Omar Tliba

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells
    A Banerjee
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
    Br J Pharmacol 155:84-92. 2008
  2. pmc The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
    Farhat Syed
    Centocor Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Respir Res 6:9. 2005
  3. ncbi request reprint CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, 19104 6160, USA
    Mol Pharmacol 69:588-96. 2006
  4. pmc Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Room 1214, Philadelphia, PA 19104 3403, USA
    Am J Respir Cell Mol Biol 38:463-72. 2008
  5. ncbi request reprint Regulation of inflammation by airway smooth muscle
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Curr Allergy Asthma Rep 8:262-8. 2008
  6. doi request reprint Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104 3403, USA
    Chest 133:236-42. 2008
  7. pmc Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
    Reena Bhandare
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 42:9-15. 2010
  8. ncbi request reprint Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 66:322-9. 2004
  9. pmc Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunobiology 213:499-509. 2008
  10. pmc Airway smooth muscle as an immunomodulatory cell
    Gautam Damera
    Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Pulm Pharmacol Ther 22:353-9. 2009

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells
    A Banerjee
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
    Br J Pharmacol 155:84-92. 2008
    ..Here, we investigated whether 1alpha, 25-dihydroxy vitamin D3 (calcitriol) modulated chemokine production in ASM...
  2. pmc The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
    Farhat Syed
    Centocor Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Respir Res 6:9. 2005
    ..In this report, we hypothesize that IL-13 may participate in the pathogenesis of asthma by activating a set of "pro-asthmatic" genes in airway smooth muscle (ASM) cells...
  3. ncbi request reprint CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, 19104 6160, USA
    Mol Pharmacol 69:588-96. 2006
    ....
  4. pmc Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 125 South 31st Street, TRL Suite 1200, Room 1214, Philadelphia, PA 19104 3403, USA
    Am J Respir Cell Mol Biol 38:463-72. 2008
    ..Collectively, our findings demonstrate for the first time that IRF-1 is a novel alternative GRbeta-independent mechanism mediating steroid dysfunction induced by pro-asthmatic cytokines, in part via the suppression of GRalpha activities...
  5. ncbi request reprint Regulation of inflammation by airway smooth muscle
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Curr Allergy Asthma Rep 8:262-8. 2008
    ....
  6. doi request reprint Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, 125 South 31st St, Philadelphia, PA 19104 3403, USA
    Chest 133:236-42. 2008
    ..This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma...
  7. pmc Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
    Reena Bhandare
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 42:9-15. 2010
    ....
  8. ncbi request reprint Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway
    Omar Tliba
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Mol Pharmacol 66:322-9. 2004
    ..Our study is the first to demonstrate that IFNbeta-dependent activation of CD38 pathway is a novel component by which TNFalpha differentially regulates the expression of inflammatory genes in ASM cells...
  9. pmc Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness
    Deepika Jain
    Pulmonary and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunobiology 213:499-509. 2008
    ..These data provide the first evidence that ASM-derived IFNbeta and CD38 may play a significant role in the development of TNFalpha-associated AHR...
  10. pmc Airway smooth muscle as an immunomodulatory cell
    Gautam Damera
    Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Pulm Pharmacol Ther 22:353-9. 2009
    ..This review provides an overview of our current understanding of the proliferative as well as synthetic properties of ASM...
  11. pmc Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, Department of Medicine, University of Pennsylvania, TRL, Room 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    Mol Pharmacol 76:766-77. 2009
    ..Thus, STAT3 may provide a novel therapeutic target for diseases associated with TSC1/TSC2 dysfunction...
  12. ncbi request reprint Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:50615-23. 2003
    ..Together these data show that TNFalpha, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis...
  13. ncbi request reprint Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity
    Stefan Keslacy
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, University of Pennsylvania School of Medicine, Translational Research Laboratories Building, Philadelphia PA 19104 3403, USA
