LINTON TRAUB

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning
    P K Umasankar
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Nat Cell Biol 14:488-501. 2012
  2. pmc Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development
    Melissa A Edeling
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 4:e8150. 2009
  3. doi request reprint Tickets to ride: selecting cargo for clathrin-regulated internalization
    Linton M Traub
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 10:583-96. 2009
  4. ncbi request reprint Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs
    Linton M Traub
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA, and Program in Cell and Lung Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Cell Sci 120:543-53. 2007
  5. ncbi request reprint Common principles in clathrin-mediated sorting at the Golgi and the plasma membrane
    Linton M Traub
    Department of Cell Biology and Physiology University of Pittsburgh School of Medicine 3500 Terrace Street, S325BST Pittsburgh, PA 15206, USA
    Biochim Biophys Acta 1744:415-37. 2005
  6. pmc Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
    Linton M Traub
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Cell Biol 163:203-8. 2003
  7. pmc Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor
    Sanjay K Mishra
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, S325BST, Pittsburgh, PA 15261, USA
    EMBO J 21:4915-26. 2002
  8. ncbi request reprint Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin
    Huamin Wang
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:14129-35. 2006
  9. ncbi request reprint Endocytic adaptor molecules reveal an endosomal population of clathrin by total internal reflection fluorescence microscopy
    Peter A Keyel
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Biol Chem 279:13190-204. 2004
  10. ncbi request reprint Cargo selection in vesicular transport: the making and breaking of a coat
    Meir Aridor
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Traffic 3:537-46. 2002

Research Grants

  1. CLATHRIN COATED VESICLES AND LYSOSOME FUNCTION
    LINTON TRAUB; Fiscal Year: 2001
  2. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2009
  3. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2007
  4. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2006
  5. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2005
  6. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2004
  7. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2003
  8. CLATHRIN COATED VESICLES AND LYSOSOME FUNCTION
    LINTON TRAUB; Fiscal Year: 2002
  9. CLATHRIN COATED VESICLES AND LYSOSOME FUNCTION
    LINTON TRAUB; Fiscal Year: 2000
  10. Clathrin-coated vesicles and endocytic function
    Linton M Traub; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning
    P K Umasankar
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Nat Cell Biol 14:488-501. 2012
    ..Still, the fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted. Our data thus challenge the primacy of FCHO1/2 in coat initiation...
  2. pmc Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development
    Melissa A Edeling
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 4:e8150. 2009
    ..Our data confirm linkage between directional migration, endocytosis and cell specification during embryonic morphogenesis and highlight a key role for Pacsin3 in this coupling in the notochord...
  3. doi request reprint Tickets to ride: selecting cargo for clathrin-regulated internalization
    Linton M Traub
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Nat Rev Mol Cell Biol 10:583-96. 2009
    ..Cargo loading also seems to govern whether coats ultimately bud or dismantle abortively at the cell surface...
  4. ncbi request reprint Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs
    Linton M Traub
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA, and Program in Cell and Lung Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Cell Sci 120:543-53. 2007
    ..Thus, an expanded repertoire of CLASPs couples the process of clathrin-coat assembly with high-fidelity incorporation of assorted, cargo-specific sorting signals...
  5. ncbi request reprint Common principles in clathrin-mediated sorting at the Golgi and the plasma membrane
    Linton M Traub
    Department of Cell Biology and Physiology University of Pittsburgh School of Medicine 3500 Terrace Street, S325BST Pittsburgh, PA 15206, USA
    Biochim Biophys Acta 1744:415-37. 2005
    ..This improved appreciation of the complex mechanisms governing clathrin-dependent sorting events reveals several common principles of clathrin operation at the Golgi and the plasma membrane...
  6. pmc Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection
    Linton M Traub
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Cell Biol 163:203-8. 2003
    ..Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site...
  7. pmc Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor
    Sanjay K Mishra
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, S325BST, Pittsburgh, PA 15261, USA
    EMBO J 21:4915-26. 2002
    ....
  8. ncbi request reprint Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin
    Huamin Wang
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:14129-35. 2006
    ..These results identify epsin as an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface...
  9. ncbi request reprint Endocytic adaptor molecules reveal an endosomal population of clathrin by total internal reflection fluorescence microscopy
    Peter A Keyel
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Biol Chem 279:13190-204. 2004
    ..Thus, highly motile clathrin structures are apparently distinct from the plasma membrane, accompany transferrin, and contain AP-1, revealing an endosomal population of clathrin structures...
  10. ncbi request reprint Cargo selection in vesicular transport: the making and breaking of a coat
    Meir Aridor
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace St, Pittsburgh, PA 15261, USA
    Traffic 3:537-46. 2002
    ..The temporal and regulated nature of the interactions provide the key to cargo selection...
  11. ncbi request reprint Clathrin: now you see me, now you don't!
    Peter A Keyel
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA
    Dev Cell 7:283-4. 2004
    ..Recent work from the Kirchhausen laboratory indicates that the lifetime of a coated vesicle is extremely short, and assembly of nascent coats aborts abruptly unless reinforced by additional regulatory inputs, most likely cargo capture...
  12. pmc The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery
    Sanjay K Mishra
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 USA
    Proc Natl Acad Sci U S A 99:16099-104. 2002
    ....
  13. pmc A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors
    Peter A Keyel
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Biol Cell 17:4300-17. 2006
    ..However, Dab2 expression is exceptionally low in hepatocytes, likely accounting for the pathological hypercholesterolemia that accompanies ARH loss...
  14. ncbi request reprint Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein
    Sanjay K Mishra
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:19270-80. 2005
    ..We suggested that biased beta subunit engagement by ARH and the only other beta2 appendage selective adaptor, beta-arrestin, promotes efficient incorporation of this mechanistically distinct subset of CLASPs into clathrin-coated buds...
  15. ncbi request reprint Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein
    Matthew J Hawryluk
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Traffic 7:262-81. 2006
    ..As epsin interacts with eps15, which also contains a UIM region that binds to polyubiquitin, epsin and eps15 appear to be central components of the vertebrate poly/multiubiquitin-sorting endocytic clathrin machinery...
  16. pmc Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage
    James R Thieman
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:13924-39. 2009
    ..A clathrin-regulated interaction with AP-2 could allow PIPKIgamma661 to be strategically positioned for regional PtdIns(4,5)P(2) generation during clathrin-coated vesicle assembly at the synapse...
  17. pmc The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis
    Peter A Keyel
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Biol Cell 19:5309-26. 2008
    ..We conclude that ARH and beta-arrestin depend on a privileged beta2 appendage site for proper cargo recruitment to clathrin bud sites...
  18. ncbi request reprint Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage
    Sanjay K Mishra
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:46191-203. 2004
    ....
  19. ncbi request reprint A novel AP-2 adaptor interaction motif initially identified in the long-splice isoform of synaptojanin 1, SJ170
    Anupma Jha
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    J Biol Chem 279:2281-90. 2004
    ..These interactions likely contribute to the appropriate targeting of certain endocytic components to clathrin bud sites assembling at the cell surface...
  20. doi request reprint Internalization of LDL-receptor superfamily yolk-protein receptors during mosquito oogenesis involves transcriptional regulation of PTB-domain adaptors
    Sanjay K Mishra
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Cell Sci 121:1264-74. 2008
    ..Temporally regulated trephin transcription and translation suggests a mechanism for controlling yolk uptake when vitellogenin and lipophorin receptors are expressed and clathrin coats operate in previtellogenic ovaries...
  21. ncbi request reprint AP-1B: polarized sorting at the endosome
    Linton M Traub
    Nat Cell Biol 5:1045-7. 2003
  22. ncbi request reprint Accessory protein recruitment motifs in clathrin-mediated endocytosis
    Tom J Brett
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Structure 10:797-809. 2002
    ..A mechanism of clathrin assembly regulation is suggested by three different AP-2 engagement modes...
  23. ncbi request reprint Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly
    Melissa A Edeling
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
    Dev Cell 10:329-42. 2006
    ..Another interaction surface on the beta2 appendage sandwich is identified for proteins such as eps15 and clathrin, suggesting a mechanism by which clathrin displaces eps15 to lattice edges during assembly...
  24. ncbi request reprint Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemia
    Anne K Soutar
    MRC Clinical Sciences Centre, Hammersmith Hospital, Faculty of Medicine, Imperial College, London, UK
    Arterioscler Thromb Vasc Biol 23:1963-70. 2003
    ....
  25. ncbi request reprint Signals for sorting of transmembrane proteins to endosomes and lysosomes
    Juan S Bonifacino
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Biochem 72:395-447. 2003
    ..This complex array of signals and recognition proteins ensures the dynamic but accurate distribution of transmembrane proteins to different compartments of the endosomal-lysosomal system...
  26. ncbi request reprint Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller
    Adriana E Miele
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Struct Mol Biol 11:242-8. 2004
    ..This property, along with the propensity of the N-terminal BAR domain to bind curved membranes, will preferentially localize amphiphysin and its partner, dynamin, to the periphery of invaginated clathrin lattices...
  27. ncbi request reprint Molecular structures of coat and coat-associated proteins: function follows form
    Tom J Brett
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Opin Cell Biol 18:395-406. 2006
    ..An emerging mechanistic theme is how sequential engagement of common interaction surfaces or network hubs can evict prior binding partners from the assembly zone to ensure vectorial progression of the coat assembly process...

