Stevan P Tofovic

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, and the VA Pittsburgh Health System, Pittsburgh, PA 15219 3138, USA
    J Cardiovasc Pharmacol 46:430-7. 2005
  2. ncbi request reprint 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, PA 15219, United States
    Vascul Pharmacol 45:358-67. 2006
  3. doi request reprint Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, 100 Technology Drive, Suite 450, Pittsburgh, PA 15219, USA
    Med Hypotheses 72:713-9. 2009
  4. pmc 2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, United States
    Vascul Pharmacol 51:190-7. 2009
  5. pmc Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease
    Stevan P Tofovic
    Division of Pulmonary, Allergy and Critical Care Medicine, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Bridge side 542, 100 Technology Drive, Pittsburgh, PA 15219, USA
    J Cardiovasc Pharmacol 56:696-708. 2010
  6. doi request reprint Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling
    Stevan P Tofovic
    Center for Clinical Pharmacology, Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    J Cardiovasc Pharmacol 56:475-83. 2010
  7. ncbi request reprint Early renal injury induced by caffeine consumption in obese, diabetic ZSF1 rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Ren Fail 29:891-902. 2007
  8. doi request reprint 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, USA
    Vascul Pharmacol 48:174-83. 2008
  9. doi request reprint Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2
    Prajakta A Sonalker
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 3130, USA
    Clin Exp Pharmacol Physiol 35:594-600. 2008
  10. doi request reprint Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats
    Victor P Bilan
    Division of Pulmonary, Allergy, and Critical Care Medicine, Vascular Medicine Institute, Departments of Medicine Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    J Endocrinol 210:293-308. 2011

