M J Toth

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Regulation of protein metabolism in middle-aged, premenopausal women: roles of adiposity and estradiol
    M J Toth
    Department of Medicine, University of Vermont, Burlington 05405, USA
    J Clin Endocrinol Metab 85:1382-7. 2000
  2. ncbi request reprint Lipid metabolism in the elderly
    M J Toth
    Department of Medicine, University of Vermont, Burlington 05405, USA
    Eur J Clin Nutr 54:S121-5. 2000
  3. ncbi request reprint Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Int J Cardiol 107:211-9. 2006
  4. ncbi request reprint Effect of age on skeletal muscle myofibrillar mRNA abundance: relationship to myosin heavy chain protein synthesis rate
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Exp Gerontol 41:1195-200. 2006
  5. ncbi request reprint Comparing energy expenditure data among individuals differing in body size and composition: statistical and physiological considerations
    M J Toth
    Division of Clinical Pharmacology and Metabolic Research, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Curr Opin Clin Nutr Metab Care 4:391-7. 2001
  6. ncbi request reprint Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women
    W F DeNino
    Division of Clinical Pharmacology and Metabolic Research, University of Vermont, Burlington 05405, USA
    Diabetes Care 24:925-32. 2001
  7. ncbi request reprint Menopause-related changes in body fat distribution
    M J Toth
    Department of Medicine, University of Vermont, Burlington 05405, USA
    Ann N Y Acad Sci 904:502-6. 2000
  8. ncbi request reprint Effects of estradiol and progesterone on body composition, protein synthesis, and lipoprotein lipase in rats
    M J Toth
    Division of Clinical Pharmacology and Metabolic Research, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 280:E496-501. 2001
  9. ncbi request reprint Racial differences in plasma leptin concentrations in obese postmenopausal women
    B J Nicklas
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    J Clin Endocrinol Metab 82:315-7. 1997
  10. pmc Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function
    Mark S Miller
    Departments of Molecular Physiology and Biophysics and Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
    Circ Heart Fail 2:700-6. 2009

Detail Information

Publications40

  1. ncbi request reprint Regulation of protein metabolism in middle-aged, premenopausal women: roles of adiposity and estradiol
    M J Toth
    Department of Medicine, University of Vermont, Burlington 05405, USA
    J Clin Endocrinol Metab 85:1382-7. 2000
    ..From these results, we conclude that adiposity and/or serum estradiol may contribute to the regulation of protein metabolism and FFM in middle-aged, premenopausal women...
  2. ncbi request reprint Lipid metabolism in the elderly
    M J Toth
    Department of Medicine, University of Vermont, Burlington 05405, USA
    Eur J Clin Nutr 54:S121-5. 2000
    ..Interventions designed to increase the mass or oxidative capacity of respiring tissue, therefore, may be effective in counteracting the age-related reduction in fat oxidation...
  3. ncbi request reprint Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, United States
    Int J Cardiol 107:211-9. 2006
    ..To address this issue, we examined the effect of heart failure on skeletal muscle myofibrillar protein content, isoform distribution and Ca2+ sensitivity...
  4. ncbi request reprint Effect of age on skeletal muscle myofibrillar mRNA abundance: relationship to myosin heavy chain protein synthesis rate
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Exp Gerontol 41:1195-200. 2006
    ....
  5. ncbi request reprint Comparing energy expenditure data among individuals differing in body size and composition: statistical and physiological considerations
    M J Toth
    Division of Clinical Pharmacology and Metabolic Research, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Curr Opin Clin Nutr Metab Care 4:391-7. 2001
    ..This review focuses on the statistical and physiological issues related to comparing energy expenditure data among individuals who differ in body size and composition...
  6. ncbi request reprint Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women
    W F DeNino
    Division of Clinical Pharmacology and Metabolic Research, University of Vermont, Burlington 05405, USA
    Diabetes Care 24:925-32. 2001
    ....
