Raymond Townsend

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Arterial compliance in the elderly: its effect on blood pressure measurement and cardiovascular outcomes
    Mary Ann Lim
    Renal Electrolyte and Hypertension Division, Department of Medicine, Hospital of the University of Pennsylvania, 1 Founders Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Geriatr Med 25:191-205. 2009
  2. doi request reprint The single pill triple combination of aliskiren, amlodipine, and hydrochlorothiazide in the treatment of hypertension
    Yonghong Huan
    University of Pennsylvania, Medicine, 1 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 13:2409-15. 2012
  3. ncbi request reprint Safety of intravenous gadolinium (Gd-BOPTA) infusion in patients with renal insufficiency
    R R Townsend
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Kidney Dis 36:1207-12. 2000
  4. pmc Aortic PWV in chronic kidney disease: a CRIC ancillary study
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Hypertens 23:282-9. 2010
  5. ncbi request reprint Alcohol and its relationship to blood pressure
    Lavanya Kodavali
    Department of Medicine, University of Pennsylvania, 1 Gibson, 3400 Spruce Street, Philadelphia, 19104, USA
    Curr Hypertens Rep 8:338-44. 2006
  6. ncbi request reprint A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension
    Raymond R Townsend
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Hypertens 17:1056-8. 2004
  7. pmc Stroke in chronic kidney disease: prevention and management
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin J Am Soc Nephrol 3:S11-6. 2008
  8. ncbi request reprint Vascular compliance and arterial calcification: impact on blood pressure reduction
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 17:93-8. 2008
  9. ncbi request reprint Salt intake and insulin sensitivity in healthy human volunteers
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Sci (Lond) 113:141-8. 2007
  10. ncbi request reprint Can we justify goal blood pressure of <140/90 mm Hg in most hypertensives?
    Raymond R Townsend
    Department of Medicine, Renal Electrolyte Hypertension and Stone Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Hypertens Rep 7:257-64. 2005

Research Grants

  1. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
  2. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
  3. Pulse wave velocity in chronic kidney disease
    Raymond Townsend; Fiscal Year: 2009
  4. Pulse wave velocity in chronic kidney disease
    Raymond Townsend; Fiscal Year: 2009
  5. Pulse wave velocity in chronic kidney disease
    Raymond Townsend; Fiscal Year: 2007
  6. Prospective Renal Insufficiency Cohort Evaluation:PRICE
    Raymond Townsend; Fiscal Year: 2007
  7. Pulse wave velocity in chronic kidney diseases
    Raymond R Townsend; Fiscal Year: 2010

Detail Information

Publications92

  1. doi request reprint Arterial compliance in the elderly: its effect on blood pressure measurement and cardiovascular outcomes
    Mary Ann Lim
    Renal Electrolyte and Hypertension Division, Department of Medicine, Hospital of the University of Pennsylvania, 1 Founders Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Geriatr Med 25:191-205. 2009
    ..Finally, the author's review the different studies that look at arterial stiffness in the elderly, its impact on hypertension and cardiovascular outcome, and what is currently known on how to prevent vascular stiffness...
  2. doi request reprint The single pill triple combination of aliskiren, amlodipine, and hydrochlorothiazide in the treatment of hypertension
    Yonghong Huan
    University of Pennsylvania, Medicine, 1 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 13:2409-15. 2012
    ..Combination therapy with antihypertensive agents of complementary actions has been advocated in the management of hypertension to maximize efficacy and minimize side effects...
  3. ncbi request reprint Safety of intravenous gadolinium (Gd-BOPTA) infusion in patients with renal insufficiency
    R R Townsend
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Kidney Dis 36:1207-12. 2000
    ..5 mg/dL more than baseline, and no patient required hospitalization or dialysis during the study period. Gadolinium (Gd-BOPTA dimeglumine) appears to be well tolerated in patients with moderate to severe renal failure...
