Kaoru Tominaga

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint The genomic organization, promoter position and expression profile of the mouse MRG15 gene
    Kaoru Tominaga
    Department of Cellular and Structural Biology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, STCBM, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Gene 294:215-24. 2002
  2. pmc PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice
    Kaoru Tominaga
    Sam and Ann Barshop Center for Longevity and Aging Studies, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 24:8366-73. 2004
  3. pmc MRG15 regulates embryonic development and cell proliferation
    Kaoru Tominaga
    Department of Cellular and Structural Biology, Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 25:2924-37. 2005
  4. pmc MrgX is not essential for cell growth and development in the mouse
    Kaoru Tominaga
    Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 25:4873-80. 2005
  5. pmc The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway
    Kaoru Tominaga
    Sam and Ann Barshop Institute for Longevity and Aging Studies UTHSCSA, STCBM, San Antonio, TX 78245, USA
    Exp Cell Res 316:92-102. 2010
  6. pmc Emerging role of the MORF/MRG gene family in various biological processes, including aging
    Meizhen Chen
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Ann N Y Acad Sci 1197:134-41. 2010
  7. pmc Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation
    Sandra N Garcia
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 15535 Lambda Drive, STCBM 3 100, San Antonio, TX 78245, USA
    FEBS Lett 581:5275-81. 2007
  8. ncbi request reprint MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner
    Kaoru Tominaga
    University of Texas Health Science Center, Sam and Ann Barshop Center for Longevity and Aging Studies, San Antonio, Texas 78245 3207, USA
    J Biol Chem 278:49618-24. 2003
  9. pmc MRG15 activates the cdc2 promoter via histone acetylation in human cells
    Andreana N Pena
    Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, TX, USA
    Exp Cell Res 317:1534-40. 2011
  10. pmc Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor
    Meizhen Chen
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Stem Cell Res 7:75-88. 2011

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The genomic organization, promoter position and expression profile of the mouse MRG15 gene
    Kaoru Tominaga
    Department of Cellular and Structural Biology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, STCBM, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Gene 294:215-24. 2002
    ..8 kb upstream of the ATG start codon. This region contains no TATA box but has GC-rich regions, consistent with the ubiquitous expression we have observed...
  2. pmc PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice
    Kaoru Tominaga
    Sam and Ann Barshop Center for Longevity and Aging Studies, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 24:8366-73. 2004
    ..PAM14 likely acts as an adaptor protein in nucleoprotein complexes and is probably compensated for by another functionally redundant protein(s)...
  3. pmc MRG15 regulates embryonic development and cell proliferation
    Kaoru Tominaga
    Department of Cellular and Structural Biology, Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 25:2924-37. 2005
    ..These findings demonstrate that MRG15 has an essential role in embryonic development via chromatin remodeling and transcriptional regulation...
  4. pmc MrgX is not essential for cell growth and development in the mouse
    Kaoru Tominaga
    Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 25:4873-80. 2005
    ....
  5. pmc The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway
    Kaoru Tominaga
    Sam and Ann Barshop Institute for Longevity and Aging Studies UTHSCSA, STCBM, San Antonio, TX 78245, USA
    Exp Cell Res 316:92-102. 2010
    ..The results suggest that levels of MORF4 in cells must be tightly controlled and one mechanism involves stability of the protein...
  6. pmc Emerging role of the MORF/MRG gene family in various biological processes, including aging
    Meizhen Chen
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Ann N Y Acad Sci 1197:134-41. 2010
    ..Further studies are needed to determine the function of this gene family in various biological processes, including neural stem and progenitor cell aging...
  7. pmc Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation
    Sandra N Garcia
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 15535 Lambda Drive, STCBM 3 100, San Antonio, TX 78245, USA
    FEBS Lett 581:5275-81. 2007
    ..Formation of phosphorylated H2AX and 53BP1 foci was delayed in Mrg15 mutant versus wild-type cells following irradiation. These data implicate a novel role for MRG15 in DNA-damage repair in mammalian cells...
  8. ncbi request reprint MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner
    Kaoru Tominaga
    University of Texas Health Science Center, Sam and Ann Barshop Center for Longevity and Aging Studies, San Antonio, Texas 78245 3207, USA
    J Biol Chem 278:49618-24. 2003
    ..The data indicate that MRGX can repress or activate the B-myb promoter depending on the cell type studied, suggesting that there may be tissue-specific functions of this protein...
  9. pmc MRG15 activates the cdc2 promoter via histone acetylation in human cells
    Andreana N Pena
    Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, TX, USA
    Exp Cell Res 317:1534-40. 2011
    ..These results suggest that MRG15 is acting in a HAT complex involving Tip60 to modify chromatin via acetylation of histone H4 at the cdc2 promoter to activate transcription...
  10. pmc Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor
    Meizhen Chen
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Stem Cell Res 7:75-88. 2011
    ..Furthermore, Mrg15 deficient NSCs exhibit severe defects in DNA damage response following ionizing radiation. Our observations highlight the importance of chromatin regulation and DNA damage response in NSC function and maintenance...
  11. pmc MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells
    Meizhen Chen
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    J Neurosci Res 87:1522-31. 2009
    ..Our results demonstrate that MRG15 has more than one function in neurogenesis and defines a novel role for this chromatin regulator that integrates proliferation and cell-fate determination in neurogenesis during development...
  12. pmc Activation of innate immune antiviral responses by Nod2
    Ahmed Sabbah
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Nat Immunol 10:1073-80. 2009
    ..Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms...
  13. ncbi request reprint Genetics of cellular senescence
    Kaoru Tominaga
    Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, STCBM, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Mech Ageing Dev 123:927-36. 2002
    ..This gene family may affect cell division by modulating gene expression. Study of this novel gene family should lead to new insights regarding the mechanisms and function of cellular senescence in aging and immortalization...
  14. ncbi request reprint Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain
    Brian R Bowman
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Structure 14:151-8. 2006
    ..Site-directed mutagenesis studies based on the X-ray structure and bioinformatics identified key residues involved in the binding of PAM14 and MRGBP...