T Town

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42
    T Town
    The Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Neurosci Lett 307:101-4. 2001
  2. ncbi request reprint The opioid receptor system and alcoholism: a genetic perspective
    T Town
    The Roskamp Institute, 3515 E Fletcher Ave, Tampa, FL 33613, USA
    Eur J Pharmacol 410:243-248. 2000
  3. ncbi request reprint Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42)
    Terrence Town
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    J Neuroimmunol 132:49-59. 2002
  4. ncbi request reprint Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E
    T Town
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:465-8. 1999
  5. ncbi request reprint Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency
    T Town
    The Roskamp Institute, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:458-61. 1999
  6. ncbi request reprint Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Immunol 163:6614-21. 1999
  7. ncbi request reprint Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism
    D Paris
    The Roskamp Institute, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Exp Neurol 157:211-21. 1999
  8. ncbi request reprint Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Neuroimmunol 97:77-85. 1999
  9. ncbi request reprint No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
    D Fallin
    Department of Psychiatry, University of South Florida, Tampa 33613, USA
    Neurosci Lett 233:145-7. 1997
  10. ncbi request reprint CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 20:7587-94. 2000

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42
    T Town
    The Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Neurosci Lett 307:101-4. 2001
    ..These data further indicate the immunogenic potential of Abeta1-42 and offer insight into the nature of the IgG anti-Abeta Ab response...
  2. ncbi request reprint The opioid receptor system and alcoholism: a genetic perspective
    T Town
    The Roskamp Institute, 3515 E Fletcher Ave, Tampa, FL 33613, USA
    Eur J Pharmacol 410:243-248. 2000
    ....
  3. ncbi request reprint Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42)
    Terrence Town
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    J Neuroimmunol 132:49-59. 2002
    ..Taken together, these results show enhanced Th2 and down-regulated Th1 immunity following immune challenge with Abeta(1-42)...
  4. ncbi request reprint Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E
    T Town
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:465-8. 1999
    ..These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions...
  5. ncbi request reprint Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency
    T Town
    The Roskamp Institute, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:458-61. 1999
    ..These results suggest that, at the molecular level, the endogenous mu-opioid receptor system is a contributing factor to the etiology of alcoholism...
  6. ncbi request reprint Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Immunol 163:6614-21. 1999
    ..Taken together, these data show that ligation of microglial CD40 triggers TNF-alpha release through the p44/42 MAPK pathway, an effect that can be opposed by TGF-beta1 and IL-10...
  7. ncbi request reprint Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism
    D Paris
    The Roskamp Institute, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Exp Neurol 157:211-21. 1999
    ..Our results suggest that therapeutic intervention aimed at reduction of microglial-mediated inflammation via inhibition of cGMP-PDE or elevation of cGMP may be beneficial in the treatment of AD...
  8. ncbi request reprint Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Neuroimmunol 97:77-85. 1999
    ....
  9. ncbi request reprint No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
    D Fallin
    Department of Psychiatry, University of South Florida, Tampa 33613, USA
    Neurosci Lett 233:145-7. 1997
    ..Further, despite the biochemical relationship between LRP and the ApoE protein, we find no significant statistical interaction between the alleles at these loci...
  10. ncbi request reprint CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 20:7587-94. 2000
    ..Taken together, these results suggest that therapeutic agents that stimulate the CD45 PTP signaling pathway may be effective in suppressing microglial activation associated with AD...
  11. ncbi request reprint The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism
    T Town
    Roskamp Laboratories, University of South Florida, Department of Psychiatry, Tampa 33613, USA
    Neurosci Lett 252:95-8. 1998
    ..Furthermore, when considering the known APOE and -491A/T polymorphisms alone, APOE epsilon4 status is the best predictor of the disease...
  12. ncbi request reprint No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 266:193-6. 1999
    ..Therefore our data do not suggest any association between these variations in the Tau gene and Alzheimer's disease...
  13. ncbi request reprint Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide
    D Paris
    Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida, 33613, USA
    Exp Neurol 152:116-22. 1998
    ..However, compounds that clear free radicals intracellularly may well be beneficial...
  14. ncbi request reprint Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway
    D Paris
    The Roskamp Institute, University of South Florida, 3515 E Fletcher Ave, 33613, Tampa, FL, USA
    Neurobiol Aging 21:183-97. 2000
    ....