  4. pmc Aortic PWV in chronic kidney disease: a CRIC ancillary study
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Hypertens 23:282-9. 2010
    ..Little data exist characterizing aortic stiffness in patients with chronic kidney disease (CKD) who are not receiving dialysis, and in particular the effect of reduced kidney function on aortic PWV...
  5. ncbi request reprint Alcohol and its relationship to blood pressure
    Lavanya Kodavali
    Department of Medicine, University of Pennsylvania, 1 Gibson, 3400 Spruce Street, Philadelphia, 19104, USA
    Curr Hypertens Rep 8:338-44. 2006
    ..Reducing excessive alcohol intake can produce a reduction in blood pressure of up to 4 mm Hg, on average, which could substantially affect the rates of stroke and ischemic heart disease...
  6. ncbi request reprint A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension
    Raymond R Townsend
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Hypertens 17:1056-8. 2004
    ..Many patients seek complementary medicine treatments like neutraceuticals for common conditions such as hypertension...
  7. pmc Stroke in chronic kidney disease: prevention and management
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin J Am Soc Nephrol 3:S11-6. 2008
    ....
  8. ncbi request reprint Vascular compliance and arterial calcification: impact on blood pressure reduction
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 17:93-8. 2008
    ..The aim of this article is to review the relationship between vascular calcification and difficult to control hypertension. This does not address antihypertensive treatment of drug resistant hypertension per se...
  9. ncbi request reprint Salt intake and insulin sensitivity in healthy human volunteers
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Sci (Lond) 113:141-8. 2007
    ....
  10. ncbi request reprint Can we justify goal blood pressure of <140/90 mm Hg in most hypertensives?
    Raymond R Townsend
    Department of Medicine, Renal Electrolyte Hypertension and Stone Division, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Hypertens Rep 7:257-64. 2005
    ..In this review, the basis for these recommendations, the practical achievement of these goals in various practice settings, and the risk versus the benefit of achieving such goals in most hypertensive patients are examined...
  11. ncbi request reprint Analyzing the radial pulse waveform: narrowing the gap between blood pressure and outcomes
    Raymond R Townsend
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Nephrol Hypertens 16:261-6. 2007
    ..This review will briefly recount the history behind this technology and discuss where it fits into the measurement of vascular properties that may predict outcomes such as death, heart attack, stroke or kidney disease progression...
  12. pmc Central pulse pressure in chronic kidney disease: a chronic renal insufficiency cohort ancillary study
    Raymond R Townsend
    University of Pennsylvania, 122 Founders Building, 3400 Spruce St, Philadelphia, PA 19104, USA
    Hypertension 56:518-24. 2010
    ..The large size of this unique chronic kidney disease cohort provides an ideal situation to study the role of brachial and central pressure measurements in kidney disease progression and cardiovascular disease incidence...
  13. ncbi request reprint Angiotensin and insulin resistance: conspiracy theory
    Raymond R Townsend
    University of Pennsylvania, 210 White Building, 3400 Spruce Street, Philadelphia 19104, USA
    Curr Hypertens Rep 5:110-6. 2003
    ..Conspiracy mechanisms by which angiotensin II and insulin resistance interact in the pathogenesis of cardiovascular disease are reviewed, with particular attention to recent developments in this engaging area of human research...
  14. pmc Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Am J Nephrol 33:477-84. 2011
    ..We determined metabolic syndrome prevalence among individuals with a broad spectrum of kidney dysfunction, examining the role of the individual elements of metabolic syndrome and their relationship to prevalent CVD...
  15. doi request reprint Blood pressure effects of naproxcinod in hypertensive patients
    Raymond Townsend
    Hospital of theUniversity of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 13:376-84. 2011
    ..4 mm Hg; P<.0001) and the 24 hours following morning dosing (LS mean: -2.4 mm Hg; P=.006). Naproxcinod may be a beneficial alternative for patients with osteoarthritis requiring nonsteroidal anti-inflammatory drugs...
