GIULIO contact TONONI

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin, United States of America
    PLoS ONE 2:e276. 2007
  2. pmc Qualia: the geometry of integrated information
    David Balduzzi
    Department of Psychiatry, University of Wisconsin, Madison, WI, USA
    PLoS Comput Biol 5:e1000462. 2009
  3. pmc Experienced mindfulness meditators exhibit higher parietal-occipital EEG gamma activity during NREM sleep
    Fabio Ferrarelli
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 8:e73417. 2013
  4. pmc Local sleep in awake rats
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA
    Nature 472:443-7. 2011
  5. pmc A neuromorphic architecture for object recognition and motion anticipation using burst-STDP
    Andrew Nere
    Department of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e36958. 2012
  6. pmc Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA Electronic address
    Neuron 81:12-34. 2014
  7. ncbi request reprint Integrated information theory of consciousness: an updated account
    G Tononi
    Department of Psychiatry, University of Wisconsin, Madison, WI, USA
    Arch Ital Biol 150:293-329. 2012
  8. doi request reprint Integrated information theory of consciousness: an updated account
    G Tononi
    Department of Psychiatry, University of Wisconsin, Mdison, WI 53719, USA
    Arch Ital Biol 150:56-90. 2012
  9. pmc Time to be SHY? Some comments on sleep and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison 6001 Research Park Boulevard, Madison, WI 53719, USA
    Neural Plast 2012:415250. 2012
  10. pmc Sleep, aging, and lifespan in Drosophila
    Daniel Bushey
    Dept of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    BMC Neurosci 11:56. 2010

Collaborators

Detail Information

Publications87

  1. pmc TMS-induced cortical potentiation during wakefulness locally increases slow wave activity during sleep
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin, United States of America
    PLoS ONE 2:e276. 2007
    ..We showed recently that SWA increases locally after a learning task involving a circumscribed brain region, suggesting that SWA may reflect plastic changes triggered by learning...
  2. pmc Qualia: the geometry of integrated information
    David Balduzzi
    Department of Psychiatry, University of Wisconsin, Madison, WI, USA
    PLoS Comput Biol 5:e1000462. 2009
    ..Ultimately, the present framework may offer a principled way for translating qualitative properties of experience into mathematics...
  3. pmc Experienced mindfulness meditators exhibit higher parietal-occipital EEG gamma activity during NREM sleep
    Fabio Ferrarelli
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 8:e73417. 2013
    ....
  4. pmc Local sleep in awake rats
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA
    Nature 472:443-7. 2011
    ..Thus, although both the EEG and behaviour indicate wakefulness, local populations of neurons in the cortex may be falling asleep, with negative consequences for performance...
  5. pmc A neuromorphic architecture for object recognition and motion anticipation using burst-STDP
    Andrew Nere
    Department of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 7:e36958. 2012
    ..As such, the building blocks and learning rules presented in this paper appear promising for scalable fully neuromorphic systems to be implemented in hardware chips...
  6. pmc Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA Electronic address
    Neuron 81:12-34. 2014
    ..This Perspective considers the rationale and evidence for SHY and points to open issues related to sleep and plasticity...
  7. ncbi request reprint Integrated information theory of consciousness: an updated account
    G Tononi
    Department of Psychiatry, University of Wisconsin, Madison, WI, USA
    Arch Ital Biol 150:293-329. 2012
    ..Finally, it summarizes how liT accounts for empirical findings about the neural substrate of consciousness, and how various aspects of phenomenology may in principle be addressed in terms of the geometry of information integration...
  8. doi request reprint Integrated information theory of consciousness: an updated account
    G Tononi
    Department of Psychiatry, University of Wisconsin, Mdison, WI 53719, USA
    Arch Ital Biol 150:56-90. 2012
    ..Finally, it summarizes how IIT accounts for empirical findings about the neural substrate of consciousness, and how various aspects of phenomenology may in principle be addressed in terms of the geometry of information integration...
  9. pmc Time to be SHY? Some comments on sleep and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison 6001 Research Park Boulevard, Madison, WI 53719, USA
    Neural Plast 2012:415250. 2012
    ....
  10. pmc Sleep, aging, and lifespan in Drosophila
    Daniel Bushey
    Dept of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    BMC Neurosci 11:56. 2010
    ..Also, sleep quality has been shown to decrease in old flies, but it remains unclear whether aging-related sleep fragmentation is a generalized phenomenon...
