M R Tonelli

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint The limits of evidence-based medicine
    M R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, and the Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195 6522, USA
    Respir Care 46:1435-40; discussion 1440-1. 2001
  2. doi request reprint Compromised autonomy and the seriously ill patient
    Mark R Tonelli
    Department of Medicine, University of Washington, 1959 NE Pacific St, Box 356522, Seattle, WA 98195 6522, USA
    Chest 137:926-31. 2010
  3. ncbi request reprint What medical futility means to clinicians
    Mark R Tonelli
    University of Washington, Box 356522, 1959 NE Pacific St, Seattle, WA 98195 6522, USA
    HEC Forum 19:83-93. 2007
  4. ncbi request reprint Advancing a casuistic model of clinical decision making: a response to commentators
    Mark R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98198 6522, USA
    J Eval Clin Pract 13:504-7. 2007
  5. ncbi request reprint Waking the dying: must we always attempt to involve critically ill patients in end-of-life decisions?
    Mark R Tonelli
    Box 356522, University of Washington Medical Center, Seattle, WA 98195 6522, USA
    Chest 127:637-42. 2005
  6. ncbi request reprint Conflict of interest in clinical practice
    Mark R Tonelli
    University of Washington, Seattle, WA 98195 6522, USA
    Chest 132:664-70. 2007
  7. ncbi request reprint Integrating evidence into clinical practice: an alternative to evidence-based approaches
    Mark R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine and, Department of Medical History and Ethics, University of Washington, Seattle, WA 98195 6522, USA
    J Eval Clin Pract 12:248-56. 2006
  8. ncbi request reprint Why alternative medicine cannot be evidence-based
    M R Tonelli
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Acad Med 76:1213-20. 2001
  9. ncbi request reprint New and emerging therapies for pulmonary complications of cystic fibrosis
    M R Tonelli
    Department of Medicine, University of Washington, Seattle, USA
    Drugs 61:1379-85. 2001
  10. doi request reprint Evidence-free medicine: forgoing evidence in clinical decision making
    Mark R Tonelli
    Department of Medicine, University of Washington, Seattle, WA 98195 6522, USA
    Perspect Biol Med 52:319-31. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The limits of evidence-based medicine
    M R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, and the Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195 6522, USA
    Respir Care 46:1435-40; discussion 1440-1. 2001
    ..The relative weight given to each of these areas is not predetermined, but varies from case to case...
  2. doi request reprint Compromised autonomy and the seriously ill patient
    Mark R Tonelli
    Department of Medicine, University of Washington, 1959 NE Pacific St, Box 356522, Seattle, WA 98195 6522, USA
    Chest 137:926-31. 2010
    ..Such an approach, under a tightly constrained set of circumstances, would permit both the provision and the withholding of medical interventions despite patient requests to the contrary...
  3. ncbi request reprint What medical futility means to clinicians
    Mark R Tonelli
    University of Washington, Box 356522, 1959 NE Pacific St, Seattle, WA 98195 6522, USA
    HEC Forum 19:83-93. 2007
  4. ncbi request reprint Advancing a casuistic model of clinical decision making: a response to commentators
    Mark R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98198 6522, USA
    J Eval Clin Pract 13:504-7. 2007
  5. ncbi request reprint Waking the dying: must we always attempt to involve critically ill patients in end-of-life decisions?
    Mark R Tonelli
    Box 356522, University of Washington Medical Center, Seattle, WA 98195 6522, USA
    Chest 127:637-42. 2005
    ....
  6. ncbi request reprint Conflict of interest in clinical practice
    Mark R Tonelli
    University of Washington, Seattle, WA 98195 6522, USA
    Chest 132:664-70. 2007
    ..Recognition and acknowledgment are the first steps in ameliorating conflicts of interest, which can then be disclosed and potentially eliminated...
  7. ncbi request reprint Integrating evidence into clinical practice: an alternative to evidence-based approaches
    Mark R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine and, Department of Medical History and Ethics, University of Washington, Seattle, WA 98195 6522, USA
    J Eval Clin Pract 12:248-56. 2006
    ..The skilled clinician must weigh these potentially conflicting evidentiary and non-evidentiary warrants for action, employing both practical and theoretical reasoning, in order to arrive at the best choice for an individual patient...
  8. ncbi request reprint Why alternative medicine cannot be evidence-based
    M R Tonelli
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Acad Med 76:1213-20. 2001
    ....
  9. ncbi request reprint New and emerging therapies for pulmonary complications of cystic fibrosis
    M R Tonelli
    Department of Medicine, University of Washington, Seattle, USA
    Drugs 61:1379-85. 2001
    ..With research proceeding on these multiple fronts, new therapies for pulmonary complications promise to continue to increase the life expectancy of individuals with CF...
  10. doi request reprint Evidence-free medicine: forgoing evidence in clinical decision making
    Mark R Tonelli
    Department of Medicine, University of Washington, Seattle, WA 98195 6522, USA
    Perspect Biol Med 52:319-31. 2009
    ..Forgoing evidence allows clinical medicine to once again be a personal and prudential undertaking, arising from and focused on the individual patient...