  16. doi request reprint Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus
    Raymond R Townsend
    University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Clin Hypertens (Greenwich) 13:889-97. 2011
    ..2%) than amlodipine (13.8%; P<.0001). Aliskiren/HCTZ provides substantial msSBP reductions and greater BP control rates than amlodipine, and offers an attractive treatment option for patients with hypertension and diabetes mellitus...
  17. pmc Retinopathy and chronic kidney disease in the Chronic Renal Insufficiency Cohort (CRIC) study
    Juan E Grunwald
    University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Arch Ophthalmol 130:1136-44. 2012
    ..To investigate the association between retinopathy and chronic kidney disease...
  18. doi request reprint Arterial pulsatile hemodynamic load induced by isometric exercise strongly predicts left ventricular mass in hypertension
    Julio A Chirinos
    University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 298:H320-30. 2010
    ....
  19. doi request reprint Is there a role for measuring central aortic pressure?
    Yonghong Huan
    Renal, Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, USA
    Curr Cardiol Rep 13:502-6. 2011
    ..Emerging data suggest that central arotic pressure and related parameters are often better and more robust predictors of cardiovascular outcome than peripheral brachial blood pressures...
  20. doi request reprint Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for hypertension on clinical end points: a cohort study
    Jason Roy
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 14:407-14. 2012
    ..93; CI, 1.22-3.07). Within a large medical-practice based population, there was no evidence of differential effectiveness between ACE inhibitors and ARBs for most outcomes, with diabetes being the notable exception...
  21. ncbi request reprint Comparison of pulse wave analysis between persons with white coat hypertension and normotensive persons
    Neil J Wimmer
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 9:513-7. 2007
    ..In summary, WCH participants had increased central aortic pressures compared with normotensives, supporting the potential for increased cardiovascular risk in WCH...
  22. ncbi request reprint Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    ....
  23. pmc Association between retinopathy and cardiovascular disease in patients with chronic kidney disease (from the Chronic Renal Insufficiency Cohort [CRIC] Study)
    Juan E Grunwald
    University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Am J Cardiol 110:246-53. 2012
    ..This would make the assessment of retinal morphology a valuable tool in CKD studies of CVD outcomes...
  24. doi request reprint Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension
    Julio A Chirinos
    University of Pennsylvania, Philadelphia, USA
    Circulation 119:2798-807. 2009
    ..We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress in hypertensive and normotensive adults...
  25. ncbi request reprint Large and small artery compliance changes during hemodialysis
    Debbie L Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Am J Hypertens 15:236-9. 2002
    ..Reduced arterial compliance is an independent predictor of cardiovascular mortality in end stage renal disease and can be measured noninvasively using pulse wave analysis technology...
  26. pmc Prevalence of ocular fundus pathology in patients with chronic kidney disease
    Juan E Grunwald
    Department of Ophthamology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
    Clin J Am Soc Nephrol 5:867-73. 2010
    ....
  27. ncbi request reprint Management of chronic kidney disease in an academic primary care clinic
    Ajay Israni
    Renal Electrolyte, Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Nephrol 23:47-54. 2003
    ..Three million people in the United States are estimated to have chronic kidney disease (CKD). Management of these CKD patients in the outpatient primary care clinic setting has not been well studied...
  28. doi request reprint Untreated hypertension and the emergency department: a chance to intervene?
    Craig A Umscheid
    Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Acad Emerg Med 15:529-36. 2008
    ..The authors investigated the accuracy of identifying HTN in the ED, the proportion of ED patients with untreated HTN, patient characteristics predicting untreated HTN, and provider documentation of untreated HTN...
  29. ncbi request reprint Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
    ..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control...
  30. ncbi request reprint The pharmacokinetics and cardiovascular effects of high-dose articaine with 1:100,000 and 1:200,000 epinephrine
    Elliot V Hersh
    Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, 240 South 40th St, Philadelphia, PA 19104 6003, USA
    J Am Dent Assoc 137:1562-71. 2006
    ..9 milliliters of 4 percent articaine hydrochloride (HCl) plus 1:100,000 epinephrine (A100) with those of 11.9 mL of 4 percent articaine HCl plus 1:200,000 epinephrine (A200)...