Research Grants

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, and the VA Pittsburgh Health System, Pittsburgh, PA 15219 3138, USA
    J Cardiovasc Pharmacol 46:430-7. 2005
    ..Further evaluation of 2ME for management of pulmonary arterial hypertension is warranted...
  2. ncbi request reprint 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, PA 15219, United States
    Vascul Pharmacol 45:358-67. 2006
    ..This study suggests that 2-methoxyestradiol (a major non-estrogenic metabolite of E2) may mediate the protective effects of estradiol in MCT-induced PH, and warrants further evaluation of 2ME for treatment of PH...
  3. doi request reprint Adenosine deaminase-adenosine pathway in hemolysis-associated pulmonary hypertension
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, 100 Technology Drive, Suite 450, Pittsburgh, PA 15219, USA
    Med Hypotheses 72:713-9. 2009
    ..We also propose that increase in extracellular ADO levels or activation of adenosine A(2A) receptors attenuates HA-PH, and we suggest further preclinical and clinical investigation of ADA inhibitors and ADO agonists in HA-PH...
  4. pmc 2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, United States
    Vascul Pharmacol 51:190-7. 2009
    ..This study suggests that 2ME may have protective effects in bleomycin-induced PH and fibrosis. Further investigation of 2ME in pulmonary fibrosis and PH is warranted...
  5. pmc Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease
    Stevan P Tofovic
    Division of Pulmonary, Allergy and Critical Care Medicine, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Bridge side 542, 100 Technology Drive, Pittsburgh, PA 15219, USA
    J Cardiovasc Pharmacol 56:696-708. 2010
    ..Furthermore, we propose that unbalanced estradiol metabolism may lead to the development of PAH. Recent animal data and studies in patients with PAH support this concept...
  6. doi request reprint Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling
    Stevan P Tofovic
    Center for Clinical Pharmacology, Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    J Cardiovasc Pharmacol 56:475-83. 2010
    ..These results indicate that 2ME is effective in experimental PAH and suggests that 2ME may provide additional therapeutic benefit over existing drugs used for the treatment of pulmonary hypertension...
  7. ncbi request reprint Early renal injury induced by caffeine consumption in obese, diabetic ZSF1 rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Ren Fail 29:891-902. 2007
    ..Tempol does not prevent early renal injury (i.e., proteinuria) induced by caffeine, yet abolishes late renal inflammatory, proliferative, and fibrotic change induced by chronic caffeine consumption in obese ZSF1 rats...
  8. doi request reprint 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, USA
    Vascul Pharmacol 48:174-83. 2008
    ..This study provides the first evidence that 2-ethoxyestradiol strongly inhibits vascular remodeling in PH and suggests that anti-proliferative agents, including synthetic analogs of estradiol metabolites may be protective in PH...
  9. doi request reprint Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2
    Prajakta A Sonalker
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 3130, USA
    Clin Exp Pharmacol Physiol 35:594-600. 2008
    ....
  10. doi request reprint Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats
    Victor P Bilan
    Division of Pulmonary, Allergy, and Critical Care Medicine, Vascular Medicine Institute, Departments of Medicine Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    J Endocrinol 210:293-308. 2011
    ....
  11. ncbi request reprint Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Cardiovasc Pharmacol 46:25-35. 2005
    ..This study provides the first evidence that, in a model of severe cardiovascular and renal injury, 2-methoxyestradiol (a major nonestrogenic estradiol metabolite) exerts renal and cardiovascular protective effects and reduces mortality...
  12. doi request reprint Renal and metabolic effects of tempol in obese ZSF1 rats--distinct role for superoxide and hydrogen peroxide in diabetic renal injury
    Olga Rafikova
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    Metabolism 57:1434-44. 2008
    ....
  13. ncbi request reprint Cellular distribution of the renal bumetanide-sensitive Na-K-2Cl cotransporter BSC-1 in the inner stripe of the outer medulla during the development of hypertension in the spontaneously hypertensive rat
    Prajakta A Sonalker
    Center for Clinical Pharmacology, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 3130, USA
    Clin Exp Pharmacol Physiol 34:1307-12. 2007
    ..7. We also conclude that the age/hypertension-related increase in BSC-1 protein levels in ISOM is accompanied by an equally marked increased trafficking of BSC-1 to PMs in SHR ISOM...
  14. ncbi request reprint 2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats
    Xinchen Zhang
    Center for Clinical Pharmacolog, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    J Cardiovasc Pharmacol 49:56-63. 2007
    ..The present study warrants further investigation of 2-ME and analogs of estradiol metabolites for treatment of kidney disease associated with the metabolic syndrome...
  15. ncbi request reprint PPAR alpha agonists improve renal preservation in kidneys subjected to chronic in vitro perfusion: interaction with mannitol
    Travis C Jackson
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219 3130, USA
    Transpl Int 20:277-90. 2007
    ..We conclude that PPARalpha agonists, particularly when combined with mannitol, protect organs from normothermic, perfusion-induced damage...
  16. ncbi request reprint 2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Am Soc Nephrol 13:2737-47. 2002
    ..These effects are mediated by estrogen receptor-independent mechanisms and are due, at least in part, to the inhibition of some of the key proliferative mechanisms involved in glomerular remodeling and sclerosis...
  17. ncbi request reprint The pancreatohepatorenal cAMP-adenosine mechanism
    Edwin K Jackson
    Department of Medicine, Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, 100 Technology Dr, Suite 450, Pittsburgh, PA 15219 3130, USA, and Clinic for Endocrinology, University Hospital Zurich, Switzerland
    J Pharmacol Exp Ther 321:799-809. 2007
    ..A specific manifestation of this is the pancreatohepatorenal cAMP-adenosine mechanism (pancreas==> portal glucagon==> liver==> circulating cAMP==> kidney==> local cAMP-adenosine pathway)...
  18. ncbi request reprint Long-term caffeine consumption exacerbates renal failure in obese, diabetic, ZSF1 (fa-fa(cp)) rats
    Stevan P Tofovic
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylavania 15213 2582, USA
    Kidney Int 61:1433-44. 2002
    ..The purpose of this study was to investigate the effects of early (beginning at 8 weeks of age) and long-term (30 weeks) caffeine treatment (0.1% solution) on renal function and structure in obese, diabetic ZSF1 rats...
  19. ncbi request reprint Increased expression of the sodium transporter BSC-1 in spontaneously hypertensive rats
    Prajakta A Sonalker
    Center for Clinical Pharmacology, University of Pittsburgh Medical Center, 623 Scaife Hall, 3550 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    J Pharmacol Exp Ther 311:1052-61. 2004
    ..We conclude that increased expression of BSC-1, and to a lesser extent, aquaporin-2, ROMK-1, NHE-3, and NBC-1 may contribute to the pathogenesis of hypertension in the SHR...
  20. pmc Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1 receptor-mediated coincident signaling
    Edwin K Jackson
    Dept of Pharmacology and Chemical Biology, 100 Technology Dr, Rm 514, Univ of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    Am J Physiol Renal Physiol 302:F466-76. 2012
    ..Likely, the coincident signaling pathway is: phospholipase C → protein kinase C → c-src → phosphatidylinositol 3-kinase → 3-phosphoinositide-dependent protein kinase-1...
  21. ncbi request reprint Rat models of the metabolic syndrome
    Stevan P Tofovic
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Methods Mol Med 86:29-46. 2003
  22. ncbi request reprint Expression of adenosine receptors in the preglomerular microcirculation
    Edwin K Jackson
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Renal Physiol 283:F41-51. 2002
    ..Thus A1 and A2B receptors, but not A2A or A3 receptors, may importantly regulate the preglomerular microcirculation...
  23. ncbi request reprint Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats
    Neal J Thomas
    Department of Critical Care Medicine, Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 17033, USA
    Eur J Pharmacol 465:133-9. 2003
    ..Clinical studies of type IV phosphodiesterase inhibitors in critically ill patients are indicated...
  24. pmc Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonary hypertension
    Olga Rafikova
    Center for Clinical Pharmacology and Vascular Medicine Institute, Department of Medicine, Pittsburgh, PA 15260, USA
    Free Radic Biol Med 56:28-43. 2013
    ..We conclude that inhibition of ET-1 signaling significantly attenuates the oxidative and nitrosative stress associated with PH and prevents its progression...
  25. pmc Plasmin activates epithelial Na+ channels by cleaving the gamma subunit
    Christopher J Passero
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 283:36586-91. 2008
    ....
  26. ncbi request reprint Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats
    Kimberly D Statler
    Safar Center for Resuscitation Research, 3434 Fifth Avenue, Suite 201, Pittsburgh, PA 15260, USA
    Crit Care Med 31:1134-9. 2003
    ..To determine whether transient, moderate hypothermia is beneficial after traumatic brain injury in fentanyl-anesthetized rats...
  27. ncbi request reprint Cardiovascular pharmacology of estradiol metabolites
    Raghvendra K Dubey
    Department of Obstetrics and Gynaecology, Clinic for Endocrinology, University Hospital Zurich, Switzerland
    J Pharmacol Exp Ther 308:403-9. 2004
    ..The take home message is simple: that when it comes to cardiovascular and renal protection, the concept that all estrogenic compounds are created equal may not be true...

Research Grants1