Research Topics
| Leonardo H TonelliSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brainLeonardo H Tonelli
Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21201 1549, MD, USA
Neuropsychopharmacology 33:1038-48. 2008..These results further our understanding of the role that the immune system may play in the pathophysiology of depression...
Airborne inflammatory factors: "from the nose to the brain"Leonardo H Tonelli
Laboratory of Behavioral Neuroimmunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Front Biosci (Schol Ed) 2:135-52. 2010..This article discusses current evidence about these mechanisms and associations with neurological and mental diseases...- Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodentsLeonardo H Tonelli
Laboratory of Behavioral Neuroimmunology, Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201 1549, USA
Brain Behav Immun 23:784-93. 2009..These studies provide experimental evidence that sensitized rodents experience neuroimmune-mediated anxiety and reduced social interaction associated with allergic rhinitis... - Elevated cytokine expression in the orbitofrontal cortex of victims of suicideL H Tonelli
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Acta Psychiatr Scand 117:198-206. 2008.... - Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challengeLeonardo H Tonelli
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201 1549, USA
Neurol Res 27:679-84. 2005..This review will discuss the importance of infections on basic neuronal processes owing to the alteration in the brain of the balance of cytokines involved in higher brain functions... - Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen seasonPartam Manalai
Mood and Anxiety Program, Department of Psychiatry, University of Maryland at Baltimore, Baltimore, MD, USA
Bipolar Disord 14:90-8. 2012..In the current study, we examined a hypothesized relationship between allergen-specific immunoglobulin E (IgE) status and changes in allergy symptoms with worsening in depression scores... - Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergensTeodor T Postolache
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
ScientificWorldJournal 7:1968-77. 2007.... 
Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disordersTimothy A Arling
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Nerv Ment Dis 197:905-8. 2009..Although preliminary and bearing replication, this is the first report, to our knowledge, of an association between attempting suicide and T. gondii...- Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disordersTeodor T Postolache
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Affect Disord 121:88-93. 2010..As the peak of suicide in spring could be a consequence of decompensation of mood disorders in spring, we hypothesized that prior history of mood disorders is predictively associated with suicide in spring... - Precipitants of adolescent suicide: possible interaction between allergic inflammation and alcohol intakeGloria M Reeves
Child and Adolescent Psychiatry Division and Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
Int J Adolesc Med Health 19:37-43. 2007..Considering the greater prevalence of allergy in adolescence when alcohol use starts, studies investigating the connection between allergy, alcohol, and suicide should be expanded to also include a focus on youth... - Expression and regulation in the brain of the chemokine CCL27 gene locusChad Gunsolly
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201 1549, USA
J Neuroimmunol 225:82-90. 2010..Intranasal administration of neutralizing antibodies against CCL27 reduced the presence of T cells in the olfactory bulbs suggesting a function in T cell activity in the brain... - Disturbed sleep: linking allergic rhinitis, mood and suicidal behaviorBeverly J Fang
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street MSTF Building Room 930, Baltimore, MD 21201, USA
Front Biosci (Schol Ed) 2:30-46. 2010.... - Mood-worsening with high-pollen-counts and seasonality: a preliminary reportAlvaro Guzman
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
J Affect Disord 101:269-74. 2007..Since pollen is absent during winter, we specifically predicted that mood sensitivity to tree pollen will predict non-winter SAD but not winter SAD... - Differential expression of splice variants of chemokine CCL27 mRNA in lens, cornea, and retina of the normal mouse eyeDolena R Ledee
National Eye Institute, NIH, Bethesda, MD, USA
Mol Vis 10:663-7. 2004.... - Allergy: a risk factor for suicide?Teodor T Postolache
Teodor T Postolache, MD Mood and Anxiety Program MAP, Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building Room 930, Baltimore, MD 21201, USA
Curr Treat Options Neurol 10:363-76. 2008.... - Depression after delivery: risk factors, diagnostic and therapeutic considerationsDebra A Scrandis
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, MSTF Building, Room 502, 685 West Baltimore Street, Baltimore, MD 21201, USA
ScientificWorldJournal 7:1670-82. 2007.... - Differential expression of class I MHC mRNA in the hypothalamus of Lewis and Fischer ratsMichael Puchowicz
Section of Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Neuroimmunol 134:35-43. 2003..Differential class I MHC expression in Lewis rats suggests an alteration in mechanisms related to cellular activity of neuroendocrine cells rather than alterations specific to neuroendocrine molecules... - Inflammatory genes and neural activity: involvement of immune genes in synaptic function and behaviorLeonardo H Tonelli
Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland 20892 4020, USA
Front Biosci 10:675-80. 2005..This review will discuss recent data indicating a role for immune genes in synaptic stability and will also discuss the implications for specific brain functions involving mood and cognition... - Differential induction of interleukin-I beta mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharidesLeonardo H Tonelli
Section of Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, DHHS, 36 Convent Drive MSC 4020, Building 36, Room 1A23, Bethesda, MD 20892 4020, USA
J Neuroimmunol 140:126-36. 2003..These data show region-specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation... - Increased pro-thyrotropin-releasing hormone transcription in hypophysiotropic neurons of Lewis ratsLeonardo H Tonelli
Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, DHHS, 36 Convent Drive MSC 4020, Building 36, Room 1A23, Bethesda, MD 20892-4020, USA
J Neuroimmunol 153:143-9. 2004..The LEW/N increase in pro-TRH mRNA was independent of changes in hormonal status suggesting alteration of the thyroid axis at the central level in this strain... - Anthrax lethal factor represses glucocorticoid and progesterone receptor activityJeanette I Webster
Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:5706-11. 2003..These finding have implications for development of new treatments and prevention of the toxic effects of anthrax... - CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirusJoao A Pedras-Vasconcelos
Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Federal Drug Administration, Bethesda, MD 20892, USA
J Immunol 176:4940-9. 2006..To our knowledge, this is the first study assessing the mechanisms by which CpG ODN can protect mice from a neurotropic viral infection... - Restraint stress modulates brain, pituitary and adrenal expression of angiotensin II AT(1A), AT(1B) and AT(2) receptorsDarren S Leong
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
Neuroendocrinology 75:227-40. 2002..There may be additional roles for adrenal AT(2) receptors during acute stress, possibly related to interaction or cross-talk with AT(1) receptors...
Research Grants
- Intranasal immune challenge, brain cytokines and gender differences in depressionLeonardo Tonelli; Fiscal Year: 2007..This information may be useful to prevent and treat depression in women. ..