  31. ncbi request reprint Lack of symptoms in patients with histologic evidence of pheochromocytoma: a diagnostic challenge
    Debbie L Cohen
    Renal Electrolyte and Hypertension Division, Department of Surgery, University of Pennsylvania, 210 White Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1073:47-51. 2006
    ..6% had tachycardia, 34.4% had sweating, and 31.3% had headaches. Initial presenting symptoms were diverse. Pheo is a rare clinical entity and remains a huge diagnostic challenge for all clinicians...
  32. pmc 48-h glucose infusion in humans: effect on hormonal responses, hunger and food intake
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, PA 19104, United States
    Physiol Behav 90:733-43. 2007
    ..These data are the first to demonstrate a relationship between leptin and hunger in normal weight, non-calorically restricted human subjects...
  33. ncbi request reprint Exaggerated systolic blood pressure response to exercise
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Hypertens (Greenwich) 9:291-2. 2007
  34. pmc Renal impairment, hypertension and plasma urotensin II
    Ari Mosenkis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nephrol Dial Transplant 26:609-14. 2011
    ..We measured the associations between kidney function [including end-stage renal disease (ESRD)] and levels of BP with plasma concentrations of UII...
  35. pmc Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:1562-9. 2009
    ..The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied...
  36. ncbi request reprint Cardiovascular function in normotensive offspring of persons with essential hypertension and black race
    Emile R Mohler
    Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Hypertens (Greenwich) 9:506-12. 2007
    ..These same studies demonstrated some early changes in vascular function based on sex...
  37. doi request reprint Is there added value to adding ARB to ACE inhibitors in the management of CKD?
    Debbie L Cohen
    Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Am Soc Nephrol 20:1666-8. 2009
    ..We suggest dual RAAS blockade be used in patients with chronic kidney disease with residual proteinuria on maximal ACE inhibitor or angiotensin II blocker therapy, anticipating additional data with ongoing trials...
  38. pmc Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Hypertens 22:1235-41. 2009
    ....
  39. doi request reprint Body mass index and hypertension hemodynamic subtypes in the adult US population
    Julio A Chirinos
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, 19104, USA
    Arch Intern Med 169:580-6. 2009
    ..Similarly, the study of hypertension subtypes provides important information regarding the relative importance of hemodynamic abnormalities contributing to obesity-related hypertension...
  40. ncbi request reprint Antihypertensive medications and weight gain
    Ari Mosenkis
    Hypertension Program, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 6:90. 2004
  41. ncbi request reprint Segmental arterial mediolysis: angioplasty of bilateral renal artery stenoses with 2-year imaging follow-up
    Michael C Soulen
    Division of Interventional Radiology, Hospital of the University of Pennsylvania, 1 Silverstein, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    J Vasc Interv Radiol 15:763-7. 2004
    ..The clinical presentation is usually catastrophic as a result of vascular occlusion or rupture. Herein an unusual case of renovascular hypertension resulting from SAM is reported, which was successfully treated with balloon angioplasty...
  42. ncbi request reprint Hypertensive patients' willingness to participate in placebo-controlled trials: implications for recruitment efficiency
    Scott D Halpern
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am Heart J 146:985-92. 2003
    ....
  43. ncbi request reprint Common questions and answers in the management of hypertension. Residual risk
    Ari Mosenkis
    Hypertension Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 5:362-3. 2003
  44. ncbi request reprint Renal artery stenosis due to fibromuscular dysplasia in an 18-week pregnant woman
    Debbie L Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obstet Gynecol 105:1232-5. 2005
    ..Hypertension is a frequent medical complication of pregnancy. Renovascular hypertension is present in 5-10% of cases of severe hypertension during pregnancy...
  45. ncbi request reprint The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods
    Harold I Feldman
    Center for Clinical Epidemiology, Philadelphia, 19104, USA
    J Am Soc Nephrol 14:S148-53. 2003
    ..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...
