Tatsushi Toyokuni

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agent
    Tatsushi Toyokuni
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1770, USA
    Bioconjug Chem 14:1253-9. 2003
  2. ncbi request reprint Practical and reliable synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose, a precursor of 2-deoxy-2-[18F]fluoro-D-glucose (FDG)
    Tatsushi Toyokuni
    Crump Institute of Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90230, USA
    Mol Imaging Biol 6:324-30. 2004
  3. ncbi request reprint Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
    Tatsushi Toyokuni
    Crump Institute for Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 15:4699-702. 2005
  4. ncbi request reprint Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism
    Andrew J Norris
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 14:571-3. 2004
  5. ncbi request reprint A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A
    Andrew J Norris
    Pasarow Mass Spectrometry Laboratory, Department of Psychiatry, and Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Lipid Res 46:2254-64. 2005
  6. pmc Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging
    Lojze M Smid
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:261-74. 2013
  7. pmc Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography
    Nona Adonai
    The Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA 90095 1770, USA
    Proc Natl Acad Sci U S A 99:3030-5. 2002
  8. ncbi request reprint Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli
    Miklos Sahin-Toth
    Howard Hughes Medical Institute, Department of Physiology, Molecular Biology Institute, University of California, Los Angeles, California 90095 1662, USA
    Biochemistry 41:13039-45. 2002

Detail Information

Publications8

  1. ncbi request reprint Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agent
    Tatsushi Toyokuni
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1770, USA
    Bioconjug Chem 14:1253-9. 2003
    ....
  2. ncbi request reprint Practical and reliable synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose, a precursor of 2-deoxy-2-[18F]fluoro-D-glucose (FDG)
    Tatsushi Toyokuni
    Crump Institute of Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90230, USA
    Mol Imaging Biol 6:324-30. 2004
    ..To develop a practical and reliable synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose (mannose triflate), a precursor of 2-deoxy-2-[18F]fluoro-D-glucose (FDG)...
  3. ncbi request reprint Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
    Tatsushi Toyokuni
    Crump Institute for Molecular Imaging and LA Tech Center, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 15:4699-702. 2005
    ....
  4. ncbi request reprint Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism
    Andrew J Norris
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Bioorg Med Chem Lett 14:571-3. 2004
    ..1+/-9.8 microM, similar to the K(m) value for GDP-Fuc (50.4+/-5.5 microM), while the C-Fuc analogue exhibited significantly weak competitive inhibition with a K(i) value of 889+/-93 microM...
  5. ncbi request reprint A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A
    Andrew J Norris
    Pasarow Mass Spectrometry Laboratory, Department of Psychiatry, and Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, CA 90024, USA
    J Lipid Res 46:2254-64. 2005
    ..The modified assay for the coupled ASA/CSAct reaction could find applicability in settings in which the assay could not be performed previously because of the need for radiolabeled substrate, which is now not required...
  6. pmc Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging
    Lojze M Smid
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:261-74. 2013
    ..This work offers a mapping brain model applicable to all imaging probes for verification of imaging results with Aβ and/or tau neuropathology brain distribution using immunohistochemistry, fluorescence microscopy, and autoradiography...
  7. pmc Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography
    Nona Adonai
    The Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA 90095 1770, USA
    Proc Natl Acad Sci U S A 99:3030-5. 2002
    ..Given the longer t(1/2) of 64Cu (12.7 h) relative to 18F (110 min), longer cell-tracking periods (up to 24-36 h) should be possible now with PET...
  8. ncbi request reprint Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli
    Miklos Sahin-Toth
    Howard Hughes Medical Institute, Department of Physiology, Molecular Biology Institute, University of California, Los Angeles, California 90095 1662, USA
    Biochemistry 41:13039-45. 2002
    ..The different positioning of this carbon atom in alpha- or beta-D-galactopyranosides thus may provide a rationale for the characteristic binding preference of the permease for alpha anomers...