Alfredo Torres

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc CadA negatively regulates Escherichia coli O157:H7 adherence and intestinal colonization
    Roberto C Vazquez-Juarez
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Infect Immun 76:5072-81. 2008
  2. pmc Burkholderia mallei cellular interactions in a respiratory cell model
    Gregory C Whitlock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Med Microbiol 58:554-62. 2009
  3. pmc Development of a multiplex PCR assay for detection of Shiga toxin-producing Escherichia coli, enterohemorrhagic E. coli, and enteropathogenic E. coli strains
    Douglas J Botkin
    Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
    Front Cell Infect Microbiol 2:8. 2012
  4. pmc Prophylactic application of CpG oligonucleotides augments the early host response and confers protection in acute melioidosis
    Barbara M Judy
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e34176. 2012
  5. pmc In vivo Bioluminescence Imaging of Burkholderia mallei Respiratory Infection and Treatment in the Mouse Model
    Shane Massey
    Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
    Front Microbiol 2:174. 2011
  6. doi request reprint Comparative Burkholderia pseudomallei natural history virulence studies using an aerosol murine model of infection
    Shane Massey
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555
    Sci Rep 4:4305. 2014
  7. pmc In vivo bioluminescence imaging of Escherichia coli O104:H4 and role of aerobactin during colonization of a mouse model of infection
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    BMC Microbiol 12:112. 2012
  8. pmc A double, long polar fimbria mutant of Escherichia coli O157:H7 expresses Curli and exhibits reduced in vivo colonization
    Sonja J Lloyd
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
    Infect Immun 80:914-20. 2012
  9. pmc Molecular mechanisms that mediate colonization of Shiga toxin-producing Escherichia coli strains
    Mauricio J Farfan
    Centro de Estudios Moleculares, Departamento de Pediatria, Hospital Dr Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Infect Immun 80:903-13. 2012
  10. pmc Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and Levofloxacin
    Barbara M Judy
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
    BMC Microbiol 9:88. 2009

Collaborators

Detail Information

Publications52

  1. pmc CadA negatively regulates Escherichia coli O157:H7 adherence and intestinal colonization
    Roberto C Vazquez-Juarez
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Infect Immun 76:5072-81. 2008
    ..In the infant rabbit model, the cadA mutant outcompeted the wild-type strain in the ileum but not in the cecum or mid-colon, raising the possibility that CadA negatively regulates EHEC pathogenicity in a tissue-specific fashion...
  2. pmc Burkholderia mallei cellular interactions in a respiratory cell model
    Gregory C Whitlock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Med Microbiol 58:554-62. 2009
    ..Overall, these data suggest that B. mallei induces apoptotic cell death, whilst the BopA effector protein participates in intracellular survival...
  3. pmc Development of a multiplex PCR assay for detection of Shiga toxin-producing Escherichia coli, enterohemorrhagic E. coli, and enteropathogenic E. coli strains
    Douglas J Botkin
    Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
    Front Cell Infect Microbiol 2:8. 2012
    ..In conclusion, our mPCR methodology permitted differentiation of EPEC, STEC and EHEC strains from other pathogenic E. coli; therefore, the assay becomes an additional tool for rapid diagnosis of these organisms...
  4. pmc Prophylactic application of CpG oligonucleotides augments the early host response and confers protection in acute melioidosis
    Barbara M Judy
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e34176. 2012
    ..In contrast, a delay in recruitment of inflammatory cell populations, despite a robust production of pro-inflammatory cytokines, was associated with poorly controlled bacterial growth, severe lung pathology, and death of control animals...
  5. pmc In vivo Bioluminescence Imaging of Burkholderia mallei Respiratory Infection and Treatment in the Mouse Model
    Shane Massey
    Department of Microbiology and Immunology, University of Texas Medical Branch Galveston, TX, USA
    Front Microbiol 2:174. 2011
    ..Finally, we report an alternative method to mini-Tn5::luxKm2 transposon using mini-Tn7-lux elements that insert site-specifically at known genomic attachment sites and that can also be used to tag bacteria...
