single PTL and 2 versions of a target channel, which can be expressed in different cell types, paves the way for engineering opponency in neurons that mediate opposing functions...
  6. pmc A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
    Harald Janovjak
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA
    Nat Neurosci 13:1027-32. 2010
    ..After optical activation, the photocurrent and optical silencing of activity persists in the dark for extended periods. The low light requirement and bi-stability of HyLighter represent advantages for the dissection of neural circuitry...
  7. pmc Photochemical control of endogenous ion channels and cellular excitability
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California Berkeley, 121 Life Sciences Addition, Berkeley, California 94720, USA
    Nat Methods 5:331-8. 2008
    ....
  8. pmc Tuning photochromic ion channel blockers
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    ACS Chem Neurosci 2:536-43. 2011
    ..Photochromic blockers of this type could be useful for the photopharmacological control of neuronal activity under mild conditions...
  9. pmc Optogenetic photochemical control of designer K+ channels in mammalian neurons
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurophysiol 106:488-96. 2011
    ..These light-regulated channels may be overexpressed in genetically targeted neurons or substituted for native channels with gene knockin technology to enable precise optopharmacological manipulation of channel function...
  10. ncbi request reprint Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 129:260-1. 2007
  11. pmc Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor
    Pau Gorostiza
    Department of Molecular and Cell Biology, College of Chemistry, and Biophysics Graduate Program, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:10865-70. 2007
    ..The system provides rapid, reversible remote control of protein function that is selective without orthogonal chemistry...
  12. doi request reprint Theoretical investigation of the rubicordifolin cascade
    Jean Philip Lumb
    Department of Chemistry, University of California, Berkeley, California 94720, United States
    Org Lett 12:5162-5. 2010
    ....
  13. doi request reprint Rapid optical control of nociception with an ion-channel photoswitch
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    Nat Methods 9:396-402. 2012
    ..Because intracellular QAQ accumulation is a consequence of nociceptive ion-channel activity, QAQ-mediated photosensitization is a platform for understanding signaling mechanisms in acute and chronic pain...
  14. pmc Optogenetic dissection of a behavioural module in the vertebrate spinal cord
    Claire Wyart
    Helen Wills Neuroscience Institute and Department of Molecular and Cell Biology, University of California in Berkeley, Berkeley, California 94720, USA
    Nature 461:407-10. 2009
    ..Our results reveal that during early development in zebrafish these cells provide a positive drive to the spinal CPG for spontaneous locomotion...
  15. ncbi request reprint Remote control of neuronal activity with a light-gated glutamate receptor
    Stephanie Szobota
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 54:535-45. 2007
    ..Our studies show that LiGluR provides robust control over neuronal activity, enabling the dissection and manipulation of neural circuitry in vivo...
  16. ncbi request reprint Light-induced depolarization of neurons using a modified Shaker K(+) channel and a molecular photoswitch
    James J Chambers
    Department of Molecular and Cell Biology, University of California, Berkley, CA 94720, USA
    J Neurophysiol 96:2792-6. 2006
    ..Hence, hyper- and depolarizing SPARK channels provide a means for eliciting opposite effects on neurons in response to the same light stimulus...
  17. doi request reprint Biomimetic synthesis of the IDO inhibitors exiguamine A and B
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Chem Biol 4:535-7. 2008
    ..The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3-dioxygenase inhibitors...
  18. doi request reprint Total synthesis of (+/-)-rhazinal using novel palladium-catalyzed cyclizations
    Alfred L Bowie
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Org Chem 74:1581-6. 2009
    ..An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described...
  19. ncbi request reprint All optical interface for parallel, remote, and spatiotemporal control of neuronal activity
    Sheng Wang
    NSF Nanoscale Science and Engineering Center NSEC, University of California, Berkeley, CA 94720 1740, USA
    Nano Lett 7:3859-63. 2007
    ..This technique should be adaptable to in vivo applications and could serve as an optical interface for communicating with complex neural circuits...
