J Tolar

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Engraftment and survival following hematopoietic stem cell transplantation for osteopetrosis using a reduced intensity conditioning regimen
    J Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 38:783-7. 2006
  2. pmc alpha-L-iduronidase therapy for mucopolysaccharidosis type I
    Jakub Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Biologics 2:743-51. 2008
  3. pmc Prediction of DNA-binding proteins from relational features
    Andrea Szabóová
    Czech Technical University, Prague, Czech Republic
    Proteome Sci 10:66. 2012
  4. doi request reprint Management of severe epidermolysis bullosa by haematopoietic transplant: principles, perspectives and pitfalls
    Jakub Tolar
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Dermatol 21:896-900. 2012
  5. pmc Fludarabine-based conditioning for marrow transplantation from unrelated donors in severe aplastic anemia: early results of a cyclophosphamide dose deescalation study show life-threatening adverse events at predefined cyclophosphamide dose levels
    Jakub Tolar
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:1007-11. 2012
  6. pmc Comparative evaluation of set-level techniques in predictive classification of gene expression samples
    Matěj Holec
    Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, 166 27, Czech Republic
    BMC Bioinformatics 13:S15. 2012
  7. pmc Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search
    Andrea Szabóová
    Czech Technical University, Department of Cybernetics, Prague, 166 27, Czech Republic
    BMC Bioinformatics 13:S3. 2012
  8. pmc Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy
    Paul J Orchard
    Department of Pediatrics, Program in Blood and Marrow Transplantation, University of Minnesota, Minneapolis, USA
    J Neuroinflammation 8:144. 2011
  9. ncbi request reprint Combination of enzyme replacement and hematopoietic stem cell transplantation as therapy for Hurler syndrome
    J Tolar
    Divisions of Hematology, Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 41:531-5. 2008
  10. pmc Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of MN, Minneapolis, MN, USA
    Blood 117:839-47. 2011

Detail Information

Publications68

  1. ncbi request reprint Engraftment and survival following hematopoietic stem cell transplantation for osteopetrosis using a reduced intensity conditioning regimen
    J Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 38:783-7. 2006
    ..An umbilical cord blood graft, however, should be used with caution for patients with OP when this or a similar reduced intensity regimen is used...
  2. pmc alpha-L-iduronidase therapy for mucopolysaccharidosis type I
    Jakub Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Biologics 2:743-51. 2008
    ....
  3. pmc Prediction of DNA-binding proteins from relational features
    Andrea Szabóová
    Czech Technical University, Prague, Czech Republic
    Proteome Sci 10:66. 2012
    ..abstract:..
  4. doi request reprint Management of severe epidermolysis bullosa by haematopoietic transplant: principles, perspectives and pitfalls
    Jakub Tolar
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Dermatol 21:896-900. 2012
    ....
  5. pmc Fludarabine-based conditioning for marrow transplantation from unrelated donors in severe aplastic anemia: early results of a cyclophosphamide dose deescalation study show life-threatening adverse events at predefined cyclophosphamide dose levels
    Jakub Tolar
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:1007-11. 2012
    ..CY dose levels 50 and 100 mg/kg remain open. Thus, CY at doses of 150 mg/kg in combination with total body irradiation (2 Gy), fludarabine (120 mg/m(2)), and antithymocyte globulin was associated with excessive organ toxicity...
  6. pmc Comparative evaluation of set-level techniques in predictive classification of gene expression samples
    Matěj Holec
    Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, 166 27, Czech Republic
    BMC Bioinformatics 13:S15. 2012
    ..The goal of this study is to provide a more conclusive evaluation by testing various components of the set-level framework within a large collection of machine learning experiments...
  7. pmc Prediction of DNA-binding propensity of proteins by the ball-histogram method using automatic template search
    Andrea Szabóová
    Czech Technical University, Department of Cybernetics, Prague, 166 27, Czech Republic
    BMC Bioinformatics 13:S3. 2012
    ..We validate our method in prediction experiments, improving on state-of-the-art accuracies. Moreover, our method also provides interpretable features involving spatial distributions of selected amino acids...
  8. pmc Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy
    Paul J Orchard
    Department of Pediatrics, Program in Blood and Marrow Transplantation, University of Minnesota, Minneapolis, USA
    J Neuroinflammation 8:144. 2011
    ..To date there is no means of quantitating neuroinflammation in C-ALD, nor is there an accepted measure to determine prognosis for more advanced patients...