  15. ncbi request reprint Isoform-specific vasoconstriction induced by apolipoprotein E and modulation of this effect by Alzheimer's beta-amyloid peptide
    D Paris
    The Roskamp Institute, University of South Florida, Department of Psychiatry, Tampa 33613, USA
    Neurosci Lett 256:73-6. 1998
    ..Our data suggest that apoE may promote hypertension and contribute to AD pathogenesis via enhancement of vasoconstriction, and support a link between hypertension, cerebral amyloid angiopathy and AD...
  16. ncbi request reprint The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 270:133-6. 1999
    ..In a subset of our larger sample we have also investigated the A2M Val1000lle polymorphism, and again find no evidence for association. We conclude that there is no genetic association between A2M and AD in our case-control sample...
  17. ncbi request reprint Novel strategies for opposing murine microglial activation
    D Paris
    The Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 278:5-8. 2000
    ..Taken together, our results suggest novel strategies for reducing microglial activation...
  18. ncbi request reprint A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances
    J A Schinka
    The Roskamp Institute, University of South Florida, Tampa, FL 33620, USA
    Mol Psychiatry 7:224-8. 2002
    ..The contribution of the gene to risk for substance dependence is small, and is detected most easily in studies that use control samples that are screened for all forms of substance dependence...
  19. ncbi request reprint Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample
    G Ait-Ghezala
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Neurosci Lett 325:87-90. 2002
    ..The ongoing investigation of the genetic source of association and linkage in this region is clearly warranted...
  20. ncbi request reprint CD40 signaling and Alzheimer's disease pathogenesis
    T Town
    Department of Psychiatry, Roskamp Institute, University of South Florida, 3515 E. Fletcher Avenue, Tampa, FL 33613, USA
    Neurochem Int 39:371-80. 2001
    ..As these cytokines have been implicated in neuronal injury, a comprehensive model of pro-inflammatory CD40 ligand and amyloid-beta initiated Alzheimer's disease pathogenesis (mediated by multiple CNS cells) is proposed...
  21. ncbi request reprint Cholesterol modulates vascular reactivity to endothelin-1 by stimulating a pro-inflammatory pathway
    D Paris
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, Florida, 33613, USA
    Biochem Biophys Res Commun 274:553-8. 2000
    ..Disruption of the MAPK/COX-2 pathway may represent a valuable therapy to block the hypertension associated with HC, as well as the development of atherosclerosis...
  22. ncbi request reprint Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    J Tan
    The Roskamp Institute, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613, USA
    Science 286:2352-5. 1999
    ..Finally, abnormal tau phosphorylation was reduced in Tg APPsw animals deficient for CD40L, suggesting that the CD40-CD40L interaction is an early event in AD pathogenesis...
  23. ncbi request reprint Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice
    T Mori
    Roskamp Institute, University of South Florida, Tampa, 33613, USA
    J Neuropathol Exp Neurol 60:778-85. 2001
    ..Taken together, our results imply a link between cholesterol and AD pathogenesis and suggest that cholesterol plays an important role in the formation and/or progression of senile plaques...
  24. ncbi request reprint CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway
    J Tan
    Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 275:37224-31. 2000
    ..Taken together, these results show that CD45 plays a novel role in suppressing CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK cascade...
  25. ncbi request reprint Bcl-X(L) inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells
    J Tan
    The Roskamp Institute, Tampa, FL 33613 4799, USA
    Neurosci Lett 272:5-8. 1999
    ..These results suggest that Bcl-X(L) exhibits both anti-necrotic as well as anti-apoptotic roles in Abeta-challenged PC12 cells...
  26. ncbi request reprint Interchromosomal associations between alternatively expressed loci
    Charalampos G Spilianakis
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 435:637-45. 2005
    ..Thus, we provide an example of eukaryotic genes located on separate chromosomes associating physically in the nucleus via interactions that may have a function in coordinating gene expression...
  27. ncbi request reprint Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation
    W Taylor Kimberly
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 25:5533-43. 2005
    ..We conclude that endogenous AICD undergoes tight temporal regulation during the differentiation of neurons and is negatively regulated by JNK3 via phosphorylation of APP at Thr668...
  28. ncbi request reprint Microglia recognize double-stranded RNA via TLR3
    Terrence Town
    Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 176:3804-12. 2006
    ..When taken together, our results demonstrate that microglia recognize dsRNA through TLR3 and associated signaling molecules and suggest that these cells are key sensors of dsRNA-producing viruses that may invade the CNS...