  6. doi request reprint Comparative Burkholderia pseudomallei natural history virulence studies using an aerosol murine model of infection
    Shane Massey
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555
    Sci Rep 4:4305. 2014
    ..Further, this protocol serves as a guideline to standardize other bacterial aerosol models of infection or to define biomarkers of infectious processes caused by other intracellular pathogens. ..
  7. pmc In vivo bioluminescence imaging of Escherichia coli O104:H4 and role of aerobactin during colonization of a mouse model of infection
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    BMC Microbiol 12:112. 2012
    ..Due to limited information regarding pathogenesis and/or virulence properties of this particular serotype, we investigated the contribution of the aerobactin iron transport system during in vitro and in vivo conditions...
  8. pmc A double, long polar fimbria mutant of Escherichia coli O157:H7 expresses Curli and exhibits reduced in vivo colonization
    Sonja J Lloyd
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
    Infect Immun 80:914-20. 2012
    ..In addition to suggesting that Lpf can contribute to EHEC intestinal colonization, our observations indicate that the regulatory pathways governing the expression of Lpf and curli are interdependent...
  9. pmc Molecular mechanisms that mediate colonization of Shiga toxin-producing Escherichia coli strains
    Mauricio J Farfan
    Centro de Estudios Moleculares, Departamento de Pediatria, Hospital Dr Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Infect Immun 80:903-13. 2012
    ....
  10. pmc Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and Levofloxacin
    Barbara M Judy
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA
    BMC Microbiol 9:88. 2009
    ..The effect of two antibiotics with different modes of action on Burkholderia mallei strain ATCC23344 was investigated by using in vitro and in vivo studies...
  11. pmc Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes
    John He Nash
    Public Health Agency of Canada, Toronto, Ontario, Canada
    BMC Genomics 11:667. 2010
    ..To address this, we present the complete genome sequence of an AIEC, revealing the genetic blueprint for this disease-associated E. coli pathotype...
  12. ncbi request reprint Bile salts induce expression of the afimbrial LDA adhesin of atypical enteropathogenic Escherichia coli
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
    Cell Microbiol 9:1039-49. 2007
    ..We concluded that bile salts increase expression of LDA, conferring a diffuse adherence pattern and having an impact on the adhesion properties of this aEPEC strain...
  13. ncbi request reprint Environmental regulation and colonization attributes of the long polar fimbriae (LPF) of Escherichia coli O157:H7
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Int J Med Microbiol 297:177-85. 2007
    ..coli O157:H7 to persist in the intestine of infected 6-week-old lambs...
  14. doi request reprint The cad locus of Enterobacteriaceae: more than just lysine decarboxylation
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555, USA
    Anaerobe 15:1-6. 2009
    ....
  15. ncbi request reprint Current aspects of Shigella pathogenesis
    Alfredo G Torres
    Department of Microbiology and Immunology, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
    Rev Latinoam Microbiol 46:89-97. 2004
    ..This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine...
  16. pmc Contribution of the Ler- and H-NS-regulated long polar fimbriae of Escherichia coli O157:H7 during binding to tissue-cultured cells
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Infect Immun 76:5062-71. 2008
    ..Overall, our data confirmed that expression of LPF is a tightly regulated process and, for the first time, demonstrated that these fimbriae are associated with adherence and hemagglutination phenotypes in EHEC O157:H7...
  17. pmc Outer membrane protein A of Escherichia coli O157:H7 stimulates dendritic cell activation
    Alfredo G Torres
    Department of Microbiology and Immunology, 301 University Blvd, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
    Infect Immun 74:2676-85. 2006
    ..While OmpA was required for bacterial binding to polarized Caco-2 cells, it was not needed for the induction of cytokine production by Caco-2 cells or for human DC migration across polarized cells...
  18. pmc Genes related to long polar fimbriae of pathogenic Escherichia coli strains as reliable markers to identify virulent isolates
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555 1070, USA
    J Clin Microbiol 47:2442-51. 2009
    ..coli O157:H7, distinguishing it from other pathogenic E. coli strains...