Research Grants11

  1. CLATHRIN COATED VESICLES AND LYSOSOME FUNCTION
    LINTON TRAUB; Fiscal Year: 2001
    ..The study is designed to provide a detailed understanding of the nature and function of the proteins responsible for coated vesicle formation on lysosomes and the role that these vesicles play in lysosome homeostasis. ..
  2. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2009
    ..It is anticipated that fundamental new information regarding the molecular mechanisms that link clathrin coat polymerization to cargo capture at the cell surface will be obtained through these investigations. ..
  3. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2007
    ..It is anticipated that fundamental new information regarding the molecular mechanisms that link clathrin coat polymerization to cargo capture at the cell surface will be obtained through these investigations. ..
  4. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2006
    ..abstract_text> ..
  5. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2005
    ..abstract_text> ..
  6. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2004
    ..abstract_text> ..
  7. Clathrin-coated vesicles and endocytic function
    LINTON TRAUB; Fiscal Year: 2003
    ..abstract_text> ..
  8. CLATHRIN COATED VESICLES AND LYSOSOME FUNCTION
    LINTON TRAUB; Fiscal Year: 2002
    ..The study is designed to provide a detailed understanding of the nature and function of the proteins responsible for coated vesicle formation on lysosomes and the role that these vesicles play in lysosome homeostasis. ..
  9. CLATHRIN COATED VESICLES AND LYSOSOME FUNCTION
    LINTON TRAUB; Fiscal Year: 2000
    ..The study is designed to provide a detailed understanding of the nature and function of the proteins responsible for coated vesicle formation on lysosomes and the role that these vesicles play in lysosome homeostasis. ..
  10. Clathrin-coated vesicles and endocytic function
    Linton M Traub; Fiscal Year: 2010
    ..It is anticipated that fundamental new information regarding the molecular mechanisms that link clathrin coat polymerization to cargo capture at the cell surface will be obtained through these investigations. ..