  29. ncbi request reprint Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice
    Takashi Mori
    Institute of Medical Science, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    J Pharmacol Exp Ther 318:571-8. 2006
    ..Based on the above results, arundic acid is considered to deserve further exploration as a promising therapeutic agent for AD...
  30. pmc Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage
    William V Nikolic
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Proc Natl Acad Sci U S A 104:2507-12. 2007
    ..Together, these data suggest that t.c. immunization constitutes an effective and potentially safe treatment strategy for AD...
  31. ncbi request reprint NSAIDs for the chemoprevention of Alzheimer's disease
    Christine A Szekely
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Subcell Biochem 42:229-48. 2007
    ..The feasibility of using NSAIDs as a chemopreventive agent in AD is discussed...
  32. ncbi request reprint Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host
    Jason W Griffith
    Department of Internal Medicine, Yale University, 300 Cedar Street, New Haven, CT 06520, USA
    J Infect Dis 196:1553-64. 2007
    ..These results suggest that TLR signaling and host genetic background influences the pathogenesis of CM via modulation of cytokine production and T(reg) cell numbers...
  33. pmc Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice
    William V Nikolic
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Stem Cells Dev 17:423-39. 2008
    ..Increased microglial phagocytic activity in this scenario was inhibited by addition of recombinant CD40L protein. These data suggest that HUCBC infusion mitigates AD-like pathology by disrupting CD40L activity...
  34. pmc Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
    Terrence Town
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520 8011, USA
    Nat Med 14:681-7. 2008
    ..Taken together, our results suggest that blockade of TGF-beta-Smad2/3 signaling in peripheral macrophages represents a new therapeutic target for Alzheimer's disease...
  35. ncbi request reprint CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide
    Kirk P Townsend
    Neuroimmunology Laboratory, Department of Psychiatry, University of South Florida College of Medicine, Tampa, USA
    Eur J Immunol 35:901-10. 2005
    ..These data provide a mechanistic explanation for our previous work showing decreased microgliosis associated with diminished cerebral Abeta/beta-amyloid pathology when blocking CD40 signaling in transgenic Alzheimer's mice...
  36. ncbi request reprint CD40-CD40L interaction in Alzheimer's disease
    Jun Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Curr Opin Pharmacol 2:445-51. 2002
    ..Conversely, the finding that reduced CD40-CD40L interaction is associated with reduced chronic microgliosis and Tau hyperphosphorylation supports the view that, in general, mechanisms that reduce microgliosis will be beneficial in AD...
  37. ncbi request reprint Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice
    J Todd Roach
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res 1015:161-8. 2004
    ..Disruption of CD40L activity has beneficial effects on pathology and cognitive behavior in the PSAPP mouse model, providing support for the therapeutic potential of interrupting the CD40-CD40L interaction in AD...
  38. ncbi request reprint Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
    Jun Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Nat Neurosci 5:1288-93. 2002
    ..These findings suggest several possible mechanisms underlying mitigation of AD pathology in response to CD40L depletion, and validate the CD40-CD40L interaction as a target for therapeutic intervention in AD...
  39. ncbi request reprint CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease
    Jun Tan
    Department of Psychiatry, Roskamp Institute, University of South Florida, 3515 E Fletcher Ave, Tampa, FL 33613, USA
    J Neuroimmunol 132:164-72. 2002
    ....
  40. pmc CD40 is expressed and functional on neuronal cells
    Jun Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613, USA
    EMBO J 21:643-52. 2002
    ..These changes occur with age, and are clearly evident at 16 months. Taken together, these data demonstrate a role of CD40 in neuronal development, maintenance and protection in vitro and in vivo...
  41. pmc Icam-1 participates in the entry of west nile virus into the central nervous system
    Jianfeng Dai
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, P O Box 208031, New Haven, CT 06520 8031, USA
    J Virol 82:4164-8. 2008
    ..These data suggest that ICAM-1 plays an important role in West Nile virus neuroinvasion and that targeting ICAM-1 signaling may help control viral encephalitis...
  42. pmc The stumpy gene is required for mammalian ciliogenesis
    Terrence Town
    Department of Immunobiology and Neurobiology, Section of Nephrology, Yale University School of Medicine, 300 Cedar Street, TAC S 569, New Haven, CT 06519 8011, USA
    Proc Natl Acad Sci U S A 105:2853-8. 2008
    ..Therefore, stumpy is essential for ciliogenesis and may be involved in the pathogenesis of human congenital malformations such as HC and PKD...