  9. ncbi request reprint Combination of enzyme replacement and hematopoietic stem cell transplantation as therapy for Hurler syndrome
    J Tolar
    Divisions of Hematology, Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 41:531-5. 2008
    ..Therefore, we recommend treatment of MPS IH patients with combination of ERT and HSCT therapy to further investigate its potential to enhance outcomes with HSCT...
  10. pmc Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of MN, Minneapolis, MN, USA
    Blood 117:839-47. 2011
    ....
  11. pmc Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells
    Jakub Tolar
    Blood and Marrow Transplant Program, Department of Pediatrics and Center for Translational Medicine, University of Minnesota, MMC 366, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Br J Haematol 147:200-6. 2009
    ..More recent studies have indicated that umbilical cord blood (UCB) is a rich source of both cell types. We will review the current data on UCB-derived Tregs and MSCs and their therapeutic implications...
  12. ncbi request reprint N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy
    J Tolar
    Division of Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 39:211-5. 2007
    ..Thus, NAC merits investigation as a therapeutic strategy for patients with advanced ALD as an intervention that could change this lethal disease to a condition amendable to treatment with hematopoietic stem cell transplantation...
  13. pmc Gender-related dimorphism in aortic insufficiency in murine mucopolysaccharidosis type I
    Jakub Tolar
    Divisions of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Heart Valve Dis 18:524-9. 2009
    ....
  14. pmc Concise review: hitting the right spot with mesenchymal stromal cells
    Jakub Tolar
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Stem Cells 28:1446-55. 2010
    ....
  15. doi request reprint Long-term metabolic, endocrine, and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease
    J Tolar
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 43:21-7. 2009
    ..We conclude that Wolman disease can be successfully treated with HCT, and that hepatic and cognitive function can be preserved with early diagnosis and timely referral to a transplant center...
  16. pmc Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells
    Jakub Tolar
    Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:1167-74. 2009
    ....
  17. pmc Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Invest Dermatol 131:848-56. 2011
    ..These data identify the potential of RDEB iPS cells to generate autologous hematopoietic grafts and skin cells with the inherent capacity to treat skin and mucosal erosions that typify this genodermatosis...
  18. ncbi request reprint The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia
    Jakub Tolar
    Cancer Center and Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Exp Hematol 35:682-90. 2007
    ..Multipotent adult progenitor cells (MAPCs) are adult stem cells derived from bone marrow. We investigated the capacity of MAPCs to aid in tissue healing after myocardial ischemia in mice with different levels of immune competence...
  19. doi request reprint Concise review: Transplantation of human hematopoietic cells for extracellular matrix protein deficiency in epidermolysis bullosa
    Jakub Tolar
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Stem Cells 29:900-6. 2011
    ..Further modifications in the use of stem cell transplantation as a durable source of extracellular matrix proteins may make this regenerative medicine approach effective in other cutaneous and extracutaneous conditions...
  20. pmc Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting
    Jakub Tolar
    Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Ther 19:1193-8. 2011
    ..The report summarizes the roadmap for the development of gene therapy for FA...
  21. ncbi request reprint Sarcoma derived from cultured mesenchymal stem cells
    Jakub Tolar
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 25:371-9. 2007
    ..More importantly, our study indicates that sarcoma can evolve from MSC cultures...
  22. pmc Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells
    Jakub Tolar
    Pediatric Hematology Oncology Blood and Marrow Transplantation Program, MMC 366, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 107:4182-8. 2006
    ..Our data indicate that the biodistribution and persistence of reporter gene-labeled MAPCs are maximized after intra-arterial delivery or host irradiation and that T cells, B cells, and NK cells contribute to in vivo MAPC rejection...
  23. ncbi request reprint Real-time in vivo imaging of stem cells following transgenesis by transposition
    Jakub Tolar
    Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:42-8. 2005
    ..This novel dual-reporter imaging approach based on the transgenesis of MAPC with Sleeping Beauty transposons sheds light on the homing patterns of MAPC and paves the way for quantification of MAPC engraftment in real time in vivo...
  24. pmc Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies
    Nathan J Palpant
    Department of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
    Am J Physiol Heart Circ Physiol 300:H356-65. 2011
    ..This study reveals that cardiac remodeling in the pathology of MPS-I involves heightened adrenergic tone at the expense of cardiac reserve with cardiac decompensation predicted on the basis of increased baseline systolic volumes...
