Pamela V Tran

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Department of Anatomy and Cell Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas and
    J Am Soc Nephrol 25:2201-12. 2014
  2. doi request reprint Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile
    Pamela V Tran
    Department of Anatomy and Cell Biology, The Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA
    Wiley Interdiscip Rev Syst Biol Med 5:83-100. 2013
  3. pmc Temporomandibular joint formation requires two distinct hedgehog-dependent steps
    Patricia Purcell
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18297-302. 2009
  4. doi request reprint THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008

Collaborators

  • Clifford J Tabin
  • Patricia Purcell
  • Richard L Maas
  • Jimmy K Hu
  • Monica L Calicchio
  • Daniel J O'Connell
  • Brian W Joo

Detail Information

Publications4

  1. pmc Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Department of Anatomy and Cell Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas and
    J Am Soc Nephrol 25:2201-12. 2014
    ..Thus, enhanced Hedgehog activity may have a general role in renal cystogenesis and thereby present a novel therapeutic target. ..
  2. doi request reprint Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile
    Pamela V Tran
    Department of Anatomy and Cell Biology, The Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA
    Wiley Interdiscip Rev Syst Biol Med 5:83-100. 2013
    ..A systems-level understanding of Hh signaling and of ciliary biology will comprehensively define all nodes and edges of the Hh signaling network and will help identify precise therapeutic targets...
  3. pmc Temporomandibular joint formation requires two distinct hedgehog-dependent steps
    Patricia Purcell
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18297-302. 2009
    ..Thus, these experiments establish that Hh signaling acts at two distinct steps in disk morphogenesis, condyle initiation, and disk-condyle separation and provide a molecular framework for future studies of the TMJ...
  4. doi request reprint THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...