Leonardo H Tonelli

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21201 1549, MD, USA
    Neuropsychopharmacology 33:1038-48. 2008
  2. ncbi request reprint Airborne inflammatory factors: "from the nose to the brain"
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Front Biosci (Schol Ed) 2:135-52. 2010
  3. pmc Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201 1549, USA
    Brain Behav Immun 23:784-93. 2009
  4. pmc Elevated cytokine expression in the orbitofrontal cortex of victims of suicide
    L H Tonelli
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Acta Psychiatr Scand 117:198-206. 2008
  5. ncbi request reprint Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge
    Leonardo H Tonelli
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201 1549, USA
    Neurol Res 27:679-84. 2005
  6. pmc Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen season
    Partam Manalai
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland at Baltimore, Baltimore, MD, USA
    Bipolar Disord 14:90-8. 2012
  7. pmc Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens
    Teodor T Postolache
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    ScientificWorldJournal 7:1968-77. 2007
  8. doi request reprint Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders
    Timothy A Arling
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nerv Ment Dis 197:905-8. 2009
  9. pmc Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders
    Teodor T Postolache
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Affect Disord 121:88-93. 2010
  10. ncbi request reprint Precipitants of adolescent suicide: possible interaction between allergic inflammation and alcohol intake
    Gloria M Reeves
    Child and Adolescent Psychiatry Division and Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Int J Adolesc Med Health 19:37-43. 2007

