Research Topics
| M R TonelliSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
The limits of evidence-based medicineM R Tonelli
Division of Pulmonary and Critical Care Medicine, Department of Medicine, and the Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195 6522, USA
Respir Care 46:1435-40; discussion 1440-1. 2001..The relative weight given to each of these areas is not predetermined, but varies from case to case...
Compromised autonomy and the seriously ill patientMark R Tonelli
Department of Medicine, University of Washington, 1959 NE Pacific St, Box 356522, Seattle, WA 98195 6522, USA
Chest 137:926-31. 2010..Such an approach, under a tightly constrained set of circumstances, would permit both the provision and the withholding of medical interventions despite patient requests to the contrary...- What medical futility means to cliniciansMark R Tonelli
University of Washington, Box 356522, 1959 NE Pacific St, Seattle, WA 98195-6522, USA
HEC Forum 19:83-93. 2007 - Advancing a casuistic model of clinical decision making: a response to commentatorsMark R Tonelli
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98198-6522, USA
J Eval Clin Pract 13:504-7. 2007 - Waking the dying: must we always attempt to involve critically ill patients in end-of-life decisions?Mark R Tonelli
Box 356522, University of Washington Medical Center, Seattle, WA 98195 6522, USA
Chest 127:637-42. 2005.... - Conflict of interest in clinical practiceMark R Tonelli
University of Washington, Seattle, WA 98195 6522, USA
Chest 132:664-70. 2007..Recognition and acknowledgment are the first steps in ameliorating conflicts of interest, which can then be disclosed and potentially eliminated... - Integrating evidence into clinical practice: an alternative to evidence-based approachesMark R Tonelli
Division of Pulmonary and Critical Care Medicine, Department of Medicine and, Department of Medical History and Ethics, University of Washington, Seattle, WA 98195 6522, USA
J Eval Clin Pract 12:248-56. 2006..The skilled clinician must weigh these potentially conflicting evidentiary and non-evidentiary warrants for action, employing both practical and theoretical reasoning, in order to arrive at the best choice for an individual patient... - Why alternative medicine cannot be evidence-basedM R Tonelli
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Acad Med 76:1213-20. 2001.... - New and emerging therapies for pulmonary complications of cystic fibrosisM R Tonelli
Department of Medicine, University of Washington, Seattle, USA
Drugs 61:1379-85. 2001..With research proceeding on these multiple fronts, new therapies for pulmonary complications promise to continue to increase the life expectancy of individuals with CF... - Evidence-free medicine: forgoing evidence in clinical decision makingMark R Tonelli
Department of Medicine, University of Washington, Seattle, WA 98195 6522, USA
Perspect Biol Med 52:319-31. 2009..Forgoing evidence allows clinical medicine to once again be a personal and prudential undertaking, arising from and focused on the individual patient... - The challenge of evidence in clinical medicineMark R Tonelli
University of Washington, Seattle, WA, USA
J Eval Clin Pract 16:384-9. 2010..The process can be formalized and made explicit, but it cannot be narrowed, simplified and focused only on the results of clinical research... - In defense of expert opinionM R Tonelli
Department of Medicine, University of Washington School of Medicine, Seattle 98195 6522, USA
Acad Med 74:1187-92. 1999..Even when the quality and quantity of empirical medical evidence are ideal, expert opinion will remain an integral part of the multifaceted knowledge required for the optimal practice of clinical medicine... - A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung diseaseM L Aitken
Department of Medicine and Pediatrics, University of Washington, Seattle, 98195, USA
Hum Gene Ther 12:1907-16. 2001..RNA-specific PCR did not detect vector-derived mRNA. This Phase I trial shows that aerosolized tgAAVCF is safe and widely delivered to the proximal airways of CF subjects by nebulization... - Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in a patient with cystic fibrosisEdward F McKone
Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, Washington, USA
Pediatr Pulmonol 34:381-3. 2002..This is followed by a review of the literature on the use of megestrol acetate in the treatment of weight loss in CF, AIDS, and cancer, with particular emphasis on the adverse effects that should be looked for in CF patients... - Meeting physicians' responsibilities in providing end-of-life careHasan Shanawani
Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, MI, USA
Chest 133:775-86. 2008.... - Studying communication about end-of-life care during the ICU family conference: development of a frameworkJ Randall Curtis
Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
J Crit Care 17:147-60. 2002..The purpose of this study was to develop an understanding of the way this communication is currently conducted... - Pseudomonal pericarditis complicating cystic fibrosisW A Altemeier
Department of Medicine, University of Washington, Seattle, USA
Pediatr Pulmonol 27:62-4. 1999..This is a previously unreported complication in cystic fibrosis prior to lung transplantation... - Complications of indwelling catheters in cystic fibrosis: a 10-year reviewM L Aitken
Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle 98195, USA
Chest 118:1598-602. 2000..We attempted to determine the type and incidence of catheter complications so that CF patients could be fully informed of the risks prior to placement of these catheters... 
Sputum induction as a research tool for sampling the airways of subjects with cystic fibrosisN R Henig
Department of Medicine, Division of Pulmonary and Critical Care, Stanford University, Stanford, California, USA
Thorax 56:306-11. 2001..CONCLUSION: SI offers safety advantages over BAL and may be a more representative airway outcome measurement in patients with CF...- Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosisMoira L Aitken
Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle 98195, USA
Chest 123:792-9. 2003..When induced-sputum samples are fractionated for research monitoring of inflammatory or microbiologic indexes, power calculations accounting for these variations over time are required... - Contraceptive practices in women with cystic fibrosisBarry J Plant
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle WA 98195 6522, United States
J Cyst Fibros 7:412-4. 2008..Despite theoretical concerns regarding efficacy and toxicity, the choices of contraception are similar to those of the general U.S. population... - Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung diseaseEdward F McKone
Department of Environmental and Occupational Health Sciences, University of Washington Mail Box 354695, Seattle, WA 98195, USA
Am J Respir Crit Care Med 174:415-9. 2006..Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury... - Pregnancy in cystic fibrosisMark R Tonelli
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
Curr Opin Pulm Med 13:537-40. 2007..This review summarizes recent knowledge regarding pregnancy in women with cystic fibrosis, including contraception, pre and postpartum medical care and outcomes, as well as reproductive decision-making... - Comparison of scholarly productivity of general and subspecialty clinician-educators in internal medicineRobert R Kempainen
Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Teach Learn Med 16:323-8. 2004..There is concern that these criteria may be disadvantageous to clinician-educators in generalist fields relative to their specialist counterparts... - Aggressive prenatal care results in successful fetal outcomes in CF womenEdith Y Cheng
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
J Cyst Fibros 5:85-91. 2006..Aggressive antepartum management is recommended for all CF women... - Fellows as teachers: the teacher-assistant experience during pulmonary subspecialty trainingRobert R Kempainen
Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA, USA
Chest 128:401-6. 2005..The purpose of this article is to describe the teacher-assistant requirement for fellows in a pulmonary and critical care training program and gain the perspectives of program graduates on their experiences as teacher assistants...