  46. ncbi request reprint Prolonged mild hyperglycemia induces vagally mediated compensatory increase in C-Peptide secretion in humans
    Karen L Teff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 89:5606-13. 2004
    ..In summary, we found that prolonged mild hyperglycemia results in a compensatory increase in C-peptide secretion, which is partially mediated by an induction in vagal efferent activity...
  47. ncbi request reprint Rapidly reversible cardiogenic shock as a pheochromocytoma presentation
    Kirsten Brukamp
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Med 120:e1-2. 2007
  48. ncbi request reprint Pulse wave analysis to assess vascular compliance changes in stable renal transplant recipients
    Debbie L Cohen
    Renal Division, Hospital of the University of Pennsylvania, 210 White Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Hypertens 17:209-12. 2004
    ..The purpose of the study was to determine whether calcineurin inhibitor drugs have any effect on arterial compliance...
  49. pmc Physicians' preferences for active-controlled versus placebo-controlled trials of new antihypertensive drugs
    Scott D Halpern
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Gen Intern Med 17:689-95. 2002
    ..To evaluate physicians' preferences for referring patients to, and using information from, active-controlled trials (ACTs) versus placebo-controlled trials (PCTs) of new antihypertensive drugs...
  50. doi request reprint Beyond conventional considerations: newer devices used in blood pressure measurement and management
    Raymond R Townsend
    Section of Clinical Pharmacology and Hypertension, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, VA, USA
    Adv Chronic Kidney Dis 18:48-54. 2011
    ....
  51. ncbi request reprint Prolonged (48-hour) modest hyperinsulinemia decreases nocturnal heart rate variability and attenuates the nocturnal decrease in blood pressure in lean, normotensive humans
    Maja Petrova
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 91:851-9. 2006
    ..Heart rate variability (HRV), an index of cardiac vagal activity, is decreased in individuals with metabolic disease. The relationship between decreased HRV and metabolic disease is unclear...
  52. pmc Measured GFR does not outperform estimated GFR in predicting CKD-related complications
    Chi yuan Hsu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    J Am Soc Nephrol 22:1931-7. 2011
    ..These results raise questions regarding the conventional view that iGFR is the "gold standard" measure of kidney function...
  53. ncbi request reprint Validation of steady-state insulin sensitivity indices in chronic kidney disease
    Michael F Crutchlow
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Room 778, Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes Care 30:1813-8. 2007
    ..The purpose of this study was to attempt to validate several commonly used steady-state insulin sensitivity (SI-SS) indices in a CKD population...
  54. ncbi request reprint How old is "too old" to start treating high blood pressure?
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 10:647-8. 2008
  55. ncbi request reprint The ankle-brachial index and peripheral pulses in hypertensive patients
    Debbie L Cohen
    Department of Meidcine, Hypertension Program, University of Pennsylvania School of Medicine, PA 19104, USA
    J Clin Hypertens (Greenwich) 9:143-4. 2007
  56. ncbi request reprint Diastolic blood pressure control: how low is too low?
    Ari Mosenkis
    Department of Medicine, University of Pennsylvania, 210 White Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 6:351-2. 2004
  57. doi request reprint Adrenal venous sampling for primary aldosteronism and clinical outcomes after unilateral adrenalectomy: a single-center experience
    Miho Murashima
    Hospital of the University of Pennsylvania, Philadelphia, 19104, USA
    J Clin Hypertens (Greenwich) 11:316-23. 2009
    ..Results suggest that these factors should not preclude AVS and subsequent adrenalectomy. Further studies are indicated to confirm these findings...
  58. ncbi request reprint Treating hypertension in the patient who has had a stroke
    Borut Cizman
    Hypertension Program, Department of Medicine, University of Pennsylvania, 210 White Building Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 4:135. 2002
  59. doi request reprint Variability--the drama of the circulation
    Mario F Rubin
    Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Clin Hypertens (Greenwich) 12:284-7. 2010
    ....
