Research Topics | LINTON TRAUBSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Tickets to ride: selecting cargo for clathrin-regulated internalizationLinton M Traub
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
Nat Rev Mol Cell Biol 10:583-96. 2009..Cargo loading also seems to govern whether coats ultimately bud or dismantle abortively at the cell surface...
Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPsLinton M Traub
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA, and Program in Cell and Lung Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
J Cell Sci 120:543-53. 2007..Thus, an expanded repertoire of CLASPs couples the process of clathrin-coat assembly with high-fidelity incorporation of assorted, cargo-specific sorting signals...- Common principles in clathrin-mediated sorting at the Golgi and the plasma membraneLinton M Traub
Department of Cell Biology and Physiology University of Pittsburgh School of Medicine 3500 Terrace Street, S325BST Pittsburgh, PA 15206, USA
Biochim Biophys Acta 1744:415-37. 2005..This improved appreciation of the complex mechanisms governing clathrin-dependent sorting events reveals several common principles of clathrin operation at the Golgi and the plasma membrane... 
Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selectionLinton M Traub
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Cell Biol 163:203-8. 2003..Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site...- Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptorSanjay K Mishra
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, S325BST, Pittsburgh, PA 15261, USA
EMBO J 21:4915-26. 2002.... - A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptorsPeter A Keyel
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Mol Biol Cell 17:4300-17. 2006..However, Dab2 expression is exceptionally low in hepatocytes, likely accounting for the pathological hypercholesterolemia that accompanies ARH loss... - Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsinHuamin Wang
Renal Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 281:14129-35. 2006..These results identify epsin as an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface... - Clathrin: now you see me, now you don't!Peter A Keyel
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA
Dev Cell 7:283-4. 2004..Recent work from the Kirchhausen laboratory indicates that the lifetime of a coated vesicle is extremely short, and assembly of nascent coats aborts abruptly unless reinforced by additional regulatory inputs, most likely cargo capture... - Endocytic adaptor molecules reveal an endosomal population of clathrin by total internal reflection fluorescence microscopyPeter A Keyel
Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Biol Chem 279:13190-204. 2004..Thus, highly motile clathrin structures are apparently distinct from the plasma membrane, accompany transferrin, and contain AP-1, revealing an endosomal population of clathrin structures... - The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinerySanjay K Mishra
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 USA
Proc Natl Acad Sci U S A 99:16099-104. 2002.... - Cargo selection in vesicular transport: the making and breaking of a coatMeir Aridor
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace St, Pittsburgh, PA 15261, USA
Traffic 3:537-46. 2002..The temporal and regulated nature of the interactions provide the key to cargo selection... - Epsin 1 is a polyubiquitin-selective clathrin-associated sorting proteinMatthew J Hawryluk
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Traffic 7:262-81. 2006..As epsin interacts with eps15, which also contains a UIM region that binds to polyubiquitin, epsin and eps15 appear to be central components of the vertebrate poly/multiubiquitin-sorting endocytic clathrin machinery... - Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia proteinSanjay K Mishra
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 280:19270-80. 2005..We suggested that biased beta subunit engagement by ARH and the only other beta2 appendage selective adaptor, beta-arrestin, promotes efficient incorporation of this mechanistically distinct subset of CLASPs into clathrin-coated buds... - The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosisPeter A Keyel
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Mol Biol Cell 19:5309-26. 2008..We conclude that ARH and beta-arrestin depend on a privileged beta2 appendage site for proper cargo recruitment to clathrin bud sites... - Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendageSanjay K Mishra
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 279:46191-203. 2004.... - Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendageJames R Thieman
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 284:13924-39. 2009..A clathrin-regulated interaction with AP-2 could allow PIPKIgamma661 to be strategically positioned for regional PtdIns(4,5)P(2) generation during clathrin-coated vesicle assembly at the synapse... - A novel AP-2 adaptor interaction motif initially identified in the long-splice isoform of synaptojanin 1, SJ170Anupma Jha
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
J Biol Chem 279:2281-90. 2004..These interactions likely contribute to the appropriate targeting of certain endocytic components to clathrin bud sites assembling at the cell surface... - Internalization of LDL-receptor superfamily yolk-protein receptors during mosquito oogenesis involves transcriptional regulation of PTB-domain adaptorsSanjay K Mishra
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Cell Sci 121:1264-74. 2008..Temporally regulated trephin transcription and translation suggests a mechanism for controlling yolk uptake when vitellogenin and lipophorin receptors are expressed and clathrin coats operate in previtellogenic ovaries... - AP-1B: polarized sorting at the endosomeLinton M Traub
Nat Cell Biol 5:1045-7. 2003 - Accessory protein recruitment motifs in clathrin-mediated endocytosisTom J Brett
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Structure 10:797-809. 2002..A mechanism of clathrin assembly regulation is suggested by three different AP-2 engagement modes... - Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assemblyMelissa A Edeling
Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
Dev Cell 10:329-42. 2006..Another interaction surface on the beta2 appendage sandwich is identified for proteins such as eps15 and clathrin, suggesting a mechanism by which clathrin displaces eps15 to lattice edges during assembly... - Molecular structures of coat and coat-associated proteins: function follows formTom J Brett
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Curr Opin Cell Biol 18:395-406. 2006..An emerging mechanistic theme is how sequential engagement of common interaction surfaces or network hubs can evict prior binding partners from the assembly zone to ensure vectorial progression of the coat assembly process... - Genetics, clinical phenotype, and molecular cell biology of autosomal recessive hypercholesterolemiaAnne K Soutar
MRC Clinical Sciences Centre, Hammersmith Hospital, Faculty of Medicine, Imperial College, London, UK
Arterioscler Thromb Vasc Biol 23:1963-70. 2003.... - Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propellerAdriana E Miele
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Struct Mol Biol 11:242-8. 2004..This property, along with the propensity of the N-terminal BAR domain to bind curved membranes, will preferentially localize amphiphysin and its partner, dynamin, to the periphery of invaginated clathrin lattices... - Signals for sorting of transmembrane proteins to endosomes and lysosomesJuan S Bonifacino
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Biochem 72:395-447. 2003..This complex array of signals and recognition proteins ensures the dynamic but accurate distribution of transmembrane proteins to different compartments of the endosomal-lysosomal system...
Research Grants
- Clathrin-coated vesicles and endocytic functionLINTON TRAUB; Fiscal Year: 2007..It is anticipated that fundamental new information regarding the molecular mechanisms that link clathrin coat polymerization to cargo capture at the cell surface will be obtained through these investigations. ..
- Clathrin-coated vesicles and endocytic functionLINTON TRAUB; Fiscal Year: 2006..abstract_text> ..
- CLATHRIN COATED VESICLES AND LYSOSOME FUNCTIONLINTON TRAUB; Fiscal Year: 2002..The study is designed to provide a detailed understanding of the nature and function of the proteins responsible for coated vesicle formation on lysosomes and the role that these vesicles play in lysosome homeostasis. ..
- Clathrin-coated vesicles and endocytic functionLinton M Traub; Fiscal Year: 2010..It is anticipated that fundamental new information regarding the molecular mechanisms that link clathrin coat polymerization to cargo capture at the cell surface will be obtained through these investigations. ..