  20. pmc Regulating enzymatic activity with a photoswitchable affinity label
    Jessica H Harvey
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Chembiochem 9:191-3. 2008
  21. pmc Photochemical restoration of visual responses in blind mice
    Aleksandra Polosukhina
    Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 75:271-82. 2012
    ..AAQ and related photoswitch molecules present a potential drug strategy for restoring retinal function in degenerative blinding diseases...
  22. pmc New photochemical tools for controlling neuronal activity
    Richard H Kramer
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, United States
    Curr Opin Neurobiol 19:544-52. 2009
    ..The three families of photochemical tools have different capabilities and uses, but they all share in enabling precise and noninvasive exploration of neural function with light...
  23. ncbi request reprint Engineering light-gated ion channels
    Matthew R Banghart
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Biochemistry 45:15129-41. 2006
    ..Very recently, naturally occurring light-gated cation channels have been discovered. This review covers the molecular principles that guide the engineering of light-gated ion channels for applications in biology and medicine...
  24. ncbi request reprint Exploring biosynthetic relationships among furanocembranoids: synthesis of (-)-bipinnatin J, (+)-intricarene, (+)-rubifolide, and (+)-isoepilophodione B
    Paul A Roethle
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Org Lett 8:5901-4. 2006
    ..Biosynthetic relationships among furanocembranoids and the possible role of 1,3-dipolar cycloadditions in biosynthesis are discussed. [reaction: see text]..
  25. pmc Allosteric control of an ionotropic glutamate receptor with an optical switch
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Chem Biol 2:47-52. 2006
    ..Our device has potential uses not only in biology but also in bioelectronics and nanotechnology...
  26. ncbi request reprint Tunable oscillations in the Purkinje neuron
    Ze ev R Abrams
    NSF Nanoscale Science and Engineering Center, 3112 Etcheverry Hall, University of California, Berkeley, California 94720, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 85:041905. 2012
    ..These findings signify an additional timing functional role of tunable oscillations within the cerebellum, as well as a dynamic control of a time scale in the brain in the range of seconds...
  27. doi request reprint Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
    Ivan Tochitsky
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Chem 4:105-11. 2012
    ..The generation of these engineered receptors should facilitate investigation of the physiological and pathological functions of neuronal nAChRs and open a general pathway to photosensitizing pentameric ligand-gated ion channels...
  28. ncbi request reprint Total synthesis of (-)-archazolid B
    Paul A Roethle
    Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 1460, USA
    J Am Chem Soc 129:8960-1. 2007
  29. doi request reprint Conjugate addition of allyl stannanes with concomitant triflation
    Ellen D Beaulieu
    Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 1460, USA
    Org Lett 10:869-72. 2008
    ..This reaction works with functionalized enones, enals, enoates, and vinylogous esters. The resulting vinyl triflates can be used for intramolecular Heck reactions to afford the products of 5-exo-trig cyclization...
  30. ncbi request reprint Photochemical tools for remote control of ion channels in excitable cells
    Richard H Kramer
    Department of Molecular and Cell Biology, 142 Life Sciences Addition, University of California, Berkeley, Berkeley, California 94720, USA
    Nat Chem Biol 1:360-5. 2005
    ..The development of chemical tools for optically stimulating or inhibiting signaling proteins has particular relevance for the nervous system, where precise, noninvasive control is an experimental and medical necessity...
  31. pmc Optical control of metabotropic glutamate receptors
    Joshua Levitz
    Biophysics Graduate Group, University of California, Berkeley, California, USA
    Nat Neurosci 16:507-16. 2013
    ..These light-gated mGluRs pave the way for determining the roles of mGluRs in synaptic plasticity, memory and disease...
