Research Topics
| Jakub TolarSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Transplacental and other routes of cancer transmission between individualsJakub Tolar
Department of Pediatrics, Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Pediatr Hematol Oncol 25:430-4. 2003..As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional guidelines are given for the screening of infants born to women with cancer...
Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous systemPaul D Harker-Murray
Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 14:685-92. 2008..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse...
Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)Patricia A Taylor
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 110:3480-8. 2007..Our data further define the mechanisms of action and provide insight as to the potential clinical uses of FTY in allogeneic bone marrow transplant recipients...- Concise review: Transplantation of human hematopoietic cells for extracellular matrix protein deficiency in epidermolysis bullosaJakub Tolar
Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Stem Cells 29:900-6. 2011..Further modifications in the use of stem cell transplantation as a durable source of extracellular matrix proteins may make this regenerative medicine approach effective in other cutaneous and extracutaneous conditions... - Gender-related dimorphism in aortic insufficiency in murine mucopolysaccharidosis type IJakub Tolar
Divisions of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
J Heart Valve Dis 18:524-9. 2009.... - Expression of telomerase and telomere length are unaffected by either age or limb regeneration in Danio rerioTroy C Lund
Division of Pediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN, USA
PLoS ONE 4:e7688. 2009..To date, there has been no longitudinal study to assess whether this retention of telomerase activity equates to the retention of chromosome telomere length through adulthood... - Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cellsJakub Tolar
Blood and Marrow Transplant Program, Department of Pediatrics and Center for Translational Medicine, University of Minnesota, MMC 366, 420 Delaware St SE, Minneapolis, MN 55455, USA
Br J Haematol 147:200-6. 2009..More recent studies have indicated that umbilical cord blood (UCB) is a rich source of both cell types. We will review the current data on UCB-derived Tregs and MSCs and their therapeutic implications... - Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cellsJakub Tolar
Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:1167-74. 2009.... - Hematopoietic cell therapy for metabolic diseasePaul J Orchard
Division of Hematology/Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
J Pediatr 151:340-6. 2007 - Granulocyte colony-stimulating factor mobilized CFU-F can be found in the peripheral blood but have limited expansion potentialTroy C Lund
Pediatric Hematology Oncology and Blood and Marrow Transplant Program, University of Minnesota, Mayo Mail Code 484, D 557 Mayo Building, 420 Delaware St S E, Minneapolis, MN 55455, USA
Haematologica 93:908-12. 2008..The rarity of CFU-F in mobilized peripheral blood and the subsequent pressure to divide in cell culture probably contribute to early cellular senescence. Their potential for use in transplant or gene therapy is, therefore, limited... - Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort reportWeston P Miller
Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Blood 118:1971-8. 2011..We describe the largest single-institution analysis of survival and neurologic function outcomes after HCT in cALD. These trials were registered at www.clinicaltrials.gov as #NCT00176904, #NCT00668564, and #NCT00383448... - Concise review: hitting the right spot with mesenchymal stromal cellsJakub Tolar
Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
Stem Cells 28:1446-55. 2010.... - Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meetingJakub Tolar
Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Mol Ther 19:1193-8. 2011..The report summarizes the roadmap for the development of gene therapy for FA... - Outcome of penetrating keratoplasty for mucopolysaccharidosesErick D Bothun
Department of Ophthalmology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 5501, USA
Arch Ophthalmol 129:138-44. 2011..To describe the outcome of penetrating keratoplasty (PK) for corneal opacification in the setting of systemic mucopolysaccharidoses (MPS)... - Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosaJakub Tolar
Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Invest Dermatol 131:848-56. 2011..These data identify the potential of RDEB iPS cells to generate autologous hematopoietic grafts and skin cells with the inherent capacity to treat skin and mucosal erosions that typify this genodermatosis... - Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type IMark J Osborn
Department of Pediatrics, Division of Bone Marrow Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Mol Ther 19:450-60. 2011..MC gene delivery combined with costimulatory pathway blockade maximizes safety, efficacy, and sustained gene expression and is a new approach in the treatment of lysosomal storage disease... - Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficienciesNathan J Palpant