  11. doi request reprint The challenge of evidence in clinical medicine
    Mark R Tonelli
    University of Washington, Seattle, WA, USA
    J Eval Clin Pract 16:384-9. 2010
    ..The process can be formalized and made explicit, but it cannot be narrowed, simplified and focused only on the results of clinical research...
  12. ncbi request reprint In defense of expert opinion
    M R Tonelli
    Department of Medicine, University of Washington School of Medicine, Seattle 98195 6522, USA
    Acad Med 74:1187-92. 1999
    ..Even when the quality and quantity of empirical medical evidence are ideal, expert opinion will remain an integral part of the multifaceted knowledge required for the optimal practice of clinical medicine...
  13. ncbi request reprint A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease
    M L Aitken
    Department of Medicine and Pediatrics, University of Washington, Seattle, 98195, USA
    Hum Gene Ther 12:1907-16. 2001
    ..RNA-specific PCR did not detect vector-derived mRNA. This Phase I trial shows that aerosolized tgAAVCF is safe and widely delivered to the proximal airways of CF subjects by nebulization...
  14. ncbi request reprint Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in a patient with cystic fibrosis
    Edward F McKone
    Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, Washington, USA
    Pediatr Pulmonol 34:381-3. 2002
    ..This is followed by a review of the literature on the use of megestrol acetate in the treatment of weight loss in CF, AIDS, and cancer, with particular emphasis on the adverse effects that should be looked for in CF patients...
  15. doi request reprint Meeting physicians' responsibilities in providing end-of-life care
    Hasan Shanawani
    Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, MI, USA
    Chest 133:775-86. 2008
    ....
  16. ncbi request reprint Studying communication about end-of-life care during the ICU family conference: development of a framework
    J Randall Curtis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
    J Crit Care 17:147-60. 2002
    ..The purpose of this study was to develop an understanding of the way this communication is currently conducted...
  17. ncbi request reprint Pseudomonal pericarditis complicating cystic fibrosis
    W A Altemeier
    Department of Medicine, University of Washington, Seattle, USA
    Pediatr Pulmonol 27:62-4. 1999
    ..This is a previously unreported complication in cystic fibrosis prior to lung transplantation...
  18. ncbi request reprint Complications of indwelling catheters in cystic fibrosis: a 10-year review
    M L Aitken
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle 98195, USA
    Chest 118:1598-602. 2000
    ..We attempted to determine the type and incidence of catheter complications so that CF patients could be fully informed of the risks prior to placement of these catheters...
  19. pmc Sputum induction as a research tool for sampling the airways of subjects with cystic fibrosis
    N R Henig
    Department of Medicine, Division of Pulmonary and Critical Care, Stanford University, Stanford, California, USA
    Thorax 56:306-11. 2001
    ..CONCLUSION: SI offers safety advantages over BAL and may be a more representative airway outcome measurement in patients with CF...
  20. ncbi request reprint Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosis
    Moira L Aitken
    Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle 98195, USA
    Chest 123:792-9. 2003
    ..The hypothesis was that the duration of SI collection would quantitatively and qualitatively alter the content of the induced sputum...
  21. doi request reprint Contraceptive practices in women with cystic fibrosis
    Barry J Plant
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle WA 98195 6522, United States
    J Cyst Fibros 7:412-4. 2008
    ..Despite theoretical concerns regarding efficacy and toxicity, the choices of contraception are similar to those of the general U.S. population...
  22. pmc Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease
    Edward F McKone
    Department of Environmental and Occupational Health Sciences, University of Washington Mail Box 354695, Seattle, WA 98195, USA
    Am J Respir Crit Care Med 174:415-9. 2006
    ..Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury...
  23. ncbi request reprint Pregnancy in cystic fibrosis
    Mark R Tonelli
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Curr Opin Pulm Med 13:537-40. 2007
    ..This review summarizes recent knowledge regarding pregnancy in women with cystic fibrosis, including contraception, pre and postpartum medical care and outcomes, as well as reproductive decision-making...
  24. ncbi request reprint Comparison of scholarly productivity of general and subspecialty clinician-educators in internal medicine
    Robert R Kempainen
    Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Teach Learn Med 16:323-8. 2004
    ..There is concern that these criteria may be disadvantageous to clinician-educators in generalist fields relative to their specialist counterparts...
  25. ncbi request reprint Aggressive prenatal care results in successful fetal outcomes in CF women
    Edith Y Cheng
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    J Cyst Fibros 5:85-91. 2006
    ..The impact of pre-pregnancy pulmonary and nutritional status in pregnancy outcomes of women with cystic fibrosis (CF) is not clearly defined...
  26. ncbi request reprint Fellows as teachers: the teacher-assistant experience during pulmonary subspecialty training
    Robert R Kempainen
    Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Chest 128:401-6. 2005
    ..The purpose of this article is to describe the teacher-assistant requirement for fellows in a pulmonary and critical care training program and gain the perspectives of program graduates on their experiences as teacher assistants...