  32. ncbi request reprint Pericyclic reactions of prenylated naphthoquinones: biomimetic syntheses of mollugin and microphyllaquinone
    Jean Philip Lumb
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Org Lett 7:5865-8. 2005
    ..Both syntheses exploit the propensity of prenylated quinones to undergo tautomerization/oxa 6pi-electrocyclizations...
  33. doi request reprint ortho-Quinone methides from para-quinones: total synthesis of rubioncolin B
    Jean Philip Lumb
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 130:9230-1. 2008
    ..The ortho-quinone methide is generated through a surprisingly facile tautomerization of a para-quinone...
  34. pmc LiGluR restores visual responses in rodent models of inherited blindness
    Natalia Caporale
    Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 2020, USA
    Mol Ther 19:1212-9. 2011
    ....
  35. doi request reprint The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products
    Paul A Roethle
    Department of Chemistry, University of California, Berkeley, CA, USA
    Nat Prod Rep 25:298-317. 2008
    ..An overview of the chemistry and biology of the diterpene natural products known as the furanocembranoids, pseudopteranes, and gersolanes is provided; 85 references are cited...
  36. ncbi request reprint Biomimetic synthesis of the shimalactones
    Vladimir Sofiyev
    Department of Chemistry, University of California Berkeley, Berkeley, California 94720 1460, USA
    Org Lett 10:149-52. 2008
    ..2.1]heptane and bicyclo[4.2.0]octadiene, respectively. The synthesis is convergent and void of protecting groups...
  37. ncbi request reprint Expedient synthesis of (+/-)-bipinnatin J
    Paul A Roethle
    Department of Chemistry, University of California, Berkeley, 94720, USA
    Org Lett 8:345-7. 2006
    ..The biosynthetic relationship between bipinnatin J and complex polycyclic diterpenes isolated from gorgonian corals is discussed...
  38. ncbi request reprint Concise synthesis of the bacterial DNA primase inhibitor (+) -Sch 642305
    Erica M Wilson
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Org Lett 9:1327-9. 2007
    ..The 10-membered macrolactone was formed through ring-closing metathesis...
  39. ncbi request reprint Biosynthetic and biomimetic electrocyclizations
    Christopher M Beaudry
    Department of Chemistry, University of California, Berkeley, 94720 1460, USA
    Chem Rev 105:4757-78. 2005
  40. doi request reprint Vinyl quinones as Diels-Alder dienes: concise synthesis of (-)-halenaquinone
    Michael A Kienzler
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    J Am Chem Soc 130:8604-5. 2008
    ..The synthesis is highly convergent and features a minimal amount of protecting group manipulations...
  41. ncbi request reprint Infrared hole burning and conformational change in a borane-ammonia complex
    Christopher A Endicott
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    J Phys Chem A 109:7714-7. 2005
    ..The ammonia is hydrogen bonded with the bond distances and reorientation barrier typical of other compounds. The N-D stretching frequencies are higher than those of comparison compounds...
  42. ncbi request reprint Dienophile twisting and substituent effects influence reaction rates of intramolecular Diels-Alder cycloadditions: a DFT study
    Kelli S Khuong
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 127:3688-9. 2005
    ....
  43. pmc Light-activated ion channels for remote control of neuronal firing
    Matthew Banghart
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Neurosci 7:1381-6. 2004
    ....
  44. ncbi request reprint Photosensitized conversion of 9,10-deoxytridachione to photodeoxytridachione
    Daniel R Zuidema
    Department of Chemistry, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Org Lett 7:4959-62. 2005
    ..The results show that some, and perhaps all, of the photoreactions of 9,10-deoxytridachione occur through a triplet excited state. The mechanistic and biosynthetic implications of these results are discussed...
  45. ncbi request reprint Concise synthesis of (+/-)-rhazinilam through direct coupling
    Alfred L Bowie
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Org Lett 7:5207-9. 2005
    ..reaction: see text] A concise synthesis of rhazinilam through direct, palladium-catalyzed, intramolecular coupling is described...