  7. ncbi request reprint Menopause-related changes in body fat distribution
    M J Toth
    Department of Medicine, University of Vermont, Burlington 05405, USA
    Ann N Y Acad Sci 904:502-6. 2000
    ..Thus, CT and MRI should be used when examining menopause-related changes in body fat distribution...
  8. ncbi request reprint Effects of estradiol and progesterone on body composition, protein synthesis, and lipoprotein lipase in rats
    M J Toth
    Division of Clinical Pharmacology and Metabolic Research, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 280:E496-501. 2001
    ..Moreover, ovarian hormones may influence skeletal muscle growth through their effects on skeletal muscle protein synthesis...
  9. ncbi request reprint Racial differences in plasma leptin concentrations in obese postmenopausal women
    B J Nicklas
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    J Clin Endocrinol Metab 82:315-7. 1997
    ..08). These findings suggest racial differences in plasma leptin levels and in leptin's role in the regulation of REE, which may play a role in the greater incidence of obesity in the African-American compared to the Caucasian population...
  10. pmc Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function
    Mark S Miller
    Departments of Molecular Physiology and Biophysics and Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
    Circ Heart Fail 2:700-6. 2009
    ..Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined...
  11. ncbi request reprint Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women
    M J Toth
    Department of Medicine, and Department of Obstetrics and Gynecology, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Endocrinol Metab 281:E113-21. 2001
    ....
  12. pmc Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity
    Brian C Cooper
    Department of Obstetrics and Gynecology, The University of Vermont College of Medicine, Burlington, VT, USA
    Am J Obstet Gynecol 196:123.e1-7. 2007
    ..This study was undertaken to determine whether insulin resistance associated with combination hormone replacement therapy (HRT) is mediated by changes in serum markers of inflammation or in serum adipocyte hormones...
  13. ncbi request reprint Effect of menopausal status on lipolysis: comparison of plasma glycerol levels in middle-aged, premenopausal and early, postmenopausal women
    Michael J Toth
    Division of Clinical Pharmacology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Metabolism 51:322-6. 2002
    ..314 to r =.493; P <.05 to P <.01), although no relationships were found in postmenopausal women. Our results suggest no effect of menopausal status on plasma glycerol levels under postabsorptive or hyperinsulinemic conditions...
  14. ncbi request reprint Evidence against a role for ovarian hormones in the regulation of blood flow
    Brian C Cooper
    Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Fertil Steril 86:440-7. 2006
    ..To determine the effect of ovarian hormone deficiency on peripheral vascular function...
  15. ncbi request reprint Skeletal muscle myofibrillar mRNA expression in heart failure: relationship to local and circulating hormones
    Michael J Toth
    Department of Medicine, Health Science Research Facility 126 B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
    J Appl Physiol 100:35-41. 2006
    ....
  16. doi request reprint The influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary disease
    P A Ades
    Division of Cardiology, University of Vermont College of Medicine, Burlington, VT 05403, USA
    Int J Obes (Lond) 32:967-74. 2008
    ..We assessed whether these relationships persist in patients with established CHD treated with evidence-based preventive pharmacologic therapies...
  17. ncbi request reprint Recovery of (13)CO(2) from infused [1-(13)C]leucine and [1,2-(13)C(2)]leucine in healthy humans
    M J Toth
    Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Endocrinol Metab 281:E233-41. 2001
    ....
  18. ncbi request reprint Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity
    Michael J Toth
    Health Science Research Facility 126 B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 288:E685-92. 2005
    ..The fact that MHC protein content was related to both exercise capacity and muscle strength further suggests that quantitative alterations in MHC protein may have functional significance...
  19. pmc Ovarian suppression with a gonadotropin-releasing hormone agonist does not alter insulin-stimulated glucose disposal
    Brian C Cooper
    Department of Obstetrics and Gynecology, University of Vermont, Burlington, Vermont 05405, USA
    Fertil Steril 87:1131-8. 2007
    ..Thus, the goal of this study was to evaluate the effect of suppression of endogenous ovarian hormone production on insulin-stimulated glucose disposal...