  25. doi request reprint Disease-specific hematopoietic cell transplantation: nonmyeloablative conditioning regimen for dyskeratosis congenita
    A C Dietz
    Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Bone Marrow Transplant 46:98-104. 2011
    ..Long-term follow-up will be crucial with respect to individualized patient care with each of the transplanted individuals...
  26. pmc Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic cell transplantation
    L E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 44:279-85. 2009
    ..One patient discontinued GH due to slipped capital femoral epiphysis. Preliminary data suggest that 1-year GH treatment may modestly improve growth velocity in children with Hurler syndrome...
  27. pmc Lower leukemia relapse in pediatric patients with pulmonary cytolytic thrombi following allogeneic transplant
    A R Smith
    Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 46:368-71. 2011
    ..02), cGVHD (P=0.01) and development of PCT (P<0.01) were independently associated with less relapse. These data suggest that patients with PCT are at greater risk for GVHD, but at lower risk of leukemia relapse...
  28. doi request reprint Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation
    L E Polgreen
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Bone Marrow Transplant 41:1005-11. 2008
    ..Growth failure is highly prevalent in children with MPS IH after HSCT. Children who had no TBI exposure and were younger at the time of HSCT had a better height outcome...
  29. doi request reprint Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system
    Paul D Harker-Murray
    Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 14:685-92. 2008
    ..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse...
  30. pmc Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)
    Patricia A Taylor
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 110:3480-8. 2007
    ..Our data further define the mechanisms of action and provide insight as to the potential clinical uses of FTY in allogeneic bone marrow transplant recipients...
  31. doi request reprint Childhood cerebral X-linked adrenoleukodystrophy: diffusion tensor imaging measurements for prediction of clinical outcome after hematopoietic stem cell transplantation
    A M McKinney
    Department of Radiology, University of Minnesota Amplatz Children s Hospital, Minneapolis, Minnesota, USA
    AJNR Am J Neuroradiol 34:641-9. 2013
    ..The purpose of this study was to study pretransplant and posttransplant DTI parameters serially and ultimately to determine the ability of pretransplant DTI parameters to predict clinical outcome after HSCT in children with ALD...
  32. doi request reprint Pre-transplant risk factors affecting outcome in Hurler syndrome
    P J Orchard
    Program in Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Bone Marrow Transplant 45:1239-46. 2010
    ..Overall, 31% of these patients were intubated. The risk of intubation was higher in older patients and in those with a history of lower airway disease. These findings have implications for the care of patients with high-risk features...
  33. pmc Expression of telomerase and telomere length are unaffected by either age or limb regeneration in Danio rerio
    Troy C Lund
    Division of Pediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN, USA
    PLoS ONE 4:e7688. 2009
    ..To date, there has been no longitudinal study to assess whether this retention of telomerase activity equates to the retention of chromosome telomere length through adulthood...
  34. doi request reprint Higher mycophenolate dose requirements in children undergoing hematopoietic cell transplant (HCT)
    Pamala Jacobson
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Pharmacol 48:485-94. 2008
    ....
  35. pmc Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I
    Mark J Osborn
    Department of Pediatrics, Division of Bone Marrow Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Ther 19:450-60. 2011
    ..MC gene delivery combined with costimulatory pathway blockade maximizes safety, efficacy, and sustained gene expression and is a new approach in the treatment of lysosomal storage disease...
  36. pmc Bone marrow transplantation for recessive dystrophic epidermolysis bullosa
    John E Wagner
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    N Engl J Med 363:629-39. 2010
    ....
  37. pmc Mesenchymal stromal cells from donors varying widely in age are of equal cellular fitness after in vitro expansion under hypoxic conditions
    Troy C Lund
    Division of Pediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cytotherapy 12:971-81. 2010
    ..Data comparing clinical-grade MSC from various ages of donors are scant. We hypothesized that MSC from older donors may display differences in cellular fitness when expanded for clinical use...
  38. doi request reprint Pharmacokinetics of clofarabine in patients with high-risk inherited metabolic disorders undergoing brain-sparing hematopoietic cell transplantation
    Janel Long-Boyle
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Pharmacol 51:679-86. 2011
    ..In patients with adequate renal function, no drug accumulation occurs with consecutive daily dosing...