  19. pmc Differential binding of Escherichia coli O157:H7 to alfalfa, human epithelial cells, and plastic is mediated by a variety of surface structures
    Alfredo G Torres
    Department of Microbiology and Immunology, Department of Pathology, and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Appl Environ Microbiol 71:8008-15. 2005
    ..Binding to the three types of surfaces appeared to be mediated by overlapping but distinct sets of genes. The only gene which appeared to be irreplaceable for binding to plant surfaces was ompA...
  20. pmc Pathoadaptive mutation that mediates adherence of shiga toxin-producing Escherichia coli O111
    Alfredo G Torres
    Department of Microbiology and Immunology and Department of Pathology and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Infect Immun 73:4766-76. 2005
    ..Our data suggest that this pathoadaptive mutation is an important mechanism to control functions potentially implicated in the pathogenesis of these organisms...
  21. pmc Adherence of diarrheagenic Escherichia coli strains to epithelial cells
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Infect Immun 73:18-29. 2005
  22. ncbi request reprint Characterization of the second long polar (LP) fimbriae of Escherichia coli O157:H7 and distribution of LP fimbriae in other pathogenic E. coli strains
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    FEMS Microbiol Lett 238:333-44. 2004
    ..Our results suggest that LP fimbriae 2 may contribute to the early stages of EHEC adhesion and that genes encoding the major LP fimbrial subunits are present in a small group of EHEC and EPEC serotypes...
  23. pmc Ler and H-NS, regulators controlling expression of the long polar fimbriae of Escherichia coli O157:H7
    Alfredo G Torres
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Bacteriol 189:5916-28. 2007
    ....
  24. ncbi request reprint Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells
    Tonyia Eaves-Pyles
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1070, USA
    Int J Med Microbiol 298:397-409. 2008
    ..These findings demonstrate that E. coli O83:H1 possesses the characteristics of the AIEC LF82 strain that may contribute to the low-grade, chronic inflammation observed in Crohn's disease...
  25. doi request reprint Construction of a reporter system to study Burkholderia mallei type III secretion and identification of the BopA effector protein function in intracellular survival
    Gregory C Whitlock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Trans R Soc Trop Med Hyg 102:S127-33. 2008
    ..mallei invasion and intracellular survival. Overall, our study elucidates how BopA can aid in the optimization of TTS and defines the function of TTS effectors in bacterial intracellular survival and invasion...
  26. doi request reprint Outbreak caused by cad-negative Shiga toxin-producing Escherichia coli O111, Oklahoma
    Veronica E Calderon
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
    Foodborne Pathog Dis 7:107-9. 2010
    ..coli, particularly Shiga toxin-producing E. coli O111 isolates, that have the potential of causing human infections and outbreaks...
  27. pmc Testing the efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens using in vitro and in vivo models of infection
    Scott T Moen
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, USA
    Infect Immun 78:1740-9. 2010
    ..Thus, DC5 may be a promising compound for treatment of diarrhea caused by ETEC and other adenylyl cyclase toxin-producing bacteria...
  28. pmc Present and future therapeutic strategies for melioidosis and glanders
    D Mark Estes
    Department of Microbiology and Immunology, Department of Pathology and The Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Expert Rev Anti Infect Ther 8:325-38. 2010
    ..This review provides a compilation of literature covering studies in antimelioidosis and antiglanders antimicrobial drug discovery, with a particular focus on potential novel therapeutic approaches to combat these diseases...
  29. doi request reprint The effects of low-shear stress on Adherent-invasive Escherichia coli
    Christopher A Allen
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    Environ Microbiol 10:1512-25. 2008
    ..Overall, our study demonstrated how mechanical stresses such as LSS altered AIEC phenotypic characteristics and identified novel functions for some RpoS-regulated proteins...
  30. pmc Host immunity in the protective response to vaccination with heat-killed Burkholderia mallei
    Gregory C Whitlock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA
    BMC Immunol 9:55. 2008
    ..We performed initial cell, cytokine and complement depletion studies to investigate the possible role of these effectors in response to vaccination with heat-killed Burkholderia mallei in a susceptible BALB/c mouse model of infection...
