Affiliation: University of Texas Southwestern Medical Center
- RAS blockade, hyperkalemia and AKI--look and you will findRobert D Toto
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Nat Rev Nephrol 8:257-8. 2012..This risk does not translate into an increased incidence of acute kidney injury, suggest the results of a meta-analysis. However, further research is needed to fully evaluate the safety of combination therapy with aliskiren...
- Lessons from the African-American Study of Kidney Disease and Hypertension: an updateRobert D Toto
Mary M Conroy Professorship in Kidney Disease, The University of Texas Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8856, USA
Curr Hypertens Rep 8:409-12. 2006....
- Angiotensin II subtype 1 receptor blockers and renal functionR Toto
Patient Oriented Research in Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Arch Intern Med 161:1492-9. 2001..Definitive evidence of the long-term protective effects of ARBs in chronic progressive renal disease is expected from these important studies...
- Reducing cardiovascular events in high-risk patients: the challenge of managing hypertension in patients with diabetic renal diseaseRobert D Toto
Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
J Clin Hypertens (Greenwich) 9:16-25. 2007..In most instances, a diuretic is also needed to reduce blood pressure...
- Rationale for combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor treatment and end-organ protection in patients with chronic kidney diseaseRobert Toto
Patient Oriented Research Nephrology, University of Southwestern Medical Center at Dallas, Dallas, TX 75225 8856, USA
Am J Nephrol 28:372-80. 2008..The National Kidney Foundation suggests that ACE inhibitors and ARBs may be used in combination to reduce proteinuria in patients with kidney disease; however, larger outcomes trials are needed...
- How to launch a successful career in clinical research: tips on making the most of available resourcesRobert D Toto
Department of Internal Medicine, The University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8856, USA
J Investig Med 56:843-6. 2008..This article provides some timely and valuable tips on how to lay the groundwork for long-term success as a clinical/translational researcher...
- Effects of calcium channel blockers on proteinuria in patients with diabetic nephropathyRobert D Toto
Department of Internal Medicine, Division of Nephrology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
J Clin Hypertens (Greenwich) 10:761-9. 2008..Both ACEI/CCB FDCs may reduce albuminuria; in the case of T/V, this appears to be independent of systolic blood pressure reduction in patients who had previously been treated and had baseline blood pressure levels of 142/77 mm Hg...
- Screening and evaluation of study subjects in patient-oriented researchRobert D Toto
University of Texas Southwestern Medical Center Dallas, Dallas, TX 75930, USA
J Investig Med 58:608-11. 2010..The design and conduct of screening and evaluation procedures should be protocol driven and compliant with regulatory requirements...
- Aldosterone blockade in chronic kidney disease: can it improve outcome?Robert D Toto
The University of Texas Southwestern Medical Center Dallas, Dallas, Texas 5323, USA
Curr Opin Nephrol Hypertens 19:444-9. 2010..The purpose of this review is to explain the rationale and limitations for use of mineralocorticoid receptor blockers (MRBs) for the treatment of chronic kidney disease (CKD) and its complications...
- Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohortRobert D Toto
The University of Texas Southwestern Medical Center Dallas, Dallas, TX 75390 8856, USA
Am J Kidney Dis 56:896-906. 2010..We hypothesized that obesity is independently associated with proteinuria, a marker of chronic kidney disease progression...
- Treatment of hypertension in chronic kidney diseaseRobert D Toto
Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
Semin Nephrol 25:435-9. 2005..Blood pressure should be monitored closely in hypertensive patients with CKD and both clinic and home blood pressure measurements may help the clinician adjust treatment...
- Heart disease in diabetic patientsRobert D Toto
University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8856, USA
Semin Nephrol 25:372-8. 2005..These and other clinical trials should provide important new insights into improving the quality of life in diabetics and ultimately preventing cardiac disease...
- Proteinuria reduction: mandatory consideration or option when selecting an antihypertensive agent?Robert D Toto
University of Texas, Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
Curr Hypertens Rep 7:374-8. 2005..Based on the combined evidence from epidemiologic and intervention studies, it seems prudent to make proteinuria reduction a mandatory consideration in the selection of antihypertensive regimens...
- Appropriate drug therapy for improving outcomes in diabetic nephropathyRobert D Toto
University of Texas Southwestern Medical Center at Dallas, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
Curr Diab Rep 2:545-52. 2002....
- Hypertensive nephrosclerosis in African AmericansRobert B Toto
University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Kidney Int 64:2331-41. 2003
- Darbepoetin alfa effectively treats anemia in patients with chronic kidney disease with de novo every-other-week administrationRobert D Toto
University of Texas Southwestern Medical Center, Dallas, TX 75390 8856, USA
Am J Nephrol 24:453-60. 2004..This multicenter, open-label study determined safety and efficacy of once-every-other-week administration of darbepoetin alfa for anemia of chronic kidney disease in erythropoietin-naive patients not on dialysis...
- Microalbuminuria: definition, detection, and clinical significanceRobert D Toto
University of Texas Southwestern Medical Center Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
J Clin Hypertens (Greenwich) 6:2-7. 2004....