Department of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
Am J Physiol Heart Circ Physiol 300:H356-65. 2011..This study reveals that cardiac remodeling in the pathology of MPS-I involves heightened adrenergic tone at the expense of cardiac reserve with cardiac decompensation predicted on the basis of increased baseline systolic volumes... - Bone marrow transplantation for recessive dystrophic epidermolysis bullosaJohn E Wagner
Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
N Engl J Med 363:629-39. 2010.... - Mesenchymal stromal cells from donors varying widely in age are of equal cellular fitness after in vitro expansion under hypoxic conditionsTroy C Lund
Division of Pediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cytotherapy 12:971-81. 2010..Data comparing clinical-grade MSC from various ages of donors are scant. We hypothesized that MSC from older donors may display differences in cellular fitness when expanded for clinical use... - Clear cells in the atrioventricular valves of infants with severe human mucopolysaccharidosis (Hurler syndrome) are activated valvular interstitial cellsElizabeth Braunlin
Department of Pediatrics, University of Minnesota Hospital Fairview, Minneapolis, MN 55455, USA
Cardiovasc Pathol 20:315-21. 2011..We hypothesized that the "clear" or "Hurler" cells within the atrioventricular valves from individuals with untreated mucopolysaccharidosis type I are activated valvular interstitial cells... - Higher mycophenolate dose requirements in children undergoing hematopoietic cell transplant (HCT)Pamala Jacobson
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Pharmacol 48:485-94. 2008.... - The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemiaJakub Tolar
Cancer Center and Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Exp Hematol 35:682-90. 2007..Multipotent adult progenitor cells (MAPCs) are adult stem cells derived from bone marrow. We investigated the capacity of MAPCs to aid in tissue healing after myocardial ischemia in mice with different levels of immune competence... - Sarcoma derived from cultured mesenchymal stem cellsJakub Tolar
Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Stem Cells 25:371-9. 2007..More importantly, our study indicates that sarcoma can evolve from MSC cultures... - Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemiaJohn E Wagner
Division of Pediatric Hematology, Oncology, and Blood Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA
Blood 103:3226-9. 2004..Our results suggest that BRCA2 testing should be considered in all patients with FA in whom the complementation group cannot be defined or in whom leukemia is diagnosed at or before 5 years of age... - Real-time in vivo imaging of stem cells following transgenesis by transpositionJakub Tolar
Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Mol Ther 12:42-8. 2005..This novel dual-reporter imaging approach based on the transgenesis of MAPC with Sleeping Beauty transposons sheds light on the homing patterns of MAPC and paves the way for quantification of MAPC engraftment in real time in vivo... - A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter systemMark J Osborn
Pediatrics, Hematology-Oncology, Blood and Marrow Transplant Program, Institute of Human Genetics, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Mol Ther 12:569-74. 2005.... - Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantationClaudio G Brunstein
Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 108:2874-80. 2006..Use of ATG in recipients of an NMA preparative regimen warrants close monitoring for evidence of EBV reactivation and potentially preemptive therapy with rituximab... - Cardiac functional and histopathologic findings in humans and mice with mucopolysaccharidosis type I: implications for assessment of therapeutic interventions in hurler syndromeElizabeth Braunlin
Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Pediatr Res 59:27-32. 2006.... - Host factors that impact the biodistribution and persistence of multipotent adult progenitor cellsJakub Tolar
Pediatric Hematology Oncology Blood and Marrow Transplantation Program, MMC 366, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 107:4182-8. 2006..Our data indicate that the biodistribution and persistence of reporter gene-labeled MAPCs are maximized after intra-arterial delivery or host irradiation and that T cells, B cells, and NK cells contribute to in vivo MAPC rejection... - Pharmacokinetics of clofarabine in patients with high-risk inherited metabolic disorders undergoing brain-sparing hematopoietic cell transplantationJanel Long-Boyle
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Pharmacol 51:679-86. 2011..In patients with adequate renal function, no drug accumulation occurs with consecutive daily dosing... - Transplant outcomes in leukodystrophiesPaul J Orchard
Department of Pediatrics, Division of Hematopoietic Stem Cell Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Semin Hematol 47:70-8. 2010..In many of these cases, the utilization of cord blood grafts allows expedient transplantation, which can be critical in achieving optimal outcomes... - Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon systemXin Huang
Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 107:483-91. 2006..This study is the first report demonstrating that the SB transposon system can mediate stable gene transfer in human primary PBLs, which may be advantageous for T-cell-based gene therapies... - Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cellsMarta Serafini
Stem Cell Institute and Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
J Exp Med 204:129-39. 2007..Because GFP+ host-derived CD45.1+ cells were not observed, fusion is not likely to account for the generation of HSCs by MAPCs... - Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemiaQing Zhou
Department of Pediatrics, Division of Blood and Marrow Transplantation, Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
Blood 114:3793-802. 2009.... - Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene productMark J Osborn
University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
Mol Ther 16:1459-66. 2008..Short-term treatment resulted in a decrease in GAGs in the cerebellum of mucopolysaccharidosis type I (MPS I) mice. This approach, therefore, represents a potential strategy for the delivery of therapeutic enzyme to the CNS... - Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignanciesXin Huang
Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Mol Ther 16:580-9. 2008..Taken together, these data indicate that T cells from PB and UCB can be stably modified using a non-viral DNA transfer system, and that such modified T cells may be useful in the treatment of refractory leukemia and lymphoma... - Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of alloprimingSteven L Highfill
University of Minnesota Masonic Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 114:693-701. 2009..Such data have implications for the use of allogeneic MAPCs and possibly other immunomodulatory nonhematopoietic stem cells for preventing GVHD in the clinic... - Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemiaQing Zhou
Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 116:2484-93. 2010..PD-1/PD-L1 blockade coupled with Treg depletion represents an important new approach that can be readily translated into the clinic to improve the therapeutic efficacy of adoptive AML-reactive CTLs in advanced AML disease... - A novel method for KIR-ligand typing by pyrosequencing to predict NK cell alloreactivityGong Yun
Division of Adult Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, MMC 806, Harvard Street at East River Road, Minneapolis, MN 55455, USA, and Anthony Nolan Research Institute, Royal Free Hospital, London, UK
Clin Immunol 123:272-80. 2007..Pyrosequencing is sensitive, specific, high-throughput, inexpensive, and can rapidly screen KIR-ligand status to evaluate potential alloreactive NK cell or transplant donors... - Lactic acidosis and hypoglycemia with ALL relapse following engrafted bone marrow transplantNathan Luscri
Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 53:223-5. 2009..Care was withdrawn on hospital day 9. Further understanding of the mechanisms that cause the combined onset of lactic acidosis and hypoglycemia will help clinicians in implementing timely therapies that may reduce mortality... - Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922Jakub Tolar
Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation, University of Minnesota, Minneapolis, USA
Pediatr Blood Cancer 45:5-9. 2005..CONCLUSION: Treatment with intravenous 6MP during a brief period of total therapy had a significant negative impact on the prognosis in childhood ALL even though oral 6MP was used during maintenance... - Bacterial meningitis from Rothia mucilaginosa in patients with malignancy or undergoing hematopoietic stem cell transplantationAlisa B Lee
University of Minnesota Medical School, Minneapolis, Minnesota, USA
Pediatr Blood Cancer 50:673-6. 2008..mucilaginosa meningitis in oncology and stem cell transplant patients, and provide updated recommendations regarding the use of antibiotic therapy in this patient population... - OsteopetrosisJakub Tolar
Program in Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
N Engl J Med 351:2839-49. 2004 - Chimerism and tolerance in a recipient of a deceased-donor liver transplantTroy Lund
N Engl J Med 358:2075; author reply 2075. 2008 - Case 4-2008: A pregnant woman with a swollen left breast and dyspneaJakub Tolar
N Engl J Med 358:2848; author reply 2848-9. 2008 - Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapyH Joachim Deeg
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mail Stop D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
Blood 108:1485-91. 2006..Thus, low-dose TBI + CY + ATG conditioning resulted in excellent outcome of unrelated transplants in patients with aplastic anemia who had received multiple transfusions... - Transplacental transfer of small-cell carcinoma of the lungJakub Tolar
N Engl J Med 346:1501-2. 2002 - Hematopoietic cell transplantation for hemoglobinopathiesLakshmanan Krishnamurti
Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center Health System, Division of Hematology/Oncology/BMT, Pittsburgh, Pennsylvania, USA
Curr Probl Pediatr Adolesc Health Care 38:6-18. 2008