  46. ncbi request reprint Synthesis of taiwaniaquinoids via Nazarov triflation
    Guangxin Liang
    Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 1460, USA
    J Am Chem Soc 128:11022-3. 2006
    ....
  47. pmc The total synthesis of (-)-crispatene
    Aubry K Miller
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Proc Natl Acad Sci U S A 101:12019-23. 2004
    ..1.0]hexene core of the natural product. The absolute configuration of (-)-crispatene and related molecules is established...
  48. ncbi request reprint Synthetic studies toward the guanacastepenes
    Chambers C Hughes
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California Berkeley, Berkeley, California 94720, USA
    Org Lett 5:4113-5. 2003
    ..reaction: see text]. An asymmetric approach toward the [6-7] ring system of the guanacastepenes is described...
  49. ncbi request reprint Stereoselective synthesis of cyercene A and the placidenes
    Guangxin Liang
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California Berkeley, Berkeley, CA 94720 USA
    Org Lett 7:819-21. 2005
    ..Two key iodovinyl pyrone building blocks were coupled to appropriately selected vinyl stannanes to assemble the highly substituted polyene side chains of the natural products. [structure: see text]..
  50. ncbi request reprint Stereoselective syntheses of the bioactive polypropionates aureothin, N-acetylaureothamine, and aureonitrile
    Guangxin Liang
    Department of Chemistry, University of California, Berkeley, 94720, USA
    Org Lett 7:2837-9. 2005
    ..reaction: see text] Concise total syntheses of the bioactive polypropionates aureothin, N-acetylaureothamine, and aureonitrile are described...
  51. ncbi request reprint Biomimetic synthesis of elysiapyrones A and B
    Jennifer E Barbarow
    Department of Chemistry, University of California, Berkeley, 94720, USA
    Org Lett 7:2901-3. 2005
    ..reaction: see text] The total synthesis of bicyclo[4.2.0]octane natural products elysiapyrones A and B is described...
  52. ncbi request reprint Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D
    Christopher M Beaudry
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Org Lett 7:4475-7. 2005
    ..The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8pi-6pi electrocyclization cascade...
  53. ncbi request reprint Reductive cyclization of delta-hydroxy nitriles: a new synthesis of glycosylamines
    Andrew D Dorsey
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California Berkeley, Berkeley, California 94720, USA
    Org Lett 5:3237-9. 2003
    ..reaction: see text] The stereoselective cyclization of delta-hydroxy nitriles to afford N,O-acetals and the application of this reaction toward the synthesis of glycosylamines is described...
  54. doi request reprint A structural link between inactivation and block of a K+ channel
    Christian Ader
    Max Planck Institute for Biophysical Chemistry, Department of NMR Based Structural Biology, Am Fassberg 11, 37077 Gottingen, Germany
    Nat Struct Mol Biol 15:605-12. 2008
    ..The results establish a structural link between inactivation and block of a K(+) channel in a membrane setting...
  55. ncbi request reprint A glimpse at the grail
    Dirk Trauner
    Nat Chem Biol 1:189-91. 2005
  56. ncbi request reprint Photochemical origin of the immunosuppressive SNF4435C/D and formation of orinocin through "polyene splicing"
    Markus Muller
    Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany
    Angew Chem Int Ed Engl 45:7835-8. 2006

Research Grants9

  1. Molecular Recognition of Potassium Channels
    Dirk Trauner; Fiscal Year: 2006
    ..x channels is proposed. Pharmacologically relevant Kv1.x channels such as Kv1.3 or Kv1.5 will receive special attention. The ability of the synthetic ligands to bind to different functional states of a given channel will be evaluated. ..
  2. Total Synthesis of Biologically Active Gamma-Pyrones
    Dirk Trauner; Fiscal Year: 2007
    ..Our synthetic material and derivatives thereof will be used to isolate binding proteins and gain further insight into of the mechanism of these promising new lead compounds for drug development. ..