  11. pmc Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii)
    Stephany G Jones
    Neuroscience Training Program, University of Wisconsin Madison, USA
    BMC Neurosci 9:47. 2008
    ..To accomplish this goal, we investigated amount of sleep, sleep time course, and measures of sleep intensity in 6 birds during baseline sleep and during recovery sleep following 6 hours of sleep deprivation...
  12. pmc Sleep in Kcna2 knockout mice
    Christopher L Douglas
    Department of Psychiatry, University of Wisconsin, Madison, WI, 53719, USA
    BMC Biol 5:42. 2007
    ..To address this issue, we studied sleep in Kcna2 knockout (KO) mice. Kcna2 codes for Kv1.2, the alpha subunit of a Shaker-like voltage-dependent potassium channel with high expression in the mammalian thalamocortical system...
  13. ncbi request reprint Consciousness as integrated information: a provisional manifesto
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Biol Bull 215:216-42. 2008
    ..Equating consciousness with integrated information carries several implications for our view of nature...
  14. ncbi request reprint Sleep function and synaptic homeostasis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Sleep Med Rev 10:49-62. 2006
    ..The hypothesis accounts for a large number of experimental facts, makes several specific predictions, and has implications for both sleep and mood disorders...
  15. doi request reprint Why does consciousness fade in early sleep?
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research, Park Blvd, Madison, WI 53719, USA
    Ann N Y Acad Sci 1129:330-4. 2008
    ....
  16. pmc Staying awake puts pressure on brain arousal systems
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Clin Invest 117:3648-50. 2007
    ..This increase in synaptic strength may be one of the mechanisms that help us to stay awake when we are sleep deprived, but it may also represent one of the signals telling the brain that it is time to sleep...
  17. ncbi request reprint Regional sleep regulation
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Sleep Med 6:575-6. 2005
  18. ncbi request reprint Information integration: its relevance to brain function and consciousness
    G Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Arch Ital Biol 148:299-322. 2010
    ....
  19. pmc Measuring information integration
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, USA
    BMC Neurosci 4:31. 2003
    ..The paper considers a measure based on effective information, a quantity capturing all causal interactions that can occur between two parts of a system...
  20. ncbi request reprint Consciousness, information integration, and the brain
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Prog Brain Res 150:109-26. 2005
    ....
  21. ncbi request reprint Sleep and synaptic homeostasis: a hypothesis
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Brain Res Bull 62:143-50. 2003
    ..Synaptic downscaling is tied to the beneficial effects of sleep on performance. The hypothesized link between sleep and synaptic homeostasis is supported by several lines of evidence and leads to testable predictions...
  22. ncbi request reprint The neuro-biomolecular basis of alertness in sleep disorders
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, USA
    Sleep Med 6:S8-12. 2005
    ....
  23. pmc An information integration theory of consciousness
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, USA
    BMC Neurosci 5:42. 2004
    ..For example, why do specific parts of the brain contribute specific qualities to our conscious experience, such as vision and audition?..
  24. pmc Cortical firing and sleep homeostasis
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuron 63:865-78. 2009
    ..Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep...
  25. pmc Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans
    Brady A Riedner
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Sleep 30:1643-57. 2007
    ..Here, we investigated the model's predictions in humans by using all-night high-density (hd)-EEG recordings to explore slow-wave parameters over the entire cortical mantle...
  26. pmc Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling
    Steve K Esser
    Department of Psychiatry and 2Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurophysiol 102:2096-111. 2009
    ..Of these mechanisms, we find that only a shift in the balance of synaptic excitation and inhibition can account for the observed in vivo response to direct cortical perturbation as well as many features of spontaneous sleep...
  27. pmc Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Sleep 30:1631-42. 2007
    ..Here we tested the model predictions by obtaining LFP recordings from the rat cerebral cortex and comparing conditions of high homeostatic sleep pressure (early sleep) and low homeostatic sleep pressure (late sleep)...
  28. pmc Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves
    Steve K Esser
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Sleep 30:1617-30. 2007
    ..Based on a recent hypothesis, we sought to determine whether a decrease in cortical synaptic strength can account for changes in sleep SWA...
  29. ncbi request reprint Exploratory behavior, cortical BDNF expression, and sleep homeostasis
    Reto Huber
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 30:129-39. 2007
    ..The aim of the study was to determine whether neuronal plasticity underlies the link between waking activities and the SWA response...
