R Toto

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Lessons from the African-American Study of Kidney Disease and Hypertension: an update
    Robert D Toto
    Mary M Conroy Professorship in Kidney Disease, The University of Texas Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8856, USA
    Curr Hypertens Rep 8:409-12. 2006
  2. doi request reprint RAS blockade, hyperkalemia and AKI--look and you will find
    Robert D Toto
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Nat Rev Nephrol 8:257-8. 2012
  3. ncbi request reprint Angiotensin II subtype 1 receptor blockers and renal function
    R Toto
    Patient Oriented Research in Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Arch Intern Med 161:1492-9. 2001
  4. ncbi request reprint Reducing cardiovascular events in high-risk patients: the challenge of managing hypertension in patients with diabetic renal disease
    Robert D Toto
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
    J Clin Hypertens (Greenwich) 9:16-25. 2007
  5. ncbi request reprint Rationale for combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor treatment and end-organ protection in patients with chronic kidney disease
    Robert Toto
    Patient Oriented Research Nephrology, University of Southwestern Medical Center at Dallas, Dallas, TX 75225 8856, USA
    Am J Nephrol 28:372-80. 2008
  6. doi request reprint How to launch a successful career in clinical research: tips on making the most of available resources
    Robert D Toto
    Department of Internal Medicine, The University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8856, USA
    J Investig Med 56:843-6. 2008
  7. doi request reprint Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathy
    Robert D Toto
    Department of Internal Medicine, Division of Nephrology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    J Clin Hypertens (Greenwich) 10:761-9. 2008
  8. doi request reprint Screening and evaluation of study subjects in patient-oriented research
    Robert D Toto
    University of Texas Southwestern Medical Center Dallas, Dallas, TX 75930, USA
    J Investig Med 58:608-11. 2010
  9. doi request reprint Aldosterone blockade in chronic kidney disease: can it improve outcome?
    Robert D Toto
    The University of Texas Southwestern Medical Center Dallas, Dallas, Texas 5323, USA
    Curr Opin Nephrol Hypertens 19:444-9. 2010
  10. doi request reprint Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort
    Robert D Toto
    The University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8856, USA
    Am J Kidney Dis 56:896-906. 2010