- Hypertension and kidney literature review 2000R D Toto
Department of Medicine, University of Texas Southwestern Medical Center Dallas, 75390 8856, USA
Clin Nephrol 58:253-9. 2002..The purpose of this review is to highlight the key elements and clinical relevance of these recent studies...
- Lessons learned from recent clinical trials in hypertensive diabetics: what's good for the kidney is good for the heart and brainRobert D Toto
Patient Oriented Research and the Department of Clinical Nephrology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
Am J Hypertens 17:7S-10S; quiz A2-4. 2004....
- Management of hypertensive chronic kidney disease: role of calcium channel blockersRobert D Toto
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Clin Hypertens (Greenwich) 7:15-20. 2005....
- Malnutrition-inflammation modifies the relationship of cholesterol with cardiovascular diseaseGabriel Contreras
Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 360E, Miami, FL 33136, USA
J Am Soc Nephrol 21:2131-42. 2010..In the M-I group, the corresponding HRs did not vary significantly by cholesterol level. In conclusion, the presence of M-I modifies the risk relationship between cholesterol level and CVD in African Americans with hypertensive CKD...
- A trial of darbepoetin alfa in type 2 diabetes and chronic kidney diseaseMarc A Pfeffer
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 361:2019-32. 2009..Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately tested...
- Use of aspirin associates with longer primary patency of hemodialysis graftsBradley S Dixon
Division of Nephrology, University of Iowa College of Medicine, E 300D GH, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
J Am Soc Nephrol 22:773-81. 2011..In conclusion, use of aspirin associates with a trend toward longer primary unassisted patency of newly placed hemodialysis grafts similar to that observed for ERDP/ASA...
- Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patientsJ K Inrig
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
Kidney Int 71:454-61. 2007..Further research should attempt to elucidate the mechanisms behind these findings...
- Dual blockade of the renin-angiotensin-aldosterone system: beyond the ACE inhibitor and angiotensin-II receptor blocker combinationAndrew S Bomback
Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Hypertens 22:1032-40. 2009..This review examines what is presently known about ACEI/ARB combination therapy and explores alternative combination strategies that include DRIs and mineralocorticoid receptor blockers (MRBs)...
- Disparate estimates of hypertension control from ambulatory and clinic blood pressure measurements in hypertensive kidney diseaseVelvie Pogue
Division of Nephrology, Department of Medicine, Columbia University Medical Center, Harlem Hospital Center, New York, NY 10037, USA
Hypertension 53:20-7. 2009..Whether lowering nighttime BP improves clinical outcomes is unknown but should be tested given the substantial burden of BP-related morbidity in this population...
- Sociodemographic factors contribute to the depressive affect among African Americans with chronic kidney diseaseMichael J Fischer
Department of Medicine, Jesse Brown VA Medical Center and University of Illinois Medical Center, Chicago, Illinois, USA
Kidney Int 77:1010-9. 2010..Sociodemographic factors have especially strong associations with this increased depressive affect. Because this study was conducted in an African-American cohort, its findings may not be generalized to other ethnic groups...
- Proteinuria and other markers of chronic kidney disease: a position statement of the national kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK)Garabed Eknoyan
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Am J Kidney Dis 42:617-22. 2003
- The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL studyWilliam F Keane
Department of Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Kidney Int 63:1499-507. 2003..We examined the risk factors that predict loss of kidney function (doubling of serum creatinine) or ESRD (dialysis or transplantation) in patients with type 2 diabetes in whom blood pressure was controlled...
- Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patientsJula K Inrig
Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
Am J Kidney Dis 50:108-18, 118.e1-4. 2007..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
- Nephrotic syndrome after bevacizumab: case report and literature reviewBetsy A George
The University of Texas Southwestern Medical Center Dallas, TX 75390 8856, USA
Am J Kidney Dis 49:e23-9. 2007..Clinicians should be aware of the potential reversible nephrotoxicity of bevacizumab and should monitor blood pressure and urine protein excretion closely during therapy with this agent...
- Non-contrast-enhanced computerized tomography and analgesic-related kidney disease: report of the national analgesic nephropathy studyWilliam L Henrich
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Am Soc Nephrol 17:1472-80. 2006..Findings of SICK are infrequent in the US ESRD population and do not occur among a sufficient proportion of heavy analgesic users to render the non-contrast-enhanced CT scan a sensitive tool to detect analgesic-associated kidney injury...
- Living kidney donation and hypertension riskThai Nguyen
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Lancet 369:87-8. 2007
- African American Study of Kidney Disease and Hypertensi*Robert Toto; Fiscal Year: 2007..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
- MENTORING PROGRAM FOR CLINICAL RESEARCHERS IN NEPHROLOGYRobert Toto; Fiscal Year: 2007....
- Improving Outcomes in Diabetic NephropathyRobert Toto; Fiscal Year: 2005..abstract_text> ..
- TRAINING CURRICULUM IN PATIENT ORIENTED RESEARCHRobert Toto; Fiscal Year: 2004..The proposed program will provide young physicians and scientists with the skills needed to conduct clinical investigations and to compete for federal and non-federal research funding. ..
- Improving Outcomes in Diabetic NephropathyRobert Toto; Fiscal Year: 2003....