Russell Tracy

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Decreased naive and increased memory CD4(+) T cells are associated with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis
    Nels C Olson
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    PLoS ONE 8:e71498. 2013
  2. pmc T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis
    Russell P Tracy
    Department of Pathology, University of Vermont, Burlington, VT 05446, USA
    J Am Heart Assoc 2:e000117. 2013
  3. pmc Circulating levels of TNF-α are associated with impaired glucose tolerance, increased insulin resistance, and ethnicity: the Insulin Resistance Atherosclerosis Study
    Nels C Olson
    Department of PathologyUniversity of Vermont College of Medicine, Burlington, VT 05405, USA
    J Clin Endocrinol Metab 97:1032-40. 2012
  4. pmc Linkage study of fibrinogen levels: the Strong Heart Family Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 9:77. 2008
  5. pmc The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
  6. pmc Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Cardiovasc Disord 7:30. 2007
  7. doi request reprint 'Deep phenotyping': characterizing populations in the era of genomics and systems biology
    Russell P Tracy
    Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, Vermont 05446, USA
    Curr Opin Lipidol 19:151-7. 2008
  8. ncbi request reprint Diabetes and atherothrombotic disease: linked through inflammation?
    Russell P Tracy
    Department of Pathology and Biochemistry, College of Medicine, University of Vermont, Colchester, Vermont 05446, USA
    Semin Vasc Med 2:67-73. 2002
  9. ncbi request reprint Thrombin, inflammation, and cardiovascular disease: an epidemiologic perspective
    Russell P Tracy
    Laboratory for Clinical Biochemistry Research, College of Medicine, University of Vermont, Colchester, VT 05446, USA
    Chest 124:49S-57S. 2003
  10. ncbi request reprint Hemostatic and inflammatory markers as risk factors for coronary disease in the elderly
    Russell P Tracy
    University of Vermont College of Medicine, Colchester, VT 05446, USA
    Am J Geriatr Cardiol 11:93-100, 107. 2002

Collaborators

Detail Information

Publications83

  1. pmc Decreased naive and increased memory CD4(+) T cells are associated with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis
    Nels C Olson
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    PLoS ONE 8:e71498. 2013
    ..We hypothesized that activation of adaptive immune responses, as reflected by higher proportions of circulating CD4(+) memory cells and lower proportions of naive cells, would be associated with subclinical atherosclerosis...
  2. pmc T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis
    Russell P Tracy
    Department of Pathology, University of Vermont, Burlington, VT 05446, USA
    J Am Heart Assoc 2:e000117. 2013
    ..Although T-helper type 1 (Th1) cells are considered important in atherosclerosis, the relationships between Th1 and Th2 cells and atherosclerosis have not been examined in population-based studies...
  3. pmc Circulating levels of TNF-α are associated with impaired glucose tolerance, increased insulin resistance, and ethnicity: the Insulin Resistance Atherosclerosis Study
    Nels C Olson
    Department of PathologyUniversity of Vermont College of Medicine, Burlington, VT 05405, USA
    J Clin Endocrinol Metab 97:1032-40. 2012
    ..We studied the relationship between TNF-α and glucose tolerance status as part of the Insulin Resistance Atherosclerosis Study...
  4. pmc Linkage study of fibrinogen levels: the Strong Heart Family Study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    BMC Med Genet 9:77. 2008
    ..The Strong Heart Study has demonstrated an increased incidence of cardiovascular disease in the American Indian population, and therefore represents an important source for genetic-epidemiological investigations...
  5. pmc The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
    ....
  6. pmc Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Cardiovasc Disord 7:30. 2007
    ..In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis...
  7. doi request reprint 'Deep phenotyping': characterizing populations in the era of genomics and systems biology
    Russell P Tracy
    Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, Vermont 05446, USA
    Curr Opin Lipidol 19:151-7. 2008
    ..There is an opportunity to enhance our understanding of genotype-phenotype associations by extending phenotypes into much greater detail ('deep phenotyping')...
  8. ncbi request reprint Diabetes and atherothrombotic disease: linked through inflammation?