  60. ncbi request reprint Blood pressure changes in the leg on standing
    Arun Malhotra
    Renal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 4:350-4. 2002
    ..47; p<0.002). These data reveal a previously unappreciated aspect of blood pressure, namely a large increase in lower extremity blood pressure values on standing, which may predispose to peripheral arterial disease...
  61. ncbi request reprint Differential effect of insulin on saturated and unsaturated fatty acids
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, Pa and the Department of Medicine, Michigan State University, East Lansing, MI
    Metabolism 51:779-82. 2002
    ..These data demonstrate a sustained differential effect of insulin on the plasma fatty acid profile...
  62. ncbi request reprint What is the best drug to prescribe for a young woman in her childbearing years with essential hypertension?
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 10:322-3. 2008
  63. ncbi request reprint Morning surges in blood pressure
    Radhika Katakam
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:450-1. 2006
  64. ncbi request reprint What's in a pulse? Part 2
    Radhika Katakam
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:288-90. 2006
  65. ncbi request reprint Can I stop taking this blood pressure medicine?
    Raymond R Townsend
    Hypertension Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 5:234. 2003
  66. ncbi request reprint What's in a pulse?
    Radhika Katakam
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:140-1. 2006
  67. ncbi request reprint Is funduscopy clinically useful in the evaluation of the hypertensive patient?
    Ari Mosenkis
    Hypertension Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 5:421-2. 2003
  68. ncbi request reprint Primary hyperaldosteronism: returning to the limelight?
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 9:476-7. 2007
  69. ncbi request reprint Non-aspirin nonsteroidal anti-inflammatory drugs
    Raymond R Townsend
    Hypertension Program, Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Hypertens (Greenwich) 4:436, 440. 2002
  70. ncbi request reprint Automated blood pressure measurement in public places
    Ari Mosenkis
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 7:620-1. 2005
  71. ncbi request reprint Sitting on the evidence: what is the proper patient position for the office measurement of blood pressure?
    Ari Mosenkis
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 7:365-6. 2005
  72. ncbi request reprint Cocoa ingestion and hypertension-another cup please?
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 9:647-8. 2007
  73. ncbi request reprint Does consumption of high-caffeine energy drinks affect blood pressure?
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:744-5. 2006
  74. ncbi request reprint Chemotherapy agents and hypertension: a focus on angiogenesis blockade
    Manish Jain
    Department of Medicine, University of Pennsylvania, 3400 Spruce Street, 1 Gibson, Philadelphia, PA 19104, USA
    Curr Hypertens Rep 9:320-8. 2007
    ....
  75. ncbi request reprint Finding vs controlling hypertension--mind the gap!
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 9:974. 2007
  76. pmc A comparison of change in measured and estimated glomerular filtration rate in patients with nondiabetic kidney disease
    Dawei Xie
    Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA 19104, USA
    Clin J Am Soc Nephrol 3:1332-8. 2008
    ..The aims of this study were to examine the concordance between use of measured GFR (mGFR) and estimated GFR (eGFR) in tracking changes in kidney function over time among patients with moderately severe chronic kidney disease...
  77. ncbi request reprint Following up angiotensin-converting enzyme inhibitor monotherapy
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 8:600-1. 2006
  78. ncbi request reprint What's new with kids and high blood pressure?
    Ari Mosenkis
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 7:243-4. 2005
  79. ncbi request reprint What time of day should I take my antihypertensive medications?
    Ari Mosenkis
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Hypertens (Greenwich) 6:593, 597. 2004
  80. ncbi request reprint Refractory or resistant hypertension
    Raymond R Townsend
    Hypertension Program, Department of Medicine, University of Pennsylvania, 210 White Building, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 4:61. 2002
  81. ncbi request reprint What is the proper workup of a patient with hypertension?