  31. ncbi request reprint Glanders: off to the races with Burkholderia mallei
    Gregory C Whitlock
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    FEMS Microbiol Lett 277:115-22. 2007
    ..Therefore, this minireview will focus on current efforts to elucidate B. mallei virulence, the associated host immune responses elicited during infection and discuss the feasibility of vaccine development...
  32. pmc Regulatory control of the Escherichia coli O157:H7 lpf1 operon by H-NS and Ler
    Maricarmen Rojas-López
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1070, USA
    J Bacteriol 193:1622-32. 2011
    ..A model of the regulation of the lpfA1 operon of E. coli O157:H7 by H-NS and Ler is discussed...
  33. ncbi request reprint Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli
    Vanessa Sperandio
    Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Mol Microbiol 43:809-21. 2002
    ....
  34. ncbi request reprint The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells
    Jorge A Giron
    Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemerita Universidad Autonoma de Puebla, Mexico
    Mol Microbiol 44:361-79. 2002
    ....
  35. ncbi request reprint StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor
    Wyndham W Lathem
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA
    Mol Microbiol 45:277-88. 2002
    ..Cleavage of C1-INH by StcE could plausibly cause localized pro-inflammatory and coagulation responses resulting in tissue damage, intestinal oedema and thrombotic abnormalities...
  36. ncbi request reprint Characterization of Cah, a calcium-binding and heat-extractable autotransporter protein of enterohaemorrhagic Escherichia coli
    Alfredo G Torres
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Microbiol 45:951-66. 2002
    ..Our results provide insight into the expression, secretion and preliminary features of the calcium-binding Cah autotransporter protein of EHEC O157:H7...
  37. pmc Identification and characterization of lpfABCC'DE, a fimbrial operon of enterohemorrhagic Escherichia coli O157:H7
    Alfredo G Torres
    Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 70:5416-27. 2002
    ..We propose that LP fimbriae participate in the interaction of E. coli O157:H7 with eukaryotic cells by assisting in microcolony formation...
  38. pmc Bacteria-host communication: the language of hormones
    Vanessa Sperandio
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:8951-6. 2003
    ..Given that eukaryotic cell-to-cell signaling typically occurs through hormones, and that bacterial cell-to-cell signaling occurs through QS, we speculate that QS might be a "language" by which bacteria and host cells communicate...
  39. pmc Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cells
    Xin Zhou
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Infect Immun 71:2120-9. 2003
    ..Our data clearly indicate that FliC of EPEC is sufficient to induce IL-8 release in T84 cells and that activation of the Erk and p38 pathways is required for IL-8 induction...
  40. pmc Multiple elements controlling adherence of enterohemorrhagic Escherichia coli O157:H7 to HeLa cells
    Alfredo G Torres
    Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 71:4985-95. 2003
    ..Our results indicate that multiple elements control adherence and OmpA acts as an adhesin in EHEC O157:H7...
  41. ncbi request reprint Identification and characterization of "pathoadaptive mutations" of the cadBA operon in several intestinal Escherichia coli
    Joerg Jores
    Institut für Mikrobiologie und Tierseuchen, Freie Universitat Berlin, Philippstrasse 13, D 10115 Berlin, Germany
    Int J Med Microbiol 296:547-52. 2006
    ..and EIEC strains. Interestingly, the alterations of the cad genes were similar to those previously reported, pointing towards a parallel evolution of LDC silencing in different intestinal E. coli pathotypes...
  42. pmc Molecular epidemiology of the iron utilization genes of enteroaggregative Escherichia coli
    Iruka N Okeke
    Department of Biomedical Sciences, University of Bradford, Bradford, United Kingdom
    J Clin Microbiol 42:36-44. 2004
    ..05). It is possible that the presence of both genes marks at least some virulent strains. The data also demonstrate geographical variation in the association of iron utilization genes with disease in EAEC...