    Russell P Tracy
    Department of Pathology and Biochemistry, College of Medicine, University of Vermont, Colchester, Vermont 05446, USA
    Semin Vasc Med 2:67-73. 2002
    ..Interventions aimed broadly at inflammation are likely to influence both diseases, and pathway-specific interventions may prove useful as well. The role of genetic variation remains poorly understood...
  9. ncbi request reprint Thrombin, inflammation, and cardiovascular disease: an epidemiologic perspective
    Russell P Tracy
    Laboratory for Clinical Biochemistry Research, College of Medicine, University of Vermont, Colchester, VT 05446, USA
    Chest 124:49S-57S. 2003
    ..Only by intervening in exquisitely precise ways can we hope to effectively and safely modify the course of lifelong chronic diseases, such as atherosclerosis...
  10. ncbi request reprint Hemostatic and inflammatory markers as risk factors for coronary disease in the elderly
    Russell P Tracy
    University of Vermont College of Medicine, Colchester, VT 05446, USA
    Am J Geriatr Cardiol 11:93-100, 107. 2002
    ....
  11. ncbi request reprint Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging
    R P Tracy
    Laboratory for Clinical Biochemistry Research, Department of Pathology, University of Vermont, Colchester, VT 05446, USA
    Int J Obes Relat Metab Disord 27:S29-34. 2003
    ..Although daunting in complexity, studies on the relation of inflammation to disease have already proven useful, and hold promise for providing fundamental advances in both basic biology and clinical medicine...
  12. ncbi request reprint Inflammation markers and coronary heart disease
    R P Tracy
    Department of Pathology, University of Vermont College of Medicine, Colchester, USA
    Curr Opin Lipidol 10:435-41. 1999
    ..This has implications for the interpretation of marker levels and the timing of the future events that they predict...
  13. ncbi request reprint Longitudinal stability of coagulation, fibrinolysis, and inflammation factors in stored plasma samples
    M R Lewis
    Department of Pathology, University of Vermont College of Medicine, Burlington, USA
    Thromb Haemost 86:1495-500. 2001
    ..Our finding of longitudinal stability in the biochemical properties of frozen plasma strengthens the presumption of sample stability on which molecular epidemiologic studies are based...
  14. ncbi request reprint Tamoxifen and cardiac risk factors in healthy women: Suggestion of an anti-inflammatory effect
    M Cushman
    Department of Medicine and Pathology, University of Vermont, Burlington 05446, USA
    Arterioscler Thromb Vasc Biol 21:255-61. 2001
    ..These findings are in contrast to recent reports of increased C-reactive protein associated with postmenopausal estrogen. The potential for beneficial cardiovascular effects of tamoxifen in healthy women is suggested...
  15. ncbi request reprint Thrombolytic therapy and proteolysis of factor V
    R P Tracy
    Department of Pathology, College of Medicine, University of Vermont, Burlington, USA
    J Am Coll Cardiol 30:716-24. 1997
    ..We sought to determine the extent of Factor V proteolysis during thrombolytic therapy...
  16. ncbi request reprint Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project
    R P Tracy
    University of Vermont, Colchester 05446, USA
    Arterioscler Thromb Vasc Biol 17:1121-7. 1997
    ..7 (CI = 1.10 to 6.60). In conclusion, CRP was associated with incident events in the elderly, especially in those with subclinical disease at baseline...
  17. ncbi request reprint Relation of coagulation parameters to patency and recurrent ischemia in the Thrombolysis in Myocardial Infarction (TIMI) Phase II Trial
    R P Tracy
    Department of Pathology, University of Vermont College of Medicine, Colchester 05446, USA
    Am Heart J 135:29-37. 1998
    ..The aPTT results support frequent monitoring during the first 24 to 48 hours to ensure optimal clinical outcome. The coagulation factor results suggest that there may be an optimum window for fibrinogenolysis in this setting...
  18. ncbi request reprint Assays for thrombosis factors: relations to plasma lipids
    R P Tracy
    Department of Pathology, University of Vermont, Colchester 05446, USA
    Am J Clin Nutr 65:1669S-1673S. 1997
    ....