  30. doi request reprint Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Nat Neurosci 11:200-8. 2008
    ..Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength...
  31. pmc Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat
    Erin C Hanlon
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 32:719-29. 2009
    ....
  32. ncbi request reprint Breakdown of cortical effective connectivity during sleep
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Science 309:2228-32. 2005
    ..Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity...
  33. pmc Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states
    Michael B Dash
    Department of Psychiatry, and Neuroscience Training Program, University of Wisconsin Madison, Madison, WI 53719, USA
    J Neurosci 29:620-9. 2009
    ..These results provide evidence for a long-term homeostasis of extracellular glutamate across sleep-waking states...
  34. pmc Triggering slow waves during NREM sleep in the rat by intracortical electrical stimulation: effects of sleep/wake history and background activity
    Vladyslav V Vyazovskiy
    Dept of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    J Neurophysiol 101:1921-31. 2009
    ..These results show that in the rat a volley of electrical activity that is sufficiently strong to excite and recruit a large cortical neuronal population is capable of inducing slow waves during natural sleep...
  35. pmc Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles
    Fabio Ferrarelli
    School of Medicine and Public Health, Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Am J Psychiatry 167:1339-48. 2010
    ....
  36. ncbi request reprint Reduced sleep spindle activity in schizophrenia patients
    Fabio Ferrarelli
    University of Wisconsin, Department of Psychiatry, 6001 Research Park Blvd, Madison, WI 53719, USA
    Am J Psychiatry 164:483-92. 2007
    ..As a first step in this direction, the authors employed high-density EEG to explore whether sleep rhythms differ between schizophrenia subjects, healthy individuals, and a psychiatric control group with a history of depression...
  37. pmc The Drosophila fragile X mental retardation gene regulates sleep need
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 29:1948-61. 2009
    ..Thus, dFmr1 expression dose-dependently affects both sleep and synapses, suggesting that changes in sleep time in dFmr1 mutants may derive from changes in synaptic physiology...
  38. pmc Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila
    Giorgio F Gilestro
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 324:109-12. 2009
    ..The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities...
  39. ncbi request reprint Modeling the effects of transcranial magnetic stimulation on cortical circuits
    Steve K Esser
    Neuroscience Training Program, University of Wisconsin, 6001 Research Park Boulevard, Madison, Wisconsin 53719 1176, USA
    J Neurophysiol 94:622-39. 2005
    ..The modeled responses to simulated TMS pulses in different experimental paradigms provide a detailed, self-consistent account of the neural and synaptic activities evoked by TMS within prototypical cortical circuits...
  40. ncbi request reprint Reduced sleep in Drosophila Shaker mutants
    Chiara Cirelli
    Department of Psychiatry, 6001 Research Park Blvd, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Nature 434:1087-92. 2005
    ..Shaker, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release, may thus regulate sleep need or efficiency...
  41. pmc Integrated information in discrete dynamical systems: motivation and theoretical framework
    David Balduzzi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    PLoS Comput Biol 4:e1000091. 2008
    ..More generally, phi appears to be a useful metric to characterize the capacity of any physical system to integrate information...
  42. pmc Sleep-dependent improvement in visuomotor learning: a causal role for slow waves
    ERIC C LANDSNESS
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 32:1273-84. 2009
    ..Here, we tested this hypothesis by studying the effects of slow wave deprivation (SWD)...
  43. ncbi request reprint Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
    ..Furthermore, we show that the local increase in SWA after learning correlates with improved performance of the task after sleep. Thus, sleep homeostasis can be induced on a local level and can benefit performance...
  44. ncbi request reprint Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nat Neurosci 9:1169-76. 2006
    ..Thus, cortical plasticity is linked to local sleep regulation without learning in the classical sense. Moreover, when synaptic strength is reduced, local sleep need is also reduced...
  45. ncbi request reprint The sleep slow oscillation as a traveling wave
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 24:6862-70. 2004
    ..The orderly propagation of correlated activity along connected pathways may play a role in spike timing-dependent synaptic plasticity during sleep...
  46. ncbi request reprint Extensive and divergent effects of sleep and wakefulness on brain gene expression
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
    Neuron 41:35-43. 2004
    ....