  43. pmc Polysaccharides cellulose, poly-beta-1,6-n-acetyl-D-glucosamine, and colanic acid are required for optimal binding of Escherichia coli O157:H7 strains to alfalfa sprouts and K-12 strains to plastic but not for binding to epithelial cells
    Ann G Matthysse
    Department of Biology, Coker Hall, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Appl Environ Microbiol 74:2384-90. 2008
    ..PGA, colanic acid, and cellulose were also required for biofilm formation by a K-12 strain on plastic, but not for the binding of E. coli O157:H7 to mammalian cells...
  44. pmc A novel two-component signaling system that activates transcription of an enterohemorrhagic Escherichia coli effector involved in remodeling of host actin
    Nicola C Reading
    Dept of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
    J Bacteriol 189:2468-76. 2007
    ..These findings suggest the QseEF is a two-component system involved in the regulation of AE lesion formation by EHEC...
  45. pmc Identification and characterization of the locus for diffuse adherence, which encodes a novel afimbrial adhesin found in atypical enteropathogenic Escherichia coli
    Isabel C A Scaletsky
    Department of Microbiology and Immunology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil 04023 062
    Infect Immun 73:4753-65. 2005
    ..coli DH5alpha lda(+) clone to HEp-2 cells. Electron microscopy revealed a nonfimbrial structure surrounding the bacterial cell...
  46. pmc The lpf gene cluster for long polar fimbriae is not involved in adherence of enteropathogenic Escherichia coli or virulence of Citrobacter rodentium
    Ichiro Tatsuno
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Infect Immun 74:265-72. 2006
    ..These data suggest that in addition to playing no apparent role in EPEC pathogenesis, lpf(cr) is not required for C. rodentium virulence in either the C3H/HeJ or C57BL/6 mouse model...
  47. pmc Cloning, expression, and characterization of fimbrial operon F9 from enterohemorrhagic Escherichia coli O157:H7
    Alison S Low
    Zoonotic and Animal Pathogens Research Laboratory, Centre for Infectious Diseases, Chancellor s Building, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom
    Infect Immun 74:2233-44. 2006
    ....
  48. ncbi request reprint Long polar fimbriae and tissue tropism in Escherichia coli O157:H7
    Robert Fitzhenry
    Centre for Paediatric Gastroenterology, Royal Free Hospital, London, UK
    Microbes Infect 8:1741-9. 2006
    ..LP fimbrial genes are the first genes to be identified outside the locus of enterocyte effacement pathogenicity island that influence O157:H7 human intestinal tissue tropism...
  49. ncbi request reprint Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic Escherichia coli signalling of human colon epithelium in vivo
    Yukiko Miyamoto
    Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA
    Cell Microbiol 8:869-79. 2006
    ..We conclude that EHEC H7 flagellin and not Stx is the major EHEC factor that directly upregulates proinflammatory chemokine production by human colon epithelium in vivo...
  50. pmc Long polar fimbriae contribute to colonization by Escherichia coli O157:H7 in vivo
    Dianna M Jordan
    Department of Veterinary Pathology, Iowa State University, Ames, Iowa 50011, USA
    Infect Immun 72:6168-71. 2004
    ..E. coli O157:H7 strains with lpfA1 and lpfA2 mutated were recovered in significantly lower numbers and caused fewer attachment and effacement lesions than the parent strain...

Research Grants3

  1. Long Polar Fimbriae of Attaching and Effacing Escherichia coli
    Alfredo Torres; Fiscal Year: 2009
    ..new and deeper insights into the process of AEEC colonization, and a better understanding of their regulatory mechanisms controlling expression, which will be a basis for developing novel therapeutics and simplified diagnostic tests ..
  2. Long Polar Fimbriae of Attaching and Effacing Escherichia coli
    Alfredo G Torres; Fiscal Year: 2010
    ..new and deeper insights into the process of AEEC colonization, and a better understanding of their regulatory mechanisms controlling expression, which will be a basis for developing novel therapeutics and simplified diagnostic tests ..
  3. Long Polar Fimbriae of Attaching and Effacing Escherichia coli
    Alfredo Torres; Fiscal Year: 2009
    ..new and deeper insights into the process of AEEC colonization, and a better understanding of their regulatory mechanisms controlling expression, which will be a basis for developing novel therapeutics and simplified diagnostic tests ..