  19. ncbi request reprint Hormone replacement therapy, inflammation, and hemostasis in elderly women
    M Cushman
    Departments of Medicine, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 19:893-9. 1999
    ..Associations with hemostasis markers indicated no association with evidence of procoagulation and a possible association with increased fibrinolytic activity...
  20. ncbi request reprint Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study
    M Cushman
    Departments of Medicine, and Biochemistry, University of Vermont, Burlington, VT 05446, USA
    Circulation 100:717-22. 1999
    ..Because higher levels of inflammation factors predict vascular disease outcomes, the effect of hormones on these factors is of interest...
  21. ncbi request reprint The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly: results from the cardiovascular health study
    R P Tracy
    Departments of Pathology and Biochemistry and the Laboratory for Clinical Biochemistry Research, University of Vermont College of Medicine, Burlington, Vermont, USA
    Arterioscler Thromb Vasc Biol 19:1776-83. 1999
    ..We conclude that, if confirmed in other studies, the measurement of fibrinogen and/or factor VIII may help identify older individuals at higher risk for CVD events and mortality...
  22. ncbi request reprint Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects
    R P Tracy
    Department of Pathology and Biochemistry, University of Vermont, Colchester 05446, USA
    Arterioscler Thromb Vasc Biol 17:2167-76. 1997
    ..Moreover, exposure to smoking affects the relation of CRP to these other factors...
  23. pmc Lipoprotein-associated phospholipase A(2) and risk of congestive heart failure in older adults: the Cardiovascular Health Study
    Takeki Suzuki
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Circ Heart Fail 2:429-36. 2009
    ..One previous study showed an association of Lp-PLA(2) activity with CHF risk, but there were only 94 CHF cases and Lp-PLA(2) antigen, which is available clinically in the United States, was not measured...
  24. ncbi request reprint Soluble intracellular adhesion molecule-1 is associated with cardiovascular disease risk and mortality in older adults
    N S Jenny
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT, USA
    J Thromb Haemost 4:107-13. 2006
    ..Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression...
  25. ncbi request reprint Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly
    P Crainich
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    J Thromb Haemost 1:1799-804. 2003
    ..Our results suggest that the PAI-1 4G/5G promoter polymorphism is not associated CVD risk factors or incident CVD events in the elderly...
  26. ncbi request reprint T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia
    S A Huber
    Department of Pathology, University of Vermont, Burlington, USA
    Circulation 103:2610-6. 2001
    ..T cells are implicated in atherosclerosis, but little is known about the genetic control or molecular pathways, especially under conditions of mild hypercholesterolemia...
  27. pmc Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, WA, United States
    Atherosclerosis 197:922-30. 2008
    ..If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks...
  28. ncbi request reprint 10-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 166:71-8. 2006
    ..The incidence of coronary heart disease (CHD) is very high among individuals 65 years or older...
  29. ncbi request reprint Fibrinogen and CRP in Israeli families: genetic and environmental sources of concentrations and longitudinal changes
    Yechiel Friedlander
    Unit of Epidemiology, Hebrew University Hadassah School of Public Health, Jerusalem, Israel
    Atherosclerosis 189:169-77. 2006
    ..To estimate the genetic and environmental determinants of plasma fibrinogen and C-reactive protein (CRP)...
  30. ncbi request reprint Cystatin-C and inflammatory markers in the ambulatory elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, Calif 94121, USA
    Am J Med 118:1416. 2005
    ..We compared cystatin-C, a novel marker of renal function, with creatinine and estimated glomerular filtration rate (eGFR) as predictors of C-reactive protein and fibrinogen levels...
  31. ncbi request reprint Metabolic syndrome and cardiovascular disease in older people: The cardiovascular health study
    Ann Marie McNeill
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    J Am Geriatr Soc 54:1317-24. 2006
    ....
  32. ncbi request reprint Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study
    Matteo Cesari
    Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 82:428-34. 2005
    ..Age-related body-composition changes are associated with health-related outcomes in elders. This relation may be explained by inflammation and hemostatic abnormalities...