    Radhika Katakam
    Instructor in Medicine, Henry Ford Health System, Detroit, MI, USA
    Cleve Clin J Med 75:663-72. 2008
    ..with an elevated pressure reading, ie, does the patient have sustained high blood pressure? And if so, is the hypertension primary or secondary, are other cardiovascular risk factors present, and is there evidence of target organ damage?..
  82. ncbi request reprint Guiding lights for antihypertensive treatment in patients with nondiabetic chronic renal disease: proteinuria and blood pressure levels?
    Cynthia D Mulrow
    Ann Intern Med 139:296-8. 2003
  83. ncbi request reprint Systematic review of the effect of daily alcohol intake on blood pressure
    Christopher B McFadden
    Cooper Medical Center, Camden, New Jersey, USA
    Am J Hypertens 18:276-86. 2005
    ..These findings indicate that the timing of BP measurements after alcohol intake has a substantial effect on the magnitude and perhaps even the direction of BP change...
  84. ncbi request reprint Roundtable discussion: hypertension in children and adolescents
    Marvin Moser
    Department of Medicine Cardiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Hypertens (Greenwich) 7:24-30. 2005
    ..Townsend, MD, of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; and Marvin Moser, MD, of the Department of Medicine/Cardiology, Yale University School of Medicine, New Haven, CT...
  85. ncbi request reprint Preventing cardiovascular and renal complications in the management of hypertension and metabolic syndrome
    Jing Chen
    Expert Opin Pharmacother 8:2001-9. 2007
    ..In addition, the article explores the link between metabolic syndrome, kidney function, insulin resistance and chronic kidney disease. Finally, the article discusses the issue of managing metabolic syndrome...
  86. ncbi request reprint Pheochromocytoma: the expanding genetic differential diagnosis
    Jennifer Bryant
    Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Natl Cancer Inst 95:1196-204. 2003
    ....
  87. ncbi request reprint What effect does potassium have on blood pressure?
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 10:158-9. 2008
  88. doi request reprint Vascular stiffness: its measurement and significance for epidemiologic and outcome studies
    Stephanie S DeLoach
    Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Clin J Am Soc Nephrol 3:184-92. 2008
    ....
  89. ncbi request reprint New recommendations for blood pressure treatment goals in coronary disease
    Debbie L Cohen
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 9:975-6. 2007
  90. ncbi request reprint The forgetful hypertensive patient
    Raymond R Townsend
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 5:89. 2003
  91. ncbi request reprint Treatment of hypertension in the very elderly: morbidity vs. mortality
    Ari Mosenkis
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 7:554, 568. 2005
  92. ncbi request reprint Common questions and answers in the management of hypertension: routine measurement of plasma renin activity in the management of patients with essential hypertension: notes from the 19th Annual ASH Meeting
    Ari Mosenkis
    Department of Medicine, Hypertension Program, University of Pennsylvania School of Medicine, 201 White Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Clin Hypertens (Greenwich) 6:720-1. 2004

Research Grants11

  1. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ....
  2. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
    ..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
  3. Pulse wave velocity in chronic kidney disease
    Raymond Townsend; Fiscal Year: 2009
    ....
  4. Pulse wave velocity in chronic kidney disease
    Raymond Townsend; Fiscal Year: 2009
    ..Determination of the pulse wave velocity (PWV) a reflection of large vessel stiffness has provided useful information in cardiovascular disease epidemiology. ..
  5. Pulse wave velocity in chronic kidney disease
    Raymond Townsend; Fiscal Year: 2007
    ..abstract_text> ..
  6. Prospective Renal Insufficiency Cohort Evaluation:PRICE
    Raymond Townsend; Fiscal Year: 2007
    ..The data collected on the proposed clinical, genetic and humoral factors at our experienced Clinical Center will contribute substantially to the understanding of CRI, and CVD in subjects with CRI.. ..
  7. Pulse wave velocity in chronic kidney diseases
    Raymond R Townsend; Fiscal Year: 2010
    ..Since the target organs of hypertension (kidney,heart,brain) are linked by the circulation this project evaluates specific aspects of the circulation which may be important in disease progression. ..