Collaborators

Detail Information

Publications23

  1. pmc Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21201 1549, MD, USA
    Neuropsychopharmacology 33:1038-48. 2008
    ..These results further our understanding of the role that the immune system may play in the pathophysiology of depression...
  2. ncbi request reprint Airborne inflammatory factors: "from the nose to the brain"
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Front Biosci (Schol Ed) 2:135-52. 2010
    ..This article discusses current evidence about these mechanisms and associations with neurological and mental diseases...
  3. pmc Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents
    Leonardo H Tonelli
    Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201 1549, USA
    Brain Behav Immun 23:784-93. 2009
    ..These studies provide experimental evidence that sensitized rodents experience neuroimmune-mediated anxiety and reduced social interaction associated with allergic rhinitis...
  4. pmc Elevated cytokine expression in the orbitofrontal cortex of victims of suicide
    L H Tonelli
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Acta Psychiatr Scand 117:198-206. 2008
    ....
  5. ncbi request reprint Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge
    Leonardo H Tonelli
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201 1549, USA
    Neurol Res 27:679-84. 2005
    ..This review will discuss the importance of infections on basic neuronal processes owing to the alteration in the brain of the balance of cytokines involved in higher brain functions...
  6. pmc Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen season
    Partam Manalai
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland at Baltimore, Baltimore, MD, USA
    Bipolar Disord 14:90-8. 2012
    ..In the current study, we examined a hypothesized relationship between allergen-specific immunoglobulin E (IgE) status and changes in allergy symptoms with worsening in depression scores...
  7. pmc Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens
    Teodor T Postolache
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    ScientificWorldJournal 7:1968-77. 2007
    ....
  8. doi request reprint Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders
    Timothy A Arling
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nerv Ment Dis 197:905-8. 2009
    ..Although preliminary and bearing replication, this is the first report, to our knowledge, of an association between attempting suicide and T. gondii...
  9. pmc Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders
    Teodor T Postolache
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Affect Disord 121:88-93. 2010
    ..As the peak of suicide in spring could be a consequence of decompensation of mood disorders in spring, we hypothesized that prior history of mood disorders is predictively associated with suicide in spring...
  10. ncbi request reprint Precipitants of adolescent suicide: possible interaction between allergic inflammation and alcohol intake
    Gloria M Reeves
    Child and Adolescent Psychiatry Division and Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Int J Adolesc Med Health 19:37-43. 2007
    ..Considering the greater prevalence of allergy in adolescence when alcohol use starts, studies investigating the connection between allergy, alcohol, and suicide should be expanded to also include a focus on youth...
  11. pmc Expression and regulation in the brain of the chemokine CCL27 gene locus
    Chad Gunsolly
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201 1549, USA
    J Neuroimmunol 225:82-90. 2010
    ..Intranasal administration of neutralizing antibodies against CCL27 reduced the presence of T cells in the olfactory bulbs suggesting a function in T cell activity in the brain...
  12. ncbi request reprint Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior
    Beverly J Fang
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street MSTF Building Room 930, Baltimore, MD 21201, USA
    Front Biosci (Schol Ed) 2:30-46. 2010
    ....
  13. pmc Mood-worsening with high-pollen-counts and seasonality: a preliminary report
    Alvaro Guzman
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Affect Disord 101:269-74. 2007
    ..Since pollen is absent during winter, we specifically predicted that mood sensitivity to tree pollen will predict non-winter SAD but not winter SAD...
  14. ncbi request reprint Differential expression of splice variants of chemokine CCL27 mRNA in lens, cornea, and retina of the normal mouse eye
    Dolena R Ledee
    National Eye Institute, NIH, Bethesda, MD, USA
    Mol Vis 10:663-7. 2004
    ..Constitutive expression of RNA sequences complementary to the chemokine CCL27 mRNA has been found in the normal mouse eye. This study examines the nature and location of these endogenous RNAs in ocular tissues...
  15. pmc Allergy: a risk factor for suicide?
    Teodor T Postolache
    Teodor T Postolache, MD Mood and Anxiety Program MAP, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building Room 930, Baltimore, MD 21201, USA
    Curr Treat Options Neurol 10:363-76. 2008
    ....
  16. ncbi request reprint Depression after delivery: risk factors, diagnostic and therapeutic considerations
    Debra A Scrandis
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, MSTF Building, Room 502, 685 West Baltimore Street, Baltimore, MD 21201, USA
    ScientificWorldJournal 7:1670-82. 2007
    ....
  17. ncbi request reprint Differential expression of class I MHC mRNA in the hypothalamus of Lewis and Fischer rats
    Michael Puchowicz
    Section of Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Neuroimmunol 134:35-43. 2003
    ..Differential class I MHC expression in Lewis rats suggests an alteration in mechanisms related to cellular activity of neuroendocrine cells rather than alterations specific to neuroendocrine molecules...
  18. ncbi request reprint Inflammatory genes and neural activity: involvement of immune genes in synaptic function and behavior
    Leonardo H Tonelli
    Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland 20892 4020, USA
    Front Biosci 10:675-80. 2005
    ..This review will discuss recent data indicating a role for immune genes in synaptic stability and will also discuss the implications for specific brain functions involving mood and cognition...
  19. ncbi request reprint Differential induction of interleukin-I beta mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides
    Leonardo H Tonelli
    Section of Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, DHHS, 36 Convent Drive MSC 4020, Building 36, Room 1A23, Bethesda, MD 20892 4020, USA
    J Neuroimmunol 140:126-36. 2003
    ..These data show region-specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation...
  20. ncbi request reprint Increased pro-thyrotropin-releasing hormone transcription in hypophysiotropic neurons of Lewis rats
    Leonardo H Tonelli
    Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, DHHS, 36 Convent Drive MSC 4020, Building 36, Room 1A23, Bethesda, MD 20892 4020, USA
    J Neuroimmunol 153:143-9. 2004
    ..The LEW/N increase in pro-TRH mRNA was independent of changes in hormonal status suggesting alteration of the thyroid axis at the central level in this strain...
  21. pmc Anthrax lethal factor represses glucocorticoid and progesterone receptor activity
    Jeanette I Webster
    Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:5706-11. 2003
    ..These finding have implications for development of new treatments and prevention of the toxic effects of anthrax...
  22. ncbi request reprint CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus
    Joao A Pedras-Vasconcelos
    Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Federal Drug Administration, Bethesda, MD 20892, USA
    J Immunol 176:4940-9. 2006
    ..To our knowledge, this is the first study assessing the mechanisms by which CpG ODN can protect mice from a neurotropic viral infection...
  23. ncbi request reprint Restraint stress modulates brain, pituitary and adrenal expression of angiotensin II AT(1A), AT(1B) and AT(2) receptors
    Darren S Leong
    Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroendocrinology 75:227-40. 2002
    ..There may be additional roles for adrenal AT(2) receptors during acute stress, possibly related to interaction or cross-talk with AT(1) receptors...

Research Grants1

  1. Intranasal immune challenge, brain cytokines and gender differences in depression
    Leonardo Tonelli; Fiscal Year: 2007
    ..This information may be useful to prevent and treat depression in women. ..