  33. ncbi request reprint Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, 05405, USA
    Int J Cardiol 109:179-87. 2006
    ..Whether humoral factors contribute to the peripheral manifestations of the heart failure syndrome, such as muscle atrophy and reduced physical work capacity, however, is not clear...
  34. ncbi request reprint Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort
    Yongmei Liu
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Kidney Dis 46:78-85. 2005
    ....
  35. ncbi request reprint Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth
    Antoinette Moran
    Deprtment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Diabetes Care 28:1763-8. 2005
    ..Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth...
  36. ncbi request reprint C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Circulation 112:25-31. 2005
    ..High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available...
  37. ncbi request reprint IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohort
    Yongmei Liu
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Soc Nephrol 17:863-70. 2006
    ..03) and higher CVD risk (hazard ratio 1.44, P=0.006) after adjustment for covariates. The IL6 gene has functional variants that affect inflammation and risk for CVD among dialysis patients, supporting a causal role for IL6 in CVD...
  38. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008
    ....
  39. ncbi request reprint USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 27:2736-42. 2007
    ....
  40. pmc Alcohol consumption, interleukin-6 and apolipoprotein E genotypes, and concentrations of interleukin-6 and serum amyloid P in older adults
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02446, USA
    Am J Clin Nutr 86:444-50. 2007
    ..Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain...
  41. ncbi request reprint Novel and traditional cardiovascular risk factors for peripheral arterial disease in incident-dialysis patients
    Bernard G Jaar
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Chronic Kidney Dis 14:304-13. 2007
    ..This study identifies several novel risk factors (eg, Lp(a) and total homocysteine) and underscores the need for further research to reduce the burden of PAD in this high-risk group of patients...
  42. ncbi request reprint Inflammation biomarkers and near-term death in older men
    Nancy Swords Jenny
    Department of Pathology, College of Medicine, University of Vermont, Colchester Research Facility, 208 South Park Drive, Colchester, VT 05446, USA
    Am J Epidemiol 165:684-95. 2007
    ..CRP and fibrinogen were more strongly associated with death in older men than women and more strongly associated with early than late death. Combining both markers may identify older men at greatest risk of near-term death...
  43. doi request reprint Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study
    Cara L Carty
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1760 Minor Avenue, Seattle, WA 98101, USA
    Thromb Haemost 99:388-95. 2008
    ..9 (95%CI: 1.3-2.7). In conclusion, while fibrinogen genetic variation was strongly associated with fibrinogen levels, there was less evidence of association with the more complex outcomes of IMT and CVD events...
  44. ncbi request reprint Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    JAMA 296:2703-11. 2006
    ..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
  45. doi request reprint Effects of acute mental stress and exercise on inflammatory markers in patients with coronary artery disease and healthy controls
    Willem J Kop
    University of Maryland Medical Center, Baltimore, Maryland, USA
    Am J Cardiol 101:767-73. 2008
    ..These stress-induced increases are larger than in healthy subjects, occur in the absence of myocardial ischemia, and are related to the neurohormonal stress response...
  46. ncbi request reprint Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health Study
    Nancy Swords Jenny
    Department of Pathology, College of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA
    Arterioscler Thromb Vasc Biol 27:352-8. 2007
    ..Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity. However, associations of SAP with cardiovascular disease (CVD) are unknown...
  47. ncbi request reprint Soluble interleukin 6 receptor: A novel marker of moderate to severe sleep-related breathing disorder
    Reena Mehra
    Department of Medicine, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Arch Intern Med 166:1725-31. 2006
    ..The objectives were to explore the relationship between moderate to severe sleep apnea with IL-6 and sIL-6R levels and to examine morning and evening variability for each cytokine...
  48. doi request reprint Additional contribution of emerging risk factors to the prediction of the risk of type 2 diabetes: evidence from the Western New York Study
    Saverio Stranges
    Department of Social and Preventive Medicine, The State University of New York at Buffalo, Buffalo, New York, USA
    Obesity (Silver Spring) 16:1370-6. 2008
    ..To examine whether several biomarkers of endothelial function and inflammation improve prediction of type 2 diabetes over 5.9 years of follow-up, independent of traditional risk factors...