  47. ncbi request reprint Changes in brain gene expression after long-term sleep deprivation
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurochem 98:1632-45. 2006
    ..These findings suggest that sustained sleep loss may trigger a generalized inflammatory and stress response in the brain...
  48. ncbi request reprint Sleep and wakefulness modulate gene expression in Drosophila
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurochem 94:1411-9. 2005
    ....
  49. pmc The effects of morning training on night sleep: a behavioral and EEG study
    Sara Maatta
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Brain Res Bull 82:118-23. 2010
    ..These results suggest that training-induced changes in sleep SWA and post-sleep improvements do not depend upon the time interval between original training and sleep...
  50. pmc Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
    Fabio Ferrarelli
    Department of Psychiatry and Anesthesiology, University of Wisconsin, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 107:2681-6. 2010
    ..Moreover, these results suggest that it might be possible to use TMS-EEG to assess consciousness during anesthesia and in pathological conditions, such as coma, vegetative state, and minimally conscious state...
  51. ncbi request reprint Locus ceruleus control of slow-wave homeostasis
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA
    J Neurosci 25:4503-11. 2005
    ....
  52. pmc Estimation of cortical connectivity from EEG using state-space models
    Bing Leung Patrick Cheung
    Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53716, USA
    IEEE Trans Biomed Eng 57:2122-34. 2010
    ..The method is further demonstrated by estimating conditional Granger causality using EEG data collected while subjects passively watch a movie...
  53. ncbi request reprint Modeling sleep and wakefulness in the thalamocortical system
    Sean Hill
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719 1176, USA
    J Neurophysiol 93:1671-98. 2005
    ....
  54. ncbi request reprint State-space multivariate autoregressive models for estimation of cortical connectivity from EEG
    B L Patrick Cheung
    Department of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:61-4. 2009
    ..The method is also applied to data from a subject watching a movie, and confirms that feedforward connections between visual and parietal cortex are generally stronger than feedback connections...
  55. ncbi request reprint Sleep homeostasis in Drosophila melanogaster
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison 53719, USA
    Sleep 27:628-39. 2004
    ....
  56. ncbi request reprint Locus ceruleus control of state-dependent gene expression
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA
    J Neurosci 24:5410-9. 2004
    ....
  57. ncbi request reprint Repetitive transcranial magnetic stimulation dissociates working memory manipulation from retention functions in the prefrontal, but not posterior parietal, cortex
    Bradley R Postle
    University of Wisconsin, USA
    J Cogn Neurosci 18:1712-22. 2006
    ..In the SPL, they illustrate the importance of supplementing the fundamentally correlational data from neuroimaging with a disruptive method, which affords stronger inference about structure-function relations...
  58. pmc Evaluating frontal and parietal contributions to spatial working memory with repetitive transcranial magnetic stimulation
    Massihullah Hamidi
    University of Wisconsin Madison, USA
    Brain Res 1230:202-10. 2008
    ..Possible factors underlying rTMS-induced behavioral facilitation are considered...
  59. pmc Direct evidence for a prefrontal contribution to the control of proactive interference in verbal working memory
    Eva Feredoes
    Department of Psychology, University of Wisconsin, Madison, WI 53703, USA
    Proc Natl Acad Sci U S A 103:19530-4. 2006
    ..These results demonstrate that unpredictable, phasic disruption of the left IFG selectively disrupts control of responses to high-conflict verbal working memory probes, and they conclusively reject nonspecific alternative accounts...
  60. pmc A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep
    Ugo Faraguna
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 28:4088-95. 2008
    ..These effects were also reversible and specific for NREM sleep. These results show a causal link between BDNF expression during wakefulness and subsequent sleep regulation...
  61. ncbi request reprint The neural bases of the short-term storage of verbal information are anatomically variable across individuals
    Eva Feredoes
    Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurosci 27:11003-8. 2007
    ..They also suggest that the brain bases of some cognitive functions may be better detected by SS than by SNGA approaches to fMRI data analysis...
  62. pmc Is sleep essential?
    Chiara Cirelli
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Biol 6:e216. 2008
  63. pmc Evaluating the role of prefrontal and parietal cortices in memory-guided response with repetitive transcranial magnetic stimulation
    Massihullah Hamidi
    Department of Psychology, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuropsychologia 47:295-302. 2009
    ..These findings confirm that the dlPFC plays an important role in memory-guided response, and suggest that the nature of this role varies depending on the processes required for making a response...