    Mol Pharmacol 71:609-18. 2007
    ..Together, our data indicate that IFNgamma is a potent inhibitor of specific TNFalpha-inducible inflammatory genes by acting on NF-kappaB transactivation via the modulation of HDAC function...
  14. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
    ..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
  15. ncbi request reprint TGF-beta potentiates airway smooth muscle responsiveness to bradykinin
    Jenny H Kim
    Pulmonary, Allergy, and Critical Care Division, Dept of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 289:L511-20. 2005
    ....
  16. ncbi request reprint Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:778-88. 2008
    ....
  17. pmc Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases
    Belaid Bouazza
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 47:464-73. 2012
    ..We propose that the novel mechanism that proasthmatic cytokine-induced CSI in ASMCs is due, in part, to PP5-mediated impairment of GR-Ser211 phosphorylation...
  18. ncbi request reprint Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent
    Altaf S Kazi
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 286:L539-45. 2004
    ..We conclude that ASM-derived VEGF, through modulation of the extracellular matrix, may play an important role in airway remodeling seen in asthma...
  19. ncbi request reprint Noncontractile functions of airway smooth muscle cells in asthma
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, Airways Biology Initiative, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 71:509-35. 2009
    ..This review provides an overview of our current understanding of the proliferative as well as the synthetic properties of ASM...
  20. ncbi request reprint IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
    ....
  21. pmc Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways
    Omar Tliba
    Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Proc Am Thorac Soc 5:106-12. 2008
    ....
  22. ncbi request reprint Bronchial hyperresponsiveness: insights into new signaling molecules
    Yassine Amrani
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Pharmacol 4:230-4. 2004
    ..Thus, a better understanding of these signaling molecules that alter calcium signaling and contractility of ASM might provide new insight into novel therapeutic targets for the control of bronchial hyperresponsiveness...
  23. ncbi request reprint TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl
    Hang Chen
    Deparment of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 1904, USA
    J Appl Physiol (1985) 95:864-72; discussion 863. 2003
    ..Taken together, these data suggest that TNF-alpha may participate in the development of airway hyperresponsiveness in asthma via the modulation of ASM responsiveness to both contractile and beta-adrenoceptor GPCR agonists...
  24. ncbi request reprint Synthetic responses in airway smooth muscle
    Peter H Howarth
    Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 114:S32-50. 2004
    ..Combinations of long-acting beta(2)-agonists and corticosteroids appear to have additive and/or synergistic effects in inhibiting inflammatory mediator release and the migration and proliferation of ASM cells...
  25. ncbi request reprint Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone
    Chien Da Huang
    Department of Thoracic Medicine II, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Respir Cell Mol Biol 28:330-8. 2003
    ..Moreover, IL-6 secretion by BK is sensitive to corticosteroids and is regulated by Th(2)-derived cytokines...
  26. ncbi request reprint G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells
    Chien Da Huang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 12:763-76. 2005
    ....
  27. ncbi request reprint Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats
    Omar Tliba
    Unité de Pathologie Aviaire et Parasitologie, INRA, Nouzilly, France
    Vet Res 33:327-32. 2002
    ..These results suggest that NK cells could be another source for the early production of IFNgamma but provide no evidence that these cells are involved in early events associated with granuloma formation...
  28. ncbi request reprint Early hepatic immune response in rats infected with Fasciola hepatica
    Omar Tliba
    Unité de Pathologie Aviaire et Parasitologie, INRA, Nouzilly, France
    Vet Res 33:261-70. 2002
    ..These findings suggested that, during the first 2 weeks of infection, F hepatica induced a transient ThO cytokine profile followed by downregulation of the cellular response and the induction of a Th2 cytokine profile...

Research Grants1

  1. Mechanism of inflammation-induced steroid resistance
    Omar Tliba; Fiscal Year: 2007
    ..We believe that our proposal is relevant to public health since improving the knowledge about the factors that lead to steroid resistance will help design new therapeutic agents or alternatives to treat steroid-resistant asthmatics. ..