  49. ncbi request reprint Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 181:175-83. 2005
    ..These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity...
  50. ncbi request reprint Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration
    Emma K Larkin
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Triangle Building Suite 260, 10400 Euclid Ave, Cleveland, OH 44106, USA
    Circulation 111:1978-84. 2005
    ..The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk...
  51. ncbi request reprint Elevated serum C-reactive protein levels and advanced atherosclerosis in youth
    Arthur W Zieske
    Louisiana State University Health Sciences Center, New Orleans 70112 1393, USA
    Arterioscler Thromb Vasc Biol 25:1237-43. 2005
    ..To determine the associations among serum C-reactive protein (CRP) concentration, age, sex, risk factors for coronary heart disease (CHD), and atherosclerosis in young people...
  52. ncbi request reprint Physical fitness and C-reactive protein level in children and young adults: the Columbia University BioMarkers Study
    Carmen R Isasi
    Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Pediatrics 111:332-8. 2003
    ..To examine the association of physical fitness with C-reactive protein (CRP) level in children and young adults...
  53. ncbi request reprint n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  54. ncbi request reprint Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children
    Steven Shea
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Obes Res 11:95-103. 2003
    ..We examined these relationships in healthy 2- to 3-year-old children...
  55. ncbi request reprint Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency
    Michael G Shlipak
    Department of Medicine, University of California, San Francisco, and the Veterans Affairs Medical Center, San Francisco 94121, USA
    Circulation 107:87-92. 2003
    ..Little is known about the association of renal insufficiency with inflammatory and procoagulant markers, which are potential mediators for the cardiovascular risk of kidney disease...
  56. ncbi request reprint Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE)
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Med 113:636-42. 2002
    ..We sought to assess prospectively whether higher levels of blood coagulation factors and inflammation markers are risk factors for venous thromboembolism...
  57. ncbi request reprint In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease
    Nancy S Jenny
    Department of Pathology, College of Medicine, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 22:2066-71. 2002
    ..We assessed IL-6 levels and the -174G>C genotype in a case-control study of men and women (average age 73 years) within the Cardiovascular Health Study...
  58. ncbi request reprint Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study
    Jeremy Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Intern Med 162:2333-41. 2002
    ..The biological basis of frailty has been difficult to establish owing to the lack of a standard definition, its complexity, and its frequent coexistence with illness...
  59. ncbi request reprint Fibrin fragment D-dimer and the risk of future venous thrombosis
    Mary Cushman
    Laboratory for Clinical Biochemistry Research and Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Blood 101:1243-8. 2003
    ..D-dimer is strongly and positively related to the occurrence of future venous thrombosis...
  60. ncbi request reprint Factor analysis of metabolic syndrome using directly measured insulin sensitivity: The Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes 51:2642-7. 2002
    ..Additional clarification of the physiologic characteristics of metabolic syndrome is required as individuals with this condition are increasingly being considered candidates for behavioral and pharmacologic intervention...
  61. ncbi request reprint No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease: results from the Cardiovascular Health Study
    Adam M Smiles
    Department of Pathology, College of Medicine, University of Vermont, Burlington, USA
    Thromb Haemost 87:614-21. 2002
    ..This is consistent with the lack of association of prothrombin levels with measures of underlying CVD or procoagulant markers...
  62. ncbi request reprint C-reactive protein and myocardial infarction
    Pamela Sakkinen
    Laboratory for Clinical Biochemistry Research, University of Vermont, Burlington, VT, USA
    J Clin Epidemiol 55:445-51. 2002
    ....
  63. ncbi request reprint Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons
    David B Reuben
    Multicampus Program in Geriatric Medicine and Gerontology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Am Geriatr Soc 50:638-44. 2002
    ..The objective of this study was to determine the prognostic value of combining four peripheral blood measures of inflammation in healthy older persons...