Research Grants

Detail Information

Publications34

  1. ncbi request reprint Lessons from the African-American Study of Kidney Disease and Hypertension: an update
    Robert D Toto
    Mary M Conroy Professorship in Kidney Disease, The University of Texas Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8856, USA
    Curr Hypertens Rep 8:409-12. 2006
    ....
  2. doi request reprint RAS blockade, hyperkalemia and AKI--look and you will find
    Robert D Toto
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Nat Rev Nephrol 8:257-8. 2012
    ..This risk does not translate into an increased incidence of acute kidney injury, suggest the results of a meta-analysis. However, further research is needed to fully evaluate the safety of combination therapy with aliskiren...
  3. ncbi request reprint Angiotensin II subtype 1 receptor blockers and renal function
    R Toto
    Patient Oriented Research in Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Arch Intern Med 161:1492-9. 2001
    ..Definitive evidence of the long-term protective effects of ARBs in chronic progressive renal disease is expected from these important studies...
  4. ncbi request reprint Reducing cardiovascular events in high-risk patients: the challenge of managing hypertension in patients with diabetic renal disease
    Robert D Toto
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
    J Clin Hypertens (Greenwich) 9:16-25. 2007
    ..In most instances, a diuretic is also needed to reduce blood pressure...
  5. ncbi request reprint Rationale for combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor treatment and end-organ protection in patients with chronic kidney disease
    Robert Toto
    Patient Oriented Research Nephrology, University of Southwestern Medical Center at Dallas, Dallas, TX 75225 8856, USA
    Am J Nephrol 28:372-80. 2008
    ..The National Kidney Foundation suggests that ACE inhibitors and ARBs may be used in combination to reduce proteinuria in patients with kidney disease; however, larger outcomes trials are needed...
  6. doi request reprint How to launch a successful career in clinical research: tips on making the most of available resources
    Robert D Toto
    Department of Internal Medicine, The University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8856, USA
    J Investig Med 56:843-6. 2008
    ..This article provides some timely and valuable tips on how to lay the groundwork for long-term success as a clinical/translational researcher...
  7. doi request reprint Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathy
    Robert D Toto
    Department of Internal Medicine, Division of Nephrology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    J Clin Hypertens (Greenwich) 10:761-9. 2008
    ..Both ACEI/CCB FDCs may reduce albuminuria; in the case of T/V, this appears to be independent of systolic blood pressure reduction in patients who had previously been treated and had baseline blood pressure levels of 142/77 mm Hg...
  8. doi request reprint Screening and evaluation of study subjects in patient-oriented research
    Robert D Toto
    University of Texas Southwestern Medical Center Dallas, Dallas, TX 75930, USA
    J Investig Med 58:608-11. 2010
    ..The design and conduct of screening and evaluation procedures should be protocol driven and compliant with regulatory requirements...
  9. doi request reprint Aldosterone blockade in chronic kidney disease: can it improve outcome?
    Robert D Toto
    The University of Texas Southwestern Medical Center Dallas, Dallas, Texas 5323, USA
    Curr Opin Nephrol Hypertens 19:444-9. 2010
    ..The purpose of this review is to explain the rationale and limitations for use of mineralocorticoid receptor blockers (MRBs) for the treatment of chronic kidney disease (CKD) and its complications...
  10. doi request reprint Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort
    Robert D Toto
    The University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8856, USA
    Am J Kidney Dis 56:896-906. 2010
    ..We hypothesized that obesity is independently associated with proteinuria, a marker of chronic kidney disease progression...
  11. ncbi request reprint Treatment of hypertension in chronic kidney disease
    Robert D Toto
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
    Semin Nephrol 25:435-9. 2005
    ..Blood pressure should be monitored closely in hypertensive patients with CKD and both clinic and home blood pressure measurements may help the clinician adjust treatment...
  12. ncbi request reprint Heart disease in diabetic patients
    Robert D Toto
    University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
    Semin Nephrol 25:372-8. 2005
    ..These and other clinical trials should provide important new insights into improving the quality of life in diabetics and ultimately preventing cardiac disease...
  13. ncbi request reprint Hypertension and kidney literature review 2000
    R D Toto
    Department of Medicine, University of Texas Southwestern Medical Center Dallas, 75390 8856, USA
    Clin Nephrol 58:253-9. 2002
    ..The purpose of this review is to highlight the key elements and clinical relevance of these recent studies...
  14. ncbi request reprint Appropriate drug therapy for improving outcomes in diabetic nephropathy
    Robert D Toto
    University of Texas Southwestern Medical Center at Dallas, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    Curr Diab Rep 2:545-52. 2002
    ....
  15. ncbi request reprint Hypertensive nephrosclerosis in African Americans
    Robert B Toto
    University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 64:2331-41. 2003
  16. ncbi request reprint Darbepoetin alfa effectively treats anemia in patients with chronic kidney disease with de novo every-other-week administration
    Robert D Toto
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Nephrol 24:453-60. 2004
    ..This multicenter, open-label study determined safety and efficacy of once-every-other-week administration of darbepoetin alfa for anemia of chronic kidney disease in erythropoietin-naive patients not on dialysis...
  17. ncbi request reprint Microalbuminuria: definition, detection, and clinical significance
    Robert D Toto
    University of Texas Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Clin Hypertens (Greenwich) 6:2-7. 2004
    ....
  18. ncbi request reprint Lessons learned from recent clinical trials in hypertensive diabetics: what's good for the kidney is good for the heart and brain