  43. ncbi request reprint p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
    Terrence Town
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Neurosci Res 69:362-72. 2002
    ..Taken together, these data indicate that sAbeta is a potent activator of the p25/Cdk5 pathway, resulting in promotion of AD-like tau phosphorylation in vitro...
  44. pmc Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia
    Takashi Mori
    Institute of Medical Science, Saitama Medical Center University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Stroke 39:2114-21. 2008
    ..Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated...
  45. pmc Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis
    Shuhui Wang
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 181:2084-91. 2008
    ..These results suggest that following a systemic infection, WNV might cross the blood brain barrier and enter the CNS by being carried by infected infiltrating T cells...
  46. pmc TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis
    Yasmina Laouar
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:10865-70. 2008
    ..Our data provide direct evidence that TGF-beta can control autoimmunity via actions on DCs...
  47. ncbi request reprint Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    Tian Wang
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Med 10:1366-73. 2004
    ..Collectively, WNV infection leads to a Tlr3-dependent inflammatory response, which is involved in brain penetration of the virus and neuronal injury...
  48. pmc Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    Jonathan A Deane
    Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
    Immunity 27:801-10. 2007
    ..These results underscore the importance of tightly regulating expression of TLR7 to prevent spontaneous triggering of harmful autoreactive and inflammatory responses...
  49. ncbi request reprint Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
    Azuma Watanabe
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 46:1509-18. 2007
    ..Stimulation of TLR9 on HSCs blocked signaling by the PDGF signaling molecule inositol 1,4,5-triphosphate and reduced PDGF-mediated increase in cytosolic Ca(2+)...
  50. ncbi request reprint Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice
    Takashi Mori
    Institute of Laboratory Animal Science, Department of Neurosurgery, Saitama Medical Center School, Kawagoe, Saitama, Japan
    J Neuropathol Exp Neurol 62:280-91. 2003
    ..Taken together, our results show that apoE affects the outcome of acute brain damage in an isoform-specific fashion (apoE4 > apoE3 = apoE2) in genetically engineered mice...
  51. ncbi request reprint ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
    Demian F Obregon
    Neuroimmunology Laboratory, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, The Byrd Alzheimer s Center and Research Institute, 3515 E Fletcher Avenue, Tampa, FL 33647, USA
    J Biol Chem 281:16419-27. 2006
    ..Thus, ADAM10 represents an important pharmacotherapeutic target for the treatment of cerebral amyloidosis in Alzheimer disease...
  52. ncbi request reprint Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production
    Ryan T Mott
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    Glia 46:369-79. 2004
    ..Furthermore, we show that neurons secrete CD22, which functions as an inhibitor of microglial proinflammatory cytokine production...
  53. ncbi request reprint T-cells in Alzheimer's disease
    Terrence Town
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuromolecular Med 7:255-64. 2005
    ..Finally, we explore the use of mouse models of AD as a system within which to definitively test the possible contribution of T-cells to AD pathogenesis...
  54. ncbi request reprint Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice
    Kavon Rezai-Zadeh
    Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 25:8807-14. 2005
    ..These data raise the possibility that EGCG dietary supplementation may provide effective prophylaxis for AD...
  55. ncbi request reprint CD45 isoform RB as a molecular target to oppose lipopolysaccharide-induced microglial activation in mice
    Kirk P Townsend
    Neuroimmunology Laboratory, Institute for Psychiatry in Research, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, 3515 East Fletcher Avenue, Tampa, FL 33613, USA
    Neurosci Lett 362:26-30. 2004
    ..Taken together, these findings suggest that therapeutic agents that specifically stimulate the microglial CD45RB signaling pathway may be effective in suppressing microglial activation associated with several neurodegenerative disorders...
  56. ncbi request reprint Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice
    Takashi Mori
    Institute of Laboratory Animal Science, Saitama Medical Center School, Kawagoe, Saitama, Japan
    J Cereb Blood Flow Metab 24:646-56. 2004
    ..Taken together, these data show that the apoE4 isoform acts to aggravate delayed infarct expansion and peri-infarct reactive astrocytosis during the subacute phase of pMCAO in genetically engineered apoE-KI mice...
  57. pmc Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
    Joshua J Breunig
    Department of Neurobiology and Kavli Institute of Neuroscience, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:13127-32. 2008
    ..Our data suggest these organelles are cellular "antennae" critically required to modulate ALNP behavior...