  64. ncbi request reprint Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study
    Andreas Festa
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78228 3900, USA
    Diabetes 51:1131-7. 2002
    ..61 [1.20-2.16]; P = 0.002). Chronic inflammation emerges as a new risk factor for the development of type 2 diabetes; PAI-1 predicts type 2 diabetes independent of insulin resistance and other known risk factors for diabetes...
  65. pmc The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study
    Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53705 2397, USA
    Br J Ophthalmol 86:84-90. 2002
    ..To describe the association of retinopathy with atherosclerosis and atherosclerotic risk factors in people with diabetes...
  66. ncbi request reprint The relation of C-reactive protein levels to total and cardiovascular mortality in older U.S. women
    Jeffrey A Tice
    Division of General Internal Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Med 114:199-205. 2003
    ..To determine whether serum C-reactive protein levels, a sensitive indicator of inflammation, are associated with the risk of cardiovascular mortality among older women...
  67. ncbi request reprint Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition study
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:1444-8. 2003
    ..Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort...
  68. ncbi request reprint Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  69. ncbi request reprint Genetic determination of acute phase reactant levels: the strong heart study
    Lyle G Best
    Missouri Breaks Industries Research Inc, Timber Lake, SD, USA
    Hum Hered 58:112-6. 2004
    ..We sought to determine the relative contributions of genetic and environmental factors influencing basal serum levels of APRs...
  70. ncbi request reprint Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation
    Michael J Toth
    Department of Medicine, Health Science Research Facility 126 B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 288:E883-91. 2005
    ..Our data show strong trends toward reduced postabsorptive muscle protein synthesis with age. Moreover, reduced muscle protein synthesis rates were related to increased circulating concentrations of several markers of immune activation...
  71. ncbi request reprint CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the laboratory science discussion group
    Gary L Myers
    Circulation 110:e545-9. 2004
  72. ncbi request reprint Association analysis of the plasminogen activator inhibitor-1 4G/5G polymorphism in Hispanics and African Americans: the IRAS family study
    Jeannette T Bensen
    Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Hered 57:128-37. 2004
    ..In addition, we explore whether transforming growth factor (TGF-beta1), a key regulator of PAI-1 expression, modifies the influence of the PAI-1 4G/5G polymorphism on these traits...
  73. ncbi request reprint The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 44:25-34. 2004
    ..Microalbuminuria is a risk factor for coronary heart disease (CHD). It occurs most commonly in the settings of diabetes and hypertension. The mechanisms by which it increases CHD risk are uncertain...
  74. ncbi request reprint Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study
    Lisa H Colbert
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    J Am Geriatr Soc 52:1098-104. 2004
    ..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...
  75. ncbi request reprint The relationship of fasting serum radioimmune insulin levels to incident coronary heart disease in an insulin-treated diabetic cohort
    Richard A Kronmal
    Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA
    J Clin Endocrinol Metab 89:2852-8. 2004
    ..These observational findings should be confirmed through larger prospective studies, given their implications for insulin therapy...
  76. ncbi request reprint Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health Study
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO 114, Boston, MA, USA
    Atherosclerosis 173:79-87. 2004
    ..We sought to determine the relation of alcohol intake and systemic inflammation in a population-based sample of older adults...
  77. ncbi request reprint The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort
    Paul Holvoet
    Center for Experimental Surgery and Anesthesiology, Catholic University, Leuven, Belgium
    Diabetes 53:1068-73. 2004
    ..22-4.15). We concluded that the metabolic syndrome, a risk factor for CHD, is associated with higher levels of circulating oxLDL that are associated with a greater disposition to atherothrombotic coronary disease...
  78. ncbi request reprint Traditional and novel risk factors in older adults: cardiovascular risk assessment late in life
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Geriatr Cardiol 13:69-80. 2004
    ..Future Cardiovascular Health Study investigations will help to clarify which combination of traditional and newer risk factors provides the best estimate of cardiovascular risk for older adults...