    Robert D Toto
    Patient Oriented Research and the Department of Clinical Nephrology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Am J Hypertens 17:7S-10S; quiz A2-4. 2004
    ....
  19. ncbi request reprint Management of hypertensive chronic kidney disease: role of calcium channel blockers
    Robert D Toto
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Clin Hypertens (Greenwich) 7:15-20. 2005
    ....
  20. ncbi request reprint Proteinuria reduction: mandatory consideration or option when selecting an antihypertensive agent?
    Robert D Toto
    University of Texas, Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    Curr Hypertens Rep 7:374-8. 2005
    ..Based on the combined evidence from epidemiologic and intervention studies, it seems prudent to make proteinuria reduction a mandatory consideration in the selection of antihypertensive regimens...
  21. pmc Malnutrition-inflammation modifies the relationship of cholesterol with cardiovascular disease
    Gabriel Contreras
    Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 360E, Miami, FL 33136, USA
    J Am Soc Nephrol 21:2131-42. 2010
    ..In the M-I group, the corresponding HRs did not vary significantly by cholesterol level. In conclusion, the presence of M-I modifies the risk relationship between cholesterol level and CVD in African Americans with hypertensive CKD...
  22. doi request reprint A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    Marc A Pfeffer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 361:2019-32. 2009
    ..Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately tested...
  23. pmc Use of aspirin associates with longer primary patency of hemodialysis grafts
    Bradley S Dixon
    Division of Nephrology, University of Iowa College of Medicine, E 300D GH, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
    J Am Soc Nephrol 22:773-81. 2011
    ..In conclusion, use of aspirin associates with a trend toward longer primary unassisted patency of newly placed hemodialysis grafts similar to that observed for ERDP/ASA...
  24. pmc Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients
    J K Inrig
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Kidney Int 71:454-61. 2007
    ..Further research should attempt to elucidate the mechanisms behind these findings...
  25. doi request reprint Disparate estimates of hypertension control from ambulatory and clinic blood pressure measurements in hypertensive kidney disease
    Velvie Pogue
    Division of Nephrology, Department of Medicine, Columbia University Medical Center, Harlem Hospital Center, New York, NY 10037, USA
    Hypertension 53:20-7. 2009
    ..Whether lowering nighttime BP improves clinical outcomes is unknown but should be tested given the substantial burden of BP-related morbidity in this population...
  26. doi request reprint Dual blockade of the renin-angiotensin-aldosterone system: beyond the ACE inhibitor and angiotensin-II receptor blocker combination
    Andrew S Bomback
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Hypertens 22:1032-40. 2009
    ..This review examines what is presently known about ACEI/ARB combination therapy and explores alternative combination strategies that include DRIs and mineralocorticoid receptor blockers (MRBs)...
  27. pmc Sociodemographic factors contribute to the depressive affect among African Americans with chronic kidney disease
    Michael J Fischer
    Department of Medicine, Jesse Brown VA Medical Center and University of Illinois Medical Center, Chicago, Illinois, USA
    Kidney Int 77:1010-9. 2010
    ..Sociodemographic factors have especially strong associations with this increased depressive affect. Because this study was conducted in an African-American cohort, its findings may not be generalized to other ethnic groups...
  28. ncbi request reprint Non-contrast-enhanced computerized tomography and analgesic-related kidney disease: report of the national analgesic nephropathy study
    William L Henrich
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Am Soc Nephrol 17:1472-80. 2006
    ..Findings of SICK are infrequent in the US ESRD population and do not occur among a sufficient proportion of heavy analgesic users to render the non-contrast-enhanced CT scan a sensitive tool to detect analgesic-associated kidney injury...
  29. ncbi request reprint The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study
    William F Keane
    Department of Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Kidney Int 63:1499-507. 2003
    ..We examined the risk factors that predict loss of kidney function (doubling of serum creatinine) or ESRD (dialysis or transplantation) in patients with type 2 diabetes in whom blood pressure was controlled...
  30. pmc Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients
    Jula K Inrig
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 50:108-18, 118.e1-4. 2007
    ..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
  31. ncbi request reprint Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)
    Garabed Eknoyan
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 42:617-22. 2003
  32. ncbi request reprint Living kidney donation and hypertension risk
    Thai Nguyen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Lancet 369:87-8. 2007
  33. ncbi request reprint Nephrotic syndrome after bevacizumab: case report and literature review
    Betsy A George
    The University of Texas Southwestern Medical Center Dallas, TX 75390 8856, USA
    Am J Kidney Dis 49:e23-9. 2007
    ..Clinicians should be aware of the potential reversible nephrotoxicity of bevacizumab and should monitor blood pressure and urine protein excretion closely during therapy with this agent...

Research Grants10

  1. African American Study of Kidney Disease and Hypertensi*
    Robert Toto; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
  2. MENTORING PROGRAM FOR CLINICAL RESEARCHERS IN NEPHROLOGY
    Robert Toto; Fiscal Year: 2007
    ....
  3. Improving Outcomes in Diabetic Nephropathy
    Robert Toto; Fiscal Year: 2005
    ..abstract_text> ..
  4. TRAINING CURRICULUM IN PATIENT ORIENTED RESEARCH
    Robert Toto; Fiscal Year: 2004
    ..The proposed program will provide young physicians and scientists with the skills needed to conduct clinical investigations and to compete for federal and non-federal research funding. ..
  5. Improving Outcomes in Diabetic Nephropathy
    Robert Toto; Fiscal Year: 2003
    ....