  20. pmc Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion
    Michael J Toth
    Department of Medicine and Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 294:E1035-45. 2008
    ..Our data do, however, support a role for ovarian hormones in the regulation of plasma adiponectin levels...
  21. ncbi request reprint Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal
    Cynthia K Sites
    Department of Obstetrics and Gynecology, The University of Vermont College of Medicne, Burlington, Vermont 05405, USA
    Fertil Steril 77:128-35. 2002
    ..To determine whether postmenopausal status is associated with elevated plasma inflammation markers compared to premenopausal status, and how this explains differences in fat distribution and insulin-stimulated glucose disposal...
  22. pmc Reduced knee extensor function in heart failure is not explained by inactivity
    Michael J Toth
    Department of Medicine, University of Vermont, College of Medicine Burlington, VT 05405, United States
    Int J Cardiol 143:276-82. 2010
    ..The goal of this study was to determine if heart failure alters knee extensor muscle torque, power production or contractile velocity...
  23. ncbi request reprint Role of ovarian hormones in the regulation of protein metabolism in women: effects of menopausal status and hormone replacement therapy
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 291:E639-46. 2006
    ....
  24. ncbi request reprint Whole-body protein metabolism in chronic heart failure: relationship to anabolic and catabolic hormones
    Michael J Toth
    Department of Medicine, Health Science Research Facility, University of Vermont, Burlington, Vermont 05405, USA
    JPEN J Parenter Enteral Nutr 30:194-201. 2006
    ..Thus, our goal was to determine if whole-body protein metabolism is altered in heart failure patients and to assess the relationship of protein kinetics to circulating levels of anabolic and catabolic hormones...
  25. ncbi request reprint Ovarian suppression with gonadotropin-releasing hormone agonist reduces whole body protein turnover in women
    Michael J Toth
    Fepartment of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 291:E483-90. 2006
    ..Our findings provide evidence that endogenous ovarian hormones participate in the regulation of protein turnover in women...
  26. pmc Impaired muscle protein anabolic response to insulin and amino acids in heart failure patients: relationship with markers of immune activation
    Michael J Toth
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Clin Sci (Lond) 119:467-76. 2010
    ..The inability to stimulate muscle protein anabolism following periods of nutritional deficiency may contribute to muscle wasting in HF patients...
  27. ncbi request reprint Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure
    Michael J Toth
    Department of Medicine, University of Vermont, Burlington, 05405, USA
    Int J Cardiol 109:179-87. 2006
    ..Whether humoral factors contribute to the peripheral manifestations of the heart failure syndrome, such as muscle atrophy and reduced physical work capacity, however, is not clear...
  28. ncbi request reprint The effect of hormone replacement therapy on body composition, body fat distribution, and insulin sensitivity in menopausal women: a randomized, double-blind, placebo-controlled trial
    Cynthia K Sites
    Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Given Building C250, 89 Beaumont Avenue, Burlington, Vermont 05405, USA
    J Clin Endocrinol Metab 90:2701-7. 2005
    ..We sought to determine whether hormone replacement therapy (HRT) reduced intraabdominal and sc abdominal fat and improved insulin sensitivity in early menopausal women...
  29. ncbi request reprint Age-related differences in skeletal muscle protein synthesis: relation to markers of immune activation
    Michael J Toth
    Department of Medicine, Health Science Research Facility 126 B, 149 Beaumont Ave, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 288:E883-91. 2005
    ..Our data show strong trends toward reduced postabsorptive muscle protein synthesis with age. Moreover, reduced muscle protein synthesis rates were related to increased circulating concentrations of several markers of immune activation...
  30. pmc Skeletal muscle contractile protein function is preserved in human heart failure
    Yoko Okada
    Univ of Vermont, College of Medicine, Burlington, VT 05405, USA
    J Appl Physiol 104:952-7. 2008
    ..Other factors, such as a decrease in total muscle myosin content, are likely contributors to the skeletal muscle strength deficit of heart failure...