  79. ncbi request reprint Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition
    Yongmei Liu
    Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 291:451-9. 2004
    ..This paradox may be explained by systemic inflammation and/or malnutrition, which are associated with lower cholesterol levels and higher mortality...
  80. ncbi request reprint Inflammation as a risk factor for atrial fibrillation
    Ronnier J Aviles
    Department of Cardiovascular Medicine, Desk F15, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44951, USA
    Circulation 108:3006-10. 2003
    ..The relationship between CRP and prediction of AF has not been studied in a large population-based cohort...
  81. ncbi request reprint Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Circulation 108:1822-30. 2003
    ..Previously, atherogenic changes in traditional CV risk factors in the prediabetic state were mainly seen in insulin-resistant subjects rather than in those with a predominant defect in insulin secretion...
  82. ncbi request reprint Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes: the strong heart study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Diabetes Care 26:2764-9. 2003
    ....
  83. ncbi request reprint Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal
    Cynthia K Sites
    Department of Obstetrics and Gynecology, The University of Vermont College of Medicne, Burlington, Vermont 05405, USA
    Fertil Steril 77:128-35. 2002
    ..To determine whether postmenopausal status is associated with elevated plasma inflammation markers compared to premenopausal status, and how this explains differences in fat distribution and insulin-stimulated glucose disposal...

Research Grants14

  1. Epidemiology of Vascular Inflammation & Atherosclerosis
    Russell Tracy; Fiscal Year: 2006
    ..In addition, these new phenotypes will prove useful as intermediate phenotypes for future studies of the role of genetic variation in human biology and disease. ..
  2. Epidemiology of Vascular Inflammation & Atherosclerosis
    Russell Tracy; Fiscal Year: 2005
    ..In addition, these new phenotypes will prove useful as intermediate phenotypes for future studies of the role of genetic variation in human biology and disease. ..
  3. Epidemiology of Vascular Inflammation & Atherosclerosis
    Russell Tracy; Fiscal Year: 2004
    ..In addition, these new phenotypes will prove useful as intermediate phenotypes for future studies of the role of genetic variation in human biology and disease. ..
  4. GIVEN BUILDING ANIMAL FACILITY UPGRADE
    Russell Tracy; Fiscal Year: 2004
    ....
  5. INFLAMMATION MARKERS OVER TIME IN CARDIOVASCULAR DISEASE
    Russell Tracy; Fiscal Year: 2002
    ..It is likely our results will have important implications for prevention, diagnosis, and future therapeutic interventions in cardiovascular disease in the elderly. ..
  6. INFLAMMATION MARKERS OVER TIME IN CARDIOVASCULAR DISEASE
    Russell Tracy; Fiscal Year: 2001
    ..It is likely our results will have important implications for prevention, diagnosis, and future therapeutic interventions in cardiovascular disease in the elderly. ..
  7. INFLAMMATION MARKERS OVER TIME IN CARDIOVASCULAR DISEASE
    Russell Tracy; Fiscal Year: 2000
    ..It is likely our results will have important implications for prevention, diagnosis, and future therapeutic interventions in cardiovascular disease in the elderly. ..
  8. EPIDEMIOLOGY OF HEMOSTASIS IN PERSONS OVER 65
    Russell Tracy; Fiscal Year: 1993
    ..These studies will increase our understanding of the relationship of thrombosis to cardiovascular risk...
  9. EPIDEMIOLOGY OF HEMOSTASIS IN PERSONS OVER 65
    Russell Tracy; Fiscal Year: 1992
    ..These studies will increase our understanding of the relationship of thrombosis to cardiovascular risk...
  10. INFLAMMATION MARKERS OVER TIME IN CARDIOVASCULAR DISEASE
    Russell Tracy; Fiscal Year: 1999
    ..It is likely our results will have important implications for prevention, diagnosis, and future therapeutic interventions in cardiovascular disease in the elderly. ..
  11. Epidemiology of Vascular Inflammation & Atherosclerosis
    Russell Tracy; Fiscal Year: 2007
    ..In addition, these new phenotypes will prove useful as intermediate phenotypes for future studies of the role of genetic variation in human biology and disease. ..