  64. pmc Measures of cortical plasticity after transcranial paired associative stimulation predict changes in electroencephalogram slow-wave activity during subsequent sleep
    Reto Huber
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 28:7911-8. 2008
    ....
  65. pmc Sleep homeostasis in the rat is preserved during chronic sleep restriction
    Susan Leemburg
    Department of Psychiatry, University of Wisconsin, Madison, 53719, USA
    Proc Natl Acad Sci U S A 107:15939-44. 2010
    ..Analysis of cumulative slow wave energy demonstrated that the loss of SWA during SR was compensated by the end of the second recovery day. Thus, the homeostatic regulation of sleep is preserved under conditions of chronic SR...
  66. pmc Triggering sleep slow waves by transcranial magnetic stimulation
    Marcello Massimini
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Proc Natl Acad Sci U S A 104:8496-501. 2007
    ..Moreover, evoked slow waves lead to a deepening of sleep and to an increase in EEG slow-wave activity (0.5-4.5 Hz), which is thought to play a role in brain restoration and memory consolidation...
  67. ncbi request reprint Sleepy dialogues between cortex and hippocampus: who talks to whom?
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Neuron 52:748-9. 2006
    ..Intriguingly, many hippocampal neurons fire during the cortical DOWN state. Thus, during sleep UP states, the cortex can talk to the hippocampus, but it is unclear whether the hippocampus talks back...
  68. ncbi request reprint Drosophila Hyperkinetic mutants have reduced sleep and impaired memory
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 27:5384-93. 2007
    ..These data identify a gene, Hk, which is necessary to maintain normal sleep, and provide genetic evidence that short sleep and poor memory are linked...
  69. ncbi request reprint Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study
    Fabio Ferrarelli
    Department of Psychiatry, University of Wisconsin, Madison, WI, USA
    Am J Psychiatry 165:996-1005. 2008
    ..The authors investigated EEG responses in schizophrenia patients and healthy comparison subjects following the application of TMS to the premotor cortex...
  70. pmc Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious state
    Eric Landsness
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Brain 134:2222-32. 2011
    ..We suggest that the study of sleep and homoeostatic regulation of slow wave activity may provide a complementary tool for the assessment of brain function in minimally conscious state and vegetative state patients...
  71. pmc The thalamic reticular nucleus and schizophrenia
    Fabio Ferrarelli
    Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin at Madison, Madison, WI 53719, USA
    Schizophr Bull 37:306-15. 2011
    ....
  72. pmc Sleep and synaptic renormalization: a computational study
    Umberto Olcese
    Perceptual Robots Laboratory, Scuola Superiore Sant Anna, Pisa, Italy
    J Neurophysiol 104:3476-93. 2010
    ....
  73. ncbi request reprint Tonic rhythmic activity of rat cerebellar neurons
    Douglas Nitz
    The Neurosciences Institute, 10640 John Jay Hopkins Dr, San Diego, CA 92121, USA
    Exp Brain Res 146:265-70. 2002
    ..The precise timing of spike discharge in these cells makes them potential candidates to participate in timing functions thought to depend on the cerebellum..
  74. ncbi request reprint Electrophysiological correlates of rest and activity in Drosophila melanogaster
    Douglas A Nitz
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Curr Biol 12:1934-40. 2002
    ....
  75. ncbi request reprint Chlorotoxin-mediated disinhibition of noradrenergic locus coeruleus neurons using a conditional transgenic approach
    J Michael Salbaum
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Brain Res 1016:20-32. 2004
    ..This method represents a powerful new tool to assess the long-term effects of LC activation and is potentially applicable to other neuronal systems...
  76. pmc Short-term limb immobilization affects motor performance
    Clara Moisello
    Department of Physiology and Pharmacology, City University of New York Medical School, University of Genoa, Italy
    J Mot Behav 40:165-76. 2008
    ..Thus, short-term limb disuse can affect interjoint coordination by acting on feedforward mechanisms. These behavioral alterations are potentially related to cortical plastic changes...
  77. doi request reprint The slow-wave components of the cyclic alternating pattern (CAP) have a role in sleep-related learning processes
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Via Conte Ruggero 73, Troina, Italy
    Neurosci Lett 432:228-31. 2008
    ..These results confirm our hypothesis that CAP slow components are modified by a learning task during the day preceding sleep and support the idea that these components may play a role in sleep-related cognitive processes...
