Research Topics
| Mauricio TohenSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Randomised, double-blind, placebo-controlled study of olanzapine in patients with bipolar I depressionMauricio Tohen
University of Texas Health Science Center, Division of Mood and Anxiety Disorders, 7526 Louis Pasteur Drive, San Antonio, TX 78229 3900, USA
Br J Psychiatry 201:376-82. 2012..Atypical antipsychotics are widely used in bipolar mania. However, the efficacy of atypical antipsychotics in bipolar depression has not been comprehensively explored...- Variables as mediators or moderators in predicting relapse to any type of mood episode in a bipolar maintenance studyMauricio Tohen
Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Clin Psychiatry 73:e913-7. 2012..The aim was to identify moderators that precede and influence other variables to affect relapse and mediators that explain how or why a second variable affects relapse... - Antipsychotic agents in the treatment of bipolar maniaMauricio Tohen
Division of Mood and Anxiety Disorders, The University of Texas Health Science Center, San Antonio TX 78229, USA
Bipolar Disord 11:45-54. 2009..Antipsychotics have been widely used in the treatment of bipolar mania. The purpose of this manuscript was to briefly review the evidence of typical and atypical antipsychotics for the treatment of bipolar mania... - The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disordersMauricio Tohen
Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA
Bipolar Disord 11:453-73. 2009.... - Baseline characteristics and outcomes in patients with first episode or multiple episodes of acute maniaMauricio Tohen
Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7526 Louis Pasteur Drive, San Antonio, TX 78229 3900, USA
J Clin Psychiatry 71:255-61. 2010..The goal of the present analyses was to describe and compare the baseline characteristics, response to treatment, and medication patterns in adult patients experiencing a first episode versus multiple episodes of mania... - Number needed to treat or harm analyses of olanzapine for maintenance treatment of bipolar disorderMauricio Tohen
Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MSC 7792, San Antonio, TX 78229 390, USA
J Clin Psychopharmacol 29:520-8. 2009..Clinicians should consider these and other potential benefits and risks in using maintenance treatments for patients with a bipolar disorder... - Olanzapine/fluoxetine combination in patients with treatment-resistant depression: rapid onset of therapeutic response and its predictive value for subsequent overall response in a pooled analysis of 5 studiesMauricio Tohen
University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Clin Psychiatry 71:451-62. 2010.... - Two-year outcomes in first-episode psychotic depression the McLean-Harvard First-Episode ProjectMauricio Tohen
University of Texas Health Science Center at San Antonio, TX 78229, USA
J Affect Disord 136:1-8. 2012..Early assessment can guide accurate diagnosis, prognosis, and treatment-planning for patients with major mental illnesses. Longitudinal studies in psychotic depression from onset are rare, encouraging the present study... 
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosisThomas H McGlashan
Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
Am J Psychiatry 163:790-9. 2006..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...- Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment StudyKeith A Hawkins
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Schizophr Res 105:1-9. 2008..We investigated whether conversion to psychosis and/or olanzapine altered the neuropsychological course of subjects within the first-ever double blind medication study of the putative schizophrenia first episode prodrome... - Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episodeDiana O Perkins
Department of Psychiatry, C.B.# 7160, University of North Carolina School of Medicine, Chapel Hill, 27599-7160, USA
Schizophr Res 83:53-63. 2006.... 
McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patientsPaola Salvatore
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 70:458-66. 2009..Since stability of DSM-IV diagnoses of disorders with psychotic features requires validation, we evaluated psychotic patients followed systematically in the McLean-Harvard International First Episode Project...- Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidolJeffrey A Lieberman
Department of Psychiatry, University of North Carolina School of Medicine, NC 27599 7160, USA
Am J Psychiatry 160:1396-404. 2003..This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial... - Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depressionPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Clin Psychiatry 66:611-6. 2005..These subanalyses compare treatment-emergent mania rates in bipolar I depressed patients treated with olanzapine, placebo, or olanzapine/fluoxetine combination... - Dissimilar morbidity following initial mania versus mixed-states in type-I bipolar disorderRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Affect Disord 126:299-302. 2010..Mixed-states of bipolar disorders (BPD) may predict worse future illness and more depressive than manic morbidity, challenging a tendency to conflate mixed-states and mania... - Suicidal events and accidents in 216 first-episode bipolar I disorder patients: predictive factorsHari Mandir Kaur Khalsa
Department of Psychiatry, Harvard Medical School, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478 9106, USA
J Affect Disord 106:179-84. 2008..Risks of life-threatening behaviors are high among bipolar disorder (BPD) patients, but early rates and associated risk factors for suicides and accidents remain ill-defined... - Substance abuse in first-episode bipolar I disorder: indications for early interventionChristopher Baethge
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Am J Psychiatry 162:1008-10. 2005..This study clarified the early characteristics of substance use disorders in patients with first-episode bipolar I disorder... - Morbidity in 303 first-episode bipolar I disorder patientsRoss J Baldessarini
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 12:264-70. 2010.... - Weight gain during treatment of bipolar I patients with olanzapineJohn Hennen
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 65:1679-87. 2004..Body weight increase during long-term treatment with olanzapine in schizophrenia patients is well documented, but weight gain and its association with other medical measures are less well evaluated in bipolar disorder patients... - An excitement subscale of the Positive and Negative Syndrome ScaleJean Pierre Lindenmayer
Department of Psychiatry, New York University School of Medicine, and Manhattan Psychiatric Center, Wards Island Complex, New York, NY, USA
Schizophr Res 68:331-7. 2004.... - Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodromeScott W Woods
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 54:453-64. 2003..Extrapyramidal symptoms with olanzapine were minimal and similar to those with placebo. Future research over the longer term with more patients will be needed before recommendations can be made regarding routine treatment... - Rates and predictors of developing a manic or hypomanic episode 1 to 2 years following a first hospitalization for major depression with psychotic featuresMelissa P DelBello
The Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
J Child Adolesc Psychopharmacol 13:173-85. 2003.... - Sex differences in clinical response to olanzapine compared with haloperidolJill M Goldstein
Harvard Institute of Psychiatric Epidemiology and Genetics, Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, MMHC, Boston, MA 02115, USA
Psychiatry Res 110:27-37. 2002..Finally, premenopausal women had a significantly better treatment response than postmenopausal women, regardless of treatment and chronicity...