JAMES TOMASEK

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Myocardin-related transcription factors A and B are key regulators of TGF-β1-induced fibroblast to myofibroblast differentiation
    Beverly J Crider
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Biomedical Research Center, Oklahoma City, Oklahoma 73104, USA
    J Invest Dermatol 131:2378-85. 2011
  2. pmc Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Wound Repair Regen 21:166-76. 2013
  3. ncbi request reprint Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Wound Repair Regen 14:313-20. 2006
  4. ncbi request reprint Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function
    James J Tomasek
    Departments of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Invest Ophthalmol Vis Sci 47:2693-700. 2006
  5. pmc Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element
    James J Tomasek
    Department of Cell Biology, BMSB 553, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 166:1343-51. 2005
  6. ncbi request reprint Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
  7. ncbi request reprint IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice
    Randle M Gallucci
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, USA
    J Invest Dermatol 126:561-8. 2006
  8. pmc TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB
    George M Risinger
    Young Blvd, Biomedical Sciences Bldg, Rm 513, Oklahoma City, OK 73104, USA
    Am J Physiol Cell Physiol 298:C191-201. 2010
  9. ncbi request reprint Characterization of neuropathic bladder smooth muscle cells in culture
    Hsueh Kung Lin
    Department of Urology and Cell Biology, Children s Hospital of Oklahoma and University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Urol 171:1348-52. 2004
  10. ncbi request reprint Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds
    Ursula Mirastschijski
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Exp Cell Res 299:465-75. 2004

Research Grants

  1. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    JAMES TOMASEK; Fiscal Year: 2009
  2. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    JAMES TOMASEK; Fiscal Year: 2007
  3. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2004
  4. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2003
  5. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    James J Tomasek; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. pmc Myocardin-related transcription factors A and B are key regulators of TGF-β1-induced fibroblast to myofibroblast differentiation
    Beverly J Crider
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Biomedical Research Center, Oklahoma City, Oklahoma 73104, USA
    J Invest Dermatol 131:2378-85. 2011
    ..These results provide direct evidence that the MRTFs are mediators of myofibroblast differentiation in response to TGF-β1...
  2. pmc Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Wound Repair Regen 21:166-76. 2013
    ....
  3. ncbi request reprint Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Wound Repair Regen 14:313-20. 2006
    ..These results are consistent with inhibition of myosin light chain phosphatase by the Rho/ROCK signaling pathway, which would account for the long-duration contraction of myofibroblasts necessary for wound closure...
  4. ncbi request reprint Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function
    James J Tomasek
    Departments of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Invest Ophthalmol Vis Sci 47:2693-700. 2006
    ....
  5. pmc Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element
    James J Tomasek
    Department of Cell Biology, BMSB 553, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 166:1343-51. 2005
    ..Taken together, these results provide the first in vivo evidence for the importance of the intronic CArG and TCE cis-elements in the regulation of alpha-SMA expression in myofibroblasts in granulation tissue...
  6. ncbi request reprint Myofibroblasts and mechano-regulation of connective tissue remodelling
    James J Tomasek
    Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Nat Rev Mol Cell Biol 3:349-63. 2002
    ....
  7. ncbi request reprint IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice
    Randle M Gallucci
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117, USA
    J Invest Dermatol 126:561-8. 2006
    ..The expression of alpha-SMA induced by rmIL-6 in fibroblasts from IL-6KO mice appears to be transcriptionally modulated, dependent on JAK1 kinase, and possibly downregulated as a result of increased SOCS3 expression...
  8. pmc TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB
    George M Risinger
    Young Blvd, Biomedical Sciences Bldg, Rm 513, Oklahoma City, OK 73104, USA
    Am J Physiol Cell Physiol 298:C191-201. 2010
    ..Together, these findings indicate that MMP-2 expression is suppressed by a threshold level of active TGF-beta, which in turn promotes a contractile VSMC phenotype that prevents the upregulation of MMP-2...
  9. ncbi request reprint Characterization of neuropathic bladder smooth muscle cells in culture
    Hsueh Kung Lin
    Department of Urology and Cell Biology, Children s Hospital of Oklahoma and University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Urol 171:1348-52. 2004
    ..We determined if neuropathic bladder smooth muscle (SM) cells (SMCs) retain functional differences when cultured in vitro...
  10. ncbi request reprint Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds
    Ursula Mirastschijski
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Exp Cell Res 299:465-75. 2004
    ..The profound impairment of skin repair by the nonselective MMP inhibitor GM 6001 suggests that keratinocyte resurfacing, wound contraction, and granulation tissue organization are highly MMP-dependent processes...

Research Grants12

  1. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    JAMES TOMASEK; Fiscal Year: 2009
    ..abstract_text> ..
  2. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    JAMES TOMASEK; Fiscal Year: 2007
    ..This study will provide the basis for translating basic science findings on the myofibroblast formation and function into the development of novel therapeutic approaches to control wound healing and pathologic contractures. ..
  3. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2004
    ..The results obtained from this project may identify a new class of potential therapeutic targets, such as MDC-L, for intervention of lymphocyte extravasation. ..
  4. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2003
    ..The results obtained from this project may identify a new class of potential therapeutic targets, such as MDC-L, for intervention of lymphocyte extravasation. ..
  5. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    James J Tomasek; Fiscal Year: 2010
    ..abstract_text> ..