Research Topics
| THEA D contact TLSTYSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancyNancy Dumont
Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California, 94143 0511, USA
Breast Cancer Res 11:R87. 2009....
Tissue states provide novel insights into attributes that drive metastasisThea D Tlsty
Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143 0511, USA
Cancer Cell 20:285-6. 2011..NSAIDs suppress tumor progression during postpartum involution, potentially providing effective agents for intervention in pregnant women...
A twist of cell fateThea D Tlsty
UCSF, Box 0506, San Francisco, CA 94143 0506, USA
Cell Stem Cell 8:126-7. 2011..2011) study breast tissue from women with heterozygous BRCA1 mutations and identify molecular mechanisms that regulate mammary progenitor cell differentiation and bias toward subsequent basal-like tumor formation...- Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosisKarla Kerlikowske
University of California, San Francisco, CA 94121, USA corrected
J Natl Cancer Inst 102:627-37. 2010..Studies have failed to identify characteristics of women who have been diagnosed with ductal carcinoma in situ (DCIS) and have a high or low risk of subsequent invasive cancer... - Tumor stroma and regulation of cancer developmentThea D Tlsty
Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
Annu Rev Pathol 1:119-50. 2006.... - Functions of p53 suppress critical consequences of damage and repair in the initiation of cancerThea D Tlsty
Department of Pathology, UCSF Comprehensive Cancer Center, University of California at San Francisco, 94143, USA
Cancer Cell 2:2-4. 2002..A pivotal study reveals a long-sought-after mechanism for gene amplification and provides important implications for oncogenesis... - Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesisThea D Tlsty
Department of Pathology and UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 0511, USA
J Mammary Gland Biol Neoplasia 9:263-74. 2004..This review will highlight some of the key alterations that have been studied in human mammary epithelial cells in culture and relate them to events observed in vivo and discussed in accompanying reviews in this volume... - p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cellsKimberly M McDermott
Department of Pathology, UCSF Comprehensive Cancer Center, University of California San Francisco, California, USA
PLoS Biol 4:e51. 2006..Gain or loss of genomic material (aneuploidy) may provide the necessary proproliferation and antiapoptotic mechanisms needed for the earliest stages of tumorigenesis... - p16INK4a modulates p53 in primary human mammary epithelial cellsJianmin Zhang
Department of Pathology and UCSF Comprehensive Cancer Center, University of California San Francisco, California 94143, USA
Cancer Res 66:10325-31. 2006..However, we have observed that p16 does not modulate p53 in fibroblasts, indicating a possible cell type-specific regulation of this pathway... - Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARFGregory R Bean
Duke University Medical Center, Durham, NC 27710, USA
Clin Cancer Res 13:6834-41. 2007..These data suggest that cells that lack p16(INK4a) activity would be at high risk for breast cancer development and may exhibit an increased frequency of DNA methylation events in early cancer... - Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant programYongping G Crawford
Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
Cancer Cell 5:263-73. 2004..These putative precursors can be selectively eliminated upon exposure to COX-2 inhibitors in vitro... - Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancersNancy Dumont
Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, CA 94143 0511, USA
Proc Natl Acad Sci U S A 105:14867-72. 2008..Given the dynamic epigenetic reprogramming that occurs in these cells, DNA methylation profiles observed in human tumors may reflect the history of environmental exposures during the genesis of a tumor... - Simulating properties of in vitro epithelial cell morphogenesisMark R Grant
University of California San Francisco University of California Berkeley Joint Graduate Group in Bioengineering, University of California Berkeley, Berkeley, California, United States of America
PLoS Comput Biol 2:e129. 2006..Analogue design facilitates gaining deeper insight into such phenomena by making it easy to replace low-resolution components with increasingly detailed and realistic components... - Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cellsPaul A Reynolds
Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143 0511, USA
J Biol Chem 281:24790-802. 2006.... - Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumorsMona L Gauthier
Department of Pathology, University of California, San Francisco, CA 94143, USA
Cancer Cell 12:479-91. 2007..Assessment of these biomarkers in DCIS begins to allow prediction of tumor formation years before it actually occurs... - Luminal cells GATA have itThea D Tlsty
Nat Cell Biol 9:135-6. 2007 - Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epitheliumVeronica Shim
University of California at San Francisco Comprehensive Cancer Center, University of California, San Francisco, California 94115 1710, USA
Cancer Res 63:2347-50. 2003..Our observations demonstrate that COX-2 is up-regulated in the normal adjacent epithelium and supports the hypothesis that the surrounding epithelial tissue is part of the disease process in DCIS... - Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epitheliaCharles R Holst
Department of Pathology and University of California at San Francisco Comprehensive Cancer Center 94143 0511, USA
Cancer Res 63:1596-601. 2003..Here we show that epithelial cells with methylation of p16 promoter sequences occur in focal patches of histologically normal mammary tissue of a substantial fraction of healthy, cancer-free women... - p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissueMona L Gauthier
Department of Pathology, University of California San Francisco Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143-0511, USA
Cancer Res 65:1792-9. 2005..These data help define the regulation of COX-2 expression in early carcinogenesis and provide alternative candidates for targeted prevention of COX-2-induced phenotypes and breast cancer...
Research Grants
- Regulation of Genomic Instability in Early Breast CancerThea Tlsty; Fiscal Year: 2007..These studies may provide novel targets for prevention or treatment of breast cancer. ..
- Regulation of DNA hypermethylation in human mammary cellsThea Tlsty; Fiscal Year: 2007..We hypothesize that the above-described properties of HMEC in vitro are critically relevant to their transformation processes in vivo and may provide clinically relevant biomarkers. ..
- Regulation of Genomic Instability in Early Breast CancerThea Tlsty; Fiscal Year: 2007..These studies may provide novel targets for prevention or treatment of breast cancer. ..
- Characterizing the Evolution of Pre-malignant Tissues at High Risk for MalignancyThea Tlsty; Fiscal Year: 2009..Development of selected markers as tools for non-invasive imaging will open an unprecedented avenue to study early aggressive pre-malignancies and risk factors that contribute to their progression. ..
- Regulation of Genomic Instability in Early Breast CancerThea D Tlsty; Fiscal Year: 2010..Our new observations in the regulation of epigenetic changes provide potential markers for assessing susceptibility to malignant transformation in individuals, as well as, potential targets for prevention and therapy. ..
- MECHANISMS OF RADIATION--INDUCED GENOMIC INSTABILITYThea Tlsty; Fiscal Year: 2001..She will determine if tumor progression alters the cellular response to high LET radiation. And finally, she will determine if cellular responses to high LET radiation are unique or are shared with that of low LET radiation. ..
- FIBROBLAST REGULATION OF HUMAN PROSTATIC CARCINOGENESISThea Tlsty; Fiscal Year: 2003..In this proposal, we have focused our attention on identifying fibroblast-induced signals which contribute to prostatic tumor progression. ..
- Characterizing the Evolution of Pre-malignant Tissues at High Risk for MalignancyTHEA D contact TLSTY; Fiscal Year: 2010..Development of selected markers as tools for non-invasive imaging will open an unprecedented avenue to study early aggressive pre-malignancies and risk factors that contribute to their progression. ..