  39. doi request reprint Outcome of penetrating keratoplasty for mucopolysaccharidoses
    Erick D Bothun
    Department of Ophthalmology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 5501, USA
    Arch Ophthalmol 129:138-44. 2011
    ..To describe the outcome of penetrating keratoplasty (PK) for corneal opacification in the setting of systemic mucopolysaccharidoses (MPS)...
  40. ncbi request reprint Hematopoietic cell therapy for metabolic disease
    Paul J Orchard
    Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    J Pediatr 151:340-6. 2007
  41. ncbi request reprint Transplacental and other routes of cancer transmission between individuals
    Jakub Tolar
    Department of Pediatrics, Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Pediatr Hematol Oncol 25:430-4. 2003
    ..As these cases represent a unique physiologic model of tumor transplantation, the biology of cancer transmission is discussed and provisional guidelines are given for the screening of infants born to women with cancer...
  42. ncbi request reprint Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA
    Blood 103:3226-9. 2004
    ..Our results suggest that BRCA2 testing should be considered in all patients with FA in whom the complementation group cannot be defined or in whom leukemia is diagnosed at or before 5 years of age...
  43. doi request reprint Granulocyte colony-stimulating factor mobilized CFU-F can be found in the peripheral blood but have limited expansion potential
    Troy C Lund
    Pediatric Hematology Oncology and Blood and Marrow Transplant Program, University of Minnesota, Mayo Mail Code 484, D 557 Mayo Building, 420 Delaware St S E, Minneapolis, MN 55455, USA
    Haematologica 93:908-12. 2008
    ..The rarity of CFU-F in mobilized peripheral blood and the subsequent pressure to divide in cell culture probably contribute to early cellular senescence. Their potential for use in transplant or gene therapy is, therefore, limited...
  44. ncbi request reprint A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system
    Mark J Osborn
    Pediatrics, Hematology Oncology, Blood and Marrow Transplant Program, Institute of Human Genetics, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:569-74. 2005
    ....
  45. ncbi request reprint Cardiac functional and histopathologic findings in humans and mice with mucopolysaccharidosis type I: implications for assessment of therapeutic interventions in hurler syndrome
    Elizabeth Braunlin
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Pediatr Res 59:27-32. 2006
    ....
  46. pmc Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation
    Claudio G Brunstein
    Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 108:2874-80. 2006
    ..Use of ATG in recipients of an NMA preparative regimen warrants close monitoring for evidence of EBV reactivation and potentially preemptive therapy with rituximab...
  47. pmc Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
    Marta Serafini
    Stem Cell Institute and Cancer Center and Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:129-39. 2007
    ..Because GFP+ host-derived CD45.1+ cells were not observed, fusion is not likely to account for the generation of HSCs by MAPCs...
  48. pmc Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene product
    Mark J Osborn
    University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
    Mol Ther 16:1459-66. 2008
    ..Short-term treatment resulted in a decrease in GAGs in the cerebellum of mucopolysaccharidosis type I (MPS I) mice. This approach, therefore, represents a potential strategy for the delivery of therapeutic enzyme to the CNS...
  49. pmc Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system
    Xin Huang
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 107:483-91. 2006
    ..This study is the first report demonstrating that the SB transposon system can mediate stable gene transfer in human primary PBLs, which may be advantageous for T-cell-based gene therapies...
  50. doi request reprint Transplant outcomes in leukodystrophies
    Paul J Orchard
    Department of Pediatrics, Division of Hematopoietic Stem Cell Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Semin Hematol 47:70-8. 2010
    ..In many of these cases, the utilization of cord blood grafts allows expedient transplantation, which can be critical in achieving optimal outcomes...
  51. pmc Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
    Qing Zhou
    Department of Pediatrics, Division of Blood and Marrow Transplantation, Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA
    Blood 114:3793-802. 2009
    ....
  52. pmc Cardiac Ultrasound Findings in Infants with Severe (Hurler Phenotype) Untreated Mucopolysaccharidosis (MPS) Type I
    L Schroeder
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    JIMD Rep 10:87-94. 2013
    ..These findings suggest that earlier intervention, including neonatal screening, may be of benefit to children with severe MPS I...
  53. ncbi request reprint Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
    Xin Huang
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Ther 16:580-9. 2008
    ..Taken together, these data indicate that T cells from PB and UCB can be stably modified using a non-viral DNA transfer system, and that such modified T cells may be useful in the treatment of refractory leukemia and lymphoma...