  78. pmc The human connectome: A structural description of the human brain
    Olaf Sporns
    Department of Psychology, Indiana University, Bloomington, Indiana, United States of America
    PLoS Comput Biol 1:e42. 2005
    ..We propose a research strategy to achieve this goal, and discuss its potential impact...
  79. ncbi request reprint Stress response genes protect against lethal effects of sleep deprivation in Drosophila
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
    Nature 417:287-91. 2002
    ..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat...
  80. pmc Sleep improves the variability of motor performance
    Sean Hill
    IBM TJ Watson Research Center, Yorktown Heights, NY, United States
    Brain Res Bull 76:605-11. 2008
    ..However, subjects who slept after a single training session showed a reduction in both directional error and variability, consistent with a downscaling mechanism during sleep...
  81. ncbi request reprint Transcranial Magnetic Stimulation in the investigation and treatment of schizophrenia: a review
    H Magnus Haraldsson
    Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI 53719, USA
    Schizophr Res 71:1-16. 2004
    ..Such studies may reveal impaired effective connectivity between specific brain areas, which could identify these regions as targets for selective stimulation with therapeutic doses of TMS...
  82. doi request reprint The neural correlates of consciousness: an update
    Giulio Tononi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA
    Ann N Y Acad Sci 1124:239-61. 2008
    ..Finally, we briefly consider how a theoretical analysis of the fundamental properties of consciousness can usefully complement neurobiological studies...
  83. ncbi request reprint A proposal for a Decade of the Mind initiative
    James S Albus
    Science 317:1321. 2007
  84. ncbi request reprint A [17F]-fluoromethane PET/TMS study of effective connectivity
    Fabio Ferrarelli
    Department of Psychiatry, University of Wisconsin, Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Brain Res Bull 64:103-13. 2004
    ..Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits...

Research Grants12

  1. Functional Changes Induced By Sleep Deprivation
    Giulio Tononi; Fiscal Year: 2001
    ..These studies should provide insights into the molecular consequences of prolonged sleep deprivation and chronic insomnia and suggest new therapeutic approaches. ..
  2. Local Sleep Regulation and Brain Plasticity
    Giulio Tononi; Fiscal Year: 2010
    ..Thus, they are highly relevant to the mission of MINDS, NIMH, and NHLBI. ..
  3. Local Sleep Regulation and Brain Plasticity
    Giulio Tononi; Fiscal Year: 2009
    ..Thus, they are highly relevant to the mission of MINDS, NIMH, and NHLBI. ..
  4. Sleep Function and Synaptic Homeostasis: Linking Neurobiology and Mental Health
    Giulio Tononi; Fiscal Year: 2007
    ..Given the central role of sleep in the life of every organism, at every age, we expect that the results of our program will have major implications for many aspects of human health and disease. ..
  5. Local Sleep Regulation and Brain Plasticity
    Giulio Tononi; Fiscal Year: 2007
    ..Thus, they are highly relevant to the mission of NINDS, NIMH, and NHLBI. ..
  6. Local Sleep Regulation and Brain Plasticity
    Giulio Tononi; Fiscal Year: 2006
    ..Thus, they are highly relevant to the mission of NINDS, NIMH, and NHLBI. ..
  7. Functional Changes Induced By Sleep Deprivation
    Giulio Tononi; Fiscal Year: 2004
    ..These studies should provide insights into the molecular consequences of prolonged sleep deprivation and chronic insomnia and suggest new therapeutic approaches. ..
  8. Functional Changes Induced By Sleep Deprivation
    Giulio Tononi; Fiscal Year: 2003
    ..These studies should provide insights into the molecular consequences of prolonged sleep deprivation and chronic insomnia and suggest new therapeutic approaches. ..
  9. Functional Changes Induced By Sleep Deprivation
    Giulio Tononi; Fiscal Year: 2002
    ..These studies should provide insights into the molecular consequences of prolonged sleep deprivation and chronic insomnia and suggest new therapeutic approaches. ..
  10. Synapses and Sleep in Neurodevelopment: A Crucial Interaction at a Critical Time
    GIULIO contact TONONI; Fiscal Year: 2010
    ..Moreover, this project will establish whether sleep can affect synaptic pruning during development. If so, changes in sleep and waking routines could help both the prevention and the therapy of mental illness. ..