  31. ncbi request reprint Effect of heart failure on the regulation of skeletal muscle protein synthesis, breakdown, and apoptosis
    Rebecca Persinger
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 284:E1001-8. 2003
    ..Instead, muscle atrophy was related to reduced body weight secondary to decreased food intake. These findings argue against the notion that heart failure is characterized by a skeletal muscle myopathy that predisposes to atrophy...
  32. ncbi request reprint A re-examination of the metabolic equivalent concept in individuals with coronary heart disease
    Patrick D Savage
    Division of Cardiology, Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT 05401, USA
    J Cardiopulm Rehabil Prev 27:143-8. 2007
    ..5 mL O2.kg(-1).min(-1). The goal of the present study was to compare the traditionally accepted value for 1 MET to direct measures of resting metabolic rate in a group of stable individuals with coronary heart disease (CHD)...
  33. ncbi request reprint Evaluation and optimization of ion-current ratio measurements by selected-ion-monitoring mass spectrometry
    M J MacCoss
    Department of Medicine, The University of Vermont, Burlington 05405, USA
    Anal Chem 73:2976-84. 2001
    ..This method allows a simple evaluation of a mass spectrometry system and can define the precision of new quantitation and tracer methods...
  34. pmc High-calorie-expenditure exercise: a new approach to cardiac rehabilitation for overweight coronary patients
    Philip A Ades
    Division of Cardiology, University of Vermont College of Medicine, Burlington, VT, USA
    Circulation 119:2671-8. 2009
    ..Current CR exercise protocols result in little weight loss and minimal changes in cardiac risk factors. We sought to design an exercise protocol that would lead to greater weight loss and risk factor change...
  35. ncbi request reprint Effect of ovariectomy and estradiol replacement on skeletal muscle enzyme activity in female rats
    Travis Beckett
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Metabolism 51:1397-401. 2002
    ..Our results suggest that, independent of alterations in food intake, estradiol availability affects the regulation of enzymes involved in nonoxidative glucose disposal (GS) and oxidative metabolism (CS) in skeletal muscle...
  36. ncbi request reprint Progesterone stimulates cardiac muscle protein synthesis via receptor-dependent pathway
    Jerald Goldstein
    Department of Medicine and Obstetrics, University of Vermont, Burlington, VT 05405, USA
    Fertil Steril 82:430-6. 2004
    ..To examine the effect of ovarian hormones on the regulation of cardiac growth...
  37. pmc Correlation of serum androgens with anthropometric and metabolic indices in healthy, nonobese postmenopausal women
    Peter R Casson
    University of Vermont, Fletcher Allen Health Care, Smith 401, 111 Colchester Avenue, Burlington, Vermont 05401, USA
    J Clin Endocrinol Metab 95:4276-82. 2010
    ..Thus, the present study sought to assess the contribution of endogenous circulating androgens to the regulation of metabolic function, body morphometry, and physical function in normal naturally postmenopausal women...
  38. ncbi request reprint Genes overexpressed in cerebral arteries following salt-induced hypertensive disease are regulated by angiotensin II, JunB, and CREB
    Patricia Rose
    Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 294:H1075-85. 2008
    ..Together, these results suggest that salt-induced hypertensive disease promotes changes in matricellular genes that are stimulated by ANG II, regulated by ERK, and selectively regulated by JunB and CREB...
  39. pmc Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women
    Cynthia K Sites
    Department of Obstetrics and Gynecology and Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Fertil Steril 88:1609-17. 2007
    ..To determine whether a supplement of soy protein improves body composition, body fat distribution, and glucose and insulin metabolism in postmenopausal women without diabetes compared with an isocaloric casein placebo...
  40. ncbi request reprint Accelerated decline of aerobic fitness with healthy aging: what is the good news?
    Philip A Ades
    Circulation 112:624-6. 2005