  54. pmc Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
    Qing Zhou
    Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 116:2484-93. 2010
    ..PD-1/PD-L1 blockade coupled with Treg depletion represents an important new approach that can be readily translated into the clinic to improve the therapeutic efficacy of adoptive AML-reactive CTLs in advanced AML disease...
  55. pmc Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming
    Steven L Highfill
    University of Minnesota Masonic Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 114:693-701. 2009
    ..Such data have implications for the use of allogeneic MAPCs and possibly other immunomodulatory nonhematopoietic stem cells for preventing GVHD in the clinic...
  56. doi request reprint Lactic acidosis and hypoglycemia with ALL relapse following engrafted bone marrow transplant
    Nathan Luscri
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 53:223-5. 2009
    ..Care was withdrawn on hospital day 9. Further understanding of the mechanisms that cause the combined onset of lactic acidosis and hypoglycemia will help clinicians in implementing timely therapies that may reduce mortality...
  57. pmc A novel method for KIR-ligand typing by pyrosequencing to predict NK cell alloreactivity
    Gong Yun
    Division of Adult Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, MMC 806, Harvard Street at East River Road, Minneapolis, MN 55455, USA, and Anthony Nolan Research Institute, Royal Free Hospital, London, UK
    Clin Immunol 123:272-80. 2007
    ..Pyrosequencing is sensitive, specific, high-throughput, inexpensive, and can rapidly screen KIR-ligand status to evaluate potential alloreactive NK cell or transplant donors...
  58. ncbi request reprint Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922
    Jakub Tolar
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota, Minneapolis, USA
    Pediatr Blood Cancer 45:5-9. 2005
    ..To compare outcomes of patients with NCI standard risk acute lymphoblastic leukemia (ALL) who relapsed after being randomized to receive either oral or intravenous 6-mercaptopurine (6MP) in the Children's Cancer Group study CCG 1922...
  59. ncbi request reprint Osteopetrosis
    Jakub Tolar
    Program in Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 351:2839-49. 2004
  60. doi request reprint Current international perspectives on hematopoietic stem cell transplantation for inherited metabolic disorders
    Jaap J Boelens
    Department of Pediatrics, Blood and Marrow Transplantation Program, UMC Utrecht, Wilhelmina Children s Hospital, KC 03 063 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Pediatr Clin North Am 57:123-45. 2010
    ..This review discusses indications for HSCT and outcomes of HSCT for selected IMD. An international perspective on progress, limitations, and future directions in the field is provided...
  61. ncbi request reprint Bacterial meningitis from Rothia mucilaginosa in patients with malignancy or undergoing hematopoietic stem cell transplantation
    Alisa B Lee
    University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Pediatr Blood Cancer 50:673-6. 2008
    ..mucilaginosa meningitis in oncology and stem cell transplant patients, and provide updated recommendations regarding the use of antibiotic therapy in this patient population...
  62. doi request reprint Case 4-2008: A pregnant woman with a swollen left breast and dyspnea
    Jakub Tolar
    N Engl J Med 358:2848; author reply 2848-9. 2008
  63. doi request reprint Chimerism and tolerance in a recipient of a deceased-donor liver transplant
    Troy Lund
    N Engl J Med 358:2075; author reply 2075. 2008
  64. ncbi request reprint Transplacental transfer of small-cell carcinoma of the lung
    Jakub Tolar
    N Engl J Med 346:1501-2. 2002
  65. pmc Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy
    H Joachim Deeg
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mail Stop D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
    Blood 108:1485-91. 2006
    ..Thus, low-dose TBI + CY + ATG conditioning resulted in excellent outcome of unrelated transplants in patients with aplastic anemia who had received multiple transfusions...
  66. ncbi request reprint Adeno-associated virus-mediated delivery of a mutant endostatin in combination with carboplatin treatment inhibits orthotopic growth of ovarian cancer and improves long-term survival
    Indira V Subramanian
    Department of Obstetrics and Gynecology and Women s Health, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Cancer Res 66:4319-28. 2006
    ..These studies suggest that AAV-mediated gene therapy of P125A-endostatin in combination with carboplatin is a useful method to inhibit peritoneal dissemination of ovarian carcinoma...
  67. ncbi request reprint Hematopoietic cell transplantation for hemoglobinopathies
    Lakshmanan Krishnamurti
    Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center Health System, Division of Hematology Oncology BMT, Pittsburgh, Pennsylvania, USA
    Curr Probl Pediatr Adolesc Health Care 38:6-18. 2008